RARE

SEC source: 0001209191-21-017567 · doc4.xml · nonDerivative · entry 1

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,978

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017537 · doc4.xml · derivative · entry 5

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2031-03-01

F7 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017537 · doc4.xml · nonDerivative · entry 4

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Emil Kakkis and Jenny Soriano Living Trust, dated June 18, 2009

Disclosed balance after: 2,289,741

F5 · kind: The sales reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $139.89 to $143.97 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001209191-21-017537 · doc4.xml · nonDerivative · entry 3

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 596,052

F3 · kind: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017537 · doc4.xml · nonDerivative · entry 2

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 612,394

F2 · shares: Represents 5,099 shares of common stock and 10,354 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017537 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 596,941

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017538 · doc4.xml · derivative · entry 4

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017538 · doc4.xml · nonDerivative · entry 3

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,139

F3 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.17 to $138.19 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017538 · doc4.xml · nonDerivative · entry 2

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,682

F2 · shares: Represents 1,530 shares of common stock and 3,106 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017538 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,046

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017561 · doc4.xml · derivative · entry 4

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017561 · doc4.xml · nonDerivative · entry 3

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,237

F3 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.17 to $138.18 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017561 · doc4.xml · nonDerivative · entry 2

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,435

F2 · shares: Represents 1,530 shares of common stock and 3,106 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017561 · doc4.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,799

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017559 · doc4.xml · derivative · entry 4

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017559 · doc4.xml · nonDerivative · entry 3

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,227

F3 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.16 to $138.18 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017559 · doc4.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,197

F2 · shares: Represents 1,530 shares of common stock and 3,106 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017559 · doc4.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,561

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017556 · doc4.xml · derivative · entry 3

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,655

Underlying: Common Stock · 4,655 shares

Expires 2031-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017556 · doc4.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,544

F2 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.16 to $138.18 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017556 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,276

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017554 · doc4.xml · derivative · entry 5

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F7 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017554 · doc4.xml · nonDerivative · entry 3

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,520

F3 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.16 to $138.20 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001209191-21-017554 · doc4.xml · nonDerivative · entry 2

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,990

F2 · shares: Represents 1,530 shares of common stock and 3,106 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017554 · doc4.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,354

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017546 · doc4.xml · derivative · entry 4

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F7 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017546 · doc4.xml · nonDerivative · entry 3

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,761

F3 · kind: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.17 to $138.19 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes 181 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2020.

F6 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-017546 · doc4.xml · nonDerivative · entry 2

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,835

F2 · shares: Represents 1,530 shares of common stock and 3,106 RSUs into which previously granted performance stock units were converted on March 1, 2021 upon certification of the performance metric. The RSUs will fully vest on March 1, 2022.

SEC source: 0001209191-21-017546 · doc4.xml · nonDerivative · entry 1

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,199

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-21-017541 · doc4.xml · derivative · entry 2

Dier Mardi · CIK 0001574591 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 11,000 shares

Expires 2031-03-01

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-21-017541 · doc4.xml · nonDerivative · entry 1

Dier Mardi · CIK 0001574591 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,500

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-013100 · doc4.xml · nonDerivative · entry 3

Aliski William · CIK 0001598426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,704

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-013100 · doc4.xml · derivative · entry 6

Aliski William · CIK 0001598426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2025-06-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option vested in full on on June 9, 2016.

SEC source: 0001209191-21-013100 · doc4.xml · nonDerivative · entry 2

Aliski William · CIK 0001598426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,704

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.00 to $149.15 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001209191-21-013100 · doc4.xml · nonDerivative · entry 1

Aliski William · CIK 0001598426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-006787 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,546

F1 · kind: Represents shares sold to pay required tax withholdings due to the vesting of Restricted Stock Units ("RSUs").

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-003992 · doc4.xml · derivative · entry 3

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested with respect to 1/4th of the shares on January 30, 2019 (the first anniversary of the grant date of the option or the "Option Anniversary Date") and 1/48th of the shares initially subject to the option continued to vest on each month as measured from the Option Anniversary Date such that the option will fully vest on the fourth anniversary of the grant dat.

SEC source: 0001209191-21-003992 · doc4.xml · nonDerivative · entry 2

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,789

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $136.69 to $141.80 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-003992 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,789

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

SEC source: 0001209191-21-002825 · doc4.xml · derivative · entry 3

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 4,000 shares

Expires 2024-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 1/4th of the option vested one year from January 29, 2014 and then 1/48th of the option vested monthly thereafter.

SEC source: 0001209191-21-002825 · doc4.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,716

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $138.04 to $143.02 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 214 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2020. Also reflects dispositions from gifts that will be reported in a Form 5 within 45 days after the Issuer's fiscal year end.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-002825 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,436

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

SEC source: 0001209191-21-001583 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Emil Kakkis and Jenny Soriano Living Trust, dated June 18, 2009

Disclosed balance after: 2,329,741

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $135.66 to $138.54 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001209191-21-007554 · doc5.xml · nonDerivative · entry 4

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 578,941

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-21-007554 · doc5.xml · nonDerivative · entry 2

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Emil Kakkis and Jenny Soriano Living Trust, dated June 18, 2009

Disclosed balance after: 2,349,741

SEC source: 0001209191-21-007552 · doc5.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,502

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-056859 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Emil Kakkis and Jenny Soriano Living Trust, dated June 18, 2009

Disclosed balance after: 2,359,741

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.00 to $100.94 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001209191-20-056428 · doc4.xml · derivative · entry 3

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 9,903 shares

Expires 2026-06-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option vested with respect to 1/4th of the shares on June 20, 2017 (the first anniversary of the grant date of the option or the "Option Anniversary Date") and 1/48th of the shares initially subject to the option continued to vest on each month as measured from the Option Anniversary Date such that the option fully vested on the fourth anniversary of the grant date.

SEC source: 0001209191-20-056428 · doc4.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,061

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.00 to $100.20 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

F4 · balance_after: Includes 93 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2020.

SEC source: 0001209191-20-056428 · doc4.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.