RXRX

SEC source: 0001601830-24-000095 · wk-form4_1719609240.xml · nonDerivative · entry 1

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 541,457

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2024.

SEC source: 0001601830-24-000094 · wk-form4_1719529999.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,177,116

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.325 to $9.82. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · derivative · entry 6

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 731,385

Underlying: Class A Common Stock · 39,375 shares

Expires 2030-03-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

F4 · derivative.exercise_date: The option, originally for 1,500,000 shares, vests incrementally upon satisfaction of certain liquidity events.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · nonDerivative · entry 4

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,267,843

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

F3 · price: This transaction was executed in multiple trades at prices ranging from $9.185 to $9.39 The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · nonDerivative · entry 3

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,282,843

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · derivative · entry 5

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 770,760

Underlying: Class A Common Stock · 39,375 shares

Expires 2030-03-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

F4 · derivative.exercise_date: The option, originally for 1,500,000 shares, vests incrementally upon satisfaction of certain liquidity events.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · nonDerivative · entry 2

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,243,468

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.125 to $9.47 The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000083 · wk-form4_1718660802.xml · nonDerivative · entry 1

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,258,468

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2024.

SEC source: 0001601830-24-000082 · wk-form4_1718314568.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,188,563

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.285 to $8.66. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000077 · wk-form4_1717790504.xml · nonDerivative · entry 4

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 708,738

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001601830-24-000077 · wk-form4_1717790504.xml · derivative · entry 5

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,401,700

Underlying: Class A Common Stock · 25,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F1 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a bona-fide gift of shares by the Reporting Person.

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

F3 · derivative.exercise_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F3 · derivative.expiration_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

SEC source: 0001601830-24-000077 · wk-form4_1717790504.xml · nonDerivative · entry 3

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 758,738

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001601830-24-000077 · wk-form4_1717790504.xml · nonDerivative · entry 2

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 808,738

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001601830-24-000077 · wk-form4_1717790504.xml · nonDerivative · entry 1

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 833,738

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a bona-fide gift of shares by the Reporting Person.

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

SEC source: 0001601830-24-000102 · wk-form4a_1720824741.xml · derivative · entry 2

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,326,700

Underlying: Class A Common Stock · 100,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F1 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a disposition of shares by the Reporting Person.

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

F4 · derivative.exercise_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F4 · derivative.expiration_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F3 · derivative.underlying_shares: This amendment corrects the amount of shares converted from Class B Common Stock to Class A Common Stock from 25,000 to 100,000 shares.

SEC source: 0001601830-24-000102 · wk-form4a_1720824741.xml · nonDerivative · entry 1

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 908,738

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a disposition of shares by the Reporting Person.

F2 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023.

F3 · shares: This amendment corrects the amount of shares converted from Class B Common Stock to Class A Common Stock from 25,000 to 100,000 shares.

SEC source: 0001601830-24-000070 · wk-form4_1717625489.xml · derivative · entry 2

Dar Zavain · CIK 0001852075 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,193

Underlying: Class A Common Stock · 26,193 shares

Expires 2034-06-03

F2 · derivative.exercise_date: The shares subject to this option will vest and become exercisable on the earlier of June 3, 2025 or the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000070 · wk-form4_1717625489.xml · nonDerivative · entry 1

Dar Zavain · CIK 0001852075 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,153

F1 · kind: Represents a grant of restricted stock units automatically granted pursuant to the Issuer's Outside Director Compensation Policy. The restricted stock units will vest on the earlier of June 3, 2025 or the day prior to the Issuer's 2025 annual meeting of stockholders, subject to Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000072 · wk-form4_1717625527.xml · derivative · entry 2

HERSHBERG ROBERT · CIK 0001274139 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,193

Underlying: Class A Common Stock · 26,193 shares

Expires 2034-06-03

F2 · derivative.exercise_date: The shares subject to this option will vest and become exercisable on the earlier of June 3, 2025 or the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000072 · wk-form4_1717625527.xml · nonDerivative · entry 1

HERSHBERG ROBERT · CIK 0001274139 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,716

F1 · kind: Represents a grant of restricted stock units automatically granted pursuant to the Issuer's Outside Director Compensation Policy. The restricted stock units will vest on the earlier of June 3, 2025 or the day prior to the Issuer's 2025 annual meeting of stockholders, subject to Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000073 · wk-form4_1717625544.xml · derivative · entry 2

Burrell Terry-Ann · CIK 0001786484 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,193

Underlying: Class A Common Stock · 26,193 shares

Expires 2034-06-03

F2 · derivative.exercise_date: The shares subject to this option will vest and become exercisable on the earlier of June 3, 2025 or the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000073 · wk-form4_1717625544.xml · nonDerivative · entry 1

Burrell Terry-Ann · CIK 0001786484 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,411

F1 · kind: Represents a grant of restricted stock units automatically granted pursuant to the Issuer's Outside Director Compensation Policy. The restricted stock units will vest on the earlier of June 3, 2025 or the day prior to the Issuer's 2025 annual meeting of stockholders, subject to Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000071 · wk-form4_1717625511.xml · derivative · entry 2

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,193

Underlying: Class A Common Stock · 26,193 shares

Expires 2034-06-03

F2 · derivative.exercise_date: The shares subject to this option will vest and become exercisable on the earlier of June 3, 2025 or the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000071 · wk-form4_1717625511.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,200,010

F1 · kind: Represents a grant of restricted stock units automatically granted pursuant to the Issuer's Outside Director Compensation Policy. The restricted stock units will vest on the earlier of June 3, 2025 or the day prior to the Issuer's 2025 annual meeting of stockholders, subject to Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000069 · wk-form4_1717625475.xml · derivative · entry 5

Li Dean Y · CIK 0001837016 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,193

Underlying: Class A Common Stock · 26,193 shares

Expires 2034-06-03

F2 · derivative.exercise_date: The shares subject to this option will vest and become exercisable on the earlier of June 3, 2025 or the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000069 · wk-form4_1717625475.xml · nonDerivative · entry 1

Li Dean Y · CIK 0001837016 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,186

F1 · kind: Represents a grant of restricted stock units automatically granted pursuant to the Issuer's Outside Director Compensation Policy. The restricted stock units will vest on the earlier of June 3, 2025 or the day prior to the Issuer's 2025 annual meeting of stockholders, subject to Reporting Person's continued service to the Issuer.

SEC source: 0001601830-24-000068 · wk-form4_1717453891.xml · derivative · entry 3

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 482,000

Underlying: Class A Common Stock · 3,000 shares

Expires 2028-07-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F4 · derivative.exercise_date: Twenty-Five percent (25%) of the shares subject to the award (the stock option grant was for a total of 765,000 shares prior to exercise) shall vest one year after July 16, 2018, or the Annual Vesting Commencement Date, and one-forty-eighth (1/48th) of the shares subject to the award shall vest each month thereafter on the same day of the month as the Annual Vesting Commencement Date.

SEC source: 0001601830-24-000068 · wk-form4_1717453891.xml · nonDerivative · entry 2

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 535,457

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $8.65 to $8.88. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000068 · wk-form4_1717453891.xml · nonDerivative · entry 1

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 538,457

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F2 · balance_after: Includes 2,224 shares purchased pursuant to the Issuer's Employee Stock Purchase Plan on May 20, 2024.

SEC source: 0001601830-24-000067 · wk-form4_1717108876.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,186,913

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.88 to $9.55. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000057 · wk-form4_1715987502.xml · nonDerivative · entry 1

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 808,738

F1 · kind: Represents shares that have been withheld by the Issuer to satisfy its tax withholding and remittance obligations in connection with the net settlement of restricted stock units.

SEC source: 0001601830-24-000059 · wk-form4_1715987524.xml · nonDerivative · entry 1

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 533,233

F1 · kind: Represents shares that have been withheld by the Issuer to satisfy its tax withholding and remittance obligations in connection with the net settlement of restricted stock units.

SEC source: 0001601830-24-000058 · wk-form4_1715987513.xml · nonDerivative · entry 1

Mauro David J · CIK 0001621172 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 243,762

F1 · kind: Represents shares that have been withheld by the Issuer to satisfy its tax withholding and remittance obligations in connection with the net settlement of restricted stock units.

SEC source: 0001601830-24-000056 · wk-form4_1715987475.xml · nonDerivative · entry 1

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,219,093

F1 · kind: Represents shares that have been withheld by the Issuer to satisfy its tax withholding and remittance obligations in connection with the net settlement of restricted stock units.

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.44 to $7.70 The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000055 · wk-form4_1715891720.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,198,360

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.74 to $10.50. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · derivative · entry 6

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,426,700

Underlying: Class A Common Stock · 21,296 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

F2 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a bona-fide gift of shares by the Reporting Person.

F3 · derivative.exercise_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F3 · derivative.expiration_date: Each share of Class B Common Stock is convertible into one share of Class A Common Stock at the option of the holder and has no expiration date.

F4 · balance_after: This number of shares represents the correct number of shares of Class B shares held by the Reporting person as of the date of this report, correcting an error in his running total from 2023.

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · nonDerivative · entry 5

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 834,820

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · nonDerivative · entry 4

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 856,116

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

F2 · kind: Represents the automatic conversion of Class B Common Stock into Class A Common Stock in connection with a bona-fide gift of shares by the Reporting Person.

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · nonDerivative · entry 3

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 834,820

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · nonDerivative · entry 2

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 863,524

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

SEC source: 0001601830-24-000047 · wk-form4_1714775052.xml · nonDerivative · entry 1

Gibson Christopher · CIK 0001856369 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 913,524

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 27, 2023

SEC source: 0001601830-24-000046 · wk-form4_1714686087.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,218,414

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.81 to $8.26. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000045 · wk-form4_1714430473.xml · derivative · entry 3

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 485,000

Underlying: Class A Common Stock · 3,000 shares

Expires 2028-07-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F4 · derivative.exercise_date: Twenty-Five percent (25%) of the shares subject to the award (the stock option grant was for a total of 765,000 shares prior to exercise) shall vest one year after July 16, 2018, or the Annual Vesting Commencement Date, and one-forty-eighth (1/48th) of the shares subject to the award shall vest each month thereafter on the same day of the month as the Annual Vesting Commencement Date.

SEC source: 0001601830-24-000045 · wk-form4_1714430473.xml · nonDerivative · entry 2

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 543,231

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.5 to $7.86. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000045 · wk-form4_1714430473.xml · nonDerivative · entry 1

Marriott Tina · CIK 0001856414 · President and COO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 546,231

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan established by the Reporting Person dated March 1, 2023.

F2 · balance_after: Since the Reporting Person's last ownership report, she has transferred 96,751 shares of RXRX Class A Common Stock to her former spouse pursuant to a domestic relations order. The Reporting Person no longer reports as beneficially owned any securities owned by her former spouse.

SEC source: 0001601830-24-000036 · wk-form4_1713474733.xml · derivative · entry 6

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 810,135

Underlying: Class A Common Stock · 37,500 shares

Expires 2030-03-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, originally for 1,500,000 shares, vests incrementally upon satisfaction of certain liquidity events.

SEC source: 0001601830-24-000036 · wk-form4_1713474733.xml · nonDerivative · entry 4

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,231,055

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2023.

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.44 to $7.70 The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000036 · wk-form4_1713474733.xml · nonDerivative · entry 3

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,254,179

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction is pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 1, 2023.

SEC source: 0001601830-24-000037 · wk-form4_1713474744.xml · nonDerivative · entry 1

Borgeson Blake · CIK 0001856094 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,229,861

F1 · kind: This transaction is pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 18, 2023.

F2 · price: This transaction was executed in multiple trades at prices ranging from $7.54 to $7.77. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001601830-24-000036 · wk-form4_1713474733.xml · derivative · entry 5

Secora Michael · CIK 0001855980 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 847,635

Underlying: Class A Common Stock · 37,500 shares

Expires 2030-03-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option, originally for 1,500,000 shares, vests incrementally upon satisfaction of certain liquidity events.