TWST

SEC source: 0001214659-21-002318 · marketforms-51607.xml · nonDerivative · entry 2

Banyai William · CIK 0001753670 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 458,698

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on August 28, 2020.

F3 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $138.12 to $138.54 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002318 · marketforms-51607.xml · nonDerivative · entry 1

Banyai William · CIK 0001753670 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 459,432

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on August 28, 2020.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $137.12 to $137.99 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002317 · marketforms-51608.xml · nonDerivative · entry 1

Green Paula · CIK 0001753672 · SVP of Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,679

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on September 16, 2020.

SEC source: 0001214659-21-002316 · marketforms-51609.xml · nonDerivative · entry 1

Daniels Mark · CIK 0001753840 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,926

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on September 15, 2020.

SEC source: 0001214659-21-002302 · marketforms-51556.xml · nonDerivative · entry 1

Finn Patrick John · CIK 0001755970 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,183

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

F2 · balance_after: Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001214659-21-002300 · marketforms-51554.xml · nonDerivative · entry 1

THORBURN JAMES M · CIK 0001252038 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,290

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

F2 · balance_after: Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001214659-21-002301 · marketforms-51557.xml · nonDerivative · entry 1

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 315,556

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

F2 · balance_after: Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001214659-21-002299 · marketforms-51555.xml · nonDerivative · entry 1

Weiss Patrick · CIK 0001755793 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,719

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

SEC source: 0001214659-21-002298 · marketforms-51553.xml · nonDerivative · entry 1

Green Paula · CIK 0001753672 · SVP of Human Resources

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,171

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

F2 · balance_after: Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001214659-21-002297 · marketforms-51552.xml · nonDerivative · entry 1

Daniels Mark · CIK 0001753840 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,907

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

F2 · balance_after: Includes shares that were acquired under the Issuer's Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0001214659-21-002296 · marketforms-51551.xml · nonDerivative · entry 1

Banyai William · CIK 0001753670 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 461,262

F1 · shares: Represents shares withheld by the Issuer to satisfy the Reporting Person's tax withholding obligation in connection with the vesting of certain Restricted Stock Units ("RSUs") previously granted to the Reporting Person. Such withholding is exempt from Section 16(b) pursuant to Rule 16b-3(e).

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 6

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,188

F4 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $170.03 to $170.99 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 5

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,688

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 4

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,788

F3 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $167.62 to $167.90 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 3

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 319,088

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $166.60 to $167.48 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 2

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 319,688

SEC source: 0001214659-21-002031 · marketforms-51489.xml · nonDerivative · entry 1

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 319,788

F1 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $164.01 to $165.00 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001062993-21-007502 · form4.xml · nonDerivative · entry 7

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Keith L. Crandell Trust

Disclosed balance after: 97,253

F1 · kind: Pro-rata distribution of Common Stock held by a limited partnership to its partners for no consideration.

F5 · kind: Change in form of ownership of shares previously reported as beneficially owned by the reporting person.

SEC source: 0001062993-21-007502 · form4.xml · nonDerivative · entry 6

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By ARCH Venture Fund VIII Overage, L.P.

Disclosed balance after: 174,584

F1 · kind: Pro-rata distribution of Common Stock held by a limited partnership to its partners for no consideration.

F5 · kind: Change in form of ownership of shares previously reported as beneficially owned by the reporting person.

F3 · ownership.nature: The shares were directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). The sole general partner of ARCH Overage is ARCH Venture Partners VIII, LLC ("ARCH VIII LLC"), which may be deemed to be the beneficial owner of the shares held by ARCH Overage. ARCH VIII LLC disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

F4 · ownership.nature: Keith Crandell is a managing director of ARCH VII LLC and ARCH VIII LLC, and may be deemed to beneficially own the shares held by ARCH Fund VII and ARCH Overage. Mr. Crandell disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001062993-21-007502 · form4.xml · nonDerivative · entry 5

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Keith L. Crandell Trust

Disclosed balance after: 97,252

F1 · kind: Pro-rata distribution of Common Stock held by a limited partnership to its partners for no consideration.

F5 · kind: Change in form of ownership of shares previously reported as beneficially owned by the reporting person.

SEC source: 0001062993-21-007502 · form4.xml · nonDerivative · entry 4

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Arch Venture Fund VII, L.P.

Disclosed balance after: 440,354

F1 · kind: Pro-rata distribution of Common Stock held by a limited partnership to its partners for no consideration.

F5 · kind: Change in form of ownership of shares previously reported as beneficially owned by the reporting person.

F2 · ownership.nature: The shares were directly held by ARCH Venture Fund VII, L.P. ("ARCH Fund VII"). The sole general partner of ARCH Fund VII is ARCH Venture Partners VII, L.P. ("ARCH Partners VII"), which may be deemed to be the beneficial owner of the shares held by ARCH Fund VII. The sole general partner of ARCH Partners VII is ARCH Venture Partners VII, LLC ("ARCH VII LLC"), which may be deemed to be the beneficial owner of the shares held by ARCH Fund VII. ARCH Partners VII and ARCH VII LLC disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

F4 · ownership.nature: Keith Crandell is a managing director of ARCH VII LLC and ARCH VIII LLC, and may be deemed to beneficially own the shares held by ARCH Fund VII and ARCH Overage. Mr. Crandell disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001214659-21-001555 · marketforms-51451.xml · derivative · entry 3

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,573

Underlying: Common Stock · 5,000 shares

Expires 2029-10-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/3rd of the shares subject to the option vested and became exercisable on October 24, 2020 and each annual anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001555 · marketforms-51451.xml · nonDerivative · entry 2

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $177.22 to $178.07 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0001214659-21-001555 · marketforms-51451.xml · nonDerivative · entry 1

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,898

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 9

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 0

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 8

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 100

F9 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $180.08 to $181.06 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 7

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 2,506

F8 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $179.06 to $180.00 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 6

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 7,595

F7 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $178.05 to $179.03 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 5

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 14,615

F6 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $177.04 to $178.04 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 4

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 27,204

F5 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $176.03 to $177.03 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001554 · marketforms-51449.xml · nonDerivative · entry 3

Leproust Emily M. · CIK 0001753655 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 33,744

F4 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $175.00 to $175.98 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · ownership.nature: The Reporting Person disclaims beneficial ownership of such shares.

SEC source: 0001214659-21-001483 · marketforms-51443.xml · nonDerivative · entry 1

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,014

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on June 8, 2020.

SEC source: 0001214659-21-001443 · marketforms-51427.xml · derivative · entry 3

Daniels Mark · CIK 0001753840 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,354

Underlying: Common Stock · 668 shares

Expires 2028-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is immediately exercisable. 25% of the shares subject to the option vest on January 1, 2019, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001443 · marketforms-51427.xml · nonDerivative · entry 2

Daniels Mark · CIK 0001753840 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,200

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on September 15, 2020.

SEC source: 0001214659-21-001443 · marketforms-51427.xml · nonDerivative · entry 1

Daniels Mark · CIK 0001753840 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,868

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001214659-21-001428 · marketforms-51430.xml · derivative · entry 2

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001428 · marketforms-51430.xml · nonDerivative · entry 1

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001429 · marketforms-51431.xml · derivative · entry 2

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001429 · marketforms-51431.xml · nonDerivative · entry 1

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,720

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001427 · marketforms-51429.xml · derivative · entry 2

CHAN NELSON C · CIK 0001242653 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001427 · marketforms-51429.xml · nonDerivative · entry 1

CHAN NELSON C · CIK 0001242653 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,200

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001431 · marketforms-51433.xml · derivative · entry 2

JOHANNESSEN JAN · CIK 0001224168 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F2 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001431 · marketforms-51433.xml · nonDerivative · entry 1

JOHANNESSEN JAN · CIK 0001224168 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001432 · marketforms-51434.xml · derivative · entry 3

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F3 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001432 · marketforms-51434.xml · nonDerivative · entry 1

RAGUSA ROBERT P · CIK 0001222644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001430 · marketforms-51432.xml · derivative · entry 5

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 973

Underlying: Common Stock · 973 shares

Expires 2031-02-02

F5 · derivative.exercise_date: 100% of the shares subject to the option will vest and become exercisable on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001430 · marketforms-51432.xml · nonDerivative · entry 1

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,898

F1 · shares: Represents a restricted stock unit award (the "RSU Award") of which 100% vests on the earlier of (i) the one-year anniversary of the date of grant and (ii) the date of the Issuer's first annual meeting of stockholders following the date of grant, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001271 · marketforms-51368.xml · derivative · entry 7

Finn Patrick John · CIK 0001755970 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,302

Underlying: Common Stock · 827 shares

Expires 2029-10-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 25% of the shares subject to the option vested and became exercisable on October 24, 2020, and 1/48th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001271 · marketforms-51368.xml · derivative · entry 6

Finn Patrick John · CIK 0001755970 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,061

Underlying: Common Stock · 1,517 shares

Expires 2028-11-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 20% of the shares subject to the option vested and became exercisable on October 31, 2019, and 1/60th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0001214659-21-001271 · marketforms-51368.xml · derivative · entry 5

Finn Patrick John · CIK 0001755970 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,131

Underlying: Common Stock · 358 shares

Expires 2027-09-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is immediately exercisable. 10% of the shares subject to the option vested on September 28, 2017, 15% of the shares subject to the option vest on September 28, 2018, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date.