QURE

SEC source: 0000904454-25-000316 · edgar.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,551

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000305 · edgar.xml · derivative · entry 2

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000305 · edgar.xml · nonDerivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,302

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000309 · edgar.xml · derivative · entry 2

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000309 · edgar.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,809

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000314 · edgar.xml · derivative · entry 2

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000314 · edgar.xml · nonDerivative · entry 1

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,458

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000311 · edgar.xml · derivative · entry 2

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000311 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,215

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000307 · edgar.xml · derivative · entry 2

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000307 · edgar.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,806

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000182 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 651,454

F2 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.25 to $10.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number os shares sold at each sparate price within the range set forth in the footnote.

SEC source: 0000904454-25-000180 · edgar.xml · nonDerivative · entry 2

Abi-Saab Walid · CIK 0001985973 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,903

F2 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.25 to $10.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000178 · edgar.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,730

F2 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.25 to $10.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000176 · edgar.xml · nonDerivative · entry 2

Potts Jeannette · CIK 0001814693 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,743

F2 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.25 to $10.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000182 · edgar.xml · derivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 171,000

Underlying: Ordinary Shares · 171,000 shares

Expires 2025-03-03

F4 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000182 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 679,795

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000180 · edgar.xml · derivative · entry 3

Abi-Saab Walid · CIK 0001985973 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,000

Underlying: Ordinary Shares · 66,000 shares

Expires 2035-03-03

F4 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000180 · edgar.xml · nonDerivative · entry 1

Abi-Saab Walid · CIK 0001985973 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,253

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000178 · edgar.xml · derivative · entry 3

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,000

Underlying: Ordinary Shares · 126,000 shares

Expires 2035-03-03

F4 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000178 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 228,168

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000176 · edgar.xml · derivative · entry 3

Potts Jeannette · CIK 0001814693 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Ordinary Shares · 60,000 shares

Expires 2035-03-03

F4 · derivative.exercise_date: The Stock Option vests 25% on the first anniversary of the date of grant, and 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000176 · edgar.xml · nonDerivative · entry 1

Potts Jeannette · CIK 0001814693 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,819

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

SEC source: 0000904454-25-000167 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 580,795

F4 · kind: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F4 · shares: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $11.28 to $11.42. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000165 · edgar.xml · nonDerivative · entry 3

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,168

F4 · security: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F4 · kind: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F4 · shares: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $11.28 to $11.41. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000167 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 587,512

F3 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 26, 2025 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000904454-25-000165 · edgar.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,084

F3 · security: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 26, 2025 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

F3 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on February 26, 2025 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000904454-25-000167 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 571,188

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.56 to $11.05. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000165 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,372

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $10.56 to $11.05. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-24-000650 · edgar.xml · derivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 100,000 shares

Expires 2025-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on August 12, 2024 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The Reporting Person's 10b5-1 trading plan relates solely to options to purchase Ordinary Shares scheduled to expire in the near-term, including those reported herein, which were scheduled to expire on January 1, 2025, and 100,000 options with an exercise price of $23.60 scheduled to expire on August 25, 2025.

F3 · derivative.exercise_date: The Stock Option vested 25% on January 2, 2016 and 6.25% quarterly thereafter.

SEC source: 0000904454-24-000650 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 597,915

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on August 12, 2024 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The Reporting Person's 10b5-1 trading plan relates solely to options to purchase Ordinary Shares scheduled to expire in the near-term, including those reported herein, which were scheduled to expire on January 1, 2025, and 100,000 options with an exercise price of $23.60 scheduled to expire on August 25, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.14. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-24-000650 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 697,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on August 12, 2024 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The Reporting Person's 10b5-1 trading plan relates solely to options to purchase Ordinary Shares scheduled to expire in the near-term, including those reported herein, which were scheduled to expire on January 1, 2025, and 100,000 options with an exercise price of $23.60 scheduled to expire on August 25, 2025.

SEC source: 0000904454-24-000644 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 597,915

F2 · kind: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

SEC source: 0000904454-24-000642 · edgar.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 166,713

F2 · kind: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · shares: The shares were sold upon the vesting of PRSUs solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Performance Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $7.48 to $7.56. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-24-000644 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 601,333

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on December 8, 2024 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000904454-24-000642 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,509

F1 · shares: Represents performance-based restricted share units ("PRSUs") granted to the Reporting Person on December 8, 2021 under the Issuer's 2014 Share Incentive Plan, as amended and restated, which were earned on December 8, 2024 as the result of the satisfaction of certain performance criteria. Each PRSU represents the contingent right to receive one Ordinary Share.

SEC source: 0000904454-24-000409 · edgar.xml · nonDerivative · entry 1

Abi-Saab Walid · CIK 0001985973 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,253

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.35 to $4.36. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-24-000397 · edgar.xml · derivative · entry 2

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000397 · edgar.xml · nonDerivative · entry 1

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,079

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000399 · edgar.xml · derivative · entry 2

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000399 · edgar.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,581

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000403 · edgar.xml · derivative · entry 2

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000403 · edgar.xml · nonDerivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,332

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000401 · edgar.xml · derivative · entry 2

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000401 · edgar.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,839

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000407 · edgar.xml · derivative · entry 2

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000407 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,245

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000405 · edgar.xml · derivative · entry 2

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000405 · edgar.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,836

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-24-000395 · edgar.xml · derivative · entry 2

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,840

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.