URGN

SEC source: 0001437749-26-003778 · rdgdoc.xml · nonDerivative · entry 1

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,472

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-26-004638 · rdgdoc.xml · derivative · entry 1

Barrett Elizabeth A. · CIK 0001764157 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,195

Underlying: Ordinary Shares · 153,195 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F2 · derivative.exercise_date: 1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

F2 · derivative.expiration_date: 1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2027, January 31, 2028 and January 31, 2029.

SEC source: 0001437749-25-036576 · rdgdoc.xml · derivative · entry 2

Holden Stuart · CIK 0001763999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036576 · rdgdoc.xml · nonDerivative · entry 1

Holden Stuart · CIK 0001763999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036565 · rdgdoc.xml · derivative · entry 2

BUTITTA CYNTHIA M · CIK 0001222082 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036565 · rdgdoc.xml · nonDerivative · entry 1

BUTITTA CYNTHIA M · CIK 0001222082 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036559 · rdgdoc.xml · derivative · entry 2

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036559 · rdgdoc.xml · nonDerivative · entry 1

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036557 · rdgdoc.xml · derivative · entry 2

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036557 · rdgdoc.xml · nonDerivative · entry 1

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036555 · rdgdoc.xml · derivative · entry 2

Wildman Daniel George · CIK 0001952679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-036555 · rdgdoc.xml · nonDerivative · entry 1

Wildman Daniel George · CIK 0001952679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-035821 · rdgdoc.xml · nonDerivative · entry 1

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,025

F1 · kind: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c). Adoption date of referenced 10b5-1(c) plan is: 08-15-2025.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 and $25.02. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001437749-25-030772 · rdgdoc.xml · derivative · entry 3

Degnan Chris · CIK 0001741968 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,967

Underlying: Ordinary Shares · 4,483 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The reporting person was granted RSUs on October 8, 2024 representing 13,450 ordinary shares. The RSUs will vest in three equal annual installments from October 8, 2025.

F3 · derivative.expiration_date: The reporting person was granted RSUs on October 8, 2024 representing 13,450 ordinary shares. The RSUs will vest in three equal annual installments from October 8, 2025.

SEC source: 0001437749-25-030772 · rdgdoc.xml · nonDerivative · entry 2

Degnan Chris · CIK 0001741968 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,280

F2 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

SEC source: 0001437749-25-030772 · rdgdoc.xml · nonDerivative · entry 1

Degnan Chris · CIK 0001741968 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,483

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-25-028707 · rdgdoc.xml · nonDerivative · entry 2

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,025

F2 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

SEC source: 0001437749-25-028705 · rdgdoc.xml · nonDerivative · entry 2

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,305

F2 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

SEC source: 0001437749-25-028707 · rdgdoc.xml · derivative · entry 3

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,667

Underlying: Ordinary Shares · 1,667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The reporting person was granted RSUs on September 7, 2023 representing 5,000 ordinary shares. The RSUs will vest in three equal annual installments from September 7, 2024.

F3 · derivative.expiration_date: The reporting person was granted RSUs on September 7, 2023 representing 5,000 ordinary shares. The RSUs will vest in three equal annual installments from September 7, 2024.

SEC source: 0001437749-25-028707 · rdgdoc.xml · nonDerivative · entry 1

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,896

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-25-028705 · rdgdoc.xml · derivative · entry 3

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,334

Underlying: Ordinary Shares · 3,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The reporting person was granted RSUs on September 7, 2023 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from September 7, 2024.

F3 · derivative.expiration_date: The reporting person was granted RSUs on September 7, 2023 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from September 7, 2024.

SEC source: 0001437749-25-028705 · rdgdoc.xml · nonDerivative · entry 1

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,825

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-25-027880 · rdgdoc.xml · derivative · entry 2

Holden Stuart · CIK 0001763999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Ordinary Shares · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F3 · derivative.exercise_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

F3 · derivative.expiration_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027880 · rdgdoc.xml · derivative · entry 1

Holden Stuart · CIK 0001763999 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027883 · rdgdoc.xml · derivative · entry 2

Wildman Daniel George · CIK 0001952679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Ordinary Shares · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

F3 · derivative.expiration_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027883 · rdgdoc.xml · derivative · entry 1

Wildman Daniel George · CIK 0001952679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027882 · rdgdoc.xml · derivative · entry 2

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Ordinary Shares · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

F3 · derivative.expiration_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027882 · rdgdoc.xml · derivative · entry 1

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027879 · rdgdoc.xml · derivative · entry 2

BUTITTA CYNTHIA M · CIK 0001222082 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Ordinary Shares · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F3 · derivative.exercise_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

F3 · derivative.expiration_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027879 · rdgdoc.xml · derivative · entry 1

BUTITTA CYNTHIA M · CIK 0001222082 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027878 · rdgdoc.xml · derivative · entry 2

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Ordinary Shares · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

F3 · derivative.expiration_date: The shares underlying the RSUs will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027878 · rdgdoc.xml · derivative · entry 1

WEN LEANA · CIK 0001847598 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-027877 · rdgdoc.xml · derivative · entry 1

Belldegrun Arie · CIK 0001296549 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Ordinary Shares · 20,000 shares

Expires 2035-08-26

F1 · derivative.exercise_date: The shares underlying the stock option will vest in equal quarterly installments over a period of one year, subject to the director's Continuous Service (as defined in the 2017 Equity Incentive Plan) through such vesting dates.

SEC source: 0001437749-25-026377 · rdgdoc.xml · nonDerivative · entry 1

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,229

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.63 and $17.76. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001437749-25-023961 · rdgdoc.xml · nonDerivative · entry 2

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,229

F3 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of performance stock units.

SEC source: 0001437749-25-023961 · rdgdoc.xml · nonDerivative · entry 1

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 163,378

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Represents the settlement of performance stock units granted on January 31, 2024 that vested upon the achievement of a corporate milestone event.

F2 · price: Each performance stock unit represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-25-023969 · rdgdoc.xml · derivative · entry 1

Barrett Elizabeth A. · CIK 0001764157 · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,615

Underlying: Ordinary Shares · 87,615 shares

Expires not disclosed

F1 · derivative.exercise_price: Each performance stock unit represents a contingent right to receive one ordinary share of the Issuer.

F2 · derivative.exercise_date: Represents performance stock units ("PSUs") granted to the reporting person on January 31, 2024 that were earned upon the achievement of a corporate milestone event. These PSUs remain subject to continued service through December 31, 2025, at which time they will vest and settle in ordinary shares.

F2 · derivative.expiration_date: Represents performance stock units ("PSUs") granted to the reporting person on January 31, 2024 that were earned upon the achievement of a corporate milestone event. These PSUs remain subject to continued service through December 31, 2025, at which time they will vest and settle in ordinary shares.

SEC source: 0001437749-25-023963 · rdgdoc.xml · nonDerivative · entry 2

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,492

F3 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of performance stock units.

SEC source: 0001437749-25-023963 · rdgdoc.xml · nonDerivative · entry 1

Smith Jason Drew · CIK 0001821479 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,014

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Represents the settlement of performance stock units granted on January 31, 2024 that vested upon the achievement of a corporate milestone event.

F2 · price: Each performance stock unit represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-25-020045 · rdgdoc.xml · nonDerivative · entry 2

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,378

F2 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

SEC source: 0001437749-25-020045 · rdgdoc.xml · derivative · entry 3

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The reporting person was granted RSUs on June 8, 2023 representing 30,000 ordinary shares. The RSUs will vest in three equal annual installments from June 8, 2024.

F3 · derivative.expiration_date: The reporting person was granted RSUs on June 8, 2023 representing 30,000 ordinary shares. The RSUs will vest in three equal annual installments from June 8, 2024.

SEC source: 0001437749-25-020045 · rdgdoc.xml · nonDerivative · entry 1

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,540

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

SEC source: 0001437749-26-006124 · rdgdoc.xml · derivative · entry 2

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Ordinary Shares · 2,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.exercise_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

F1 · derivative.expiration_date: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-26-006124 · rdgdoc.xml · nonDerivative · entry 1

Robinson James A. Jr. · CIK 0001734295 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer

SEC source: 0001437749-25-002688 · rdgdoc.xml · derivative · entry 10

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Ordinary Shares · 20,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F6 · derivative.exercise_date: 1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2026, January 31, 2027 and January 31, 2028.

F6 · derivative.expiration_date: 1/3 of the shares underlying the restricted stock units will vest on each of January 31, 2026, January 31, 2027 and January 31, 2028.

SEC source: 0001437749-25-002688 · rdgdoc.xml · derivative · entry 9

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,667

Underlying: Ordinary Shares · 3,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F5 · derivative.exercise_date: The reporting person was granted RSUs on January 31, 2024 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2025.

F5 · derivative.expiration_date: The reporting person was granted RSUs on January 31, 2024 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2025.

SEC source: 0001437749-25-002688 · rdgdoc.xml · derivative · entry 8

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,334

Underlying: Ordinary Shares · 3,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F4 · derivative.exercise_date: The reporting person was granted RSUs on January 31, 2023 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2024.

F4 · derivative.expiration_date: The reporting person was granted RSUs on January 31, 2023 representing 10,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2024.

SEC source: 0001437749-25-002688 · rdgdoc.xml · derivative · entry 7

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,334 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.

F3 · derivative.exercise_date: The reporting person was granted RSUs on January 31, 2022 representing 4,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2023.

F3 · derivative.expiration_date: The reporting person was granted RSUs on January 31, 2022 representing 4,000 ordinary shares. The RSUs will vest in three equal annual installments from January 31, 2023.

SEC source: 0001437749-25-002688 · rdgdoc.xml · nonDerivative · entry 6

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,540

F2 · shares: Represents shares sold to satisfy withholding tax obligations upon the settlement of restricted stock units.

SEC source: 0001437749-25-002688 · rdgdoc.xml · nonDerivative · entry 5

Schoenberg Mark · CIK 0001763581 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,436

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one ordinary share of the Issuer.