RNAC

SEC source: 0000899243-17-022598 · doc4.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 32,235

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.00 to $19.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPE V"). Polaris Venture Management Co. V, L.L.C. ("PVM V") is the general partner of PVPE V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F3 · ownership.nature: Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPE V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 8

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,694,676

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.20 to $20.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (11) to this Form 4.

F9 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners V, L.P. ("PVP V"). PVM V is the general partner of PVP V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F10 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVP V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 7

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 16,944

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.20 to $20.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (11) to this Form 4.

F7 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V"). PVM V is the general partner of PVPSFF V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F8 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPSFF V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 6

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 11,605

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.20 to $20.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (11) to this Form 4.

F4 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"). PVM V is the general partner of PVPFF V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F5 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPFF V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 5

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 33,025

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.20 to $20.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (11) to this Form 4.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPE V"). Polaris Venture Management Co. V, L.L.C. ("PVM V") is the general partner of PVPE V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F3 · ownership.nature: Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPE V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001638599-17-000948 · doc4_4980.xml · derivative · entry 6

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 14,230 shares

Expires 2021-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000948 · doc4_4980.xml · derivative · entry 5

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,194 shares

Expires 2020-09-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000948 · doc4_4980.xml · nonDerivative · entry 4

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000948 · doc4_4980.xml · nonDerivative · entry 3

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,230

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000948 · doc4_4980.xml · nonDerivative · entry 2

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000948 · doc4_4980.xml · nonDerivative · entry 1

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,194

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 4

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,795,587

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.95 to $20.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F9 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners V, L.P. ("PVP V"). PVM V is the general partner of PVP V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F10 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVP V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 3

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 17,953

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.95 to $20.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (6) to this Form 4.

F7 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Special Founders' Fund V, L.P. ("PVPSFF V"). PVM V is the general partner of PVPSFF V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F8 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPSFF V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 2

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 12,295

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.95 to $20.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F4 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Founders' Fund V, L.P. ("PVPFF V"). PVM V is the general partner of PVPFF V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F5 · ownership.nature: Each of Flint and McGuire are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPFF V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-17-022441 · doc4.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 34,992

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.95 to $20.62, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("PVPE V"). Polaris Venture Management Co. V, L.L.C. ("PVM V") is the general partner of PVPE V. PVM V disclaims beneficial ownership of these securities and this report shall not be deemed an admission that PVM V is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein.

F3 · ownership.nature: Each of Jonathan A. Flint ("Flint") and Terrance G. McGuire ("McGuire") are the managing members of PVM V. The Reporting Person, who is a member of the Issuer's Board of Directors, is a member of PVM V. Each of Flint, McGuire and the Reporting Person, in their respective capacities with regard to PVM V, may be deemed to have shared voting and dispositive power of the shares held by PVPE V. Each of Flint, McGuire and the Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001638599-17-000704 · doc4_4848.xml · derivative · entry 1

Siewers David · CIK 0001676906 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000703 · doc4_4846.xml · derivative · entry 1

Sands Earl · CIK 0001676902 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000702 · doc4_4844.xml · derivative · entry 1

Johnston Lloyd P. · CIK 0001676905 · COO & Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000701 · doc4_4845.xml · derivative · entry 1

Kishimoto Takashi Kei · CIK 0001676930 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000700 · doc4_4843.xml · derivative · entry 1

CAUTREELS WERNER · CIK 0001237419 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000698 · doc4_4847.xml · derivative · entry 1

Keller Peter · CIK 0001676904 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000697 · doc4_4849.xml · derivative · entry 1

Abraham David · CIK 0001676903 · GC and Corporate Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2027-07-06

F1 · derivative.exercise_date: This option vests as to 25% of the shares on June 16, 2018. The remainder of the shares will vest in 36 equal monthly installments thereafter.

SEC source: 0001638599-17-000685 · doc4_4832.xml · derivative · entry 4

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 126

Underlying: Common Stock · 5,959 shares

Expires 2023-06-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000685 · doc4_4832.xml · nonDerivative · entry 3

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,606

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.605 to $19.40, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001638599-17-000685 · doc4_4832.xml · nonDerivative · entry 2

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,465

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.72 to $19.76, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001638599-17-000685 · doc4_4832.xml · nonDerivative · entry 1

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,565

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001638599-17-000675 · doc4_4830.xml · derivative · entry 3

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,194

Underlying: Common Stock · 7,420 shares

Expires 2020-09-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F3 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000675 · doc4_4830.xml · nonDerivative · entry 2

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $20.00 to $20.02, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001638599-17-000675 · doc4_4830.xml · nonDerivative · entry 1

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,420

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000668 · doc4_4828.xml · derivative · entry 6

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,614

Underlying: Common Stock · 5,770 shares

Expires 2020-09-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: The transactions reported for the 5,770 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F5 · derivative.exercise_date: All shares underlying this option are fully vested.

F2 · derivative.underlying_shares: The transactions reported for the 5,770 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000668 · doc4_4828.xml · derivative · entry 5

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,846 shares

Expires 2019-09-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The transactions reported for the 3,846 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F5 · derivative.exercise_date: All shares underlying this option are fully vested.

F1 · derivative.underlying_shares: The transactions reported for the 3,846 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000668 · doc4_4828.xml · nonDerivative · entry 4

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F4 · shares: The 36 shares sold were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 14, 2016.

SEC source: 0001638599-17-000668 · doc4_4828.xml · nonDerivative · entry 3

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36

F1 · shares: The transactions reported for the 3,846 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · shares: The transactions reported for the 5,770 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.00 to $20.01, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange commission, upon request, full information regarding the number of shares sold at each separate price within the set forth herein.

SEC source: 0001638599-17-000668 · doc4_4828.xml · nonDerivative · entry 2

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,652

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: The transactions reported for the 5,770 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000668 · doc4_4828.xml · nonDerivative · entry 1

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,882

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: The transactions reported for the 3,846 shares were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

SEC source: 0001638599-17-000662 · doc4_4824.xml · derivative · entry 4

SPRINGER TIMOTHY A · CIK 0001055624 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,130

Underlying: Common Stock · 79,130 shares

Expires 2022-06-27

SEC source: 0001638599-17-000662 · doc4_4824.xml · nonDerivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 355,413

SEC source: 0001638599-17-000661 · doc4_4823.xml · derivative · entry 3

Keller Peter · CIK 0001676904 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,588

Underlying: Common Stock · 4,595 shares

Expires 2021-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000661 · doc4_4823.xml · nonDerivative · entry 2

Keller Peter · CIK 0001676904 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 405

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $19.20 to $19.49, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001638599-17-000661 · doc4_4823.xml · nonDerivative · entry 1

Keller Peter · CIK 0001676904 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001638599-17-000660 · doc4_4822.xml · nonDerivative · entry 1

Siewers David · CIK 0001676906 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36

SEC source: 0001638599-17-000638 · doc4_4809.xml · derivative · entry 1

SPRINGER TIMOTHY A · CIK 0001055624 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000640 · doc4_4810.xml · derivative · entry 1

HUTT PETER BARTON · CIK 0001171527 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000637 · doc4_4805.xml · derivative · entry 1

ZENNER PATRICK J · CIK 0001139036 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,820

Underlying: Common Stock · 12,820 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in thirty-six (36) substantially equal monthly installments over three years following the date of grant.

SEC source: 0001638599-17-000642 · doc4_4808.xml · derivative · entry 1

Farokhzad Omid · CIK 0001586852 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000641 · doc4_4811.xml · derivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000639 · doc4_4807.xml · derivative · entry 1

Sallin Aymeric · CIK 0001677660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000630 · doc4_4806.xml · derivative · entry 1

BARABE TIMOTHY C · CIK 0001237409 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,410

Underlying: Common Stock · 6,410 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2018 or the day immediately prior to the company's 2018 annual meeting of shareholders.

SEC source: 0001638599-17-000626 · doc4_4803.xml · derivative · entry 3

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,512 shares

Expires 2019-07-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: All shares underlying this option are fully vested.

SEC source: 0001638599-17-000626 · doc4_4803.xml · nonDerivative · entry 2

Johnston Lloyd P. · CIK 0001676905 · COO and SVP, R*D · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,606

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 21, 2016.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.95 to $17.10, inclusive. The reporting person undertakes to provide to Issuer, any security holder of Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.