RARE

SEC source: 0001209191-20-015760 · doc4.xml · derivative · entry 5

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,100

Underlying: Common Stock · 56,100 shares

Expires 2030-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015760 · doc4.xml · nonDerivative · entry 3

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 504,800

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015760 · doc4.xml · nonDerivative · entry 2

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 511,696

F3 · shares: Represents 6,198 shares of common stock and 12,584 RSUs which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015760 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 492,914

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015735 · doc4.xml · derivative · entry 4

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2030-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015735 · doc4.xml · nonDerivative · entry 3

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,300

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015735 · doc4.xml · nonDerivative · entry 2

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,549

F3 · shares: Represents 1,859 shares of common stock and 3,775 RSUs into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015735 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,915

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015736 · doc4.xml · nonDerivative · entry 2

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,832

F3 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015736 · doc4.xml · nonDerivative · entry 1

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,157

F1 · shares: Represents 1,859 shares of common stock and 3,775 restricted stock units ("RSUs") into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015766 · doc4.xml · derivative · entry 4

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2030-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015766 · doc4.xml · nonDerivative · entry 3

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,572

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015766 · doc4.xml · nonDerivative · entry 2

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,396

F3 · shares: Represents 1,085 shares of common stock and 2,202 RSUs into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015766 · doc4.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,109

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015763 · doc4.xml · derivative · entry 4

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2030-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015763 · doc4.xml · nonDerivative · entry 3

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,400

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015763 · doc4.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,518

F3 · shares: Represents 1,859 shares of common stock and 3,775 RSUs into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015763 · doc4.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,884

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015757 · doc4.xml · derivative · entry 3

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,480

Underlying: Common Stock · 7,480 shares

Expires 2030-03-01

F4 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015757 · doc4.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,058

F3 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015757 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,446

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015752 · doc4.xml · derivative · entry 4

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2030-03-01

F6 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015752 · doc4.xml · nonDerivative · entry 3

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,475

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

F5 · balance_after: Includes 241 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2019.

SEC source: 0001209191-20-015752 · doc4.xml · nonDerivative · entry 2

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,013

F3 · shares: Represents 1,859 shares of common stock and 3,775 RSUs into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015752 · doc4.xml · nonDerivative · entry 1

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,379

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015750 · doc4.xml · derivative · entry 4

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,000

Underlying: Common Stock · 22,000 shares

Expires 2030-03-01

F5 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-015750 · doc4.xml · nonDerivative · entry 3

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,487

F4 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015750 · doc4.xml · nonDerivative · entry 2

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,572

F3 · shares: Represents 1,859 shares of common stock and 3,775 RSUs into which previously granted performance stock units were converted on March 1, 2020 upon certification of the performance metric. The RSUs will fully vest on March 1, 2021.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-015750 · doc4.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,938

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-016374 · doc4a.xml · derivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,280

Underlying: Common Stock · 13,280 shares

Expires 2030-03-01

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

SEC source: 0001209191-20-016374 · doc4a.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,958

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2014 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-005730 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,615

F1 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-20-003425 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,946

F1 · kind: The sales reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

F3 · balance_after: Includes 161 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2019

SEC source: 0001209191-19-053325 · doc4.xml · nonDerivative · entry 1

Kassberg Thomas Richard · CIK 0001303811 · CBO & EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,675

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053326 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 475,914

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053321 · doc4.xml · nonDerivative · entry 1

Bedrosian Camille L · CIK 0001326969 · EVP and Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,239

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053322 · doc4.xml · nonDerivative · entry 1

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,523

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053320 · doc4.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Controller and PAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,785

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053328 · doc4.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,309

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053327 · doc4.xml · nonDerivative · entry 1

Huang Dennis Karl · CIK 0001641217 · EVP & Chief Tech Ops Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,579

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053324 · doc4.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,084

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-053323 · doc4.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,138

F1 · shares: Represents restricted stock units (RSUs) into which previously granted performance stock units were converted on October 14, 2019 upon certification of the applicable performance metric. Half of these RSUs will vest on the first anniversary of the certification date and the other half will vest on the second anniversary of the certification date.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-052722 · doc4.xml · nonDerivative · entry 1

Hogenhuis Wladimir · CIK 0001755074 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,703

F1 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-049950 · doc4.xml · derivative · entry 4

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,998

Underlying: Common Stock · 24,880 shares

Expires 2023-10-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: 1/4th of the option vested one year from November 1, 2013 and then 1/48th of the option vested monthly thereafter.

SEC source: 0001209191-19-049950 · doc4.xml · derivative · entry 3

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,963 shares

Expires 2022-08-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/4th of the option vested one year from May 21, 2012 and then 1/48th of the option vested monthly thereafter.

SEC source: 0001209191-19-049950 · doc4.xml · nonDerivative · entry 2

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 99,089

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-049950 · doc4.xml · nonDerivative · entry 1

Sharp Shalini · CIK 0001377202 · CFO & Executive Vice President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,209

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-049117 · doc4.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 472,479

SEC source: 0001209191-19-042404 · doc4.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,704

F1 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of Restricted Stock Units.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

SEC source: 0001209191-19-041642 · doc4.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,101

F1 · shares: Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of Restricted Stock Units.

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.