QURE

SEC source: 0000904454-26-000141 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 639,076

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $23.64 to $24.06. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-26-000139 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 211,513

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $23.64 to $24.06. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-26-000021 · edgar.xml · derivative · entry 5

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 17,810 shares

Expires 2032-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · derivative.exercise_date: The Stock Option vested in full on June 15, 2023.

SEC source: 0000904454-26-000021 · edgar.xml · nonDerivative · entry 4

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 32,342

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-26-000021 · edgar.xml · nonDerivative · entry 3

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,145

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.02 to $25.04. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-26-000021 · edgar.xml · nonDerivative · entry 2

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,645

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $24.02 to $25.00. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-26-000021 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,955

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-26-000013 · edgar.xml · derivative · entry 3

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 6,390 shares

Expires 2028-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The Stock Option vested in full on January 26, 2019.

SEC source: 0000904454-26-000013 · edgar.xml · nonDerivative · entry 2

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,439

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.19 to $27.39. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-26-000013 · edgar.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,829

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000568 · edgar.xml · derivative · entry 4

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 15,840 shares

Expires 2034-06-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · derivative.exercise_date: The Stock Option vested in full on June 19, 2025.

SEC source: 0000904454-25-000568 · edgar.xml · nonDerivative · entry 3

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,145

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000568 · edgar.xml · nonDerivative · entry 2

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,739

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.00 to $27.38. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000568 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,579

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on July 8, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · balance_after: Adjusted to reflect (i) the sale of 1,120 shares under the Reporting Person's 10b5-1 plan on June 23, 2020, which was inadvertently omitted from the Form 4 filed on June 24, 2020, and (ii) the correction to a typographical error in the number of shares sold by the Reporting Person on June 13, 2024 reported on the Form 4 filed on June 17, 2024. The Form 4 reported the sale of 3,504 shares but should have reported the sale of 3,524 shares.

SEC source: 0000904454-25-000560 · edgar.xml · derivative · entry 9

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 17,810 shares

Expires 2032-06-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F7 · derivative.exercise_date: The Stock Option vested in full on June 15, 2023.

SEC source: 0000904454-25-000560 · edgar.xml · derivative · entry 8

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 11,000 shares

Expires 2027-01-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · derivative.exercise_date: The Stock Option vested in full on January 27, 2018.

SEC source: 0000904454-25-000560 · edgar.xml · derivative · entry 7

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 10,000 shares

Expires 2027-06-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · derivative.exercise_date: The Stock Option vested 25% on June 30, 2018 and 6.25% quarterly thereafter.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 6

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,439

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.90. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 5

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 38,249

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 4

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,439

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.16 to $30.75. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 3

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,439

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 2

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,439

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.20 to $30.79. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000560 · edgar.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,439

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on June 16, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000455 · edgar.xml · derivative · entry 6

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 15,000 shares

Expires 2027-01-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · derivative.exercise_date: The Stock Option vested 25% on January 27, 2018 and 6.25% quarterly thereafter, and is scheduled to expire on January 27, 2027.

SEC source: 0000904454-25-000455 · edgar.xml · nonDerivative · entry 4

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 217,730

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in muliple transactions at prices ranging from $55.00 to $55.02. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000455 · edgar.xml · nonDerivative · entry 3

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 232,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000457 · edgar.xml · derivative · entry 9

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 175,000 shares

Expires 2027-03-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F9 · derivative.exercise_date: The Stock Option vested 25% on March 14, 2018 and 6.25% quarterly thereafter.

SEC source: 0000904454-25-000457 · edgar.xml · derivative · entry 8

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 51,316 shares

Expires 2026-09-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F7 · derivative.exercise_date: The Stock Option vested 25% on September 29, 2017 and 6.25% quarterly thereafter.

F8 · balance_after: Adjusted to reflect the exercise and sale of 7,501 option shares under the Reporting Person's 10b5-1 plan on February 19, 2020.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 7

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 651,454

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.00 to $45.30. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 6

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 711,454

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.56 to $41.76. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 5

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 716,476

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $40.42 to $41.42 The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 4

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 766,454

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $40.00 to $40.15. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 826,454

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $39.20 to $40.15. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 877,770

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000457 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, Managing Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 702,770

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 28, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000455 · edgar.xml · derivative · entry 5

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,000 shares

Expires 2026-04-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: The Stock Option vested 25% on April 15, 2016 and 6.25% quarterly thereafter, and is scheduled to expire on April 15, 2026.

SEC source: 0000904454-25-000455 · edgar.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 217,730

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $40.00 to $40.15. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000455 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 220,730

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on January 13, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

SEC source: 0000904454-25-000350 · edgar.xml · nonDerivative · entry 1

Abi-Saab Walid · CIK 0001985973 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,437

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $13.90 to $14.05. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000338 · edgar.xml · nonDerivative · entry 1

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,937

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000336 · edgar.xml · nonDerivative · entry 1

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,439

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000328 · edgar.xml · nonDerivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,190

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000330 · edgar.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,697

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000340 · edgar.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,694

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000334 · edgar.xml · nonDerivative · entry 1

Jacques Rachelle Suzanne · CIK 0001772610 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,346

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000332 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,879

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $14.40 to $14.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000326 · edgar.xml · nonDerivative · entry 1

Potts Jeannette · CIK 0001814693 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,073

F1 · kind: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F1 · shares: The shares were sold upon the vesting of restricted share units solely to cover estimated withholding taxes, pursuant to automatic sale instructions included in the relevant Restricted Share Unit Agreement. The sale was not a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $15.00 to $15.22. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000904454-25-000318 · edgar.xml · derivative · entry 2

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000318 · edgar.xml · nonDerivative · entry 1

POST LEONARD E · CIK 0001235862 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,049

F1 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.

SEC source: 0000904454-25-000316 · edgar.xml · derivative · entry 2

Kaye Jack · CIK 0001376099 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,630

Underlying: Ordinary Shares · 15,630 shares

Expires 2035-06-11

F2 · derivative.exercise_date: The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date.