Last 12 months
Inside the activity.
15 purchase rows · 2 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 0 |
| Dec 2025 | 0 | 0 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 0 |
| Mar 2026 | 0 | 0 |
| Apr 2026 | 0 | 0 |
| May 2026 | 1 | 0 |
| Jun 2026 | 4 | 0 |
| Jul 2026 | 0 | 2 |
| Aug 2026 | 3 | 0 |
| Sep 2026 | 4 | 0 |
| Oct 2026 | 3 | 0 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| September 13, 2023 Filed Sep 13, 2023 23:32 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 3,886 | $55.48 | $215,584.01 |
DisclosureSEC source: 0000905148-23-000918 · form4.xml · nonDerivative · entry 2 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 114 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F2 · price: This transaction was executed in multiple trades in prices ranging from $54.925 to $55.84, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| September 13, 2023 Filed Sep 13, 2023 23:32 UTC |
Smith Brandon S.Chief Operating Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 4,000 | $11.12 | $44,480.00 |
DisclosureSEC source: 0000905148-23-000918 · form4.xml · nonDerivative · entry 1 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 4,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| September 06, 2023 Filed Sep 6, 2023 19:42 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $12.15 | $0.00 |
DisclosureSEC source: 0000905148-23-000853 · form4.xml · derivative · entry 4 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 50,000 Underlying: Ordinary Shares · 5,000 shares Expires 2030-02-25 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on February 25, 2021, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| September 06, 2023 Filed Sep 6, 2023 19:42 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 6 | $55.27 | $331.62 |
DisclosureSEC source: 0000905148-23-000853 · form4.xml · nonDerivative · entry 3 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. Read SEC document |
| September 06, 2023 Filed Sep 6, 2023 19:42 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 4,994 | $54.76 | $273,471.94 |
DisclosureSEC source: 0000905148-23-000853 · form4.xml · nonDerivative · entry 2 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 6 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. F2 · price: This transaction was executed in multiple trades in prices ranging from $54.23 to $55.20, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnote 2 of this Form 4. Read SEC document |
| September 06, 2023 Filed Sep 6, 2023 19:42 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $12.15 | $60,750.00 |
DisclosureSEC source: 0000905148-23-000853 · form4.xml · nonDerivative · entry 1 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 30, 2023 Filed Aug 30, 2023 23:24 UTC |
Malecek Michael JChief Legal Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $10.27 | $0.00 |
DisclosureSEC source: 0000905148-23-000803 · form4.xml · derivative · entry 5 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 95,000 Underlying: Ordinary Shares · 5,000 shares Expires 2029-07-01 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 30, 2023 Filed Aug 30, 2023 23:24 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 14 | $56.21 | $786.94 |
DisclosureSEC source: 0000905148-23-000803 · form4.xml · nonDerivative · entry 4 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. Read SEC document |
| August 30, 2023 Filed Aug 30, 2023 23:24 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,664 | $55.39 | $147,551.23 |
DisclosureSEC source: 0000905148-23-000803 · form4.xml · nonDerivative · entry 3 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 14 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. F3 · price: The transaction was executed in multiple trades in prices ranging from $55.16 to $55.755, inclusive. Read SEC document |
| August 30, 2023 Filed Aug 30, 2023 23:24 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,322 | $54.58 | $126,727.79 |
DisclosureSEC source: 0000905148-23-000803 · form4.xml · nonDerivative · entry 2 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 2,678 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. F2 · price: This transaction was executed in multiple trades in prices ranging from $54.09 to $55.01, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| August 30, 2023 Filed Aug 30, 2023 23:24 UTC |
Malecek Michael JChief Legal Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $10.27 | $51,350.00 |
DisclosureSEC source: 0000905148-23-000803 · form4.xml · nonDerivative · entry 1 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 18, 2023 Filed Aug 19, 2023 00:37 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0000905148-23-000772 · form4.xml · derivative · entry 3 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,481 Underlying: Ordinary Shares · 5,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 18, 2023 Filed Aug 19, 2023 00:37 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 5,000 | $57.18 | $285,922.50 |
DisclosureSEC source: 0000905148-23-000772 · form4.xml · nonDerivative · entry 2 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022. F2 · price: The transaction was executed in multiple trades in prices ranging from $56.95 to $57.67, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnote 2 of this Form 4. Read SEC document |
| August 18, 2023 Filed Aug 19, 2023 00:37 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $15.04 | $75,200.00 |
DisclosureSEC source: 0000905148-23-000772 · form4.xml · nonDerivative · entry 1 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 16, 2023 Filed Aug 16, 2023 21:15 UTC |
Garren HidekiChief Medical Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 2,000 | $0.00 Strike: $24.90 | $0.00 |
DisclosureSEC source: 0001140361-23-040143 · form4.xml · derivative · entry 5 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 194,000 Underlying: Ordinary Shares · 2,000 shares Expires 2031-04-05 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on April 5, 2022, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 16, 2023 Filed Aug 16, 2023 21:15 UTC |
Garren HidekiChief Medical Officer
|
SaleOrdinary Shares, par value $0.01 per share | 374 | $59.74 | $22,341.45 |
DisclosureSEC source: 0001140361-23-040143 · form4.xml · nonDerivative · entry 4 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023. F4 · price: The transaction was executed in multiple trades in prices ranging from $59.65 to $60.26, inclusive. Read SEC document |
| August 16, 2023 Filed Aug 16, 2023 21:15 UTC |
Garren HidekiChief Medical Officer
|
SaleOrdinary Shares, par value $0.01 per share | 748 | $58.93 | $44,079.19 |
DisclosureSEC source: 0001140361-23-040143 · form4.xml · nonDerivative · entry 3 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 374 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $58.585 to $59.24, inclusive. Read SEC document |
| August 16, 2023 Filed Aug 16, 2023 21:15 UTC |
Garren HidekiChief Medical Officer
|
SaleOrdinary Shares, par value $0.01 per share | 878 | $58.15 | $51,059.39 |
DisclosureSEC source: 0001140361-23-040143 · form4.xml · nonDerivative · entry 2 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,122 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $57.555 to $58.545, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4. Read SEC document |
| August 16, 2023 Filed Aug 16, 2023 21:15 UTC |
Garren HidekiChief Medical Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 2,000 | $24.90 | $49,800.00 |
DisclosureSEC source: 0001140361-23-040143 · form4.xml · nonDerivative · entry 1 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 2,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 16, 2023 Filed Aug 17, 2023 01:15 UTC |
Smith Brandon S.Chief Operating Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 4,000 | $0.00 Strike: $11.12 | $0.00 |
DisclosureSEC source: 0001140361-23-040142 · form4.xml · derivative · entry 5 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 226,667 Underlying: Ordinary Shares · 4,000 shares Expires 2030-03-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on March 2, 2021, and will vest with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 16, 2023 Filed Aug 17, 2023 01:15 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 401 | $59.91 | $24,025.27 |
DisclosureSEC source: 0001140361-23-040142 · form4.xml · nonDerivative · entry 4 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F4 · price: The transaction was executed in multiple trades in prices ranging from $59.76 to $60.26, inclusive. Read SEC document |
| August 16, 2023 Filed Aug 17, 2023 01:15 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,373 | $59.15 | $81,216.66 |
DisclosureSEC source: 0001140361-23-040142 · form4.xml · nonDerivative · entry 3 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 401 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $58.73 to $59.705, inclusive. Read SEC document |
| August 16, 2023 Filed Aug 17, 2023 01:15 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,226 | $58.22 | $129,602.17 |
DisclosureSEC source: 0001140361-23-040142 · form4.xml · nonDerivative · entry 2 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,774 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $57.70 to $58.655, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4. Read SEC document |
| August 16, 2023 Filed Aug 17, 2023 01:15 UTC |
Smith Brandon S.Chief Operating Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 4,000 | $11.12 | $44,480.00 |
DisclosureSEC source: 0001140361-23-040142 · form4.xml · nonDerivative · entry 1 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 4,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 02, 2023 Filed Aug 3, 2023 01:00 UTC |
Zago Wagner M.Chief Scientific Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 4,000 | $0.00 Strike: $12.15 | $0.00 |
DisclosureSEC source: 0001140361-23-037713 · form4.xml · derivative · entry 4 Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 58,000 Underlying: Ordinary Shares · 4,000 shares Expires 2030-02-25 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on February 25, 2021, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 02, 2023 Filed Aug 3, 2023 01:00 UTC |
Zago Wagner M.Chief Scientific Officer
|
SaleOrdinary Shares, par value $0.01 per share | 229 | $68.07 | $15,588.63 |
DisclosureSEC source: 0001140361-23-037713 · form4.xml · nonDerivative · entry 3 Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $67.92 to $68.39, inclusive. Read SEC document |
| August 02, 2023 Filed Aug 3, 2023 01:00 UTC |
Zago Wagner M.Chief Scientific Officer
|
SaleOrdinary Shares, par value $0.01 per share | 3,771 | $66.98 | $252,592.89 |
DisclosureSEC source: 0001140361-23-037713 · form4.xml · nonDerivative · entry 2 Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 229 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.495 to $67.46, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| August 02, 2023 Filed Aug 3, 2023 01:00 UTC |
Zago Wagner M.Chief Scientific Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 4,000 | $12.15 | $48,600.00 |
DisclosureSEC source: 0001140361-23-037713 · form4.xml · nonDerivative · entry 1 Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 4,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| August 02, 2023 Filed Aug 2, 2023 21:00 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $12.15 | $0.00 |
DisclosureSEC source: 0001140361-23-037712 · form4.xml · derivative · entry 4 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 55,000 Underlying: Ordinary Shares · 5,000 shares Expires 2030-02-25 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on February 25, 2021, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| August 02, 2023 Filed Aug 2, 2023 21:00 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 328 | $67.95 | $22,288.09 |
DisclosureSEC source: 0001140361-23-037712 · form4.xml · nonDerivative · entry 3 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $67.63 to $68.61, inclusive. Read SEC document |
| August 02, 2023 Filed Aug 2, 2023 21:00 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 4,672 | $66.95 | $312,783.86 |
DisclosureSEC source: 0001140361-23-037712 · form4.xml · nonDerivative · entry 2 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 328 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.46 to $67.33, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| August 02, 2023 Filed Aug 2, 2023 21:00 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $12.15 | $60,750.00 |
DisclosureSEC source: 0001140361-23-037712 · form4.xml · nonDerivative · entry 1 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| July 26, 2023 Filed Jul 26, 2023 23:45 UTC |
Malecek Michael JChief Legal Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $10.27 | $0.00 |
DisclosureSEC source: 0001140361-23-036291 · form4.xml · derivative · entry 5 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 100,000 Underlying: Ordinary Shares · 5,000 shares Expires 2029-07-01 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| July 26, 2023 Filed Jul 26, 2023 23:45 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 620 | $63.40 | $39,309.05 |
DisclosureSEC source: 0001140361-23-036291 · form4.xml · nonDerivative · entry 4 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. F4 · price: The transaction was executed in multiple trades in prices ranging from $63.285 to $64.04, inclusive. Read SEC document |
| July 26, 2023 Filed Jul 26, 2023 23:45 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,903 | $62.69 | $119,297.36 |
DisclosureSEC source: 0001140361-23-036291 · form4.xml · nonDerivative · entry 3 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 620 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. F3 · price: The transaction was executed in multiple trades in prices ranging from $62.27 to $63.235, inclusive. Read SEC document |
| July 26, 2023 Filed Jul 26, 2023 23:45 UTC |
Malecek Michael JChief Legal Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,477 | $61.78 | $153,031.78 |
DisclosureSEC source: 0001140361-23-036291 · form4.xml · nonDerivative · entry 2 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 2,523 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022. F2 · price: The transaction was executed in multiple trades in prices ranging from $61.25 to $62.23, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4. Read SEC document |
| July 26, 2023 Filed Jul 26, 2023 23:45 UTC |
Malecek Michael JChief Legal Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $10.27 | $51,350.00 |
DisclosureSEC source: 0001140361-23-036291 · form4.xml · nonDerivative · entry 1 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| July 19, 2023 Filed Jul 20, 2023 00:50 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionStock Option (right to buy) · Derivative | 5,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001140361-23-035280 · form4.xml · derivative · entry 4 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 10,481 Underlying: Ordinary Shares · 5,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| July 19, 2023 Filed Jul 20, 2023 00:50 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,034 | $70.08 | $72,459.00 |
DisclosureSEC source: 0001140361-23-035280 · form4.xml · nonDerivative · entry 3 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022. F3 · price: The transaction was executed in multiple trades in prices ranging from $69.95 to $70.17, inclusive. Read SEC document |
| July 19, 2023 Filed Jul 20, 2023 00:50 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 3,966 | $68.96 | $273,484.26 |
DisclosureSEC source: 0001140361-23-035280 · form4.xml · nonDerivative · entry 2 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,034 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022. F2 · price: The transaction was executed in multiple trades in prices ranging from $68.635 to $69.45, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| July 19, 2023 Filed Jul 20, 2023 00:50 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $15.04 | $75,200.00 |
DisclosureSEC source: 0001140361-23-035280 · form4.xml · nonDerivative · entry 1 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 5,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| July 12, 2023 Filed Jul 12, 2023 20:45 UTC |
Garren HidekiChief Medical Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 2,000 | $0.00 Strike: $24.90 | $0.00 |
DisclosureSEC source: 0001140361-23-034304 · form4.xml · derivative · entry 4 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 196,000 Underlying: Ordinary Shares · 2,000 shares Expires 2031-04-05 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on April 5, 2022, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| July 12, 2023 Filed Jul 12, 2023 20:45 UTC |
Garren HidekiChief Medical Officer
|
SaleOrdinary Shares, par value $0.01 per share | 92 | $68.20 | $6,274.00 |
DisclosureSEC source: 0001140361-23-034304 · form4.xml · nonDerivative · entry 3 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $68.12 to $68.20, inclusive. Read SEC document |
| July 12, 2023 Filed Jul 12, 2023 20:45 UTC |
Garren HidekiChief Medical Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,908 | $67.48 | $128,752.60 |
DisclosureSEC source: 0001140361-23-034304 · form4.xml · nonDerivative · entry 2 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 92 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.94 to $67.86, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| July 12, 2023 Filed Jul 12, 2023 20:45 UTC |
Garren HidekiChief Medical Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 2,000 | $24.90 | $49,800.00 |
DisclosureSEC source: 0001140361-23-034304 · form4.xml · nonDerivative · entry 1 Garren Hideki · CIK 0001854126 · Chief Medical Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 2,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| July 12, 2023 Filed Jul 13, 2023 00:45 UTC |
Smith Brandon S.Chief Operating Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 4,000 | $0.00 Strike: $11.12 | $0.00 |
DisclosureSEC source: 0001140361-23-034303 · form4.xml · derivative · entry 4 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 230,667 Underlying: Ordinary Shares · 4,000 shares Expires 2030-03-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on March 2, 2021, and will vest with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| July 12, 2023 Filed Jul 13, 2023 00:45 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 800 | $67.95 | $54,358.40 |
DisclosureSEC source: 0001140361-23-034303 · form4.xml · nonDerivative · entry 3 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F3 · price: The transaction was executed in multiple trades in prices ranging from $67.855 to $68.295, inclusive. Read SEC document |
| July 12, 2023 Filed Jul 13, 2023 00:45 UTC |
Smith Brandon S.Chief Operating Officer
|
SaleOrdinary Shares, par value $0.01 per share | 3,200 | $67.40 | $215,667.20 |
DisclosureSEC source: 0001140361-23-034303 · form4.xml · nonDerivative · entry 2 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 800 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 13, 2023. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.815 to $67.76, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4. Read SEC document |
| July 12, 2023 Filed Jul 13, 2023 00:45 UTC |
Smith Brandon S.Chief Operating Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 4,000 | $11.12 | $44,480.00 |
DisclosureSEC source: 0001140361-23-034303 · form4.xml · nonDerivative · entry 1 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 4,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| July 05, 2023 Filed Jul 6, 2023 01:32 UTC |
Zago Wagner M.Chief Scientific Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 4,000 | $0.00 Strike: $12.15 | $0.00 |
DisclosureSEC source: 0001140361-23-033192 · form4.xml · derivative · entry 4 Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 62,000 Underlying: Ordinary Shares · 4,000 shares Expires 2030-02-25 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on February 25, 2021, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.