VBIO

SEC source: 0001683168-26-007398 · ownership.xml · derivative · entry 1

Zikria Dean · CIK 0001877611 · Director · Interim CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: One fourth (1/4) of the Restricted Stock Units shall vest quarterly, with the first vesting occurring on December 22, 2026.

F2 · derivative.expiration_date: One fourth (1/4) of the Restricted Stock Units shall vest quarterly, with the first vesting occurring on December 22, 2026.

F3 · balance_after: These numbers have been adjusted to reflect the reverse stock split of the common stock of Valion Bio, Inc., which underwent a reverse stock split at a ratio of 1-for-25 on August 31, 2026.

SEC source: 0001683168-26-007396 · ownership.xml · derivative · entry 3

Wolf Lisa G · CIK 0001861556 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19

Underlying: Common Stock · 4 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F3 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F4 · balance_after: These numbers have been adjusted to reflect the reverse stock split of the Common Stock of Valion Bio, Inc., which underwent a reverse stock split at a ratio of 1-for-25 on August 31, 2026.

SEC source: 0001683168-26-007396 · ownership.xml · nonDerivative · entry 2

Wolf Lisa G · CIK 0001861556 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27

F2 · kind: The Reporting Person forfeited 2 shares of Common Stock upon vesting and settlement of 4 outstanding Restricted Stock Units to cover tax withholdings, using the market price of the Issuer's Common Stock at the time of forfeiture.

F4 · balance_after: These numbers have been adjusted to reflect the reverse stock split of the Common Stock of Valion Bio, Inc., which underwent a reverse stock split at a ratio of 1-for-25 on August 31, 2026.

SEC source: 0001683168-26-007396 · ownership.xml · nonDerivative · entry 1

Wolf Lisa G · CIK 0001861556 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F3 · balance_after: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-26-004970 · ownership.xml · derivative · entry 2

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 551

Underlying: Common Stock · 92 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F2 · derivative.expiration_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-26-004970 · ownership.xml · nonDerivative · entry 1

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 618

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

SEC source: 0001683168-26-004192 · ownership.xml · derivative · entry 2

Handley Michael K · CIK 0001451334 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,265

Underlying: Common Stock · 2,206 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of common stock.

F2 · derivative.exercise_date: Twenty percent (25%) of the grant of 35,294 Restricted Stock Units vested upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of twelve (12) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the fourth anniversary of the Vesting Commencement Date.

F2 · derivative.expiration_date: Twenty percent (25%) of the grant of 35,294 Restricted Stock Units vested upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of twelve (12) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001683168-26-004192 · ownership.xml · nonDerivative · entry 1

Handley Michael K · CIK 0001451334 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,030

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of common stock.

SEC source: 0001683168-26-003448 · ownership.xml · derivative · entry 1

Lackey Melinda · CIK 0001898184 · General Counsel & SVP of Legal

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2036-05-01

F1 · derivative.exercise_date: The stock option vests as follows: (i) 25% upon the first anniversary of the grant date, and (ii) the remaining 75% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-26-003073 · ownership.xml · nonDerivative · entry 1

Bolton Sheryle · CIK 0001418947 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

SEC source: 0001683168-26-002599 · ownership.xml · nonDerivative · entry 1

Valauri Christina Rizopoulos · CIK 0002005448 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

SEC source: 0001683168-26-002034 · ownership.xml · derivative · entry 2

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 643

Underlying: Common Stock · 92 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F3 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: Fifty percent (50%) of the Restricted Stock Units vested upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F2 · balance_after: These numbers have been adjusted to reflect the reverse stock split of the common stock of Tivic Health Systems, Inc., which underwent a reverse stock split at a ratio of 1-for-17 on March 7, 2025.

SEC source: 0001683168-26-002034 · ownership.xml · nonDerivative · entry 1

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 526

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · balance_after: These numbers have been adjusted to reflect the reverse stock split of the common stock of Tivic Health Systems, Inc., which underwent a reverse stock split at a ratio of 1-for-17 on March 7, 2025.

SEC source: 0001683168-26-001220 · ownership.xml · derivative · entry 2

Handley Michael K · CIK 0001451334 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,471

Underlying: Common Stock · 26,471 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: Twenty percent (25%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of twelve (12) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the fourth anniversary of the Vesting Commencement Date.

F2 · derivative.expiration_date: Twenty percent (25%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of twelve (12) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001683168-26-001220 · ownership.xml · nonDerivative · entry 1

Handley Michael K · CIK 0001451334 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,824

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

SEC source: 0001683168-25-009305 · ownership.xml · derivative · entry 3

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,706

Underlying: Common Stock · 14,706 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F3 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-25-009305 · ownership.xml · nonDerivative · entry 2

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,691

F2 · kind: The Reporting Person forfeited 5,262 shares of Common Stock upon vesting and settlement of 14,706 outstanding Restricted Stock Units to cover tax withholdings, using the market price of the Issuer's common stock at the time of forfeiture.

SEC source: 0001683168-25-009305 · ownership.xml · nonDerivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,953

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

SEC source: 0001683168-25-009306 · ownership.xml · derivative · entry 3

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 735

Underlying: Common Stock · 736 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F3 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the date of grant, December 18, 2024 (the "Vesting Commencement Date"), and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-25-009306 · ownership.xml · nonDerivative · entry 2

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 434

F2 · kind: The Reporting Person forfeited 302 shares of Common Stock upon vesting and settlement of 736 outstanding Restricted Stock Units to cover tax withholdings, using the market price of the Issuer's common stock at the time of forfeiture.

SEC source: 0001683168-25-009306 · ownership.xml · nonDerivative · entry 1

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 736

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit is convertible into one share of Common Stock.

SEC source: 0001683168-25-007223 · ownership.xml · nonDerivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,247

SEC source: 0001683168-25-005837 · ownership.xml · derivative · entry 1

Zikria Dean · CIK 0001877611 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests in a series of four (4) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the grant date, such that 100% of the stock option will be vested upon the first anniversary of the grant date.

SEC source: 0001683168-25-005835 · ownership.xml · derivative · entry 1

Valauri Christina Rizopoulos · CIK 0002005448 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests in a series of four (4) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the grant date, such that 100% of the stock option will be vested upon the first anniversary of the grant date.

SEC source: 0001683168-25-005833 · ownership.xml · derivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests as follows: (i) 50% upon the first anniversary of the grant date, and (ii) the remaining 50% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-005836 · ownership.xml · derivative · entry 1

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests as follows: (i) 50% upon the first anniversary of the grant date, and (ii) the remaining 50% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-005834 · ownership.xml · derivative · entry 1

Handley Michael K · CIK 0001451334 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests as follows: (i) 50% upon the first anniversary of the grant date, and (ii) the remaining 50% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-005832 · ownership.xml · derivative · entry 1

Bolton Sheryle · CIK 0001418947 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2035-08-05

F1 · derivative.exercise_date: The stock option vests in a series of four (4) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the grant date, such that 100% of the stock option will be vested upon the first anniversary of the grant date.

SEC source: 0001683168-25-006428 · ownership.xml · derivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: This Amendment No. 1 ("Form 4/A") to the Form 4 filed by the reporting person on August 8, 2025 (the "Original Form 4") is being filed to correct an administrative error, resulting in the incorrect vesting schedule for the stock option being included in the Original Form 4. As reflected in this Form 4/A, the stock option vests as follows: (i) 25% upon the first anniversary of the grant date, and (ii) the remaining 75% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-006430 · ownership.xml · derivative · entry 1

Wolf Lisa G · CIK 0001861556 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: This Amendment No. 1 ("Form 4/A") to the Form 4 filed by the reporting person on August 8, 2025 (the "Original Form 4") is being filed to correct an administrative error, resulting in the incorrect vesting schedule for the stock option being included in the Original Form 4. As reflected in this Form 4/A, the stock option vests as follows: (i) 25% upon the first anniversary of the grant date, and (ii) the remaining 75% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-006429 · ownership.xml · derivative · entry 1

Handley Michael K · CIK 0001451334 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2035-08-05

F1 · derivative.exercise_date: This Amendment No. 1 ("Form 4/A") to the Form 4 filed by the reporting person on August 8, 2025 (the "Original Form 4") is being filed to correct an administrative error, resulting in the incorrect vesting schedule for the stock option being included in the Original Form 4. As reflected in this Form 4/A, the stock option vests as follows: (i) 25% upon the first anniversary of the grant date, and (ii) the remaining 75% in a series of twelve (12) successive equal quarterly installments, rounded downward to the nearest whole share, measured from the first anniversary of the grant date, such that 100% of the stock option will be vested upon the fourth anniversary of the grant date.

SEC source: 0001683168-25-001207 · ownership.xml · derivative · entry 1

Handley Michael K · CIK 0001451334 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2035-02-17

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of common stock.

F2 · shares: Represents 600,000 restricted stock units granted to the Reporting Person outside of the Issuer's Amended and Restated 2021 Equity Incentive Plan (the "Plan"), in connection with, and as a material inducement to, the hiring and appointment of the Reporting Person as Chief Operating Officer of the Issuer.

F3 · derivative.exercise_date: Twenty percent (25%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of twelve (12) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008902 · ownership.xml · derivative · entry 1

Zikria Dean · CIK 0001877611 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2034-12-17

F1 · derivative.exercise_date: The Option Shares will vest and become exercisable in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, measured from the Vesting Commencement Date, such that 100% of the Option Shares will be vested and exercisable upon the first (1st) anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008897 · ownership.xml · derivative · entry 1

Valauri Christina Rizopoulos · CIK 0002005448 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2034-12-17

F1 · derivative.exercise_date: The Option Shares will vest and become exercisable in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, measured from the Vesting Commencement Date, such that 100% of the Option Shares will be vested and exercisable upon the first (1st) anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008900 · ownership.xml · derivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 500,000 shares

Expires 2034-12-17

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008899 · ownership.xml · derivative · entry 1

Wolf Lisa G · CIK 0001861556 · Interim CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2034-12-17

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008898 · ownership.xml · derivative · entry 1

Bolton Sheryle · CIK 0001418947 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-12-17

F1 · derivative.exercise_date: The Option Shares will vest and become exercisable in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, measured from the Vesting Commencement Date, such that 100% of the Option Shares will be vested and exercisable upon the first (1st) anniversary of the Vesting Commencement Date.

SEC source: 0001683168-24-008901 · ownership.xml · derivative · entry 1

Gurfein Blake · CIK 0001891888 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2034-12-17

F1 · derivative.exercise_price: Each Restricted Stock Unit is convertible into one share of Common Stock.

F2 · derivative.exercise_date: Fifty percent (50%) of the Restricted Stock Units will vest upon the one (1) year anniversary of the Vesting Commencement Date, and the balance of the Restricted Stock Units will be vested in a series of eight (8) successive equal quarterly installments measured from the first anniversary of the Vesting Commencement Date such that one hundred percent (100%) of the Restricted Stock Units shall have vested on the third anniversary of the Vesting Commencement Date.

SEC source: 0000950170-24-096479 · ownership.xml · derivative · entry 1

Zikria Dean · CIK 0001877611 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 3,000 shares

Expires 2034-08-08

F1 · derivative.exercise_date: The option vests in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, from the grant date, such that 100% of the option will be vested upon the first anniversary of the grant date.

SEC source: 0000950170-24-096483 · ownership.xml · derivative · entry 1

Valauri Christina Rizopoulos · CIK 0002005448 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 3,000 shares

Expires 2034-08-08

F1 · derivative.exercise_date: The option vests in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, from the grant date, such that 100% of the option will be vested upon the first anniversary of the grant date.

SEC source: 0000950170-24-096480 · ownership.xml · derivative · entry 1

Bolton Sheryle · CIK 0001418947 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 3,000 shares

Expires 2034-08-08

F1 · derivative.exercise_date: The option vests in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, from the grant date, such that 100% of the option will be vested upon the first anniversary of the grant date.

SEC source: 0000950170-24-096472 · ownership.xml · derivative · entry 1

Drexler Karen · CIK 0001504699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 3,000 shares

Expires 2034-08-08

F1 · derivative.exercise_date: The option vests in a series of twelve (12) successive equal monthly installments, rounded downward to the nearest whole share, from the grant date, such that 100% of the option will be vested upon the first anniversary of the grant date.

SEC source: 0000950170-24-035553 · ownership.xml · derivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-03-11

F1 · derivative.exercise_date: The option vests as follows: (i) 50% on the first anniversary of the grant date and (ii) the remaining 50% in 12 equal monthly installments over the 12 months thereafter.

SEC source: 0000950170-24-035557 · ownership.xml · nonDerivative · entry 1

Bambach Kimberly Ann · CIK 0001977203 · Interim CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

SEC source: 0000950170-24-035555 · ownership.xml · derivative · entry 1

Gurfein Blake · CIK 0001891888 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2034-03-11

F1 · derivative.exercise_date: The option vests as follows: (i) 50% on the first anniversary of the grant date and (ii) the remaining 50% in 12 equal monthly installments over the 12 months thereafter.

SEC source: 0000899243-23-015785 · doc4.xml · derivative · entry 1

Zikria Dean · CIK 0001877611 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-06-13

F1 · derivative.exercise_date: The option vests as follows: (i) 50% on the first anniversary of the grant date, (ii) 25% on the second anniversary of the grant date, and (iii) 25% on the third anniversary of the grant date.

SEC source: 0000899243-23-015784 · doc4.xml · derivative · entry 1

Bolton Sheryle · CIK 0001418947 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-06-13

F1 · derivative.exercise_date: The option vests as follows: (i) 50% on the first anniversary of the grant date, (ii) 25% on the second anniversary of the grant date, and (iii) 25% on the third anniversary of the grant date.

SEC source: 0000899243-23-015786 · doc4.xml · derivative · entry 1

Drexler Karen · CIK 0001504699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-06-13

F1 · derivative.exercise_date: The option vests as follows: (i) 50% on the first anniversary of the grant date, (ii) 25% on the second anniversary of the grant date, and (iii) 25% on the third anniversary of the grant date.

SEC source: 0000899243-23-012535 · doc4.xml · derivative · entry 1

Ernst Jennifer · CIK 0001889915 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2033-05-07

F1 · derivative.exercise_date: The option vests as follows: (i) 25% one year from the grant date, and (ii) the remaining 75% in equal monthly installments over the 36 months thereafter.

SEC source: 0000899243-23-012534 · doc4.xml · derivative · entry 1

Sabia Ryan · CIK 0001892415 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-05-07

F1 · derivative.exercise_date: The option vests as follows: (i) 25% one year from the grant date, and (ii) the remaining 75% in equal monthly installments over the 36 months thereafter.