TRXB

SEC source: 0001193125-26-420734 · ownership.xml · derivative · entry 2

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 41,871 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On October 13, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 3.8649-to-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On October 13, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 3.8649-to-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On October 13, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 3.8649-to-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001193125-26-420734 · ownership.xml · nonDerivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: On October 13, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a 3.8649-to-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001829126-26-011084 · ownership.xml · derivative · entry 12

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Trex Coinvestment, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 669,939 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.exercise_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.expiration_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F3 · ownership.nature: The shares are held directly by SV Trex Coinvestment, L.P. ("SV Coinvestment"). GP LP is the general partner of SV Coinvestment, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Coinvestment are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · derivative · entry 11

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI Strategic Partners, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 16,277 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.exercise_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.expiration_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F2 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SV Strategic Partners VI"). GP LP is the general partner of SV Strategic Partners VI, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Strategic Partners VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · derivative · entry 10

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI Strategic Partners, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 53,892 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.exercise_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.expiration_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F2 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SV Strategic Partners VI"). GP LP is the general partner of SV Strategic Partners VI, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Strategic Partners VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · derivative · entry 9

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 475,411 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.exercise_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.expiration_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F1 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI, L.P. ("SV Fund VI"). SV Life Sciences Fund VI (GP), L.P. (the "GP LP") is the general partner of SV Fund VI, and SVLSF VI, LLC ("SVLSF") is the general partner of GP LP. Investment and voting decisions of SV Fund VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · derivative · entry 8

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI, L.P.

Disclosed balance after: 0

Underlying: Common Stock · 1,574,074 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.exercise_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F4 · derivative.expiration_date: On October 13, 2026, 3.8649 shares of preferred stock automatically converted into one share of common stock upon the closing of the issuer's initial public offering, for no additional consideration. The preferred stock has no expiration date.

F1 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI, L.P. ("SV Fund VI"). SV Life Sciences Fund VI (GP), L.P. (the "GP LP") is the general partner of SV Fund VI, and SVLSF VI, LLC ("SVLSF") is the general partner of GP LP. Investment and voting decisions of SV Fund VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 7

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Trex Coinvestment, L.P.

Disclosed balance after: 669,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · ownership.nature: The shares are held directly by SV Trex Coinvestment, L.P. ("SV Coinvestment"). GP LP is the general partner of SV Coinvestment, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Coinvestment are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 6

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI Strategic Partners, L.P.

Disclosed balance after: 77,525

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SV Strategic Partners VI"). GP LP is the general partner of SV Strategic Partners VI, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Strategic Partners VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 5

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI Strategic Partners, L.P.

Disclosed balance after: 61,248

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SV Strategic Partners VI"). GP LP is the general partner of SV Strategic Partners VI, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Strategic Partners VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 3

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI, L.P.

Disclosed balance after: 2,264,354

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI, L.P. ("SV Fund VI"). SV Life Sciences Fund VI (GP), L.P. (the "GP LP") is the general partner of SV Fund VI, and SVLSF VI, LLC ("SVLSF") is the general partner of GP LP. Investment and voting decisions of SV Fund VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 2

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI, L.P.

Disclosed balance after: 1,788,943

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI, L.P. ("SV Fund VI"). SV Life Sciences Fund VI (GP), L.P. (the "GP LP") is the general partner of SV Fund VI, and SVLSF VI, LLC ("SVLSF") is the general partner of GP LP. Investment and voting decisions of SV Fund VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 4

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI Strategic Partners, L.P.

Disclosed balance after: 7,356

F2 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI Strategic Partners, L.P. ("SV Strategic Partners VI"). GP LP is the general partner of SV Strategic Partners VI, and SVLSF is the general partner of GP LP. Investment and voting decisions of SV Strategic Partners VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

F6 · ownership.nature: Represents shares purchased by SV Strategic Partners VI in the issuer's initial public offering.

SEC source: 0001829126-26-011084 · ownership.xml · nonDerivative · entry 1

SVLSF VI, LLC · CIK 0001717728 · 10% owner

SV Life Sciences Fund VI (GP), L.P. · CIK 0001717730 · 10% owner

SV Life Sciences Fund VI, L.P. · CIK 0001642251 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By SV Life Sciences Fund VI, L.P.

Disclosed balance after: 214,869

F1 · ownership.nature: The shares are held directly by SV Life Sciences Fund VI, L.P. ("SV Fund VI"). SV Life Sciences Fund VI (GP), L.P. (the "GP LP") is the general partner of SV Fund VI, and SVLSF VI, LLC ("SVLSF") is the general partner of GP LP. Investment and voting decisions of SV Fund VI are made by the investment committee of SVLSF. Each of GP LP and SVLSF disclaims beneficial ownership except to the extent of its pecuniary interest, and this report is not an admission of beneficial ownership for any other purpose.

F5 · ownership.nature: Represents shares purchased by SV Fund VI in the issuer's initial public offering.

SEC source: 0001193125-26-418302 · ownership.xml · derivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.

SEC source: 0001193125-26-418298 · ownership.xml · derivative · entry 1

Coy Travis Alan · CIK 0001969524 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.

SEC source: 0001193125-26-418296 · ownership.xml · derivative · entry 1

Ross Michael Jay · CIK 0001254452 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.

SEC source: 0001193125-26-418293 · ownership.xml · derivative · entry 1

Hirth Peter · CIK 0001813780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.

SEC source: 0001193125-26-418292 · ownership.xml · derivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.

SEC source: 0001193125-26-418291 · ownership.xml · derivative · entry 1

Gilmore Julie Ann · CIK 0002155359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2036-10-08

F1 · derivative.exercise_date: The option vests in full on October 8, 2027, subject to the reporting person's continued service through such date.