RENXF

SEC source: 0000950170-24-121609 · ownership.xml · nonDerivative · entry 1

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · CIK 0001883139 · 10% owner

MOUNT SINAI HEALTH SYSTEM, INC. · CIK 0001883135 · 10% owner

MOUNT SINAI HOSPITAL · CIK 0001899689 · 10% owner

MOUNT SINAI HOSPITALS GROUP, INC. · CIK 0001885494 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,683,998

F1 · shares: On November 1, 2024, Icahn School of Medicine at Mount Sinai ("ISMMS") acquired 13,366,750 Ordinary Shares of the Issuer in a private placement of the Issuer (the "Private Placement") pursuant to the Subscription Letter dated as of September 30, 2024, after the Issuer's receipt of the requisite shareholder approval. In connection with the Private Placement, the Issuer, in two tranches, issued (a) an aggregate of 92,773,922 Ordinary Shares pursuant to a Placing Agreement with Oberon Investments Limited, (b) an aggregate of 38,387,634 Ordinary Shares (including the Ordinary Shares issued to ISMMS) to certain investors pursuant to Subscription Letters, and (c) an aggregate of 36,550,543 Ordinary Shares as a result of the restructuring of certain convertible bonds.

F2 · price: ISMMS acquired the Ordinary Shares for approximately $1.55 million, which is equivalent to a price of 9 pence per Ordinary Share (or approximately $0.116 per share based on a conversion rate of 1 GBP to $1.2920 on November 1, 2024).

F3 · ownership.direct: The securities reported herein are held directly by ISMMS.

F4 · ownership.direct: As the sole member of The Mount Sinai Hospital ("MSH"), Mount Sinai Hospitals Group, Inc. ("MSHG") may be deemed to beneficially own the securities held by MSH. As the sole member of MSHG, Mount Sinai Health System, Inc. ("MSHS") may be deemed to beneficially own the securities beneficially owned by MSHG. As the sole member of ISMMS, MSHS may be deemed to beneficially own the securities held by ISMMS. Each of the reporting persons disclaims beneficial ownership of all such securities reported herein, except to the extent of its pecuniary interest, if any.

SEC source: 0001415889-24-016663 · form4-06132024_040602.xml · derivative · entry 1

Jung Joel R · CIK 0001373488 · Interim Chief Financial Office

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Ordinary Shares · 60,000 shares

Expires 2034-06-10

F1 · derivative.exercise_price: The exercise price is 0.1625 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.2067 using the Bank of England rate as of June 10, 2024 (1.00 pound sterling = $1.272).

F2 · derivative.exercise_date: One fourth (1/4th) of the shares subject to the option award shall vest on August 28, 2024, and the remaining shares shall vest in nine equal monthly installments thereafter, subject to the Reporting Person's continuous service.

SEC source: 0000950172-24-000236 · form4.xml · nonDerivative · entry 1

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · CIK 0001883139 · 10% owner

MOUNT SINAI HOSPITAL · CIK 0001899689 · 10% owner

MOUNT SINAI HEALTH SYSTEM, INC. · CIK 0001883135 · 10% owner

MOUNT SINAI HOSPITALS GROUP, INC. · CIK 0001885494 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,317,248

F1 · shares: On April 24, 2024, Icahn School of Medicine at Mount Sinai ("ISMMS") acquired 9,360,374 Ordinary Shares of the Issuer in the second tranche (the "Second Tranche") of a private placement of the Issuer (the "Private Placement") pursuant to the Placing Agreement dated March 12, 2024 with Stifel Nicolaus Europe Limited ("Stifel"). The Issuer issued 19,986,031 Ordinary Shares in the first tranche of the Private Placement, which was closed on March 14, 2024, and 26,815,841 Ordinary Shares in the Second Tranche, which was closed on April 24, 2024 after the receipt of the requisite shareholder approval.

F2 · price: ISMMS purchased the Ordinary Shares for approximately $2.3 million, which is equivalent to a price of 20 pence per Ordinary Share (or approximately $0.25 per share based on a conversion rate of 1 GBP to $1.2498 on April 23, 2024).

F3 · ownership.direct: The securities reported herein are held directly by ISMMS.

F4 · ownership.direct: As the sole member of The Mount Sinai Hospital ("MSH"), Mount Sinai Hospitals Group, Inc. ("MSHG") may be deemed to beneficially own the securities held by MSH. As the sole member of MSHG, Mount Sinai Health System, Inc. ("MSHS") may be deemed to beneficially own the securities beneficially owned by MSHG. As the sole member of ISMMS, MSHS may be deemed to beneficially own the securities held by ISMMS. Each of the reporting persons disclaims beneficial ownership of all such securities reported herein, except to the extent of its pecuniary interest, if any.

SEC source: 0001209191-23-056478 · doc4.xml · derivative · entry 1

Coste Catherine · CIK 0001821432 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Ordinary Shares · 95,000 shares

Expires 2033-11-19

F1 · derivative.exercise_price: The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on February 20, 2024, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-056477 · doc4.xml · derivative · entry 1

LEVANGIE DANIEL J · CIK 0001187406 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Ordinary Shares · 95,000 shares

Expires 2033-11-19

F1 · derivative.exercise_price: The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on February 20, 2024, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-056475 · doc4.xml · derivative · entry 1

MILLS CHRISTOPHER · CIK 0001223129 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Ordinary Shares · 95,000 shares

Expires 2033-11-19

F1 · derivative.exercise_price: The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on February 20, 2024, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-056476 · doc4.xml · derivative · entry 1

Parikh Chirag R. · CIK 0001973565 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Ordinary Shares · 95,000 shares

Expires 2033-11-19

F1 · derivative.exercise_price: The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on February 20, 2024, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-056474 · doc4.xml · derivative · entry 1

Doran Howard JR · CIK 0001415965 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Ordinary Shares · 300,000 shares

Expires 2033-11-19

F1 · derivative.exercise_price: The exercise price is 0.245 pounds sterling. The U.S. dollar equivalent of the exercise price is $0.304 using the Bank of England rate as of November 17, 2023 (1.00 pound sterling = $1.243).

F2 · derivative.exercise_date: One third (1/3rd) of the shares subject to the option award shall vest on September 1, 2024, and one eighth (1/8th) of the remaining shares subject to the option award shall vest in equal quarterly installments thereafter, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-042021 · doc4.xml · derivative · entry 1

MCLAIN THOMAS H · CIK 0001206465 · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Ordinary Shares · 200,000 shares

Expires 2033-07-09

F1 · derivative.exercise_price: The exercise price is 1.175 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.506 using the Bank of England rate as of July 10, 2023 (1.00 pound sterling = $1.282).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 10, 2023, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041795 · doc4.xml · derivative · entry 1

Sterling O. James · CIK 0001851144 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 575,160

Underlying: Ordinary Shares · 575,160 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 6, 2023, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041802 · doc4.xml · derivative · entry 1

Donovan Michael J. · CIK 0001975278 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,731

Underlying: Ordinary Shares · 85,731 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 6, 2023, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041800 · doc4.xml · derivative · entry 1

Coste Catherine · CIK 0001821432 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Ordinary Shares · 190,000 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One third (1/3rd) of the shares subject to the option award shall vest on July 6, 2024, and one eighth (1/8th) of the remaining shares subject to the option award shall vest in equal quarterly installments thereafter, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041799 · doc4.xml · derivative · entry 1

McCullough James Renwick · CIK 0001974146 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 875,017

Underlying: Ordinary Shares · 875,017 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 6, 2023, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041797 · doc4.xml · derivative · entry 1

MCLAIN THOMAS H · CIK 0001206465 · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 394,486

Underlying: Ordinary Shares · 394,486 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 6, 2023, subject to the Reporting Person's continuous service.

SEC source: 0001209191-23-041796 · doc4.xml · derivative · entry 1

Fleming Fergus · CIK 0001973429 · Director · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 352,902

Underlying: Ordinary Shares · 352,902 shares

Expires 2033-07-05

F1 · derivative.exercise_price: The exercise price is 1.025 pounds sterling. The U.S. dollar equivalent of the exercise price is $1.301 using the Bank of England rate as of July 6, 2023 (1.00 pound sterling = $1.269).

F2 · derivative.exercise_date: One twelfth (1/12th) of the shares subject to the option award shall vest in equal quarterly installments commencing on October 6, 2023, subject to the Reporting Person's continuous service.