SDGR

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,388

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042424 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,814

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,199,621

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.19 to $75.905, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,210,240

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.19 to $75.18, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,225,535

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.16 to $74.15, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,252,405

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.46 to $76.85, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,261,960

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.46 to $76.45, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,295,179

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.46 to $75.43 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042220 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,302,102

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.44 to $74.42, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-042096 · doc4.xml · derivative · entry 1

Chodakewitz Jeffrey · CIK 0001610876 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-042102 · doc4.xml · derivative · entry 1

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-042099 · doc4.xml · derivative · entry 1

Lynton Michael · CIK 0001606115 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-042100 · doc4.xml · derivative · entry 1

Sender Gary · CIK 0001659085 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-042103 · doc4.xml · derivative · entry 1

GINSBERG GARY L · CIK 0001236136 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service

SEC source: 0001209191-21-042097 · doc4.xml · derivative · entry 1

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-042098 · doc4.xml · derivative · entry 1

Friesner Richard · CIK 0001798426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,736

Underlying: Common Stock · 8,736 shares

Expires 2031-06-17

F1 · derivative.exercise_date: The option was granted on June 17, 2021. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 10

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,304,350

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F11 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.78 to $75.49, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 9

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,314,209

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.775 to $74.76, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,333,316

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.77 to $73.765, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,341,545

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,342,045

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.69 to $75.28, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,355,871

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.69 to $74.68, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,393,236

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.69 to $73.68, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-040645 · doc4.xml · derivative · entry 5

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,756

Underlying: Common Stock · 5,574 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F5 · derivative.exercise_date: The option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on November 14, 2019 and the remainder vest in equal monthly installments through November 14, 2022.

SEC source: 0001209191-21-040645 · doc4.xml · nonDerivative · entry 4

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.49 to $78.71, inclusive.

SEC source: 0001209191-21-040645 · doc4.xml · nonDerivative · entry 3

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $77.42 to $78.39, inclusive.

SEC source: 0001209191-21-040645 · doc4.xml · nonDerivative · entry 2

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,481

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $76.29 to $77.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-040645 · doc4.xml · nonDerivative · entry 1

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,574

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,401,959

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $78.20 to $78.35, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,404,999

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $77.17 to $78.13 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-041052 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,436,511

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.165 to $77.15, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-039215 · doc4.xml · derivative · entry 7

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,165

Underlying: Common Stock · 10,242 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F5 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-039215 · doc4.xml · nonDerivative · entry 5

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $76.00 to $76.16, inclusive.

SEC source: 0001209191-21-039215 · doc4.xml · nonDerivative · entry 4

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.00 to $75.95, inclusive.

SEC source: 0001209191-21-039215 · doc4.xml · nonDerivative · entry 3

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,242

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

SEC source: 0001209191-21-039217 · doc4.xml · derivative · entry 3

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,509

Underlying: Common Stock · 1,000 shares

Expires 2029-01-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F2 · derivative.exercise_date: This option was granted on January 30, 2019. The shares underlying the option vested with respect to 25% of the shares on January 9, 2020 and the remainder are scheduled to vest in equal monthly installments through January 9, 2023.

SEC source: 0001209191-21-039217 · doc4.xml · nonDerivative · entry 2

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

SEC source: 0001209191-21-039217 · doc4.xml · nonDerivative · entry 1

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

SEC source: 0001209191-21-039215 · doc4.xml · derivative · entry 6

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,407

Underlying: Common Stock · 6,479 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F5 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-039215 · doc4.xml · nonDerivative · entry 2

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.00 to $75.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-039215 · doc4.xml · nonDerivative · entry 1

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,479

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 17, 2021.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,445,422

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.365 to $69.61, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,445,722

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.30 to $69.18, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,446,402

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.52 to $69.05, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,473,366

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.52 to $68.51, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,489,104

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.52 to $67.51, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,491,884

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.81 to $66.10, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,495,296

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $64.81 to $65.805 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-036002 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 7,518,363

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $63.80 to $64.79, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.