RGEN

SEC source: 0000899243-21-034897 · doc4.xml · nonDerivative · entry 2

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,141

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F2 · price: $280.27 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $279.90 to $280.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-034897 · doc4.xml · nonDerivative · entry 1

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,380

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

SEC source: 0000899243-21-034834 · doc4.xml · nonDerivative · entry 1

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,354

F1 · price: $282.13 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $282.10 to $282.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 11

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,921

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 10

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,961

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F10 · price: $260.91 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $260.80 to $261.01, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 9

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,039

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F9 · price: $259.93 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $259.39 to $260.38, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 8

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,427

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F8 · price: $258.91 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $258.32 to $259.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 7

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,061

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F7 · price: $257.66 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $257.14 to $258.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033450 · doc4.xml · nonDerivative · entry 1

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 189,495

F1 · kind: The shares were disposed of in connection with a bona fide gift by the Reporting Person to a donor advised fund.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 6

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,363

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 5

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,557

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F6 · price: $255.07 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $254.73 to $255.72, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 4

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,788

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F5 · price: $254.09 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $253.71 to $254.63, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 3

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,368

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F4 · price: $253.34 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $252.69 to $253.66, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 2

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,033

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F3 · price: $251.92 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $251.66 to $252.48, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-033643 · doc4.xml · nonDerivative · entry 1

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,953

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F2 · price: $251.15 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $250.63 to $251.48, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-031820 · doc4.xml · nonDerivative · entry 1

RYAN THOMAS F JR · CIK 0001263366 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 971

SEC source: 0000899243-21-029561 · doc4.xml · nonDerivative · entry 4

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,877

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F5 · price: $203.11 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $202.78 to $203.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029561 · doc4.xml · nonDerivative · entry 3

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,491

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F4 · price: $202.29 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $201.76 to $202.73, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029561 · doc4.xml · nonDerivative · entry 2

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,368

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F3 · price: $201.37 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $200.76 to $201.73, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029561 · doc4.xml · nonDerivative · entry 1

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,174

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F2 · price: $200.01 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $199.56 to $200.20, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-028505 · doc4.xml · derivative · entry 3

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,929 shares

Expires 2025-07-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This option is fully vested and exercisable.

SEC source: 0000899243-21-028505 · doc4.xml · nonDerivative · entry 2

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,462

F1 · price: $202.23 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $201.27 to $204.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-028505 · doc4.xml · nonDerivative · entry 1

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,982

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-21-029533 · doc4a.xml · derivative · entry 6

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,929 shares

Expires 2025-07-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: This option is fully vested and exercisable.

SEC source: 0000899243-21-029533 · doc4a.xml · nonDerivative · entry 5

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,462

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F5 · price: $204.02 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $204.01 to $204.07, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029533 · doc4a.xml · nonDerivative · entry 4

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,467

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F4 · price: $203.09 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $202.86 to $203.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029533 · doc4a.xml · nonDerivative · entry 3

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,911

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F3 · price: $202.29 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $201.77 to $202.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029533 · doc4a.xml · nonDerivative · entry 2

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,541

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on June 8, 2021.

F2 · price: $201.27 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $200.77 to $201.67, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-029533 · doc4a.xml · nonDerivative · entry 1

DAWES KAREN A · CIK 0001261506 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,982

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-21-023674 · doc4.xml · derivative · entry 5

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,092

Underlying: Common Stock · 1,045 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1,045 of the shares underlying the option have vested. The remaining shares vest as follows: 1,046 shares on February 27, 2022 and February 27, 2023.

SEC source: 0000899243-21-023674 · doc4.xml · derivative · entry 4

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,354

Underlying: Common Stock · 2,557 shares

Expires 2029-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 2,707 of the shares underlying the option have vested. The remaining 1,354 shares shall vest on February 28, 2022.

SEC source: 0000899243-21-023674 · doc4.xml · nonDerivative · entry 3

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,355

F1 · price: $189.19 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $188.70 to $189.59, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-023674 · doc4.xml · nonDerivative · entry 2

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,157

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-21-023674 · doc4.xml · nonDerivative · entry 1

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,112

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 8

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,495

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F9 · price: $175.15 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $174.98 to $175.53, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 7

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 190,875

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F8 · price: $174.41 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $173.98 to $174.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 6

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 193,694

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F7 · price: $173.19 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $172.96 to $173.83, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 5

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,254

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F6 · price: $172.52 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $171.96 to $172.91, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 4

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,290

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F5 · price: $171.32 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $170.93 to $171.86, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 3

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 201,710

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F4 · price: $170.28 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $169.91 to $170.88, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 2

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 209,621

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F3 · price: $169.45 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $168.90 to $169.88, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-020294 · doc4.xml · nonDerivative · entry 1

Hunt Anthony · CIK 0001606030 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 212,150

F1 · kind: Sale of common stock was effected pursuant to a 10(b)5-1 trading plan adopted on December 9, 2020.

F2 · price: $168.29 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $167.61 to $168.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-019723 · doc4.xml · nonDerivative · entry 1

Gebski Christine · CIK 0001849585 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,695

F1 · kind: Sale of shares in the open market to cover tax liability resulting from the release of restricted stock units.

F2 · price: $172.25 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $172.16 to $172.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-019721 · doc4.xml · nonDerivative · entry 1

KURIYEL RALF · CIK 0001733143 · Senior VP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,555

F1 · kind: Sale of shares in the open market to cover tax liability resulting from the release of restricted stock units.

F2 · price: $172.29 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $172.26 to $172.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-019720 · doc4.xml · nonDerivative · entry 1

Snodgres Jon · CIK 0001613498 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,893

F1 · kind: Sale of shares in the open market to cover tax liability resulting from the release of restricted stock units.

F2 · price: $172.60 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $172.59 to $172.67, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-21-019713 · doc4.xml · derivative · entry 2

EGLINTON MANNER CARRIE · CIK 0001696776 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,151

Underlying: Common Stock · 1,151 shares

Expires 2031-05-13

F2 · derivative.exercise_date: Award vests in full on the earlier of May 13, 2022, one year from grant date, or on the date of the next annual meeting of the Company's shareholders, which has not yet been determined.

SEC source: 0000899243-21-019713 · doc4.xml · nonDerivative · entry 1

EGLINTON MANNER CARRIE · CIK 0001696776 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 457

F1 · shares: Ms. Eglinton Manner was awarded 457 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of Repligen Corporation's Common Stock. The restricted stock units vest on the earlier of May 13, 2022, one year from the grant date, or the date of the next annual meeting of the Company's shareholders, which has not yet been determined. The restricted stock units may be settled only by delivering shares of Repligen Corporation's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

SEC source: 0000899243-21-019712 · doc4.xml · derivative · entry 2

MUIR GLENN P · CIK 0001181190 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,151

Underlying: Common Stock · 1,151 shares

Expires 2031-05-13

F2 · derivative.exercise_date: Award vests in full on the earlier of May 13, 2022, one year from grant date, or on the date of the next annual meeting of the Company's shareholders, which has not yet been determined.

SEC source: 0000899243-21-019712 · doc4.xml · nonDerivative · entry 1

MUIR GLENN P · CIK 0001181190 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,362

F1 · shares: Mr. Muir was awarded 457 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of Repligen Corporation's Common Stock. The restricted stock units vest on the earlier of May 13, 2022, one year from the grant date, or the date of the next annual meeting of the Company's shareholders, which has not yet been determined. The restricted stock units may be settled only by delivering shares of Repligen Corporation's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

SEC source: 0000899243-21-019710 · doc4.xml · derivative · entry 2

BARTHELEMY NICOLAS · CIK 0001283576 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,151

Underlying: Common Stock · 1,151 shares

Expires 2031-05-13

F2 · derivative.exercise_date: Award vests in full on the earlier of May 13, 2022, one year from grant date, or on the date of the next annual meeting of the Company's shareholders, which has not yet been determined.