PTGX

SEC source: 0001209191-16-145799 · doc4.xml · derivative · entry 1

HODDER WILLIAM A · CIK 0001217311 · Sr. VP - Corporate Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2026-10-11

F1 · derivative.exercise_date: The shares subject to the option shall vest in 48 equal monthly installments from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-141587 · doc4.xml · derivative · entry 1

KHOSLA CHAITAN PHD · CIK 0001135139 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2026-09-13

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a three-year period from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-141585 · doc4.xml · derivative · entry 1

Papanek Julie · CIK 0001673237 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2026-09-13

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a three-year period from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-141592 · doc4.xml · derivative · entry 1

Shanafelt Armen · CIK 0001656151 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2026-09-13

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a three-year period from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-141595 · doc4.xml · derivative · entry 1

Waddill William D. · CIK 0001553338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2026-09-13

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a three-year period from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-141588 · doc4.xml · derivative · entry 1

SELICK HAROLD E · CIK 0001287233 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2026-09-13

F1 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a three-year period from the vesting commencement date of August 10, 2016.

SEC source: 0001209191-16-143095 · doc4a.xml · derivative · entry 1

KHOSLA CHAITAN PHD · CIK 0001135139 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-09-13

F1 · security: This option was inadvertently omitted from the Reporting Person's original Form 4 filed with the SEC on September 15, 2016.

F2 · derivative.exercise_date: The shares subject to the option shall vest in equal monthly installments over a one-year period from the vesting commencement date of August 10, 2016.

SEC source: 0000904454-16-001373 · edgar.xml · derivative · entry 5

JOHNSON & JOHNSON · CIK 0000200406 · 10% owner

Johnson & Johnson Innovation - JJDC, Inc. · CIK 0000924020 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Johnson & Johnson Innovation - JJDC, Inc.

Disclosed balance after: 0

Underlying: Common Stock · 900,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.exercise_date: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.expiration_date: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F2 · derivative.underlying_shares: The number of shares of Common Stock reflects a 1-for-14.5 reverse stock split, which became effective on August 1, 2016. Pursuant to the reverse stock split, every 14.5 shares of Series B Preferred Stock and Series C Preferred Stock converted into one share of Common Stock at the closing of the Issuer's initial public offering, for no additional consideration.

F3 · ownership.nature: The securities reported as being indirectly beneficially owned by the designated Reporting Person are directly beneficially owned by Johnson & Johnson Innovation - JJDC, Inc., a wholly-owned subsidiary of the designated Reporting Person.

SEC source: 0000904454-16-001373 · edgar.xml · derivative · entry 4

JOHNSON & JOHNSON · CIK 0000200406 · 10% owner

Johnson & Johnson Innovation - JJDC, Inc. · CIK 0000924020 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Johnson & Johnson Innovation - JJDC, Inc.

Disclosed balance after: 0

Underlying: Common Stock · 965,517 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.exercise_date: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.expiration_date: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F2 · derivative.underlying_shares: The number of shares of Common Stock reflects a 1-for-14.5 reverse stock split, which became effective on August 1, 2016. Pursuant to the reverse stock split, every 14.5 shares of Series B Preferred Stock and Series C Preferred Stock converted into one share of Common Stock at the closing of the Issuer's initial public offering, for no additional consideration.

F3 · ownership.nature: The securities reported as being indirectly beneficially owned by the designated Reporting Person are directly beneficially owned by Johnson & Johnson Innovation - JJDC, Inc., a wholly-owned subsidiary of the designated Reporting Person.

SEC source: 0000904454-16-001373 · edgar.xml · nonDerivative · entry 3

JOHNSON & JOHNSON · CIK 0000200406 · 10% owner

Johnson & Johnson Innovation - JJDC, Inc. · CIK 0000924020 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Johnson & Johnson Innovation - JJDC, Inc.

Disclosed balance after: 2,449,183

F3 · ownership.nature: The securities reported as being indirectly beneficially owned by the designated Reporting Person are directly beneficially owned by Johnson & Johnson Innovation - JJDC, Inc., a wholly-owned subsidiary of the designated Reporting Person.

SEC source: 0000904454-16-001373 · edgar.xml · nonDerivative · entry 2

JOHNSON & JOHNSON · CIK 0000200406 · 10% owner

Johnson & Johnson Innovation - JJDC, Inc. · CIK 0000924020 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Johnson & Johnson Innovation - JJDC, Inc.

Disclosed balance after: 1,865,850

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: The number of shares of Common Stock reflects a 1-for-14.5 reverse stock split, which became effective on August 1, 2016. Pursuant to the reverse stock split, every 14.5 shares of Series B Preferred Stock and Series C Preferred Stock converted into one share of Common Stock at the closing of the Issuer's initial public offering, for no additional consideration.

F1 · price: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F3 · ownership.nature: The securities reported as being indirectly beneficially owned by the designated Reporting Person are directly beneficially owned by Johnson & Johnson Innovation - JJDC, Inc., a wholly-owned subsidiary of the designated Reporting Person.

SEC source: 0000904454-16-001373 · edgar.xml · nonDerivative · entry 1

JOHNSON & JOHNSON · CIK 0000200406 · 10% owner

Johnson & Johnson Innovation - JJDC, Inc. · CIK 0000924020 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Johnson & Johnson Innovation - JJDC, Inc.

Disclosed balance after: 965,517

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · shares: The number of shares of Common Stock reflects a 1-for-14.5 reverse stock split, which became effective on August 1, 2016. Pursuant to the reverse stock split, every 14.5 shares of Series B Preferred Stock and Series C Preferred Stock converted into one share of Common Stock at the closing of the Issuer's initial public offering, for no additional consideration.

F1 · price: Each share of the Issuer's Series B Preferred Stock and Series C Preferred Stock automatically converted into the Issuer's Common Stock on a 1-for-14.5 basis at the closing of the Issuer's initial public offering and had no expiration date.

F3 · ownership.nature: The securities reported as being indirectly beneficially owned by the designated Reporting Person are directly beneficially owned by Johnson & Johnson Innovation - JJDC, Inc., a wholly-owned subsidiary of the designated Reporting Person.