SRRK

SEC source: 0001415889-24-010735 · form4-04122024_120418.xml · derivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,767

Underlying: Common Stock · 35,767 shares

Expires 2034-04-09

F2 · derivative.exercise_date: Options to vest in monthly installments over three years following the date of appointment, with the next installment to vest on April 15, 2024 and each additional installment to vest monthly thereafter, subject to continued service to the Issuer through each such date.

SEC source: 0001415889-24-010735 · form4-04122024_120418.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,825

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in monthly installments over three years following the date of appointment, with the next installment to vest on April 15, 2024 and each additional installment to vest monthly thereafter, subject to continued service to the Issuer through each such date.

SEC source: 0001415889-24-004393 · form4-02202024_090233.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,744

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 13, 2023. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 29,458 shares of common stock and 128,286 RSUs.

SEC source: 0001415889-24-004379 · form4-02202024_090207.xml · nonDerivative · entry 1

Backstrom Jay T. · CIK 0001796398 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 352,671

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 13, 2023. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 25,886 shares of common stock and 326,785 RSUs.

SEC source: 0001415889-24-004401 · form4-02202024_090235.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,019

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 13, 2023. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 10,447 shares of common stock and 136,572 RSUs.

SEC source: 0001415889-24-004385 · form4-02202024_090209.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,771

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 13, 2023. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 63,787 shares of common stock and 144,984 RSUs.

SEC source: 0001415889-24-004674 · form4-02212024_110256.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,976

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 13, 2023. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 24,971 shares of common stock and 186,005 RSUs.

SEC source: 0001415889-24-003626 · form4-02142024_120209.xml · derivative · entry 2

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,855

Underlying: Common Stock · 62,855 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003626 · form4-02142024_120209.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 161,495

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 21,491 shares of common stock and 140,004 RSUs.

SEC source: 0001415889-24-003630 · form4-02142024_120208.xml · derivative · entry 2

Backstrom Jay T. · CIK 0001796398 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,715

Underlying: Common Stock · 285,715 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003630 · form4-02142024_120208.xml · nonDerivative · entry 1

Backstrom Jay T. · CIK 0001796398 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 364,285

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists solely of RSUs.

SEC source: 0001415889-24-003629 · form4-02142024_120206.xml · derivative · entry 2

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,145

Underlying: Common Stock · 97,145 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003629 · form4-02142024_120206.xml · nonDerivative · entry 1

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,855

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists solely of RSUs.

SEC source: 0001415889-24-003628 · form4-02142024_120249.xml · derivative · entry 2

Sacco Tracey · CIK 0001980334 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,715

Underlying: Common Stock · 65,715 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003628 · form4-02142024_120249.xml · nonDerivative · entry 1

Sacco Tracey · CIK 0001980334 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,285

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists solely of RSUs.

SEC source: 0001415889-24-003627 · form4-02142024_120210.xml · derivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,285

Underlying: Common Stock · 94,285 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003627 · form4-02142024_120210.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,531

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 4,522 shares of common stock and 145,009 RSUs.

SEC source: 0001415889-24-003625 · form4-02142024_120246.xml · derivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,430

Underlying: Common Stock · 71,430 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003625 · form4-02142024_120246.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 215,720

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 13,778 shares of common stock and 201,942 RSUs.

SEC source: 0001415889-24-003624 · form4-02142024_120248.xml · derivative · entry 2

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 77,145

Underlying: Common Stock · 77,145 shares

Expires 2034-02-12

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-24-003624 · form4-02142024_120248.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 212,260

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2025 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 55,558 shares of common stock and 156,702 RSUs.

SEC source: 0001415889-24-001522 · form4-01182024_090154.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,350

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 14, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 21,491 shares of common stock and 92,859 RSUs.

SEC source: 0001415889-24-001524 · form4-01182024_090104.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · SVP AND HEAD OF RESEARCH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,816

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 14, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 4,522 shares of common stock and 74,294 RSUs.

SEC source: 0001415889-24-001521 · form4-01182024_090129.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,150

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 1, 2021 and February 14, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 13,778 shares of common stock and 148,372 RSUs.

SEC source: 0001415889-24-001516 · form4-01182024_090132.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,405

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2024. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 1, 2021 and February 14, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 55,558 shares of common stock and 98,847 RSUs.

SEC source: 0001104659-23-130581 · tm2333989-1_4seq1.xml · derivative · entry 4

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,836

Underlying: Common Stock · 24,914 shares

Expires 2032-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F7 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-23-130581 · tm2333989-1_4seq1.xml · nonDerivative · entry 3

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 168,784

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.25 to $19.64, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F6 · balance_after: Consists solely of RSUs.

SEC source: 0001104659-23-130581 · tm2333989-1_4seq1.xml · nonDerivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 169,084

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.24 to $19.17, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 168,784 RSUs and 300 shares of common stock.

SEC source: 0001104659-23-130581 · tm2333989-1_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 181,243

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F2 · balance_after: Consists of 12,459 shares of common stock and 168,784 restricted stock units ("RSU").

SEC source: 0000950170-23-073873 · ownership.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,506

F1 · ownership.direct: Reflects the bona fide gift of common stock to a charitable donor-advised fund.

SEC source: 0001062993-23-023195 · form4.xml · nonDerivative · entry 2

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,339

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

SEC source: 0001062993-23-023195 · form4.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 2,345,711

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: The shares are held by ARCH Venture Fund VIII, L.P. ("ARCH VIII"). ARCH Venture Partners VIII, L.P. ("GPLP"), as the sole general partner of ARCH VIII, may be deemed to beneficially own the shares held by ARCH VIII. ARCH Venture Partners VIII, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by GPLP. The GPLP and GPLLC disclaim beneficial ownership of such securities, except to the extent of any pecuniary interest therein.

F3 · ownership.nature: The managing directors of the GPLLC are Keith L. Crandell, Clinton Bybee and Robert Nelsen, and they may be deemed to beneficially own the shares held by ARCH VIII. Messrs. Crandell, Bybee and Nelsen disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. The Reporting Person is a managing director of the GPLP. The Reporting Person owns an interest in the GPLP but does not have voting or investment control over the shares held by ARCH VIII. The Reporting Person disclaims ownership of such shares, except to the extent of her pecuniary interest therein.

SEC source: 0001062993-23-022621 · form4.xml · derivative · entry 3

Qatanani Mo · CIK 0001980298 · SVP AND HEAD OF RESEARCH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,563

Underlying: Common Stock · 8,437 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 36,563 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2023 and the remainder will vest in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001062993-23-022621 · form4.xml · nonDerivative · entry 2

Qatanani Mo · CIK 0001980298 · SVP AND HEAD OF RESEARCH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,818

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $17.96 to $18.36. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 899 shares of common stock and 79,919 RSUs.

SEC source: 0001062993-23-022621 · form4.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · SVP AND HEAD OF RESEARCH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,480

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Consists of 25,561 shares of common stock and 79,919 restricted stock units ("RSUs").

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 9

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,839

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 8

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 7

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 548

F11 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 6

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 1,147

F9 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F10 · ownership.nature: The reportable securities are owned by North Star Profit Sharing Trust for the benefit of the Reporting Person.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 5

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 124,080

F7 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI") to its partners.

F8 · ownership.nature: The reportable securities are owned directly by PVPFF VI. PVM VI is the general partner of PVPFF VI. PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVPFF VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVPFF VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 4

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,766

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 3

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 2

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 196,520

F3 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares in the in-kind distribution of common stock of the Issuer for no consideration by PVP VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-070770 · ownership.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 2,123,347

F1 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners VI, L.P. ("PVP VI") to its partners.

F2 · ownership.nature: The reportable securities are owned directly by PVP VI. Polaris Venture Management Co. VI, L.L.C. ("PVM VI") is the general partner of PVP VI and PVM VI is managed by its managing members, one of whom is the Reporting Person and a member of the Issuer's Board of Directors (collectively, the "Managing Members"). PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVP VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVP VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-23-016038 · form4-12082023_091200.xml · derivative · entry 3

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,836

Underlying: Common Stock · 24,914 shares

Expires 2032-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F5 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001415889-23-016038 · form4-12082023_091200.xml · nonDerivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 168,784

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $17.5 to $17.55. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: Consists of 168,784 RSUs.

SEC source: 0001415889-23-016038 · form4-12082023_091200.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 193,698

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F2 · balance_after: Consists of 24,914 shares of common stock and 168,784 restricted stock units ("RSU").

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 9

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,574

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 8

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 7

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 276

F11 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.