RVMD

SEC source: 0001567619-21-002350 · doc1.xml · nonDerivative · entry 3

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $51.35 to $51.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-002350 · doc1.xml · nonDerivative · entry 2

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,708

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $50.00 to $50.485, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-002350 · doc1.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,808

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-002062 · doc1.xml · derivative · entry 3

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,489

Underlying: Common Stock · 5,336 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

SEC source: 0001567619-21-002062 · doc1.xml · nonDerivative · entry 2

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-002062 · doc1.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,144

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-002063 · doc1.xml · derivative · entry 7

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,486

Underlying: Common Stock · 5,000 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F11 · derivative.exercise_date: This option is early exercisable. One forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary measured from March 29, 2018 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-002063 · doc1.xml · nonDerivative · entry 3

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 744

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $46.04 to $46.32, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002063 · doc1.xml · nonDerivative · entry 2

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,544

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $45.00 to $45.96, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002063 · doc1.xml · nonDerivative · entry 1

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-000102 · doc1.xml · derivative · entry 4

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,489

Underlying: Common Stock · 5,336 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

SEC source: 0001567619-21-000102 · doc1.xml · nonDerivative · entry 3

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-000102 · doc1.xml · nonDerivative · entry 2

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,908

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $40.27 to $41.17, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-000102 · doc1.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,144

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-000828 · doc1.xml · derivative · entry 2

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,825

Underlying: N/A · 0 shares

Expires 2028-04-19

F1 · date: On January 4, 2021, the reporting person filed a Form 4 reporting the exercise and sale of 5,336 shares of common stock. This Form 4 was mistakenly filed due to broker error and the exercise and sale did not in fact occur.

F1 · kind: On January 4, 2021, the reporting person filed a Form 4 reporting the exercise and sale of 5,336 shares of common stock. This Form 4 was mistakenly filed due to broker error and the exercise and sale did not in fact occur.

F3 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

F1 · balance_after: On January 4, 2021, the reporting person filed a Form 4 reporting the exercise and sale of 5,336 shares of common stock. This Form 4 was mistakenly filed due to broker error and the exercise and sale did not in fact occur.

SEC source: 0001567619-21-002063 · doc1.xml · nonDerivative · entry 6

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · Trust

Disclosed balance after: 247,093

F8 · shares: This transaction involved a gift of securities by the Reporting Person.

F9 · balance_after: On December 2, 2020, Third Rock Ventures GP III, L.P. distributed 245 shares to the Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust through an in-kind, pro rata distribution without value. This distribution was exempt from Section 16 of the Exchange Act pursuant to Rule 16a-9.

F10 · ownership.nature: Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 7

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,302

F11 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG III GP.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 6

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 46

F9 · kind: Represents a change in the form of ownership of The Column Group, LLC ("TCG LLC") by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG III GP.

F10 · ownership.nature: The securities are directly held TCG LLC. The managing members of TCG LLC are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 5

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F8 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by TCG III GP to its partners.

F4 · ownership.nature: The securities are directly held by TCG III GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 4

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 46,868

F7 · kind: Represents a change in the form of ownership of TCG III GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG III-A LP.

F4 · ownership.nature: The securities are directly held by TCG III GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 3

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,898,815

F5 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by The Column Group III-A, LP ("TCG III-A LP") to its general and limited partners.

F6 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 2

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 22,011

F3 · kind: Represents a change in the form of ownership of TCG III GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG III LP.

F4 · ownership.nature: The securities are directly held by TCG III GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-20-033611 · doc4.xml · nonDerivative · entry 1

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,681,391

F1 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by The Column Group III, LP ("TCG III LP") to its general and limited partners.

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-20-032784 · doc4.xml · nonDerivative · entry 1

Third Rock Ventures III, L.P. · CIK 0001569705 · 10% owner

Third Rock Ventures GP III, L.P. · CIK 0001637300 · 10% owner

TRV GP III, LLC · CIK 0001637299 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,024,031

F1 · kind: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration, 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F1 · price: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration, 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F2 · ownership.direct: These shares are directly held by TRV III. The general partner of TRV III is TRV GP III. The general partner of TRV GP III is TRV GP III, LLC ("TRV GP III LLC"). The individual managers of TRV GP III LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP III, TRV GP III LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares.

SEC source: 0000899243-20-032782 · doc4.xml · nonDerivative · entry 1

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · kind: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 7,024,031 shares of Common Stock of the Issuer.

F1 · shares: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 7,024,031 shares of Common Stock of the Issuer.

F1 · price: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 7,024,031 shares of Common Stock of the Issuer.

F1 · balance_after: On December 2, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,000,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 7,024,031 shares of Common Stock of the Issuer.

F2 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III and Third Rock Ventures GP IV, L.P. which is the general partner of each of Third Rock Ventures II, L.P. ("TRV II"), TRV III and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0000899243-20-031483 · doc4.xml · nonDerivative · entry 2

COLUMN GROUP III, LP · CIK 0001668159 · 10% owner

COLUMN GROUP III-A, LP · CIK 0001668085 · 10% owner

COLUMN GROUP III GP, LP · CIK 0001790965 · 10% owner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,429,180

F2 · ownership.nature: The securities are directly held by The Column Group III-A, LP ("TCG III-A LP"). TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares

SEC source: 0000899243-20-031483 · doc4.xml · nonDerivative · entry 1

COLUMN GROUP III, LP · CIK 0001668159 · 10% owner

COLUMN GROUP III-A, LP · CIK 0001668085 · 10% owner

COLUMN GROUP III GP, LP · CIK 0001790965 · 10% owner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,151,026

F1 · ownership.direct: The securities are directly held by The Column Group III, LP ("TCG III LP"). The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, Peter Svennilson, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares

SEC source: 0000899243-20-031482 · doc4.xml · nonDerivative · entry 2

Svennilson Peter · CIK 0001606074 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,429,180

F2 · ownership.nature: The securities are directly held by The Column Group III-A, LP ("TCG III-A LP"). TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares

SEC source: 0000899243-20-031482 · doc4.xml · nonDerivative · entry 1

Svennilson Peter · CIK 0001606074 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,151,026

F1 · ownership.nature: The securities are directly held by The Column Group III, LP ("TCG III LP"). The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares

SEC source: 0001567619-20-017889 · doc1.xml · nonDerivative · entry 2

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 26,990

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · ownership.nature: Held by David W. Anderson 1996 Irrevocable Trust.

SEC source: 0001567619-20-017887 · doc1.xml · derivative · entry 3

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,201

Underlying: Common Stock · 10,000 shares

Expires 2028-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vest on the first anniversary measured from August 16, 2018 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-20-017887 · doc1.xml · nonDerivative · entry 2

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-20-017887 · doc1.xml · nonDerivative · entry 1

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-20-017889 · doc1.xml · nonDerivative · entry 1

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 31,770

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · ownership.nature: Held by David W. Anderson 1996 Irrevocable Trust.

SEC source: 0001567619-20-017693 · doc1.xml · derivative · entry 3

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,201

Underlying: Common Stock · 10,000 shares

Expires 2028-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vest on the first anniversary measured from August 16, 2018 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-20-017693 · doc1.xml · nonDerivative · entry 2

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-20-017693 · doc1.xml · nonDerivative · entry 1

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-20-017694 · doc1.xml · nonDerivative · entry 1

Miller Vincent A. · CIK 0001584999 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,133

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017692 · doc1.xml · nonDerivative · entry 1

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 31,990

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · ownership.nature: Held by David W. Anderson 1996 Irrevocable Trust.

SEC source: 0001567619-20-017604 · doc1.xml · derivative · entry 9

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,825

Underlying: Common Stock · 7,196 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F6 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 6

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $36.00 to $36.52, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 5

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,004

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017529 · doc1.xml · nonDerivative · entry 2

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · Trust

Disclosed balance after: 53,302

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $35.00 to $36.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · ownership.nature: Held by Margaret A. Horn Revocable Living Trust.

SEC source: 0001567619-20-017604 · doc1.xml · derivative · entry 8

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,021

Underlying: Common Stock · 804 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F6 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 4

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $36.00 to $36.10, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 3

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,612

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017529 · doc1.xml · nonDerivative · entry 1

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · Trust

Disclosed balance after: 65,797

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $35.00 to $35.37, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · ownership.nature: Held by Margaret A. Horn Revocable Living Trust.

SEC source: 0001567619-20-017604 · doc1.xml · derivative · entry 7

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,825

Underlying: Common Stock · 2,000 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F6 · derivative.exercise_date: This option is early exercisable. Twenty-five percent of the total shares subject to the option vested on the first anniversary measured from April 20, 2018 (the "Vesting Commencement Date") and one sixteenth (1/16th) of the shares subject to the option will vest quarterly thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 2

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,808

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $34.26 to $35.21, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-20-017604 · doc1.xml · nonDerivative · entry 1

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,808

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 1,808 Restricted Stock Units.