SEPN

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 5

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,682

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.25 to $29.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 4

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,028

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.24 to $28.23. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,728

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,091

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-255997 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,148

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-245713 · ownership.xml · derivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,043

Underlying: Common Stock · 11,798 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-245713 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.24. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-245713 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,591

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-161987 · ownership.xml · derivative · entry 5

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,911

Underlying: Common Stock · 4,000 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-161987 · ownership.xml · nonDerivative · entry 4

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,209

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.81 to $25.91. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-161987 · ownership.xml · nonDerivative · entry 3

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,535

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.79 to $25.75. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-161987 · ownership.xml · nonDerivative · entry 2

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 175,636

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $23.33 to $24.22. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-161987 · ownership.xml · nonDerivative · entry 1

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 178,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 8

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,101

Underlying: Common Stock · 5,101 shares

Expires 2034-03-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 7

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,460

Underlying: Common Stock · 11,638 shares

Expires 2033-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date.

SEC source: 0001193125-26-092050 · ownership.xml · derivative · entry 6

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,969

Underlying: Common Stock · 53,714 shares

Expires 2033-03-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such vesting date.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 5

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 793

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $27.90 to $28.70. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 4

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,156

F2 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $26.90 to $27.89. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 3

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,246

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 2

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 66,145

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-092050 · ownership.xml · nonDerivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,507

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 793 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in a transaction that was exempt under Rule 16b-3(c).

SEC source: 0001193125-26-061675 · ownership.xml · derivative · entry 4

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 88,911

Underlying: Common Stock · 92,911 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-061675 · ownership.xml · nonDerivative · entry 3

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 174,209

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.12 to $29.98. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-061675 · ownership.xml · nonDerivative · entry 2

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176,009

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 20, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.09 to $29.07. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001193125-26-061675 · ownership.xml · nonDerivative · entry 1

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 178,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193125-26-045118 · ownership.xml · derivative · entry 1

Long Daniel D. · CIK 0002040349 · SVP, Drug Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045092 · ownership.xml · derivative · entry 1

Finer Jeffrey · CIK 0002040376 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045112 · ownership.xml · derivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045115 · ownership.xml · derivative · entry 1

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045106 · ownership.xml · derivative · entry 1

Kim Jae B. · CIK 0001819159 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045086 · ownership.xml · derivative · entry 1

Wilson Mark Andrew · CIK 0001808356 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,000

Underlying: Common Stock · 165,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 25% of the shares underlying this option will vest on January 5, 2027, and the remaining 75% of the shares underlying this option will vest in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service to the Issuer on each such vesting date.

SEC source: 0001193125-26-045109 · ownership.xml · derivative · entry 1

Labrucherie Gil M · CIK 0001394875 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-26-045097 · ownership.xml · derivative · entry 1

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,000

Underlying: Common Stock · 155,000 shares

Expires 2036-02-05

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0001193125-25-280756 · ownership.xml · nonDerivative · entry 1

Long Daniel D. · CIK 0002040349 · SVP, Drug Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,911

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.04 to $18.16. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F2 · balance_after: Includes 3,501 shares acquired under the Septerna, Inc. 2024 Employee Stock Purchase Plan on October 31, 2025 in transactions that were exempt under Rule 16b-3(c).

SEC source: 0001193125-25-223384 · ownership.xml · derivative · entry 1

Gottesdiener Keith Michael · CIK 0001615856 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,246

Underlying: Common Stock · 33,246 shares

Expires 2035-09-24

F1 · derivative.exercise_date: 1/36th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of September 25, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-110177 · ownership.xml · derivative · entry 7

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,027

Underlying: Common Stock · 7,621 shares

Expires 2034-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, contingent upon the consummation of the Issuer's initial public offering, and subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-110177 · ownership.xml · derivative · entry 6

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,001

Underlying: Common Stock · 4,935 shares

Expires 2034-03-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-110177 · ownership.xml · derivative · entry 5

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,453

Underlying: Common Stock · 10,452 shares

Expires 2033-11-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2023, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-110177 · ownership.xml · nonDerivative · entry 3

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,008

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-110177 · ownership.xml · nonDerivative · entry 2

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,387

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-110177 · ownership.xml · nonDerivative · entry 1

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,452

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-106792 · ownership.xml · derivative · entry 1

Long Daniel D. · CIK 0002040349 · SVP, Drug Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106790 · ownership.xml · derivative · entry 1

Klein Uwe · CIK 0002040350 · SVP, Biological Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2025-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106799 · ownership.xml · derivative · entry 1

Shaikhly Samira · CIK 0002040363 · Chief People Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106793 · ownership.xml · derivative · entry 1

Finer Jeffrey · CIK 0002040376 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106796 · ownership.xml · derivative · entry 1

Kim Jae B. · CIK 0001819159 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 2/48th of the shares subject to such option shall vest and become exercisable on October 1, 2025 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106795 · ownership.xml · derivative · entry 1

Labrucherie Gil M · CIK 0001394875 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 6/48th of the shares subject to such option shall vest and become exercisable on February 1, 2026 and the remaining shares subject to the option shall vest in 42 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-106798 · ownership.xml · derivative · entry 1

Bhatt Elizabeth · CIK 0001748622 · President and COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2035-08-06

F1 · derivative.exercise_date: 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

SEC source: 0000950170-25-088616 · ownership.xml · derivative · entry 1

Bassan Abraham · CIK 0001864485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,623

Underlying: Common Stock · 16,623 shares

Expires 2035-06-16

F1 · derivative.exercise_date: The shares underlying the stock option will vest in full upon the earlier of (i) June 17, 2026 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

SEC source: 0000950170-25-088618 · ownership.xml · derivative · entry 1

Simson Jake · CIK 0001863094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,623

Underlying: Common Stock · 16,623 shares

Expires 2035-06-16

F1 · derivative.exercise_date: The shares underlying the stock option will vest in full upon the earlier of (i) June 17, 2026 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the option for the benefit of the R.A. Capital Healthcare Fund, L.P. (the "Fund") and R.A. Capital Nexus Fund III, L.P. (the "Nexus Fund III"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund III to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the option and underlying common stock.