RARE

SEC source: 0000950170-24-071548 · ownership.xml · nonDerivative · entry 1

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,248

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-052788 · ownership.xml · nonDerivative · entry 1

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,431

F1 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-046055 · ownership.xml · nonDerivative · entry 1

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,785

F1 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-045670 · ownership.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,366

F1 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-029780 · ownership.xml · nonDerivative · entry 1

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 252,823

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.92 to $50.06 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-029040 · ownership.xml · nonDerivative · entry 3

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,860

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.53 to $51.78 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-029040 · ownership.xml · nonDerivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,360

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.00 to $51.78 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-029040 · ownership.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,505

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $50.53 to $51.78 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-026661 · ownership.xml · derivative · entry 5

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,400

Underlying: Common Stock · 31,400 shares

Expires 2034-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026661 · ownership.xml · nonDerivative · entry 4

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 264,332

F4 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026661 · ownership.xml · nonDerivative · entry 3

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 265,343

F3 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

SEC source: 0000950170-24-026661 · ownership.xml · nonDerivative · entry 2

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 265,617

F2 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

SEC source: 0000950170-24-026661 · ownership.xml · nonDerivative · entry 1

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 264,660

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026625 · ownership.xml · derivative · entry 5

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,094

Underlying: Common Stock · 70,094 shares

Expires 2034-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026625 · ownership.xml · nonDerivative · entry 3

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 563,913

F3 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026625 · ownership.xml · nonDerivative · entry 2

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 560,781

F2 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

SEC source: 0000950170-24-026625 · ownership.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 578,198

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026672 · ownership.xml · derivative · entry 2

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,200

Underlying: Common Stock · 34,200 shares

Expires 2034-03-01

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026672 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,766

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions. The amount of securities beneficially owned in column 5 reflects the correction of a typographical error in the Form 4 filed by the Reporting Person on October 10, 2023 (the "October 2023 Form 4"). The accurate number of securities beneficially owned by the Reporting Person in Column 5 of the October 2023 Form 4 is 80,366.

SEC source: 0000950170-24-026666 · ownership.xml · derivative · entry 4

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,400

Underlying: Common Stock · 31,400 shares

Expires 2034-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026666 · ownership.xml · nonDerivative · entry 3

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,340

F3 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · balance_after: Includes 357 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on October 31, 2023.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026666 · ownership.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,739

F2 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

SEC source: 0000950170-24-026666 · ownership.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,782

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026652 · ownership.xml · derivative · entry 4

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,400

Underlying: Common Stock · 31,400 shares

Expires 2034-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026652 · ownership.xml · nonDerivative · entry 3

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,002

F3 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026652 · ownership.xml · nonDerivative · entry 2

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,472

F2 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

SEC source: 0000950170-24-026652 · ownership.xml · nonDerivative · entry 1

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,515

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026648 · ownership.xml · derivative · entry 5

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,400

Underlying: Common Stock · 31,400 shares

Expires 2034-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026648 · ownership.xml · nonDerivative · entry 4

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,268

F4 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026648 · ownership.xml · nonDerivative · entry 3

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,441

F3 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

SEC source: 0000950170-24-026648 · ownership.xml · nonDerivative · entry 2

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,501

F2 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

SEC source: 0000950170-24-026648 · ownership.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,544

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026641 · ownership.xml · derivative · entry 5

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,351

Underlying: Common Stock · 2,351 shares

Expires 2027-03-01

F6 · derivative.exercise_date: On March 1, 2022, the Reporting Person was granted an option to purchase 2,351 shares of common stock. The option vests upon the achievement of specified performance criteria. Upon achievement of the performance criteria, 1/3 of the option vests on the date of certification by the Issuer's compensation committee of achievement of the performance criteria, 1/3 of the option vests on March 1, 2024 and 1/3 of the option vests on March 1, 2025. On March 1, 2024, the Issuer's compensation committee certified achievement of the performance criteria for the option, resulting in the vesting of the option of 1,568 shares on that date.

SEC source: 0000950170-24-026641 · ownership.xml · derivative · entry 4

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,200

Underlying: Common Stock · 8,200 shares

Expires 2034-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026641 · ownership.xml · nonDerivative · entry 3

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,380

F3 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026641 · ownership.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,721

F2 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

SEC source: 0000950170-24-026641 · ownership.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,842

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026635 · ownership.xml · derivative · entry 4

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,351

Underlying: Common Stock · 2,351 shares

Expires 2027-03-01

F6 · derivative.exercise_date: On March 1, 2022, the Reporting Person was granted an option to purchase 2,351 shares of common stock. The option vests upon the achievement of specified performance criteria. Upon achievement of the performance criteria, 1/3 of the option vests on the date of certification by the Issuer's compensation committee of achievement of the performance criteria, 1/3 of the option vests on March 1, 2024 and 1/3 of the option vests on March 1, 2025. On March 1, 2024, the Issuer's compensation committee certified achievement of the performance criteria for the option, resulting in the vesting of the option of 1,568 shares on that date.

SEC source: 0000950170-24-026635 · ownership.xml · derivative · entry 3

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,200

Underlying: Common Stock · 34,200 shares

Expires 2034-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026635 · ownership.xml · nonDerivative · entry 2

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,927

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · balance_after: Includes 253 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on October 31, 2023.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026635 · ownership.xml · nonDerivative · entry 1

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,912

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0000950170-24-026629 · ownership.xml · derivative · entry 4

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,200

Underlying: Common Stock · 34,200 shares

Expires 2034-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0000950170-24-026629 · ownership.xml · nonDerivative · entry 3

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,163

F3 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F4 · balance_after: Includes 293 shares acquired under the Company's Amended & Restated Employee Stock Purchase Plan on October 31, 2023.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0000950170-24-026629 · ownership.xml · nonDerivative · entry 2

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,638

F2 · shares: Represents shares of common stock which previously granted performance stock units were converted on March 1, 2024 upon certification of the performance metric.

SEC source: 0000950170-24-026629 · ownership.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,681

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

SEC source: 0001209191-24-002989 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 539,770

F1 · shares: The sales reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person prior to February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.69 to $45.87 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-24-000070 · doc4.xml · derivative · entry 3

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,000 shares

Expires 2024-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/4th of the option vested one year from January 29, 2014 and then 1/48th of the option vested monthly thereafter.

SEC source: 0001209191-24-000070 · doc4.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,892

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Includes 278 shares acquired under the Company's Amended and Restated 2014 Employee Stock Purchase Plan on October 31, 2023.

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-24-000071 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 569,770

F1 · shares: The sales reported on this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person prior to February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.54 to $48.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 27 shares acquired under the Company's Amended and Restated 2014 Employee Stock Purchase Plan on October 31, 2023.

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-24-000070 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,614

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.