SPRO

SEC source: 0000899243-23-003945 · doc4.xml · nonDerivative · entry 2

Shukla Sath · CIK 0001782817 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 312,517

F3 · kind: The reported transaction is a sale of common stock pursuant to a preexisting 10b5-1 plan upon the vesting of RSUs that were granted to the Reporting Person on February 1, 2022.

F4 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $1.81 to $1.86 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F2 · balance_after: Includes 312,518 RSUs held by the Reporting Person.

SEC source: 0000899243-23-003948 · doc4.xml · nonDerivative · entry 1

Keutzer Timothy · CIK 0001798155 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,538

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2024, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 312,518 RSUs held by the Reporting Person.

SEC source: 0000899243-23-003946 · doc4.xml · nonDerivative · entry 1

JOSEPH TAMARA L · CIK 0001433991 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 328,038

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2024, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 312,518 RSUs held by the Reporting Person.

SEC source: 0000899243-23-003945 · doc4.xml · nonDerivative · entry 1

Shukla Sath · CIK 0001782817 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 322,021

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2024, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 312,518 RSUs held by the Reporting Person.

SEC source: 0000899243-23-003942 · doc4.xml · nonDerivative · entry 1

HAMED KAMAL · CIK 0001946366 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 475,957

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2024, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 475,957 RSUs held by the Reporting Person.

SEC source: 0000899243-23-003939 · doc4.xml · nonDerivative · entry 1

Mahadevia Ankit · CIK 0001720974 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 810,118

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2024, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Amount includes 65,817 shares of common stock held by the Mahadevia-Mehta Family Trust, of which the Reporting Person is a trustee. Amount also includes 691,205 RSUs held by the Reporting Person.

SEC source: 0000899243-23-000983 · doc4.xml · derivative · entry 1

VINK PATRICK V.J.J. · CIK 0001557501 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,471

Underlying: Common Stock · 15,471 shares

Expires 2033-01-03

F2 · price: This stock option was issued to the Reporting Person, who elected to take stock options in lieu of $20,000 in cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation policy.

F1 · derivative.exercise_date: This stock option shall vest in four quarterly installments on the last day of each calendar quarter during the calendar year subject to the Reporting Person's continued service as a non-employee director.

SEC source: 0000899243-23-000990 · doc4.xml · derivative · entry 1

Tregoning Kathleen · CIK 0001830764 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,943

Underlying: Common Stock · 30,943 shares

Expires 2033-01-03

F2 · price: This stock option was issued to the Reporting Person, who elected to take stock options in lieu of $40,000 in cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation policy.

F1 · derivative.exercise_date: This stock option shall vest in four quarterly installments on the last day of each calendar quarter during the calendar year subject to the Reporting Person's continued service as a non-employee director.

SEC source: 0001591986-22-000018 · primary_doc.xml · nonDerivative · entry 2

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,419,435

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F3 · balance_after: Aquilo Capital, LP owns only 2,176,470 of the 3,419,435 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not sell any of the 566,284 shares sold in this transaction on 09/22/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000018 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 3,985,719

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns 2,176,470 of the 3,985,719 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP sold 1,335,512 shares in this transaction on 09/22/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-22-031505 · doc4.xml · nonDerivative · entry 1

Jackson Scott Thomas · CIK 0001566617 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031504 · doc4.xml · nonDerivative · entry 1

Deshpande Milind · CIK 0001378588 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,454

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031503 · doc4.xml · nonDerivative · entry 1

Pottage John C Jr · CIK 0001378587 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031502 · doc4.xml · nonDerivative · entry 1

Smith Cynthia · CIK 0001609480 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031498 · doc4.xml · nonDerivative · entry 1

THOMAS FRANK E · CIK 0001242616 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031497 · doc4.xml · nonDerivative · entry 1

Tregoning Kathleen · CIK 0001830764 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031495 · doc4.xml · nonDerivative · entry 1

VINK PATRICK V.J.J. · CIK 0001557501 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest on September 15, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-031094 · doc4.xml · nonDerivative · entry 1

HAMED KAMAL · CIK 0001946366 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on September 12, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-030087 · doc4.xml · nonDerivative · entry 1

Shukla Sath · CIK 0001782817 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,064

F1 · kind: The reported transaction is a sale of common stock pursuant to a preexisting 10b5-1 plan upon the vesting on August 26, 2022 of a portion of restricted stock units ("RSUs") granted to the Reporting Person on August 26, 2021.

F2 · price: Represents the weighted average sales price per share. The shares sold at prices ranging from $0.8839 to $0.9002 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer.

F3 · balance_after: Consists of RSUs. Each RSU represents the right to receive one share of common stock upon vesting. 18,050 of the RSUs vest in three equal annual installments beginning on August 26, 2023 and 38,014 of the RSUs vest in four equal annual installments beginning on February 1, 2023, in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001591986-22-000015 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,321,231

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP only owns 3,511,982 of the 5,321,231 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 39,727 shares in this transaction on 4/26/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000014 · primary_doc.xml · nonDerivative · entry 2

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,281,504

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F3 · balance_after: Aquilo Capital, LP only owns 3,472,255 of the 5,281,504 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 16,885 shares purchased in this transaction on 03/30/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000014 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,264,619

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP only owns 3,472,255 of the 5,264,619 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 33,115 shares in this transaction on 3/30/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000013 · primary_doc.xml · nonDerivative · entry 2

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,231,504

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F3 · balance_after: Aquilo Capital, LP only owns 3,439,140 of the 5,231,504 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 8,006 shares purchased in this transaction on 03/14/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000013 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 5,223,498

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP only owns 3,439,140 of the 5,223,498 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 15,702 shares in this transaction on 3/14/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000011 · primary_doc.xml · nonDerivative · entry 2

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,207,796

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F3 · balance_after: Aquilo Capital, LP owns only 3,423,438 of the 5,207,796 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 15,104 shares purchased in this transaction on 02/28/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000011 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,192,692

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns 3,423,438 of the 5,192,692 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 29,729 shares in this transaction on 2/28/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000010 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,162,963

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns 3,393,709 of the 5,162,963 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP purchased 14,828 shares in this transaction on 2/18/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-22-004594 · doc4.xml · derivative · entry 2

Melnick David A. · CIK 0001726485 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,190

Underlying: Common Stock · 53,190 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004594 · doc4.xml · nonDerivative · entry 1

Melnick David A. · CIK 0001726485 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,081

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Consists of 62,081 RSUs held by the Reporting Person.

SEC source: 0000899243-22-004592 · doc4.xml · derivative · entry 2

Larkin Cristina · CIK 0001721173 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,190

Underlying: Common Stock · 53,190 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004592 · doc4.xml · nonDerivative · entry 1

Larkin Cristina · CIK 0001721173 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,581

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 1,500 shares of common stock and 62,081 RSUs held by the Reporting Person.

SEC source: 0000899243-22-004593 · doc4.xml · derivative · entry 2

Shukla Sath · CIK 0001782817 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,190

Underlying: Common Stock · 53,190 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004593 · doc4.xml · nonDerivative · entry 1

Shukla Sath · CIK 0001782817 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,081

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Consists of 62,081 RSUs held by the Reporting Person.

SEC source: 0000899243-22-004591 · doc4.xml · derivative · entry 2

Mahadevia Ankit · CIK 0001720974 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 187,730

Underlying: Common Stock · 187,730 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004591 · doc4.xml · nonDerivative · entry 1

Mahadevia Ankit · CIK 0001720974 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 278,204

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Amount includes 65,817 shares of common stock held by the Mahadevia-Mehta Family Trust, of which the Reporting Person is a trustee. Amount also includes 212,387 RSUs held by the Reporting Person.

SEC source: 0000899243-22-004586 · doc4.xml · derivative · entry 2

JOSEPH TAMARA L · CIK 0001433991 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,190

Underlying: Common Stock · 53,190 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004586 · doc4.xml · nonDerivative · entry 1

JOSEPH TAMARA L · CIK 0001433991 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,081

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Consists of 62,081 RSUs held by the Reporting Person.

SEC source: 0000899243-22-004589 · doc4.xml · derivative · entry 2

Keutzer Timothy · CIK 0001798155 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,190

Underlying: Common Stock · 53,190 shares

Expires 2032-02-01

F3 · derivative.exercise_date: The shares underlying this option vest as to 25% on February 1, 2023, with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000899243-22-004589 · doc4.xml · nonDerivative · entry 1

Keutzer Timothy · CIK 0001798155 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,581

F1 · shares: Consists of restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock upon vesting. The RSUs vest in four equal annual installments beginning on February 1, 2023, subject to the Reporting Person's continued service through the applicable vesting date.

F2 · balance_after: Includes 2,500 shares of common stock and 62,081 RSUs held by the Reporting Person.

SEC source: 0001591986-22-000004 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,148,135

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 5,148,135 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 125,000 shares purchased in this transaction on 01/31/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000003 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,023,135

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 5,023,135 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 1,599 shares purchased in this transaction on 01/24/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000002 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,021,536

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 5,021,536 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 48,488 shares purchased in this transaction on 01/18/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001591986-22-000001 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,973,048

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 4,973,048 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 8,867 shares purchased in this transaction on 01/10/2022.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-22-001380 · doc4.xml · derivative · entry 1

Tregoning Kathleen · CIK 0001830764 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,428

Underlying: Common Stock · 4,428 shares

Expires 2032-01-05

F2 · price: This stock option was issued to the Reporting Person, who elected to take stock options in lieu of $40,000 in cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation policy.

F1 · derivative.exercise_date: This stock option shall vest in four quarterly installments on the last day of each calendar quarter during the calendar year subject to the Reporting Person's continued service as a non-employee director.

SEC source: 0000899243-22-001378 · doc4.xml · derivative · entry 1

THOMAS FRANK E · CIK 0001242616 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,214

Underlying: Common Stock · 2,214 shares

Expires 2032-01-05

F2 · price: This stock option was issued to the Reporting Person, who elected to take stock options in lieu of $20,000 in cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation policy.

F1 · derivative.exercise_date: This stock option shall vest in four quarterly installments on the last day of each calendar quarter during the calendar year subject to the Reporting Person's continued service as a non-employee director.

SEC source: 0000899243-22-001376 · doc4.xml · derivative · entry 1

VINK PATRICK V.J.J. · CIK 0001557501 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,214

Underlying: Common Stock · 2,214 shares

Expires 2032-01-05

F2 · price: This stock option was issued to the Reporting Person, who elected to take stock options in lieu of $20,000 in cash compensation for services as a director, pursuant to the Issuer's non-employee director compensation policy.

F1 · derivative.exercise_date: This stock option shall vest in four quarterly installments on the last day of each calendar quarter during the calendar year subject to the Reporting Person's continued service as a non-employee director.

SEC source: 0001691902-22-000001 · primary_doc.xml · nonDerivative · entry 3

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,964,181

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F4 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 4,964,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 125,000 shares purchased in this transaction on 12/31/2021.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001691902-22-000001 · primary_doc.xml · nonDerivative · entry 2

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 4,839,181

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F3 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 4,839,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 50,000 shares purchased in this transaction on 12/30/2021.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0001691902-22-000001 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

Aquilo Capital, L.P. · CIK 0001491371 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 4,789,181

F1 · security: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F2 · balance_after: Aquilo Capital, LP owns only 3,378,881 of the 4,789,181 shares deemed to be beneficially owned by Aquilo Capital Management, LLC. Aquilo Capital, LP did not purchase any of the 75,493 shares purchased in this transaction on 12/29/2021.

F1 · ownership.nature: The reporting persons are Aquilo Capital, L.P. (the "Fund"), Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of the Fund and other funds managed by Aquilo that hold securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of the Fund and affiliated funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of, Aquilo, the Fund and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-21-050049 · doc4.xml · derivative · entry 3

Mahadevia Ankit · CIK 0001720974 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 486,809

Underlying: Common Stock · 8,000 shares

Expires 2027-07-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: All of the option exercises reported herein were made with respect to options granted pursuant to the Company's 2017 Equity Incentive Plan on July 6, 2017 with vesting schedules generally consisting of 25% cliff vesting on specified dates and with the remainder vesting in 36 equal monthly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.