PRTA

SEC source: 0001140361-23-013190 · form4.xml · nonDerivative · entry 3

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $48.33 to $48.73, inclusive.

SEC source: 0001140361-23-013190 · form4.xml · nonDerivative · entry 2

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,097

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $47.305 to $48.22, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-23-013190 · form4.xml · nonDerivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-005288 · doc1.xml · derivative · entry 4

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Ordinary Shares · 12,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on April 5, 2022, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-23-005288 · doc1.xml · nonDerivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $48.44 to $49.06, inclusive.

SEC source: 0001567619-23-005288 · doc1.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $47.43 to $48.42, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001567619-23-005288 · doc1.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-005291 · doc1.xml · derivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately one month and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F5 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 901,837 shares at exercise prices ranging from $6.73 to $52.97, of which 721,837 are currently exercisable, and 180,000 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-23-005291 · doc1.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $48.43 to $49.03, inclusive.

SEC source: 0001567619-23-005291 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,398

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $47.43 to $48.405, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001567619-23-005291 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-005293 · doc1.xml · derivative · entry 4

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,481

Underlying: Ordinary Shares · 20,000 shares

Expires 2028-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-23-005293 · doc1.xml · nonDerivative · entry 3

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $48.43 to $49.06, inclusive.

SEC source: 0001567619-23-005293 · doc1.xml · nonDerivative · entry 2

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,569

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $47.43 to $48.42, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001567619-23-005293 · doc1.xml · nonDerivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-005290 · doc1.xml · derivative · entry 4

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-23-005290 · doc1.xml · nonDerivative · entry 3

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $48.435 to $49.13, inclusive.

SEC source: 0001567619-23-005290 · doc1.xml · nonDerivative · entry 2

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,564

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $47.43 to $48.39, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001567619-23-005290 · doc1.xml · nonDerivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-010182 · form4.xml · derivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-010185 · form4.xml · derivative · entry 1

Smith Brandon S. · CIK 0001805226 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-010184 · form4.xml · derivative · entry 1

Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-010186 · form4.xml · derivative · entry 1

Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-010183 · form4.xml · derivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

F2 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 911,837 shares at exercise prices ranging from $6.73 to $52.97, of which 731,837 are currently exercisable, and 180,000 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to an order regarding the separation of assets in accordance with a divorce settlement agreement.

SEC source: 0001140361-23-010187 · form4.xml · derivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-010181 · form4.xml · derivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 155,000

Underlying: Ordinary Shares · 155,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

F2 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,159,700 shares at exercise prices ranging from $12.15 to $52.97, of which 1,642,200 are currently exercisable, and 517,500 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-23-010180 · form4.xml · derivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,000

Underlying: Ordinary Shares · 38,000 shares

Expires 2033-03-02

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on March 2, 2024 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-23-003363 · doc1.xml · derivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately two months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F5 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 863,837 shares at exercise prices ranging from $6.73 to $32.45, of which 704,669 are currently exercisable, and 159,168 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-23-003363 · doc1.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $53.87 to $53.88, inclusive.

SEC source: 0001567619-23-003363 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,864

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $52.835 to $53.83, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001567619-23-003363 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-001097 · doc1.xml · derivative · entry 5

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately two months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F6 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 873,837 shares at exercise prices ranging from $6.73 to $32.45, of which 708,753 are currently exercisable, and 165,084 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-23-001097 · doc1.xml · nonDerivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F4 · price: The transaction was executed in multiple trades in prices ranging from $56.815 to $57.355, inclusive.

SEC source: 0001567619-23-001097 · doc1.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,838

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $55.78 to $56.755, inclusive.

SEC source: 0001567619-23-001097 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,923

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $54.77 to $55.755, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 4 of this Form 4.

SEC source: 0001567619-23-001097 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-000905 · doc1.xml · derivative · entry 3

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option would have expired in approximately one month and would have been forfeited to the extent it was not exercised on or prior to January 29, 2023.

F3 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option would have expired in approximately one month and would have been forfeited to the extent it was not exercised on or prior to January 29, 2023.

SEC source: 0001567619-23-000905 · doc1.xml · nonDerivative · entry 2

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $52.28 to $53.175, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnote 2 of this Form 4.

SEC source: 0001567619-23-000905 · doc1.xml · nonDerivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-000573 · doc1.xml · derivative · entry 3

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option would have expired in approximately one month and would have been forfeited to the extent it was not exercised on or prior to January 29, 2023.

F3 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option would have expired in approximately one month and would have been forfeited to the extent it was not exercised on or prior to January 29, 2023.

SEC source: 0001567619-23-000573 · doc1.xml · nonDerivative · entry 2

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $52.215 to $53.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnote 2 of this Form 4.

SEC source: 0001567619-23-000573 · doc1.xml · nonDerivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,219

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-23-000574 · doc1.xml · derivative · entry 9

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 15,834 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option would have expired in approximately one month and would have been forfeited to the extent it was not exercised on or prior to January 29, 2023.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 8

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 243

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F7 · price: The transaction was executed in multiple trades in prices ranging from $60.77 to $61.00, inclusive.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 7

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 312

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 6

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 322

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F6 · price: The transaction was executed in multiple trades in prices ranging from $58.195 to $58.92, inclusive.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 5

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,845

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $56.76 to $57.31, inclusive.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 4

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,148

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $55.76 to $56.755, inclusive.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 3

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,769

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $54.75 to $55.74, inclusive.

SEC source: 0001567619-23-000574 · doc1.xml · nonDerivative · entry 2

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,666

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $53.74 to $54.68, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 7 of this Form 4.