SNDX

SEC source: 0001193125-26-299803 · ownership.xml · derivative · entry 3

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 32,375 shares

Expires 2029-02-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option is fully vested.

SEC source: 0001193125-26-299803 · ownership.xml · nonDerivative · entry 2

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 484,843

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person. Following the sales reported in this Form 4, the Reporting Person has a total of 1,564,551 options to purchase shares of common stock that are vested and immediately exercisable and a total of 813,949 options to purchase shares of common stock that have not yet vested.

F2 · price: The sale prices ranged from $24.00 to $24.43

SEC source: 0001193125-26-299803 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 517,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-269694 · ownership.xml · derivative · entry 6

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 31,235 shares

Expires 2035-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares sold in this transaction were fully vested.

SEC source: 0001193125-26-269694 · ownership.xml · nonDerivative · entry 4

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,885

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person. Following the sales reported in this Form 4, the Reporting Person has a total of 16,537 options to purchase shares of common stock that are vested and immediately exercisable and a total of 289,413 options to purchase shares of common stock that have not yet vested.

F3 · price: These transactions were executed in multiple trades at prices ranging from $18.00 to $18.32. The price reported above reflects the weighted-average sale price of all transactions executed on that date.

SEC source: 0001193125-26-269694 · ownership.xml · nonDerivative · entry 3

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 92,120

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-269694 · ownership.xml · derivative · entry 5

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 22,515 shares

Expires 2035-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares sold in this transaction were fully vested.

SEC source: 0001193125-26-269694 · ownership.xml · nonDerivative · entry 2

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,885

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person. Following the sales reported in this Form 4, the Reporting Person has a total of 16,537 options to purchase shares of common stock that are vested and immediately exercisable and a total of 289,413 options to purchase shares of common stock that have not yet vested.

F2 · price: These transactions were executed in multiple trades at prices ranging from $17.31 to $18.10. The price reported above reflects the weighted-average sale price of all transactions executed on that date.

SEC source: 0001193125-26-269694 · ownership.xml · nonDerivative · entry 1

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 95,165

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-253603 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 139,252

F1 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-253601 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 484,843

F1 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-043813 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,429

F1 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-043814 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 491,690

F1 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-041497 · ownership.xml · nonDerivative · entry 4

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 143,839

F4 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-041500 · ownership.xml · nonDerivative · entry 3

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 508,849

F3 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0001193125-26-041334 · ownership.xml · derivative · entry 3

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,700

Underlying: Common Stock · 144,700 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/48th of the shares subject to the option shall vest monthly over a four-year period.

SEC source: 0001193125-26-041334 · ownership.xml · nonDerivative · entry 2

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,165

F2 · shares: Award of RSUs, representing the right to receive one share of Common Stock for each RSU. The number of shares of Common Stock acquired upon vesting of the RSUs is contingent upon the achievement of pre-established performance metrics, as approved by the Company's Compensation Committee, subject to the Reporting Person's continued service as an employee, consultant, director or officer of the Company.

SEC source: 0001193125-26-041334 · ownership.xml · nonDerivative · entry 1

Botwood Nicholas A.J. · CIK 0002066784 · Head of R&D, CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,165

F1 · shares: Award of restricted stock units ("RSUs"), representing the right to receive one share of Common Stock for each RSU. One third (1/3rd) of the shares of Common Stock subject to such RSU shall vest annually on the anniversary of the Vesting Commencement Date, during the Reporting Person's continued service as an employee, consultant, director or officer of the Company over the three (3) years following the date of grant, until all of the shares subject to such RSU are fully vested.

SEC source: 0001193125-26-041412 · ownership.xml · nonDerivative · entry 1

Jarrett Jennifer · CIK 0001671311 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,000

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041497 · ownership.xml · derivative · entry 5

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,000

Underlying: Common Stock · 118,000 shares

Expires 2036-02-04

F5 · derivative.exercise_date: 1/48th of the shares subject to the option shall vest monthly over a four-year period.

SEC source: 0001193125-26-041497 · ownership.xml · nonDerivative · entry 3

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,921

F3 · shares: Award of RSUs, representing the right to receive one share of Common Stock for each RSU. The number of shares of Common Stock acquired upon vesting of the RSUs is contingent upon the achievement of pre-established performance metrics, as approved by the Company's Compensation Committee, subject to the Reporting Person's continued service as an employee, consultant, director or officer of the Company.

SEC source: 0001193125-26-041497 · ownership.xml · nonDerivative · entry 2

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,171

F2 · shares: Award of restricted stock units ("RSUs"), representing the right to receive one share of Common Stock for each RSU. One third (1/3rd) of the shares of Common Stock subject to such RSU shall vest annually on the anniversary of the Vesting Commencement Date, during the Reporting Person's continued service as an employee, consultant, director or officer of the Company over the three (3) years following the date of grant, until all of the shares subject to such RSU are fully vested.

SEC source: 0001193125-26-041200 · ownership.xml · nonDerivative · entry 1

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 239,763

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041192 · ownership.xml · nonDerivative · entry 1

Katkin Keith · CIK 0001314596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,000

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041500 · ownership.xml · derivative · entry 4

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 440,000

Underlying: Common Stock · 440,000 shares

Expires 2036-02-04

F4 · derivative.exercise_date: 1/48th of the shares subject to the option shall vest monthly over a four-year period.

SEC source: 0001193125-26-041500 · ownership.xml · nonDerivative · entry 2

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 516,261

F2 · shares: Award of RSUs, representing the right to receive one share of Common Stock for each RSU. The number of shares of Common Stock acquired upon vesting of the RSUs is contingent upon the achievement of pre-established performance metrics, as approved by the Company's Compensation Committee, subject to the Reporting Person's continued service as an employee, consultant, director or officer of the Company.

SEC source: 0001193125-26-041500 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 371,661

F1 · shares: Award of restricted stock units ("RSUs"), representing the right to receive one share of Common Stock for each RSU. One third (1/3rd) of the shares of Common Stock subject to such RSU shall vest annually on the anniversary of the Vesting Commencement Date, during the Reporting Person's continued service as an employee, consultant, director or officer of the Company over the three (3) years following the date of grant, until all of the shares subject to such RSU are fully vested.

SEC source: 0001193125-26-041344 · ownership.xml · nonDerivative · entry 1

Huber Martin H. Jr. · CIK 0001653276 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,000

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041167 · ownership.xml · nonDerivative · entry 1

Legault Pierre · CIK 0001391045 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,000

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041194 · ownership.xml · nonDerivative · entry 1

Rizo Aleksandra · CIK 0001766210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,000

F1 · shares: Award of Restricted Stock Units that vests one year from the date of grant. The shares underlying such Restricted Stock Units will not be delivered to the Reporting Person and may not be transferred or sold until the earlier of a separation from service, death, disability or change in control.

SEC source: 0001193125-26-041497 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,671

F1 · kind: The Reporting Person is voluntarily filing this Form 4 to report the acquisition of 1,219 shares by the Reporting Person on 1/30/2026 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001193125-25-303941 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,452

SEC source: 0000950170-25-113659 · ownership.xml · derivative · entry 3

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 157,307 shares

Expires 2025-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option is fully vested.

SEC source: 0000950170-25-113659 · ownership.xml · nonDerivative · entry 2

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298,661

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person solely covering equity grants with expiration dates prior to September 10, 2025. Following the sales reported in this Form 4, the Reporting Person has a total of 1,319,634 options to purchase shares of common stock that are vested and immediately exercisable and a total of 651,241 options to purchase shares of common stock that have not yet vested.

F2 · price: The sale prices ranged from $16.21 to $17.06.

SEC source: 0000950170-25-113659 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 455,968

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-109815 · ownership.xml · derivative · entry 10

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,200 shares

Expires 2025-08-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option is fully vested.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 6

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 191,763

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person solely covering equity grants with expiration dates prior to August 21, 2025. Following the sales reported in this Form 4, the Reporting Person has a total of 135,000 options to purchase shares of common stock that are vested and immediately exercisable and no unvested options to purchase shares of common stock.

F4 · price: The sale prices ranged from $15.61 to $16.00.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 5

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,963

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-109815 · ownership.xml · derivative · entry 9

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,800 shares

Expires 2025-08-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option is fully vested.

SEC source: 0000950170-25-109815 · ownership.xml · derivative · entry 8

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,400 shares

Expires 2025-08-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option is fully vested.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 4

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 191,763

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person solely covering equity grants with expiration dates prior to August 21, 2025. Following the sales reported in this Form 4, the Reporting Person has a total of 135,000 options to purchase shares of common stock that are vested and immediately exercisable and no unvested options to purchase shares of common stock.

F3 · price: The sale prices ranged from $14.88 to $15.91.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 3

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,963

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-109815 · ownership.xml · derivative · entry 7

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,200 shares

Expires 2025-08-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option is fully vested.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 2

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 191,763

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person solely covering equity grants with expiration dates prior to August 21, 2025. Following the sales reported in this Form 4, the Reporting Person has a total of 135,000 options to purchase shares of common stock that are vested and immediately exercisable and no unvested options to purchase shares of common stock.

F2 · price: The sale prices ranged from $13.30 to $14.80.

SEC source: 0000950170-25-109815 · ownership.xml · nonDerivative · entry 1

Podlesak Dennis · CIK 0001314595 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,963

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-105258 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,676

F1 · kind: The Reporting Person is voluntarily filing this Form 4 to report the acquisition of 1,226 shares by the Reporting Person on 07/31/2025 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0000950170-25-096948 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,450

F1 · price: Represents the number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0000950170-25-096947 · ownership.xml · nonDerivative · entry 1

Metzger Michael A · CIK 0001507220 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 298,661

F1 · price: Represents the number of shares sold by the reporting person to cover tax withholding obligations in connection with the vesting of restricted stock units.

SEC source: 0000950170-25-074304 · ownership.xml · nonDerivative · entry 1

Goldan Keith A. · CIK 0001495411 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,746

F1 · price: The purchase prices ranged from $8.8465 to $9.2825.

SEC source: 0000950170-25-074289 · ownership.xml · nonDerivative · entry 1

Katkin Keith · CIK 0001314596 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000