SRRK

SEC source: 0001104659-26-013588 · tm266077-8_4seq1.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 642,788

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 45,767 shares of common stock, 147,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-013585 · tm266077-6_4seq1.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,918

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 114,918 RSUs.

SEC source: 0001104659-26-013582 · tm266077-4_4seq1.xml · nonDerivative · entry 1

Marantz Jing L. · CIK 0001834528 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,169

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 24,974 shares of common stock and 105,195 RSUs.

SEC source: 0001104659-26-013581 · tm266077-3_4seq1.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,125

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 121,471 shares of common stock and 129,654 RSUs.

SEC source: 0001104659-26-013580 · tm266077-2_4seq1.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,669,649

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 166,645 shares of common stock, 378,004 RSUs subject to time-based vesting conditions and 1,125,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-013578 · tm266077-1_4seq1.xml · nonDerivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 630,275

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 33,254 shares of common stock, 147,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001980298-26-000007 · form4-01232026_040101.xml · nonDerivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,660

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.43 to $47.31, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 85,660 RSUs.

SEC source: 0001980298-26-000007 · form4-01232026_040101.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,439

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.43 to $46.42, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 12,779 shares of common stock and 85,660 RSUs.

SEC source: 0001922346-26-000002 · form4-01222026_120123.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,864

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 14, 2022 and February 12, 2024. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 78,283 shares of common stock and 70,581 RSUs.

SEC source: 0001980298-26-000004 · form4-01222026_120155.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,558

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 14, 2022 and February 12, 2024. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 14,898 shares of common stock and 85,660 RSUs.

SEC source: 0001834528-26-000003 · form4-01222026_120152.xml · nonDerivative · entry 1

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,687

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 12, 2024. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 24,974 shares of common stock and 70,713 RSUs.

SEC source: 0001868114-26-000002 · form4-01222026_120158.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 214,553

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 14, 2022 and February 12, 2024. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 121,471 shares of common stock and 93,082 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · derivative · entry 11

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,142

Underlying: Common Stock · 2,678 shares

Expires 2035-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F13 · derivative.exercise_date: 32,142 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2025 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · derivative · entry 10

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,143

Underlying: Common Stock · 5,893 shares

Expires 2034-02-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F12 · derivative.exercise_date: 47,143 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2024 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · derivative · entry 9

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,250

Underlying: Common Stock · 2,813 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F11 · derivative.exercise_date: 11,250 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · derivative · entry 8

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 961

Underlying: Common Stock · 321 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F10 · derivative.exercise_date: 961 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · derivative · entry 7

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,407 shares

Expires 2032-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F9 · derivative.exercise_date: No shares remain unvested under this stock option.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 6

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,964

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.00 to $45.45, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F8 · balance_after: Consists of 108,964 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 5

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,076

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F6 · balance_after: Consists of 13,112 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 4

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,398

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F5 · balance_after: Consists of 10,434 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 3

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,505

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F4 · balance_after: Consists of 4,541 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,692

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F3 · balance_after: Consists of 1,728 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-26-000002 · form4-01162026_110114.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,371

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · balance_after: Consists of 1,407 shares of common stock and 108,964 RSUs.

SEC source: 0001104659-26-004224 · tm263352-4_4seq1.xml · nonDerivative · entry 1

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 583,245

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units subject to performance-and time-based vesting conditions ("PSUs"). The sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. Each PSU represents the contingent right to receive upon vesting of the PSU, one share of the Issuer's common stock.

F2 · shares: (continued) The shares vested pursuant to awards that were granted on April 27, 2025. 50,000 shares subject to this PSU vested on January 12, 2026, with an additional 50,000 shares scheduled to vest on April 27, 2027 and the remaining shares vesting in tranches of a combination of performance-based vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four year, provided the Reporting Person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

F3 · balance_after: 33,245 shares of common stock, 100,000 restricted stock units and 450,000 PSUs.

SEC source: 0001104659-26-004223 · tm263352-3_4seq1.xml · nonDerivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 583,254

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units subject to performance- and time-based vesting conditions ("PSUs"). This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. Each PSU represents the contingent right to receive upon vesting of the PSU, one share of the Issuer's common stock.

F2 · shares: (continued) The shares vested pursuant to awards that were granted on April 27, 2025. 50,000 shares subject to this PSU vested on January 12, 2026, with an additional 50,000 shares scheduled to vest on April 27, 2027 and the remaining shares vesting in tranches of a combination of performance-based vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four years, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

F3 · balance_after: Consists of 33,254 shares of common stock, 100,000 restricted stock units subject to time-based vesting conditions and 450,000 PSUs.

SEC source: 0001104659-26-004222 · tm263352-2_4seq1.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 595,767

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units subject to performance-and time-based vesting conditions ("PSUs"). The sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. Each PSU represents the contingent right to receive upon vesting of the PSU, one share of the Issuer's common stock.

F2 · shares: (continued) The shares vested pursuant to awards that were granted on April 27, 2025. 50,000 shares subject to this PSU vested on January 12, 2026, with an additional 50,000 shares scheduled to vest on April 27, 2027 and the remaining shares vesting in tranches of a combination of performance-based vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four year, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

F3 · balance_after: 45,767 shares of common stock, 100,000 restricted stock units and 450,000 PSUs.

SEC source: 0001104659-26-004221 · tm263352-1_4seq1.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,541,645

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units subject to performance-and time-based vesting conditions ("PSUs"). The sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. Each PSU represents the contingent right to receive upon vesting of the PSU, one share of the Issuer's common stock.

F2 · shares: (continued) The shares vested pursuant to awards that were granted on April 27, 2025. 125,000 shares subject to this PSU vested on January 12, 2026, with an additional 125,000 shares scheduled to vest on April 27, 2027 and the remaining shares vesting in tranches of a combination of performance-based vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four year, provided the Reporting Person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

F3 · balance_after: 166,645 shares of common stock, 250,000 restricted stock units and 1,125,000 PSUs.

SEC source: 0001983850-25-000005 · form4-12182025_041201.xml · nonDerivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,908

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $44.39 to $45.23, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 14,844 shares of common stock and 18,064 RSUs.

SEC source: 0001983850-25-000005 · form4-12182025_041201.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,188

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $43.39 to $44.38, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 15,124 shares of common stock and 18,064 RSUs.

SEC source: 0001253170-25-000025 · form4-12172025_021252.xml · derivative · entry 6

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara BioCapital LP

Disclosed balance after: 0

Underlying: Common Stock · 1,064,804 shares

Expires 2025-12-31

F5 · ownership.nature: Securities are directly held by Samsara BioCapital LP ("Samsara LP"). Samsara BioCapital GP, LLC ("Samsara LLC") is the general partner of Samsara LP and may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person has voting and investment power over the securities held by Samsara LP and, accordingly, may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000025 · form4-12172025_021252.xml · nonDerivative · entry 4

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara BioCapital, L.P.

Disclosed balance after: 6,367,614

F5 · ownership.nature: Securities are directly held by Samsara BioCapital LP ("Samsara LP"). Samsara BioCapital GP, LLC ("Samsara LLC") is the general partner of Samsara LP and may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person has voting and investment power over the securities held by Samsara LP and, accordingly, may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001193125-26-041456 · ownership.xml · derivative · entry 2

Invus Global Management, LLC · CIK 0002005369 · 10% owner

Siren, L.L.C. · CIK 0002005245 · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,575,008 shares

Expires 2025-12-31

F1 · ownership.direct: The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The managing member of Invus Public Equities Advisors, LLC is Invus Global Management, LLC. The managing member of Invus Global Management, LLC is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.

F2 · ownership.direct: Each of the reporting persons (other than to the extent it directly holds securities reported herein), disclaims beneficial ownership of the securities held by the other reporting persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001193125-26-041456 · ownership.xml · nonDerivative · entry 1

Invus Global Management, LLC · CIK 0002005369 · 10% owner

Siren, L.L.C. · CIK 0002005245 · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,825,013

F1 · ownership.direct: The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The managing member of Invus Public Equities Advisors, LLC is Invus Global Management, LLC. The managing member of Invus Global Management, LLC is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.

F2 · ownership.direct: Each of the reporting persons (other than to the extent it directly holds securities reported herein), disclaims beneficial ownership of the securities held by the other reporting persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 15

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,820

Underlying: Common Stock · 8,035 shares

Expires 2035-03-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F15 · derivative.exercise_date: 34,820 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2025 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 14

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,036

Underlying: Common Stock · 23,571 shares

Expires 2034-12-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F14 · derivative.exercise_date: 53,036 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2024 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 13

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,063

Underlying: Common Stock · 11,250 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F13 · derivative.exercise_date: 14,063 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 12

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,282

Underlying: Common Stock · 1,281 shares

Expires 2032-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F11 · derivative.exercise_date: 1,282 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vest in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 11

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,607 shares

Expires 2032-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F11 · derivative.exercise_date: 1,282 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vest in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 10

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,407

Underlying: Common Stock · 21,093 shares

Expires 2032-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F12 · derivative.exercise_date: 1,407 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2022 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · derivative · entry 9

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,375

Underlying: Common Stock · 65,625 shares

Expires 2031-10-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F11 · derivative.exercise_date: 1,282 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vest in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 8

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,964

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.00 to $45.46, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F10 · balance_after: Consists of 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 7

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 245,426

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F8 · balance_after: Consists of 136,462 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 6

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 237,391

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F7 · balance_after: Consists of 128,427 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 5

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,820

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F6 · balance_after: Consists of 104,856 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 4

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 202,570

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F5 · balance_after: Consists of 93,606 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 3

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 201,289

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F4 · balance_after: Consists of 92,325 shares of common stock and 108,964 RSUs

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 195,682

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F3 · balance_after: Consists of 86,718 shares of common stock and 108,964 RSUs.

SEC source: 0001980298-25-000007 · form4-12052025_091222.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · balance_after: Consists of 65,625 shares of common stock and 108,964 RSUs.

SEC source: 0001457477-25-000004 · form4-10092025_091053.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,599,095

F1 · kind: On October 8, 2025, the Reporting Person transferred 205,000 shares of the Issuer's Common Stock to the Hallal Family Irrevocable Trust - 2012 dated November 19, 2012 (the "Hallal Trust") for no consideration. The Reporting Person's spouse serves as a trustee of the Hallal Trust. The Reporting Person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F2 · balance_after: Consists of 99,095 shares of Common Stock and 1,500,000 restricted stock units.

SEC source: 0001253170-25-000025 · form4-12172025_021252.xml · nonDerivative · entry 3

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 530,038

F4 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $40.87 to $41.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the securities held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.