TNGX

SEC source: 0000950170-24-012991 · ownership.xml · nonDerivative · entry 2

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,478

F1 · kind: The Issuer has adopted a "sell-to-cover" policy to satisfy the tax withholding obligations of the Reporting Person. The sales reported on this Form 4 represent the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F3 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $12.43 to $12.77 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0000950170-24-012999 · ownership.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,539,624

F1 · kind: The Issuer has adopted a "sell-to-cover" policy to satisfy the tax withholding obligations of the Reporting Person. The sales reported on this Form 4 represent the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $12.22 to $12.83 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0000950170-24-012997 · ownership.xml · nonDerivative · entry 1

Barry Douglas · CIK 0001890662 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,335

F1 · kind: The Issuer has adopted a "sell-to-cover" policy to satisfy the tax withholding obligations of the Reporting Person. The sales reported on this Form 4 represent the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $12.22 to $12.83 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0000950170-24-012996 · ownership.xml · nonDerivative · entry 1

Beckman Daniella · CIK 0001513422 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 134,214

F1 · kind: The Issuer has adopted a "sell-to-cover" policy to satisfy the tax withholding obligations of the Reporting Person. The sales reported on this Form 4 represent the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $12.22 to $12.83 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0000950170-24-012991 · ownership.xml · nonDerivative · entry 1

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 123,561

F1 · kind: The Issuer has adopted a "sell-to-cover" policy to satisfy the tax withholding obligations of the Reporting Person. The sales reported on this Form 4 represent the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. Such sales were automatic and not at the discretion of the Reporting Person.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $12.22 to $12.83 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

SEC source: 0000950170-24-011263 · ownership.xml · derivative · entry 2

Beckman Daniella · CIK 0001513422 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 236,475

Underlying: Common Stock · 236,475 shares

Expires 2034-02-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2025, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000950170-24-011263 · ownership.xml · nonDerivative · entry 1

Beckman Daniella · CIK 0001513422 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,413

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 3, 2025, 1/3 on February 2, 2026 and 1/3 on February 1, 2027, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000950170-24-011257 · ownership.xml · derivative · entry 2

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 279,593

Underlying: Common Stock · 279,593 shares

Expires 2034-02-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2025, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000950170-24-011257 · ownership.xml · nonDerivative · entry 1

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,599

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 3, 2025, 1/3 on February 2, 2026 and 1/3 on February 1, 2027, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000950170-24-011253 · ownership.xml · derivative · entry 2

Weber Barbara · CIK 0001800670 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 523,012

Underlying: Common Stock · 523,012 shares

Expires 2034-02-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2025, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000950170-24-011253 · ownership.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,168

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 3, 2025, 1/3 on February 2, 2026 and 1/3 on February 1, 2027, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000950170-24-011248 · ownership.xml · derivative · entry 2

Barry Douglas · CIK 0001890662 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,156

Underlying: Common Stock · 137,156 shares

Expires 2034-02-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2025, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000950170-24-011248 · ownership.xml · nonDerivative · entry 1

Barry Douglas · CIK 0001890662 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,859

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 3, 2025, 1/3 on February 2, 2026 and 1/3 on February 1, 2027, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000950170-23-058314 · ownership.xml · nonDerivative · entry 1

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,250

F1 · shares: Includes 7,507 shares that were acquired on October 31, 2023 pursuant to the Tango Therapeutics, Inc. 2021 Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0000895345-23-000589 · form4.xml · nonDerivative · entry 2

Boxer Capital, LLC · CIK 0001465837 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,198,642

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.54 to $7.01, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F3 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000588 · form4.xml · nonDerivative · entry 2

Boxer Capital, LLC · CIK 0001465837 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,198,642

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.54 to $7.01, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F3 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000589 · form4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,698,642

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.95 to $7.10, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F3 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000588 · form4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,698,642

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.95 to $7.10, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F3 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000574 · form4.xml · nonDerivative · entry 2

Boxer Capital, LLC · CIK 0001465837 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,948,642

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.6943 to $10.1829, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F4 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000574 · form4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 693,524

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $ 9.6500 to $9.9800, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F2 · ownership.nature: These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000950170-23-045783 · ownership.xml · derivative · entry 2

Ketchum John B · CIK 0001991806 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2033-08-29

F2 · derivative.exercise_date: This option shall vest and become exercisable in 36 substantially equal monthly installments over a period of three years beginning on August 29, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000950170-23-045783 · ownership.xml · nonDerivative · entry 1

Ketchum John B · CIK 0001991806 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in three substantially equal annual installments on each of August 19, 2024, August 18, 2025 and August 17, 2026, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000895345-23-000498 · form4.xml · derivative · entry 6

Boxer Capital, LLC · CIK 0001465837 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,340,597

Underlying: Common Stock · 2,340,579 shares

Expires not disclosed

F6 · derivative.exercise_price: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F6 · derivative.exercise_date: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F6 · derivative.expiration_date: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F2 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000498 · form4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · See remarks

LEWIS JOSEPH · CIK 0001015747 · See remarks

MVA Investors, LLC · CIK 0001468223 · See remarks

Davis Aaron I. · CIK 0001465914 · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 743,542

F1 · ownership.direct: These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

F1 · ownership.nature: These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000573 · form4.xml · derivative · entry 6

Boxer Capital, LLC · CIK 0001465837 · Director · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · Director · See remarks

LEWIS JOSEPH · CIK 0001015747 · Director · See remarks

MVA Investors, LLC · CIK 0001468223 · Director · See remarks

Davis Aaron I. · CIK 0001465914 · Director · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,340,579

Underlying: Common Stock · 2,340,579 shares

Expires not disclosed

F6 · derivative.exercise_price: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F6 · derivative.exercise_date: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F6 · derivative.expiration_date: The prefunded warrants have an exercise price of $0.001 per share of Common Stock and are immediately exercisable and remain exercisable until exercised in full, subject to a 9.99% beneficial ownership limitation which may be increased or decreased by the holder upon 61 days' notice to the Issuer.

F2 · ownership.direct: These securities are owned directly by Boxer Capital, LLC ("Boxer Capital"). Boxer Asset Management Inc. is the managing member of Boxer Capital. Joseph Lewis is the sole indirect owner of Boxer Asset Management Inc. Mr. Davis is a member of Boxer Capital. Each reporting person other than Boxer Capital disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000895345-23-000573 · form4.xml · nonDerivative · entry 1

Boxer Capital, LLC · CIK 0001465837 · Director · See remarks

Boxer Asset Management Inc. · CIK 0001465836 · Director · See remarks

LEWIS JOSEPH · CIK 0001015747 · Director · See remarks

MVA Investors, LLC · CIK 0001468223 · Director · See remarks

Davis Aaron I. · CIK 0001465914 · Director · See remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 743,542

F1 · ownership.direct: These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

F1 · ownership.nature: These securities are owned directly by MVA Investors, LLC ("MVA Investors"). Aaron I. Davis is a member of and has voting and dispositive power over securities held by MVA Investors. Each reporting person other than MVA Investors disclaims beneficial ownership of these securities except to the extent of such person's pecuniary interest therein, if any.

SEC source: 0000899243-23-015020 · doc4.xml · derivative · entry 2

Rothenberg Mace · CIK 0001873988 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-06

F2 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015020 · doc4.xml · nonDerivative · entry 1

Rothenberg Mace · CIK 0001873988 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015016 · doc4.xml · derivative · entry 2

Borisy Alexis · CIK 0001319446 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-06

F2 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015016 · doc4.xml · nonDerivative · entry 1

Borisy Alexis · CIK 0001319446 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015019 · doc4.xml · derivative · entry 2

Calhoun Lesley Ann · CIK 0001730866 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-06

F2 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015019 · doc4.xml · nonDerivative · entry 1

Calhoun Lesley Ann · CIK 0001730866 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015015 · doc4.xml · derivative · entry 2

Huber Reid M · CIK 0001607052 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-06

F2 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015015 · doc4.xml · nonDerivative · entry 1

Huber Reid M · CIK 0001607052 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015014 · doc4.xml · derivative · entry 2

Peters Malte · CIK 0001876563 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-06-06

F2 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015014 · doc4.xml · nonDerivative · entry 1

Peters Malte · CIK 0001876563 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015012 · doc4.xml · derivative · entry 5

Davis Aaron I. · CIK 0001465914 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2023-06-06

F5 · derivative.exercise_date: This option shall vest and become exercisable in 12 substantially equal monthly installments over a period of one year beginning on July 6, 2023, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-015012 · doc4.xml · nonDerivative · entry 1

Davis Aaron I. · CIK 0001465914 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest in its entirety on the earlier of: (i) June 6, 2024 and (ii) the date of the next annual meeting of stockholders, subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-006728 · doc4.xml · derivative · entry 2

Huang Alan · CIK 0001877364 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,181

Underlying: Common Stock · 190,181 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-006728 · doc4.xml · nonDerivative · entry 1

Huang Alan · CIK 0001877364 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 167,584

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-006736 · doc4.xml · derivative · entry 2

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 487,500

Underlying: Common Stock · 487,500 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on February 27, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-006736 · doc4.xml · nonDerivative · entry 1

Crystal Adam · CIK 0001825445 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,250

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-006735 · doc4.xml · derivative · entry 2

Weber Barbara · CIK 0001800670 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 537,273

Underlying: Common Stock · 537,273 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-006735 · doc4.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,457,137

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-006733 · doc4.xml · derivative · entry 2

Beckman Daniella · CIK 0001513422 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197,051

Underlying: Common Stock · 197,051 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-006733 · doc4.xml · nonDerivative · entry 1

Beckman Daniella · CIK 0001513422 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,709

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-23-006732 · doc4.xml · derivative · entry 2

Barry Douglas · CIK 0001890662 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,391

Underlying: Common Stock · 143,391 shares

Expires 2033-03-01

F2 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on January 1, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-006732 · doc4.xml · nonDerivative · entry 1

Barry Douglas · CIK 0001890662 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,898

F1 · shares: These shares are represented by restricted stock units (the "RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. The RSUs will vest over a three year period at a rate of 1/3 on February 5, 2024, 1/3 on February 3, 2025 and 1/3 on February 2, 2026 subject to the Reporting Person's continuous service with the Issuer as of each such vesting date.

SEC source: 0000899243-22-037607 · doc4.xml · derivative · entry 1

Weitzman Aaron · CIK 0001952088 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2032-12-01

F1 · derivative.exercise_date: This option shall vest and become exercisable over a four-year period, at a rate of 25% on December 1, 2023, with the remaining option shares vesting in 36 equal monthly installments thereafter.

SEC source: 0000899243-22-033595 · doc4.xml · nonDerivative · entry 3

Boxer Capital, LLC · CIK 0001465837 · 10% owner

Boxer Asset Management Inc. · CIK 0001465836 · 10% owner

LEWIS JOSEPH · CIK 0001015747 · 10% owner

MVA Investors, LLC · CIK 0001468223 · 10% owner

Davis Aaron I. · CIK 0001465914 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,123,642

F2 · ownership.direct: These securities are owned directly by Boxer Capital. Each member of the Boxer Group other than Boxer Capital disclaims beneficial ownership of these securities to the extent it or he does not have a pecuniary interest therein.