VANI

SEC source: 0001615774-17-003028 · s106456_form4.xml · nonDerivative · entry 2

Greenberg Robert J. · CIK 0001625594 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 172,911

F1 · balance_after: 13,090 shares, acquired as part of scheduled ESPP purchases, were sold on 6/5/2017.

SEC source: 0001615774-17-002951 · s106448_form4.xml · nonDerivative · entry 1

LINK WILLIAM J PHD · CIK 0001228684 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,668

F1 · shares: Awarded to Mr. Link as compensation for serving on the Board of Directors and its committees.

F2 · price: Price per share constitutes an average closing price of Company's stock for the preceding twenty trading days on its principal exchange.

SEC source: 0001615774-17-002949 · s106447_form4.xml · nonDerivative · entry 1

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 19,440,948

F1 · shares: Awarded to Mr. Williams as compensation for serving on the Board of Directors and its committees.

F2 · price: Price per share constitutes an average closing price of Company's stock for the preceding twenty trading days on its principal exchange.

F3 · ownership.nature: Of which (i) Gregg Williams 2006 Trust, owns 13,581,826 shares and warrants to purchase 7,019,426 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001615774-17-002941 · s106449_form4.xml · nonDerivative · entry 1

PFEFFER MATTHEW J · CIK 0001192063 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,768

F1 · shares: Awarded to Mr. Pfeffer as compensation for serving on the Board of Directors and its committees.

F2 · price: Price per share constitutes an average closing price of Company's stock for the preceding twenty trading days on its principal exchange.

SEC source: 0001615774-17-002933 · s106450_form4.xml · nonDerivative · entry 1

Mendelsohn Aaron · CIK 0001625195 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,365

F1 · shares: Awarded to Mr. Mendelsohn as compensation for serving on the Board of Directors and its committees.

F2 · price: Price per share constitutes an average closing price of Company's stock for the preceding twenty trading days on its principal exchange.

SEC source: 0001615774-17-003028 · s106456_form4.xml · nonDerivative · entry 1

Greenberg Robert J. · CIK 0001625594 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 186,001

F1 · balance_after: 13,090 shares, acquired as part of scheduled ESPP purchases, were sold on 6/5/2017.

SEC source: 0001615774-17-002629 · s106296_form4.xml · derivative · entry 5

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 86,135

Underlying: Common Stock · 5,500 shares

Expires 2022-03-14

SEC source: 0001615774-17-002629 · s106296_form4.xml · derivative · entry 4

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,635

Underlying: Common Stock · 5,000 shares

Expires 2022-03-14

SEC source: 0001615774-17-002629 · s106296_form4.xml · derivative · entry 3

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,635

Underlying: Common Stock · 5,200 shares

Expires 2022-03-14

SEC source: 0001615774-17-002606 · s106170_form4.xml · derivative · entry 7

McGuire Jonathan Will · CIK 0001345539 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,875

Underlying: Common Stock · 190,000 shares

Expires 2019-08-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Company.

F5 · price: Not Applicable.

F3 · derivative.exercise_date: Options and RSUs vest over a 4 year term, with 25% vesting on the Date Exercisable as set forth in this Form 4 and thereafter vesting in 12 equal quarterly installments of 6.25%.

SEC source: 0001615774-17-002606 · s106170_form4.xml · nonDerivative · entry 2

McGuire Jonathan Will · CIK 0001345539 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,111

F2 · balance_after: 4,562 shares were sold to satisfy the tax withholding requirements on vesting of RSUs.

SEC source: 0001615774-17-002629 · s106296_form4.xml · derivative · entry 2

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,435

Underlying: Common Stock · 3,000 shares

Expires 2022-03-14

SEC source: 0001615774-17-002606 · s106170_form4.xml · nonDerivative · entry 1

McGuire Jonathan Will · CIK 0001345539 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,673

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: 11,875 shares of common stock acquired upon quarterly vesting of Restricted Stock Units (RSUs).

SEC source: 0001615774-17-001614 · s105841_form4.xml · derivative · entry 3

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 408,548

Underlying: COMMON STOCK · 168,548 shares

Expires 2018-02-28

F1 · kind: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F1 · shares: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F2 · ownership.nature: Of which (i) Gregg G. Williams 2006 Trust, owns 13,542,298 shares and warrants to purchase 7,019,426 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001615774-17-001614 · s105841_form4.xml · derivative · entry 2

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 263,078

Underlying: COMMON STOCK · 48,157 shares

Expires 2017-07-31

F1 · kind: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F1 · shares: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F2 · ownership.nature: Of which (i) Gregg G. Williams 2006 Trust, owns 13,542,298 shares and warrants to purchase 7,019,426 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001615774-17-001614 · s105841_form4.xml · nonDerivative · entry 1

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · .

Disclosed balance after: 19,384,634

F1 · kind: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F1 · shares: Gregg G. Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants in a private transaction.

F2 · ownership.nature: Of which (i) Gregg G. Williams 2006 Trust, owns 13,542,298 shares and warrants to purchase 7,019,426 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001209191-17-034536 · doc4.xml · derivative · entry 15

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 280,000 shares

Expires 2018-02-28

F14 · kind: Private sale to group of individual accredited private investors.

SEC source: 0001209191-17-034536 · doc4.xml · derivative · entry 14

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 80,000 shares

Expires 2017-07-31

F14 · kind: Private sale to group of individual accredited private investors.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 13

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F14 · kind: Private sale to group of individual accredited private investors.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 12

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 0

F14 · kind: Private sale to group of individual accredited private investors.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001615774-17-001110 · s105599_form4.xml · derivative · entry 2

PFEFFER MATTHEW J · CIK 0001192063 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,582

Underlying: Common Stock · 5,582 shares

Expires 2022-03-14

F1 · shares: Mr. Pfeffer acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · price: Mr. Pfeffer acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

SEC source: 0001615774-17-001110 · s105599_form4.xml · nonDerivative · entry 1

PFEFFER MATTHEW J · CIK 0001192063 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,043

F1 · shares: Mr. Pfeffer acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · price: Mr. Pfeffer acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

SEC source: 0001615774-17-001109 · s105598_form4.xml · derivative · entry 5

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 6,802,721

Underlying: COMMON STOCK · 6,802,721 shares

Expires 2022-03-14

F1 · shares: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · price: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F2 · ownership.nature: Of which (i) Gregg Williams 2006 Trust, owns 9,525,512 shares and warrants to purchase 6,802,721 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001615774-17-001109 · s105598_form4.xml · nonDerivative · entry 1

Williams Gregg · CIK 0001624919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 15,367,848

F1 · date: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · kind: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · shares: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F1 · price: Gregg Williams 2006 Trust, a trust of which Mr. Williams is trustee, acquired common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocations of units were confirmed on March 14, 2017.

F2 · ownership.nature: Of which (i) Gregg Williams 2006 Trust, owns 9,525,512 shares and warrants to purchase 6,802,721 shares, (ii) Williams International Co. LLC, whose manager is Mr. Williams, owns 1,484,254 shares and warrants to purchase 240,000 shares, and (iii) Sam Williams Family Investments LLC, whose manager is Mr. Williams, owns 4,358,082 shares and warrants to purchase 214,921 shares.

SEC source: 0001615774-17-001106 · s105585_form4.xml · derivative · entry 2

Cosendai Gregoire · CIK 0001625468 · VP of European Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,366

Underlying: Common Stock · 3,366 shares

Expires 2022-03-14

F1 · shares: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

F1 · price: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

SEC source: 0001615774-17-001106 · s105585_form4.xml · nonDerivative · entry 1

Cosendai Gregoire · CIK 0001625468 · VP of European Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,395

F1 · balance_after: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

SEC source: 0001615774-17-001101 · s105584_form4.xml · derivative · entry 2

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,794

Underlying: Common Stock · 6,794 shares

Expires 2022-03-14

F1 · shares: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

F1 · price: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

SEC source: 0001615774-17-001101 · s105584_form4.xml · nonDerivative · entry 1

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,798

SEC source: 0001615774-17-001104 · s105573_form4.xml · derivative · entry 2

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,435

Underlying: Common Stock · 67,435 shares

Expires 2022-03-14

F1 · shares: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

F1 · price: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

SEC source: 0001615774-17-001104 · s105573_form4.xml · nonDerivative · entry 1

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,354

F1 · balance_after: Common stock and warrants reported on this Form 4 pursuant to an exercise of subscription rights previously distributed by the Company to all holders of the Company's common stock. Each stockholder received a right to invest $0.47 for every share held of record on February 10, 2017, the record date, to purchase units consisting of one share of common stock and one warrant to purchase one share of common stock. The final allocation numbers of units were distributed on March 14, 2017.

SEC source: 0001615774-17-001042 · s105567_form4.xml · derivative · entry 6

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,750

Underlying: Common Stock · 190,000 shares

Expires 2019-08-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock of the Company.

F5 · price: Not Applicable.

F3 · derivative.exercise_date: Options and RSUs vest over a 4 year term, with 25% vesting on the date exercisable as set forth in this Form 4 and thereafter vesting in 12 equal quarterly installments of 6.25%.

SEC source: 0001615774-17-001042 · s105567_form4.xml · nonDerivative · entry 2

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,004

F2 · balance_after: 4,562 shares were sold to satisfy the tax withholding requirements on vesting of RSUs.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 11

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,426,571

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.35 to $1.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001615774-17-001042 · s105567_form4.xml · nonDerivative · entry 1

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,566

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: 11,875 shares of common stock acquired upon quarterly vesting of Restricted Stock Units (RSUs).

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 10

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,450,487

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.32 to $1.47, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 9

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,569,227

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.48 to $1.76, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 8

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,675,092

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.53 to $1.79, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 7

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,858,009

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.40 to $1.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 6

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 1,952,093

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.38 to $1.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 5

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 2,065,452

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.51 to $1.56, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 4

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 2,087,167

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.50 to $1.59, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 3

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 2,142,991

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.59 to $1.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 2

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 2,187,117

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.61 to $1.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001209191-17-034536 · doc4.xml · nonDerivative · entry 1

Alfred E. Mann Living Trust · CIK 0001678706 · 10% owner

Incumed, LLC · CIK 0001678708 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Incumed, LLC

Disclosed balance after: 2,226,145

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 14, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.62 to $1.72, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above.

F3 · ownership.nature: The Alfred E. Mann Living Trust is the sole manager and member of Incumed, LLC.

SEC source: 0001615774-17-000054 · s105065_form4.xml · derivative · entry 2

MILLER THOMAS B · CIK 0001236896 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 181,980

Underlying: Common Stock · 181,980 shares

Expires 2027-01-03

F2 · shares: Options to purchase 181,980 shares of the Company's common stock were granted to Mr. Miller under the Company's 2011 Equity Incentive Plan.

F5 · price: Not Applicable

F3 · derivative.exercise_date: Options vest over a four year term of which one-fourth vests on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.

SEC source: 0001615774-17-000052 · s105064_form4.xml · derivative · entry 2

McGuire Jonathan Will · CIK 0001345539 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 571,330

Underlying: Common Stock · 571,330 shares

Expires 2027-01-03

F2 · shares: Options to purchase 571,330 shares of the Company's common stock were granted to Mr. McGuire under the Company's 2011 Equity Incentive Plan.

F5 · price: Not Applicable.

F3 · derivative.exercise_date: Options and RSU vest over a four year term of which one-fourth vests on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.

SEC source: 0001615774-17-000048 · s105062_form4.xml · derivative · entry 2

Randolph Edward David · CIK 0001625133 · Vice President of Manufacturin

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 151,170

Underlying: Common Stock · 151,170 shares

Expires 2027-01-03

F2 · shares: Options to purchase 151,170 shares of the Company's common stock were granted to Mr. Randolph under the Company's 2011 Equity Incentive Plan.

F5 · price: Not Applicable.

F3 · derivative.exercise_date: Options vest over a four year term of which one-fourth vests on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.

SEC source: 0001615774-17-000050 · s105063_form4.xml · derivative · entry 2

Cosendai Gregoire · CIK 0001625468 · VP of European Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 228,190

Underlying: Common Stock · 228,190 shares

Expires 2027-01-03

F2 · shares: Options to purchase 228,190 shares of the Company's common stock were granted to Mr. Cosendai under the Company's 2011 Equity Incentive Plan.

F6 · price: Not Applicable

F3 · derivative.exercise_date: Options vest over a four year term of which one-fourth vest on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.

SEC source: 0001615774-17-000044 · s105060_form4.xml · derivative · entry 2

Greenberg Robert J. · CIK 0001625594 · Director · Chairman of Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 256,410

Underlying: Common Stock · 256,410 shares

Expires 2027-01-03

F1 · shares: Options to purchase 256,410 shares of the Company's common stock were granted to Dr. Greenberg under the Company's 2011 Equity Incentive Plan.

F5 · price: Not Applicable

F2 · derivative.exercise_date: Options vest over a four year term of which one-fourth vests on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.

SEC source: 0001615774-17-000046 · s105061_form4.xml · derivative · entry 2

OKLAND STEPHEN D · CIK 0001261287 · Commercial VP, North America

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,840

Underlying: Common Stock · 220,840 shares

Expires 2027-01-03

F2 · shares: Options to purchase 220,840 shares of the Company's common stock were granted to Mr. Okland under the Company's 2011 Equity Incentive Plan.

F4 · price: Not Applicable

F3 · derivative.exercise_date: Options vest over a four year term of which one-fourth vests on the Date Exercisable, with the remaining options vesting quarterly over three years thereafter.