STTK

SEC source: 0000950170-24-004670 · ownership.xml · derivative · entry 2

Shukla Abhinav A. · CIK 0001923377 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,850

Underlying: Common Stock · 66,850 shares

Expires 2034-01-10

F3 · derivative.exercise_date: This option represents a right to purchase a total of 66,850 shares of the Issuer's common stock, one quarter of which will vest on January 10, 2025, with the remaining three quarters vesting in equal monthly installments through January 10, 2028, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-24-004670 · ownership.xml · nonDerivative · entry 1

Shukla Abhinav A. · CIK 0001923377 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,717

F1 · shares: Consists of 33,425 restricted stock units, which will vest in four equal annual installments beginning on January 10, 2025, subject to the Reporting Person's continued service to the Issuer.

F2 · balance_after: Includes 600 shares acquired by the Reporting Person under the Issuer's 2020 Employee Stock Purchase Plan on each of February 14, 2023 and August 14, 2023.

SEC source: 0000950170-24-004656 · ownership.xml · derivative · entry 4

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,000

Underlying: Common Stock · 113,000 shares

Expires 2034-01-10

F2 · derivative.exercise_date: This option represents a right to purchase a total of 113,000 shares of the Issuer's common stock, one quarter of which will vest on January 10, 2025, with the remaining three quarters vesting in equal monthly installments through January 10, 2028, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-24-004656 · ownership.xml · nonDerivative · entry 3

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,446

SEC source: 0000950170-24-004656 · ownership.xml · nonDerivative · entry 2

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 198,446

SEC source: 0000950170-24-004656 · ownership.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 200,916

F1 · shares: Consists of 56,500 restricted stock units, which will vest in four equal annual installments beginning on January 10, 2025, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-23-129340 · tm2333671-2_4seq1.xml · derivative · entry 1

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 3,100,823

Underlying: Common Stock · 3,100,823 shares

Expires not disclosed

F1 · security: On December 21, 2023, the Issuer entered into a securities purchase agreement (the "Purchase Agreement") with certain private investment vehicles and sub-advised accounts managed by Redmile Group, LLC (collectively, the "Redmile Funds"). Pursuant to the terms of the Purchase Agreement, the Issuer in a private placement, which closed on the second trading day following the date of the Purchase Agreement, issued and sold to the Redmile Funds pre-funded warrants (the "Warrants") to purchase up to an aggregate of 3,100,823 shares of the Issuer's common stock (the "Warrant Shares") at a purchase price per share equal to $6.4499, which represents the offering price per share of the Common Stock less the exercise price per share of $0.0001.

F2 · price: The Warrants are exercisable by the Redmile Funds at any time on or after the original issuance date of the Purchase Agreement until fully exercised at an exercise price per share equal to $0.0001, subject to a 9.99% beneficial ownership blocker. The Warrants have no expiration date.

F2 · derivative.exercise_date: The Warrants are exercisable by the Redmile Funds at any time on or after the original issuance date of the Purchase Agreement until fully exercised at an exercise price per share equal to $0.0001, subject to a 9.99% beneficial ownership blocker. The Warrants have no expiration date.

F2 · derivative.expiration_date: The Warrants are exercisable by the Redmile Funds at any time on or after the original issuance date of the Purchase Agreement until fully exercised at an exercise price per share equal to $0.0001, subject to a 9.99% beneficial ownership blocker. The Warrants have no expiration date.

F3 · ownership.nature: These securities may be deemed beneficially owned by Redmile Group, LLC ("Redmile") as investment manager of the Redmile Funds. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile (collectively with Redmile, the "Reporting Persons"). Each of the Reporting Persons disclaims beneficial ownership of the reported securities except to the extent of its or his pecuniary interest therein. This report shall not be deemed an admission that the Reporting Persons are a beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

SEC source: 0000950170-23-025368 · ownership.xml · derivative · entry 1

Brownstein Carrie · CIK 0001894232 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents the right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-23-025380 · ownership.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents the right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-23-066721 · tm2317377-2_4seq1.xml · derivative · entry 1

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to Mr. Michael Lee's continued service to the Issuer through such date.

F2 · ownership.nature: The stock option was granted to Mr. Lee, a managing director of Redmile Group, LLC ("Redmile"), in connection with his service as a member of the Board of Directors of the Issuer. Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.nature: Mr. Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000950170-23-025373 · ownership.xml · derivative · entry 1

Gibson Neil W · CIK 0001555918 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents the right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-23-025375 · ownership.xml · derivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2023-05-26

F1 · derivative.exercise_date: This option represents the right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-23-066719 · tm2317377-1_4seq1.xml · derivative · entry 1

Lee Michael Stewart · CIK 0001748010 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of (i) the one-year anniversary of the grant date or (ii) immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer through such date.

F2 · ownership.direct: The stock option was granted to Mr. Lee in connection with his service as a member of the Board of Directors of the Issuer. Mr. Lee, a managing director of Redmile Group, LLC ("Redmile"), was elected to the board of the Issuer as a representative of Redmile. Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.direct: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.direct: Mr. Lee was elected to the board of directors of the Issuer as a representative of Redmile. As a result, Redmile and Mr. Green are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000950170-23-025365 · ownership.xml · derivative · entry 1

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2033-05-26

F1 · derivative.exercise_date: This option represents the right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-23-021768 · ownership.xml · derivative · entry 2

Stout Stephen · CIK 0001970664 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,800

Underlying: Common Stock · 31,800 shares

Expires 2033-05-10

F2 · derivative.exercise_date: This option represents a right to purchase a total of 31,800 shares of the Issuer's common stock, one quarter of which will vest on May 10, 2024, with the remaining three quarters vesting in equal monthly installments through May 10, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-23-021768 · ownership.xml · nonDerivative · entry 1

Stout Stephen · CIK 0001970664 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,875

F1 · shares: Consists of 15,900 restricted stock units, which will vest in four equal annual installments beginning on May 10, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002884 · doc4.xml · derivative · entry 2

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,750

Underlying: Common Stock · 69,750 shares

Expires 2033-01-25

F2 · derivative.exercise_date: This option represents a right to purchase a total of 69,750 shares of the Issuer's common stock, one quarter of which will vest on January 25, 2024, with the remaining three quarters vesting in equal monthly installments through January 25, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002884 · doc4.xml · nonDerivative · entry 1

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,792

F1 · shares: Consists of 37,875 restricted stock units, which will vest in four equal annual installments beginning on January 25, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002880 · doc4.xml · derivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,050

Underlying: Common Stock · 165,050 shares

Expires 2033-01-25

F1 · derivative.exercise_date: This option represents the right to purchase a total of 165,050 shares of the Issuer's common stock, and will vest upon the Issuer's common stock achieving specified share prices during the four years following the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002883 · doc4.xml · derivative · entry 2

DeYoung Casi · CIK 0001652066 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,200

Underlying: Common Stock · 54,200 shares

Expires 2033-01-25

F2 · derivative.exercise_date: This option represents a right to purchase a total of 54,200 shares of the Issuer's common stock, one quarter of which will vest on January 25, 2024, with the remaining three quarters vesting in equal monthly installments through January 25, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002883 · doc4.xml · nonDerivative · entry 1

DeYoung Casi · CIK 0001652066 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,880

F1 · shares: Consists of 27,100 restricted stock units, which will vest in four equal annual installments beginning on January 25, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002890 · doc4.xml · derivative · entry 2

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,850

Underlying: Common Stock · 69,850 shares

Expires 2033-01-25

F2 · derivative.exercise_date: This option represents a right to purchase a total of 69,850 shares of the Issuer's common stock, one quarter of which will vest on January 25, 2024, with the remaining three quarters vesting in equal monthly installments through January 25, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002890 · doc4.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 144,416

F1 · shares: Consists of 34,925 restricted stock units, which will vest in four equal annual installments beginning on January 25, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002889 · doc4.xml · derivative · entry 2

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,250

Underlying: Common Stock · 48,250 shares

Expires 2033-01-25

F2 · derivative.exercise_date: This option represents a right to purchase a total of 48,250 shares of the Issuer's common stock, one quarter of which will vest on January 25, 2024, with the remaining three quarters vesting in equal monthly installments through January 25, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002889 · doc4.xml · nonDerivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,209

F1 · shares: Consists of 24,125 restricted stock units, which will vest in four equal annual installments beginning on January 25, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002887 · doc4.xml · derivative · entry 2

Shukla Abhinav A. · CIK 0001923377 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,200

Underlying: Common Stock · 52,200 shares

Expires 2033-01-25

F2 · derivative.exercise_date: This option represents a right to purchase a total of 52,200 shares of the Issuer's common stock, one quarter of which will vest on January 25, 2024, with the remaining three quarters vesting in equal monthly installments through January 25, 2027, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-002887 · doc4.xml · nonDerivative · entry 1

Shukla Abhinav A. · CIK 0001923377 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,092

F1 · shares: Consists of 26,100 restricted stock units, which will vest in four equal annual installments beginning on January 25, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-23-001683 · doc4.xml · nonDerivative · entry 1

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,917

SEC source: 0000899243-23-001684 · doc4.xml · nonDerivative · entry 1

DeYoung Casi · CIK 0001652066 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,780

SEC source: 0000899243-23-001682 · doc4.xml · nonDerivative · entry 1

Shukla Abhinav A. · CIK 0001923377 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,992

F1 · balance_after: Includes 600 shares acquired by the Reporting Person under the Issuer's 2020 Employee Stock Purchase Plan on August 14, 2022.

SEC source: 0000899243-22-021924 · doc4.xml · derivative · entry 1

Brownstein Carrie · CIK 0001894232 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-021923 · doc4.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-22-070289 · tm2218131-2_4.xml · derivative · entry 1

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: ) This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to Mr. Michael Lee's continued service to the Issuer through such date.

F2 · ownership.nature: The stock option was granted to Mr. Lee, a managing director of Redmile Group, LLC ("Redmile"), in connection with his service as a member of the Board of Directors of the Issuer. Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.nature: Mr. Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-22-021922 · doc4.xml · derivative · entry 1

Gibson Neil W · CIK 0001555918 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-021918 · doc4.xml · derivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-22-070287 · tm2218131-1_4.xml · derivative · entry 1

Lee Michael Stewart · CIK 0001748010 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of (i) the one-year anniversary of the grant date or (ii) immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer through such date.

F2 · ownership.direct: The stock option was granted to Mr. Lee in connection with his service as a member of the Board of Directors of the Issuer. Mr. Lee, a managing director of Redmile Group, LLC ("Redmile"), was elected to the board of the Issuer as a representative of Redmile. Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.direct: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.direct: Mr. Lee was elected to the board of directors of the Issuer as a representative of Redmile. As a result, Redmile and Mr. Green are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-22-021928 · doc4.xml · derivative · entry 1

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,258

Underlying: Common Stock · 40,258 shares

Expires 2032-06-08

F1 · derivative.exercise_date: This option represents a right to purchase a total of 40,258 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-015764 · doc4.xml · nonDerivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,613

F1 · price: This transaction was executed in multiple trades at prices ranging from $3.505 to $3.78. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-22-015609 · doc4.xml · nonDerivative · entry 2

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,283

SEC source: 0000899243-22-015609 · doc4.xml · nonDerivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,049

F1 · price: This transaction was executed in multiple trades at prices ranging from $3.62 to $3.80. The price reported above reflects the weighted average purchase price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-22-003671 · doc4.xml · derivative · entry 3

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,597

Underlying: Common Stock · 3,926 shares

Expires 2030-08-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option represents the right to purchase a total of 188,375 shares of the Issuer's common stock, one quarter of which vested on August 6, 2021, with the remaining three quarters vesting in equal monthly installments through August 6, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-003671 · doc4.xml · nonDerivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,052

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-22-002496 · doc4.xml · nonDerivative · entry 3

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 229,672

SEC source: 0000899243-22-002496 · doc4.xml · nonDerivative · entry 2

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 226,672

SEC source: 0000899243-22-002496 · doc4.xml · nonDerivative · entry 1

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 224,172

SEC source: 0000899243-22-001791 · doc4.xml · derivative · entry 4

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,705

Underlying: Common Stock · 10,000 shares

Expires 2028-09-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option represents the right to purchase a total of 63,705 shares of the Issuer's common stock, 15,925 of which vested on May 15, 2019, with the remaining shares vesting in equal monthly installments through May 15, 2022.

SEC source: 0000899243-22-001791 · doc4.xml · nonDerivative · entry 2

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,084

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-22-001797 · doc4.xml · derivative · entry 2

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,475

Underlying: Common Stock · 69,475 shares

Expires 2032-01-10

F2 · derivative.exercise_date: This option represented a right to purchase a total of 69,475 shares of the Issuer's common stock, one quarter of which will vest on January 10, 2023, with the remaining three quarters vesting in equal monthly installments through January 10, 2026, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-001797 · doc4.xml · nonDerivative · entry 1

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,904

F1 · shares: Consists of 34,738 restricted stock units, which will vest in four equal annual installments beginning on January 10, 2023, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-22-001790 · doc4.xml · derivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 178,150

Underlying: Common Stock · 178,150 shares

Expires 2032-01-10

F1 · derivative.exercise_date: This option represents the right to purchase a total of 178,150 shares of the Issuer's common stock, and will vest upon the Issuer's common stock achieving a specified price per share, subject to the Reporting Person's continued service to the Issuer.