RLYB

SEC source: 0001739410-25-000007 · wk-form4_1736201216.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,571

Underlying: Common Stock · 73,571 shares

Expires 2035-01-02

F2 · price: This option was issued to the reporting person pursuant to the Company's 2021 Equity Incentive Plan in lieu of retainer fees of $51,500.

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2025.

SEC source: 0001739410-25-000006 · wk-form4_1736201189.xml · derivative · entry 1

Hopfner Robert Lorne · CIK 0001551966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,571

Underlying: Common Stock · 73,571 shares

Expires 2035-01-02

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2025.

F2 · balance_after: This option was issued to the reporting person pursuant to the Company's 2021 Equity Incentive Plan in lieu of retainer fees of $51,500.

SEC source: 0001739410-25-000005 · wk-form4_1736201159.xml · derivative · entry 1

Liu Hui · CIK 0001790518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,857

Underlying: Common Stock · 67,857 shares

Expires 2035-01-02

F2 · price: This option was issued to the reporting person pursuant to the Company's 2021 Equity Incentive Plan in lieu of retainer fees of $47,500.

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2025.

SEC source: 0001739410-24-000087 · wk-form4_1715979779.xml · derivative · entry 1

Chung Wendy · CIK 0001922605 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000094 · wk-form4_1715979961.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000093 · wk-form4_1715979949.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000092 · wk-form4_1715979915.xml · derivative · entry 1

Liu Hui · CIK 0001790518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000091 · wk-form4_1715979881.xml · derivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000090 · wk-form4_1715979851.xml · derivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000089 · wk-form4_1715979821.xml · derivative · entry 1

Nash Christine A · CIK 0001554403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000088 · wk-form4_1715979797.xml · derivative · entry 1

Hopfner Robert Lorne · CIK 0001551966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2034-05-15

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 15, 2025 or the date of the Company's 2025 Annual Meeting of Stockholders.

SEC source: 0001739410-24-000020 · wk-form4_1708125735.xml · derivative · entry 1

Uden Stephen · CIK 0001332141 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 216,000

Underlying: Common Stock · 216,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 15, 2028.

SEC source: 0001739410-24-000019 · wk-form4_1708125672.xml · derivative · entry 1

MACKAY MARTIN · CIK 0001414815 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 216,000

Underlying: Common Stock · 216,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 15, 2028.

SEC source: 0001739410-24-000018 · wk-form4_1708125606.xml · derivative · entry 1

Lieber Jonathan I · CIK 0001350090 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 15, 2028.

SEC source: 0001739410-24-000017 · wk-form4_1708125519.xml · derivative · entry 1

Ryder Steven · CIK 0001872868 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 15, 2028.

SEC source: 0001739410-24-000004 · wk-form4_1704409080.xml · derivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,118

Underlying: Common Stock · 27,118 shares

Expires 2034-01-02

F2 · price: This option was issued to the reporting person pursuant to the Company's 2021 Equity Incentive Plan in lieu of retainer fees of $48,000.

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2024.

SEC source: 0001739410-24-000003 · wk-form4_1704408977.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,096

Underlying: Common Stock · 29,096 shares

Expires 2034-01-02

F2 · price: This option was issued to the reporting person pursuant to the Company's 2021 Equity Incentive Plan in lieu of retainer fees of $51,500.

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2024.

SEC source: 0000899243-23-013393 · doc4.xml · derivative · entry 1

Chung Wendy · CIK 0001922605 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,353

Underlying: Common Stock · 12,353 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013407 · doc4.xml · derivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013406 · doc4.xml · derivative · entry 1

Nash Christine A · CIK 0001554403 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013405 · doc4.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013404 · doc4.xml · derivative · entry 1

Hopfner Robert Lorne · CIK 0001551966 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013402 · doc4.xml · derivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013398 · doc4.xml · derivative · entry 1

Liu Hui · CIK 0001790518 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000899243-23-013396 · doc4.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,490

Underlying: Common Stock · 15,490 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 17, 2024 or the date of the Company's 2024 Annual Meeting of Stockholders.

SEC source: 0000950170-23-008553 · ownership.xml · nonDerivative · entry 1

Lieber Jonathan I · CIK 0001350090 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.17 to $5.24, inclusive. The reporting person undertakes to provide to Rallybio Corporation, any security holder of Rallybio Corporation, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.

SEC source: 0001209191-23-017538 · doc4.xml · nonDerivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Ventures V, L.P.

Disclosed balance after: 2,378,969

F1 · ownership.nature: These securities are held directly by 5AM Ventures V, L.P. ("Ventures V"). 5AM Partners V, LLC ("Partners V") is the sole general partner of Ventures V. Dr. Parmar is a managing member of Partners V and may be deemed to share voting and investment power over the securities held by Ventures V. Dr. Parmar disclaims beneficial ownership of the securities held by Ventures V except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-017533 · doc4.xml · nonDerivative · entry 1

5AM Partners V, LLC · CIK 0001791889 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Ventures V, L.P. · CIK 0001674324 · 10% owner

ROCKLAGE SCOTT M · CIK 0001219014 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Ventures V, L.P.

Disclosed balance after: 2,378,969

F1 · ownership.nature: Shares are held by 5AM Ventures V, L.P. ("Ventures V"). 5AM Partners V, LLC is the general partner of Ventures V and may be deemed to have sole investment and voting power over the shares held by Ventures V. Each of Andrew Schwab, Dr. Kush Parmar and Dr. Scott Rocklage is a Managing Member of 5AM Partners V, LLC, and may be deemed to have shared voting and dispositive power over the shares held by Ventures V. Therefore, each of Andrew Schwab, Dr. Kush Parmar, Dr. Scott Rocklage, and 5AM Partners V, LLC may be deemed to beneficially own the shares held by Ventures V, and each disclaims beneficial ownership over the shares held by Ventures V except to the extent of his or its pecuniary interest therein. Dr. Parmar is a director of the issuer and files separate Section 16 reports.

SEC source: 0000899243-23-004078 · doc4.xml · derivative · entry 1

Uden Stephen · CIK 0001332141 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,000

Underlying: Common Stock · 214,000 shares

Expires 2033-02-06

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 6, 2027.

SEC source: 0000899243-23-004077 · doc4.xml · derivative · entry 1

Ryder Steven · CIK 0001872868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,000

Underlying: Common Stock · 119,000 shares

Expires 2033-02-06

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 6, 2027.

SEC source: 0000899243-23-004074 · doc4.xml · derivative · entry 1

MACKAY MARTIN · CIK 0001414815 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,000

Underlying: Common Stock · 214,000 shares

Expires 2033-02-06

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in 48 equal monthly installments until fully vested on February 6, 2027.

SEC source: 0000899243-23-003156 · doc4.xml · derivative · entry 1

Lieber Jonathan I · CIK 0001350090 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 240,000

Underlying: Common Stock · 240,000 shares

Expires 2033-02-01

F1 · derivative.exercise_date: The option vests as to 25% of the underlying shares of Common Stock on February 1, 2024 and as to the remaining 75% of the underlying shares of Common Stock in 36 equal monthly installments thereafter.

SEC source: 0000899243-23-001046 · doc4.xml · derivative · entry 1

Chung Wendy · CIK 0001922605 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,482

Underlying: Common Stock · 9,482 shares

Expires 2033-01-03

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2023.

SEC source: 0000899243-23-001049 · doc4.xml · derivative · entry 1

Liu Hui · CIK 0001790518 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,237

Underlying: Common Stock · 10,237 shares

Expires 2033-01-03

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2023.

SEC source: 0000899243-23-001044 · doc4.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,099

Underlying: Common Stock · 11,099 shares

Expires 2033-01-03

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2023.

SEC source: 0000899243-23-001048 · doc4.xml · derivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,344

Underlying: Common Stock · 10,344 shares

Expires 2033-01-03

F1 · derivative.exercise_date: The option vests as to the underlying shares of Common Stock in 12 equal installments, each on the last day of each month of calendar year 2023.

SEC source: 0001140361-22-042081 · form4.xml · derivative · entry 1

VIKING GLOBAL INVESTORS LP · CIK 0001103804 · 10% owner

Viking Global Opportunities Illiquid Investments Sub-Master LP · CIK 0001629482 · 10% owner

Viking Global Opportunities Parent GP LLC · CIK 0001886738 · 10% owner

Viking Global Opportunities Portfolio GP LLC · CIK 0001629472 · 10% owner

Viking Global Opportunities GP LLC · CIK 0001629476 · 10% owner

HALVORSEN OLE ANDREAS · CIK 0001133006 · 10% owner

Ott David C. · CIK 0001621842 · 10% owner

Shabet Rose Sharon · CIK 0001711393 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Explanation of Responses

Disclosed balance after: 3,333,388

Underlying: Common Stock · 3,333,388 shares

Expires not disclosed

F1 · derivative.exercise_date: On November 15, 2022, Opportunities Fund acquired 3,333,388 pre-funded warrants, each with an exercise price of $0.0001, ("Pre-Funded Warrants") for an aggregate purchase price of $20 million. Each Pre-Funded Warrant represents the right to purchase one share of the Issuer's common stock ("Common Stock"), subject to the Blocker (defined in footnote 2), and can be exercised on a cash or cashless basis. The Pre-Funded Warrants will not expire.

F2 · derivative.exercise_date: The Pre-Funded Warrants cannot be exercised to the extent that, upon giving effect to such exercise, the aggregated number of shares of Common Stock beneficially owned by the holder (together with its affiliates, any "group" or any other persons whose beneficial ownership could be aggregated with the holders) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise, which percentage may be increased or decreased at the holder's election only upon 61 days' advance notice to the Issuer, provided that such percentage may in no event exceed 19.99% (the "Blocker"). As of the date of this Form 4, the Reporting Persons (as defined in footnote 3) cannot exercise their Pre-Funded Warrants due to the Blocker.

F1 · derivative.expiration_date: On November 15, 2022, Opportunities Fund acquired 3,333,388 pre-funded warrants, each with an exercise price of $0.0001, ("Pre-Funded Warrants") for an aggregate purchase price of $20 million. Each Pre-Funded Warrant represents the right to purchase one share of the Issuer's common stock ("Common Stock"), subject to the Blocker (defined in footnote 2), and can be exercised on a cash or cashless basis. The Pre-Funded Warrants will not expire.

F2 · derivative.expiration_date: The Pre-Funded Warrants cannot be exercised to the extent that, upon giving effect to such exercise, the aggregated number of shares of Common Stock beneficially owned by the holder (together with its affiliates, any "group" or any other persons whose beneficial ownership could be aggregated with the holders) would exceed 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise, which percentage may be increased or decreased at the holder's election only upon 61 days' advance notice to the Issuer, provided that such percentage may in no event exceed 19.99% (the "Blocker"). As of the date of this Form 4, the Reporting Persons (as defined in footnote 3) cannot exercise their Pre-Funded Warrants due to the Blocker.

F3 · ownership.nature: Andreas Halvorsen, David C. Ott and Rose S. Shabet are Executive Committee members of certain management entities, including Viking Global Partners LLC, the general partner of Viking Global Investors LP ("VGI"), and Viking Global Opportunities Parent GP LLC ("Opportunities Parent"), the sole member of Viking Global Opportunities GP LLC ("Opportunities GP"), which is the sole member of Viking Global Opportunities Portfolio GP LLC ("Opportunities Portfolio GP"), which is the general partner of Viking Global Opportunities Illiquid Investments Sub-Master LP ("Opportunities Fund"). VGI provides managerial services to various investment funds, including Opportunities Fund. Each of VGI, Opportunities Parent, Opportunities GP, Opportunities Portfolio GP, Opportunities Fund, Mr. Halvorsen, Mr. Ott and Ms. Shabet (collectively the "Reporting Persons") may be deemed to beneficially own the shares reported on this form.

F4 · ownership.nature: These Pre-Funded Warrants are held directly by Opportunities Fund. Because of the relationship between VGI, Opportunities Parent, Opportunities GP, Opportunities Portfolio GP, Mr. Halvorsen, Mr. Ott, Ms. Shabet and Opportunities Fund, each of VGI, Opportunities Parent, Opportunities GP, Opportunities Portfolio GP, Mr. Halvorsen, Mr. Ott and Ms. Shabet may be deemed to beneficially own the shares held directly by Opportunities Fund.

F5 · ownership.nature: The Reporting Persons disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or for any other purpose.

SEC source: 0000899243-22-027631 · doc4.xml · derivative · entry 1

Chung Wendy · CIK 0001922605 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,880

Underlying: Common Stock · 26,880 shares

Expires 2032-08-01

F1 · derivative.exercise_date: The option is granted under the Company's 2021 Equity Incentive Plan. The option vests in three equal annual installments beginning on August 1, 2023.

SEC source: 0001209191-22-034860 · doc4.xml · nonDerivative · entry 2

PARMAR KUSH · CIK 0001664281 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Opportunities I, L.P.

Disclosed balance after: 1,251,755

F2 · ownership.nature: These securities are held directly by 5AM Opportunities I, L.P. ("Opportunities I, L.P."). 5AM Opportunities I (GP), LLC ("Opportunities I (GP)") is the general partner of Opportunities I, L.P. Dr. Parmar is a managing member of Opportunities I (GP), and may be deemed to share voting and dispositive power over the securities held by Opportunities I, L.P. Dr. Parmar disclaims beneficial ownership of the securities held by Opportunities I, L.P. except to the extent of his pecuniary interest therein.

SEC source: 0001209191-22-034860 · doc4.xml · nonDerivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Ventures V, L.P.

Disclosed balance after: 2,478,969

F1 · ownership.nature: These securities are held directly by 5AM Ventures V, L.P. ("Ventures V"). 5AM Partners V, LLC ("Partners V") is the sole general partner of Ventures V. Dr. Parmar is a managing member of Partners V and may be deemed to share voting and investment power over the securities held by Ventures V. Dr. Parmar disclaims beneficial ownership of the securities held by Ventures V except to the extent of his pecuniary interest therein.

SEC source: 0001209191-22-034858 · doc4.xml · nonDerivative · entry 2

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Partners V, LLC · CIK 0001791889 · 10% owner

5AM Ventures V, L.P. · CIK 0001674324 · 10% owner

ROCKLAGE SCOTT M · CIK 0001219014 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Ventures V, L.P.

Disclosed balance after: 2,478,969

F2 · ownership.nature: Shares are held by 5AM Ventures V, L.P. ("Ventures V"). 5AM Partners V, LLC is the general partner of Ventures V and may be deemed to have sole investment and voting power over the shares held by Ventures V. Each of Andrew Schwab, Dr. Kush Parmar and Dr. Scott Rocklage is a Managing Member of 5AM Partners V, LLC, and may be deemed to have shared voting and dispositive power over the shares held by Ventures V. Therefore, each of Andrew Schwab, Dr. Kush Parmar, Dr. Scott Rocklage, and 5AM Partners V, LLC may be deemed to beneficially own the shares held by Ventures V, and each disclaims beneficial ownership over the shares held by Ventures V except to the extent of his or its pecuniary interest therein. Dr. Parmar is a director of the issuer and files separate Section 16 reports.

SEC source: 0001209191-22-034858 · doc4.xml · nonDerivative · entry 1

5AM Opportunities I, L.P. · CIK 0001753000 · 10% owner

Schwab Andrew J. · CIK 0001598549 · 10% owner

5AM Opportunities I (GP), LLC · CIK 0001790778 · 10% owner

5AM Partners V, LLC · CIK 0001791889 · 10% owner

5AM Ventures V, L.P. · CIK 0001674324 · 10% owner

ROCKLAGE SCOTT M · CIK 0001219014 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Opportunities I, L.P.

Disclosed balance after: 1,251,755

F1 · ownership.nature: Shares are held by 5AM Opportunities I, L.P. ("Opportunities I"). 5AM Opportunities I (GP), LLC is the general partner of Opportunities I and may be deemed to have sole investment and voting power over the shares held by Opportunities I. Each of Andrew Schwab and Dr. Kush Parmar is a Managing Member of 5AM Opportunities I (GP), LLC, and may be deemed to have shared voting and dispositive power over the shares held by Opportunities I. Therefore, each of Andrew Schwab, Dr. Kush Parmar and 5AM Opportunities I(GP), LLC may be deemed to beneficially own the shares held by Opportunities I, and each disclaims beneficial ownership over the shares held by Opportunities I except to the extent of his or its pecuniary interest therein. Dr. Parmar is a director of the issuer and files separate Section 16 reports.

SEC source: 0000899243-22-019827 · doc4.xml · derivative · entry 1

PARMAR KUSH · CIK 0001664281 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,440

Underlying: Common Stock · 13,440 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019835 · doc4.xml · derivative · entry 1

Liu Hui · CIK 0001790518 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,240

Underlying: Common Stock · 2,240 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019834 · doc4.xml · derivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,440

Underlying: Common Stock · 13,440 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019832 · doc4.xml · derivative · entry 1

HUNT RONALD · CIK 0001247851 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,440

Underlying: Common Stock · 13,440 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019830 · doc4.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,440

Underlying: Common Stock · 13,440 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019829 · doc4.xml · derivative · entry 1

Hopfner Robert Lorne · CIK 0001551966 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,440

Underlying: Common Stock · 13,440 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0000899243-22-019828 · doc4.xml · derivative · entry 1

Nash Christine A · CIK 0001554403 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,240

Underlying: Common Stock · 2,240 shares

Expires 2032-05-24

F1 · derivative.exercise_date: The option was granted under the Company's 2021 Equity Incentive Plan. The option vests on the earlier of May 24, 2023 or the date of the Company's 2023 Annual Meeting of Stockholders.

SEC source: 0001209191-22-031969 · doc4.xml · nonDerivative · entry 2

PARMAR KUSH · CIK 0001664281 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By 5AM Opportunities I, L.P.

Disclosed balance after: 1,302,084

F2 · ownership.nature: These securities are held directly by 5AM Opportunities I, L.P. ("Opportunities I, L.P."). 5AM Opportunities I (GP), LLC ("Opportunities I (GP)") is the general partner of Opportunities I, L.P. Dr. Parmar is a managing member of Opportunities I (GP), and may be deemed to share voting and dispositive power over the securities held by Opportunities I, L.P. Dr. Parmar disclaims beneficial ownership of the securities held by Opportunities I, L.P. except to the extent of his pecuniary interest therein.