SOPH

SEC source: 0001840706-26-000343 · wk-form4_1792008234.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 541,493

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.09 to $7.24, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000344 · wk-form4_1792008240.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 195,993

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.17 to $7.38, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000340 · wk-form4_1792008118.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,387,150

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.15 to $7.38, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000335 · wk-form4_1791403474.xml · nonDerivative · entry 1

Valente Manuela · CIK 0002009280 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 206,210

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.99 to $8.31, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000336 · wk-form4_1791403479.xml · nonDerivative · entry 1

Van Well Daan · CIK 0002006414 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 332,716

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.91 to $8.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000333 · wk-form4_1791403462.xml · nonDerivative · entry 2

Puylaert Kevin · CIK 0002119354 · Chief Sales Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,732

F2 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 3, 2026.

SEC source: 0001840706-26-000333 · wk-form4_1791403462.xml · nonDerivative · entry 1

Puylaert Kevin · CIK 0002119354 · Chief Sales Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,763

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2, 2026.

SEC source: 0001840706-26-000334 · wk-form4_1791403468.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 166,887

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.91 to $8.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000330 · wk-form4_1791403446.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,395,650

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.90 to $8.35, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000331 · wk-form4_1791403451.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 200,993

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.91 to $8.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000332 · wk-form4_1791403457.xml · nonDerivative · entry 1

CARDOZA GEORGE · CIK 0001518734 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 306,726

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.00 to $8.23, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000328 · wk-form4_1791403434.xml · nonDerivative · entry 1

Muken Ross · CIK 0002005463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 660,391

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.91 to $8.34, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000329 · wk-form4_1791403440.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 545,493

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on October 2 and 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.99 to $8.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000318 · wk-form4_1790107327.xml · nonDerivative · entry 1

CARDOZA GEORGE · CIK 0001518734 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 308,318

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on September 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

SEC source: 0001840706-26-000317 · wk-form4_1790107319.xml · nonDerivative · entry 1

Muken Ross · CIK 0002005463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 670,229

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on September 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

SEC source: 0001840706-26-000314 · wk-form4_1789588884.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,387

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.78 to $7.99, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000313 · wk-form4_1789588876.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 552,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.78 to $7.99, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000310 · wk-form4_1789416108.xml · nonDerivative · entry 1

Van Well Daan · CIK 0002006414 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 338,884

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.55 to $7.85, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000309 · wk-form4_1789416100.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,435,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.57 to $7.79, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000306 · wk-form4_1789070532.xml · nonDerivative · entry 1

HIBBS KATHY L · CIK 0001267487 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,992

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.90 to $8.35, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000304 · wk-form4_1788206534.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 556,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.90 to $8.92, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000302 · wk-form4_1787774694.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,387

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.37 to $8.84, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000301 · wk-form4_1787774686.xml · nonDerivative · entry 1

HIBBS KATHY L · CIK 0001267487 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,242

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.31 to $8.83 inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000298 · wk-form4_1787774586.xml · nonDerivative · entry 2

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 172,171

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000292 · wk-form4_1787342516.xml · nonDerivative · entry 3

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 566,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.40 to $8.42, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000292 · wk-form4_1787342516.xml · nonDerivative · entry 2

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 572,295

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.40 to $8.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000293 · wk-form4_1787342522.xml · derivative · entry 3

Valente Manuela · CIK 0002009280 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 10,000 shares

Expires 2029-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · derivative.exercise_date: The share options are fully vested and exercisable.

F4 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 554, 276 derivative share options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000293 · wk-form4_1787342522.xml · nonDerivative · entry 2

Valente Manuela · CIK 0002009280 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,450

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.90 to $8.01, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000293 · wk-form4_1787342522.xml · nonDerivative · entry 1

Valente Manuela · CIK 0002009280 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,450

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000292 · wk-form4_1787342516.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 576,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.90 to $8.01, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000298 · wk-form4_1787774586.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,171

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000282 · wk-form4_1786740012.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 586,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.43 to $7.62, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000283 · wk-form4_1786740018.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 218,387

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.40 to $7.60, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000278 · wk-form4_1786396489.xml · nonDerivative · entry 2

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,444,322

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.50 to $7.80, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · derivative · entry 7

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 7,000 shares

Expires 2027-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The share options are fully vested and exercisable.

F6 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 975,041 derivative share options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · nonDerivative · entry 5

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 590,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.40 to $7.56, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · nonDerivative · entry 4

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 600,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.00 to $7.08, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · nonDerivative · entry 3

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 607,887

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000278 · wk-form4_1786396489.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,452,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.20 to $7.27, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000279 · wk-form4_1786396497.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 182,171

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · derivative · entry 6

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,000

Underlying: Ordinary Shares · 3,000 shares

Expires 2027-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F4 · derivative.exercise_date: The share options are fully vested and exercisable.

F5 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 982,041 derivative share options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · nonDerivative · entry 2

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 600,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000275 · wk-form4_1786138524.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 603,887

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000269 · wk-form4_1785960834.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 600,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.90 to $6.95, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000270 · wk-form4_1785960841.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,472,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.90 to $6.98, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000271 · wk-form4_1785960847.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 187,171

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.95 to $6.98, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000265 · wk-form4_1785268998.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 223,387

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.57 to $5.83, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000263 · wk-form4_1784750500.xml · nonDerivative · entry 4

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,492,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.60 to $6.72, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000263 · wk-form4_1784750500.xml · derivative · entry 5

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 4,581 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The share options are fully vested and exercisable.

F6 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,641,476 derivative share options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000263 · wk-form4_1784750500.xml · nonDerivative · entry 3

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,512,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.10 to $6.20, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.