RLAY

SEC source: 0001193125-26-418096 · ownership.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 471,301

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $17.87 to $18.46. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001193125-26-418094 · ownership.xml · nonDerivative · entry 2

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,134

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $19.20 to $19.27. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 6,538 shares underlying restricted stock units.

SEC source: 0001193125-26-418094 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,340

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.20 to $19.17. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 6,538 shares underlying restricted stock units.

SEC source: 0001193125-26-386473 · ownership.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 399,130

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.56 to $19.24. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 10,025 shares underlying restricted stock units.

SEC source: 0001193125-26-386464 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,851

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.34 to $19.25. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 6,538 shares underlying restricted stock units.

SEC source: 0001193125-26-386455 · ownership.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 519,500

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.33 to $19.25. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001193125-26-374645 · ownership.xml · nonDerivative · entry 1

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 223,657

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 31, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $20.00 to $20.11. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 6,102 shares underlying restricted stock units.

SEC source: 0001493152-26-040513 · ownership.xml · nonDerivative · entry 1

SVF Pauling (Cayman) Ltd · CIK 0001817592 · 10% owner

SOFTBANK VISION FUND (AIV M2) L.P. · CIK 0001805808 · 10% owner

SB INVESTMENT ADVISERS (UK) LTD · CIK 0001731509 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 21,904,963

F1 · ownership.nature: Securities held of record by SVF Pauling (Cayman) Limited, a wholly owned subsidiary of SoftBank Vision Fund (AIV M2) L.P. ("AIV M2"). SB Investment Advisers (UK) Limited ("SBIA UK") has been appointed as alternative investment fund manager ("AIFM") and is exclusively responsible for managing AIV M2 in accordance with the Alternative Investment Fund Managers Directive and is authorized and regulated by the UK Financial Conduct Authority accordingly. As AIFM of AIV M2, SBIA UK is exclusively responsible for making all decisions related to the acquisition, structuring, financing, voting and disposal of SVF Pauling (Cayman) Limited's investments.

SEC source: 0001193125-26-355502 · ownership.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 567,699

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $19.56 to $20.73. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001193125-26-355493 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 140,568

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $19.51 to $19.96. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 6,538 shares underlying restricted stock units.

SEC source: 0001193125-26-326142 · ownership.xml · nonDerivative · entry 1

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,165

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 3,051 shares of restricted stock units ("RSUs") on July 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 6,102 shares underlying RSUs.

SEC source: 0001193125-26-326144 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,285

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 3,269 shares of restricted stock units ("RSUs") on July 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 6,538 shares underlying RSUs.

SEC source: 0001193125-26-326137 · ownership.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 407,660

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 5,012 shares of restricted stock units ("RSUs") on July 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 10,025 shares underlying RSUs.

SEC source: 0001193125-26-298681 · ownership.xml · nonDerivative · entry 2

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 615,898

F3 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $18.52 to $20.20. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001193125-26-298679 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 159,744

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.39 to $19.38. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-298688 · ownership.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 409,897

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.45 to $19.36. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 15,037 shares underlying restricted stock units.

SEC source: 0001193125-26-294528 · ownership.xml · nonDerivative · entry 2

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 228,913

F4 · kind: The shares were acquired under the Relay Therapeutics, Inc. 2020 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The reporting person is voluntarily reporting this transaction.

F5 · price: In accordance with the ESPP, these shares were purchased at a price equal to 85% of the closing price of the Issuer's common stock on January 2, 2026.

F3 · balance_after: Includes 9,153 shares underlying restricted stock units.

SEC source: 0001193125-26-294528 · ownership.xml · nonDerivative · entry 1

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 225,857

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 31, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $18.66 to $19.78. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,153 shares underlying restricted stock units.

SEC source: 0001193125-26-298681 · ownership.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 664,097

F1 · kind: The shares were acquired under the Relay Therapeutics, Inc. 2020 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The reporting person is voluntarily reporting this transaction.

F2 · price: In accordance with the ESPP, these shares were purchased at a price equal to 85% of the closing price of the Issuer's common stock on January 2, 2026.

SEC source: 0001193125-26-281061 · ownership.xml · derivative · entry 10

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 223,440

Underlying: Common Stock · 51,560 shares

Expires 2035-01-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F7 · derivative.exercise_date: The shares underlying this stock option shall vest in sixteen (16) equal quarterly installments after January 10, 2025, subject to the reporting person's continued service with the Issuer through each vesting date.

SEC source: 0001193125-26-281061 · ownership.xml · derivative · entry 9

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 61,563 shares

Expires 2030-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F6 · derivative.exercise_date: On March 2, 2020, the reporting person was granted an option to purchase 63,363 shares of common stock, subject to determination by the Board of Directors of the Issuer (the "Board") that the Issuer met, in whole or in part, certain milestones (the "2020 Option Grant Criteria"). On June 23, 2020, the Board determined that the 2020 Option Grant Criteria related to 25% of the option had been achieved, and the shares underlying 25% of this option, or 15,841 shares, commenced vesting in sixteen (16) equal quarterly installments following September 23, 2020. On December 11, 2020, the Board determined that the 2020 Option Grant Criteria related to the remaining 75% of the option had been achieved. The shares underlying 75% of this option, or 47,522 shares, vested in sixteen (16) equal quarterly installments following March 11, 2021.

SEC source: 0001193125-26-281061 · ownership.xml · derivative · entry 8

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 56,323 shares

Expires 2029-04-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F5 · derivative.exercise_date: The shares underlying this stock option vested in sixteen (16) equal quarterly installments following the vesting commencement date of April 23, 2019.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 7

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,461

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $16.15 to $17.39. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 6

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,021

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 5

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,461

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $16.15 to $17.39. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 4

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 239,024

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 3

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,461

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · price: This transaction was executed in multiple trades at prices ranging from $16.15 to $17.39. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 2

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 233,784

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281061 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 177,461

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $16.38 to $17.28. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-281059 · ownership.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 93,456 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder vested in equal quarterly installments over the remaining thirty-six (36) months.

SEC source: 0001193125-26-281059 · ownership.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 418,557

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · price: This transaction was executed in multiple trades at prices ranging from $16.15 to $17.39. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 15,037 shares underlying restricted stock units.

SEC source: 0001193125-26-281059 · ownership.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 512,013

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · balance_after: Includes 15,037 shares underlying restricted stock units.

SEC source: 0001193125-26-265907 · ownership.xml · derivative · entry 1

HILL LINDA A · CIK 0001130483 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265913 · ownership.xml · derivative · entry 1

Mazumdar Claire · CIK 0002034671 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265904 · ownership.xml · derivative · entry 1

Murcko Mark · CIK 0001816130 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265906 · ownership.xml · derivative · entry 1

Borisy Alexis · CIK 0001319446 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265911 · ownership.xml · derivative · entry 1

Dable Habib J · CIK 0001690773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265905 · ownership.xml · derivative · entry 1

INGRAM DOUGLAS S · CIK 0001190644 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-265908 · ownership.xml · derivative · entry 1

COATS LONNEL · CIK 0001612528 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,947

Underlying: Common Stock · 32,947 shares

Expires 2036-06-08

F1 · derivative.exercise_date: This option was granted on June 9, 2026 with respect to 32,947 shares of the Issuer's common stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the grant date.

SEC source: 0001193125-26-224545 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 195,178

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.67 to $13.42. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 9,807 shares underlying restricted stock units.

SEC source: 0001193125-26-197415 · ownership.xml · nonDerivative · entry 1

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,857

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 3,051 shares of restricted stock units ("RSUs") on April 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 9,153 shares underlying RSUs.

SEC source: 0001193125-26-197419 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 212,895

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 3,268 shares of restricted stock units ("RSUs") on April 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 9,807 shares underlying RSUs.

SEC source: 0001193125-26-197395 · ownership.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 418,557

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 5,012 shares of restricted stock units ("RSUs") on April 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 15,037 shares underlying RSUs.

SEC source: 0001193125-26-150044 · ownership.xml · derivative · entry 4

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,563

Underlying: Common Stock · 1,800 shares

Expires 2030-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F4 · derivative.exercise_date: On March 2, 2020, the reporting person was granted an option to purchase 63,363 shares of common stock, subject to determination by the Board of Directors of the Issuer (the "Board") that the Issuer met, in whole or in part, certain milestones (the "2020 Option Grant Criteria"). On June 23, 2020, the Board determined that the 2020 Option Grant Criteria related to 25% of the option had been achieved, and the shares underlying 25% of this option, or 15,841 shares, commenced vesting in sixteen (16) equal quarterly installments following September 23, 2020. On December 11, 2020, the Board determined that the 2020 Option Grant Criteria related to the remaining 75% of the option had been achieved. The shares underlying 75% of this option, or 47,522 shares, vested in sixteen (16) equal quarterly installments following March 11, 2021.

SEC source: 0001193125-26-150044 · ownership.xml · nonDerivative · entry 3

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,867

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · balance_after: Includes 13,075 shares underlying restricted stock units.

SEC source: 0001193125-26-150044 · ownership.xml · nonDerivative · entry 2

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 215,667

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F3 · balance_after: Includes 13,075 shares underlying restricted stock units.

SEC source: 0001193125-26-150044 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 213,867

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.42 to $13.46. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 13,075 shares underlying restricted stock units.

SEC source: 0001193125-26-102270 · ownership.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 231,584

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025.

F2 · price: This transaction was executed in multiple trades at prices ranging from $9.77 to $10.35. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 13,075 shares underlying restricted stock units.

SEC source: 0001193125-26-029412 · ownership.xml · nonDerivative · entry 3

Rahmer Peter · CIK 0001959229 · See remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 276,610

F6 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 5,506 shares of RSUs on January 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F7 · balance_after: Includes 12,204 shares underlying RSUs.

SEC source: 0001193125-26-029403 · ownership.xml · nonDerivative · entry 2

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 249,301

F3 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 5,724 shares of RSUs on January 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F4 · balance_after: Includes 13,075 shares underlying RSUs.