Last 12 months
Inside the activity.
15 purchase rows · 2 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 0 |
| Dec 2025 | 0 | 0 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 0 |
| Mar 2026 | 0 | 0 |
| Apr 2026 | 0 | 0 |
| May 2026 | 1 | 0 |
| Jun 2026 | 4 | 0 |
| Jul 2026 | 0 | 2 |
| Aug 2026 | 3 | 0 |
| Sep 2026 | 4 | 0 |
| Oct 2026 | 3 | 0 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| February 23, 2022 Filed Feb 26, 2022 02:32 UTC |
Kinney Gene G.President and CEO
|
GrantStock Option (Right to Buy) · Derivative | 250,000 | $0.00 Strike: $32.45 | $0.00 |
DisclosureSEC source: 0001140361-22-006900 · form4.xml · derivative · entry 1 Kinney Gene G. · CIK 0001564380 · President and CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 250,000 Underlying: Ordinary Shares · 250,000 shares Expires 2032-02-23 F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| February 23, 2022 Filed Feb 26, 2022 02:31 UTC |
Walker Karin LChief Accounting Officer
|
GrantStock Option (Right to Buy) · Derivative | 45,500 | $0.00 Strike: $32.45 | $0.00 |
DisclosureSEC source: 0001140361-22-006898 · form4.xml · derivative · entry 1 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 45,500 Underlying: Ordinary Shares · 45,500 shares Expires 2032-02-23 F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| February 23, 2022 Filed Feb 26, 2022 02:31 UTC |
Tripuraneni RadhikaChief Development Officer
|
GrantStock Option (Right to Buy) · Derivative | 50,000 | $0.00 Strike: $32.45 | $0.00 |
DisclosureSEC source: 0001140361-22-006893 · form4.xml · derivative · entry 1 Tripuraneni Radhika · CIK 0001761114 · Chief Development Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 50,000 Underlying: Ordinary Shares · 50,000 shares Expires 2032-02-23 F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| February 23, 2022 Filed Feb 26, 2022 02:30 UTC |
Malecek Michael JChief Legal Officer
|
GrantStock Option (Right to Buy) · Derivative | 85,000 | $0.00 Strike: $32.45 | $0.00 |
DisclosureSEC source: 0001140361-22-006888 · form4.xml · derivative · entry 1 Malecek Michael J · CIK 0001779336 · Chief Legal Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 85,000 Underlying: Ordinary Shares · 85,000 shares Expires 2032-02-23 F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| January 12, 2022 Filed Jan 12, 2022 23:12 UTC |
EcoR1 Capital, LLC10% owner
|
PurchaseOrdinary Shares | 300,000 | $37.50 | $11,250,300.00 |
DisclosureSEC source: 0001567619-22-001133 · doc1.xml · nonDerivative · entry 1 EcoR1 Capital, LLC · CIK 0001587114 · 10% owner 10b5-1 filing: Not disclosed Ownership: Indirect · See Note 1 Disclosed balance after: 11,584,280 F2 · shares: Qualified Fund purchased all of the Ordinary Shares acquired in this transaction. F3 · balance_after: After this transaction, Qualified Fund directly owned 9,785,116 Ordinary Shares. F1 · ownership.nature: The filing persons (the "Filers") are EcoR1 Capital, LLC ("EcoR1"), Oleg Nodelman and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund"). EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 indirectly beneficially owns them as the investment adviser to the Funds, and Mr. Nodelman indirectly beneficially owns them as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein. Read SEC document |
| January 03, 2022 Filed Jan 6, 2022 02:02 UTC |
Selkoe Dennis J.Director
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $9.23 | $0.00 |
DisclosureSEC source: 0001567619-22-000673 · doc1.xml · derivative · entry 6 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 6,000 Underlying: Ordinary Shares · 5,000 shares Expires 2029-05-22 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| January 03, 2022 Filed Jan 6, 2022 02:02 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 492 | $49.48 | $24,342.83 |
DisclosureSEC source: 0001567619-22-000673 · doc1.xml · nonDerivative · entry 4 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,845 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $49.03 to $49.77, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| January 03, 2022 Filed Jan 6, 2022 02:02 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 2,375 | $47.60 | $113,054.04 |
DisclosureSEC source: 0001567619-22-000673 · doc1.xml · nonDerivative · entry 3 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,337 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $47.30 to $48.08, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| January 03, 2022 Filed Jan 6, 2022 02:02 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 2,133 | $46.81 | $99,835.92 |
DisclosureSEC source: 0001567619-22-000673 · doc1.xml · nonDerivative · entry 2 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,712 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $46.30 to $47.26, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| January 03, 2022 Filed Jan 6, 2022 02:02 UTC |
Selkoe Dennis J.Director
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $9.23 | $46,150.00 |
DisclosureSEC source: 0001567619-22-000673 · doc1.xml · nonDerivative · entry 1 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 7,845 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 23, 2021 Filed Nov 27, 2021 02:19 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionStock Option (right to buy) · Derivative | 4,519 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001567619-21-021197 · doc1.xml · derivative · entry 4 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 85,481 Underlying: Ordinary Shares · 4,519 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| November 23, 2021 Filed Nov 27, 2021 02:19 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,819 | $58.43 | $106,285.99 |
DisclosureSEC source: 0001567619-21-021197 · doc1.xml · nonDerivative · entry 3 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $58.10 to $58.84, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| November 23, 2021 Filed Nov 27, 2021 02:19 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,700 | $57.51 | $155,286.99 |
DisclosureSEC source: 0001567619-21-021197 · doc1.xml · nonDerivative · entry 2 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 1,819 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $56.97 to $57.95, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| November 23, 2021 Filed Nov 27, 2021 02:19 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 4,519 | $15.04 | $67,965.76 |
DisclosureSEC source: 0001567619-21-021197 · doc1.xml · nonDerivative · entry 1 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,519 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 19, 2021 Filed Nov 20, 2021 02:32 UTC |
Malecek Michael JSee Remarks
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 10,000 | $0.00 Strike: $10.27 | $0.00 |
DisclosureSEC source: 0001567619-21-020909 · doc1.xml · derivative · entry 3 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 230,000 Underlying: Ordinary Shares · 10,000 shares Expires 2029-07-01 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_date: The shares subject to the option vest and become exercisable as to 25% of the total number of shares subject to the option on July 1, 2020 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| November 19, 2021 Filed Nov 20, 2021 02:32 UTC |
Malecek Michael JSee Remarks
|
SaleOrdinary Shares, par value $0.01 per share | 10,000 | $55.00 | $550,000.00 |
DisclosureSEC source: 0001567619-21-020909 · doc1.xml · nonDerivative · entry 2 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. Read SEC document |
| November 19, 2021 Filed Nov 20, 2021 02:32 UTC |
Malecek Michael JSee Remarks
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 10,000 | $10.27 | $102,700.00 |
DisclosureSEC source: 0001567619-21-020909 · doc1.xml · nonDerivative · entry 1 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 10,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 01, 2021 Filed Nov 3, 2021 21:17 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 10,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001567619-21-019301 · doc1.xml · derivative · entry 5 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 120,000 Underlying: Ordinary Shares · 10,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The shares subject to the option vest and become exercisable as to 25% of the total number of shares subject to the option on June 21, 2019 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| November 01, 2021 Filed Nov 3, 2021 21:17 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 4,937 | $58.51 | $288,854.00 |
DisclosureSEC source: 0001567619-21-019301 · doc1.xml · nonDerivative · entry 4 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $58.14 to $58.76, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| November 01, 2021 Filed Nov 3, 2021 21:17 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,725 | $56.65 | $154,379.15 |
DisclosureSEC source: 0001567619-21-019301 · doc1.xml · nonDerivative · entry 3 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,937 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $56.185 to $56.89, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| November 01, 2021 Filed Nov 3, 2021 21:17 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,338 | $55.00 | $128,585.32 |
DisclosureSEC source: 0001567619-21-019301 · doc1.xml · nonDerivative · entry 2 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 7,662 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $54.92 to $55.16, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| November 01, 2021 Filed Nov 3, 2021 21:17 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 10,000 | $15.04 | $150,400.00 |
DisclosureSEC source: 0001567619-21-019301 · doc1.xml · nonDerivative · entry 1 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 10,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 10,000 | $0.00 Strike: $10.27 | $0.00 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · derivative · entry 6 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 240,000 Underlying: Ordinary Shares · 10,000 shares Expires 2029-07-01 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F6 · derivative.exercise_date: The shares subject to the option vest and become exercisable as to 25% of the total number of shares subject to the option on July 1, 2020 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
SaleOrdinary Shares, par value $0.01 per share | 20 | $60.89 | $1,217.70 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · nonDerivative · entry 5 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F5 · price: The transaction was executed in multiple trades in prices ranging from $60.88 to $60.89, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
SaleOrdinary Shares, par value $0.01 per share | 1,066 | $60.03 | $63,992.73 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · nonDerivative · entry 4 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 20 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $59.52 to $60.46, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
SaleOrdinary Shares, par value $0.01 per share | 2,950 | $58.88 | $173,707.51 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · nonDerivative · entry 3 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 1,086 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $58.52 to $59.51, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
SaleOrdinary Shares, par value $0.01 per share | 5,964 | $58.07 | $346,331.87 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · nonDerivative · entry 2 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,036 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $57.35 to $58.30, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 27, 2021 Filed Oct 29, 2021 21:00 UTC |
Malecek Michael JSee Remarks
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 10,000 | $10.27 | $102,700.00 |
DisclosureSEC source: 0001567619-21-019011 · doc1.xml · nonDerivative · entry 1 Malecek Michael J · CIK 0001779336 · See Remarks 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 10,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionStock Option (right to buy) · Derivative | 3,000 | $0.00 Strike: $29.81 | $0.00 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · derivative · entry 7 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 3,000 shares Expires 2024-02-04 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F6 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on February 4, 2015, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionStock Option (right to buy) · Derivative | 20,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · derivative · entry 6 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 90,000 Underlying: Ordinary Shares · 20,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,185 | $61.94 | $135,340.43 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · nonDerivative · entry 5 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $61.84 to $62.22, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,700 | $60.91 | $103,543.94 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · nonDerivative · entry 4 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,185 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $60.75 to $61.71, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
SaleOrdinary Shares, par value $0.01 per share | 19,115 | $60.00 | $1,146,938.23 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · nonDerivative · entry 3 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,885 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $59.71 to $60.43, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 3,000 | $29.81 | $89,430.00 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · nonDerivative · entry 2 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 20, 2021 Filed Oct 22, 2021 21:53 UTC |
Walker Karin LChief Accounting Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 20,000 | $15.04 | $300,800.00 |
DisclosureSEC source: 0001567619-21-018621 · doc1.xml · nonDerivative · entry 1 Walker Karin L · CIK 0001559422 · Chief Accounting Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 20,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 10,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · derivative · entry 7 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 130,000 Underlying: Ordinary Shares · 10,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F6 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on June 21, 2019 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 213 | $70.44 | $15,003.72 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 6 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,600 | $69.61 | $180,996.92 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 5 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 213 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F5 · price: The transaction was executed in multiple trades in prices ranging from $69.33 to $70.115, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 1,967 | $68.68 | $135,084.91 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 4 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,813 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $68.33 to $69.13, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,620 | $67.98 | $178,097.91 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 3 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,780 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $67.33 to $68.30, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
SaleOrdinary Shares, par value $0.01 per share | 2,600 | $66.60 | $173,152.46 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 2 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 7,400 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.29 to $67.035, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 1, 2021 20:46 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 10,000 | $15.04 | $150,400.00 |
DisclosureSEC source: 0001140361-21-033345 · form4.xml · nonDerivative · entry 1 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 10,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 5,000 | $0.00 Strike: $9.23 | $0.00 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · derivative · entry 7 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 11,000 Underlying: Ordinary Shares · 5,000 shares Expires 2029-05-22 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 706 | $69.69 | $49,201.63 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · nonDerivative · entry 5 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,845 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F5 · price: The transaction was executed in multiple trades in prices ranging from $69.49 to $70.44, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 1,237 | $68.74 | $85,037.44 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · nonDerivative · entry 4 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,551 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F4 · price: The transaction was executed in multiple trades in prices ranging from $68.44 to $69.30, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 1,300 | $67.96 | $88,352.81 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · nonDerivative · entry 3 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,788 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F3 · price: The transaction was executed in multiple trades in prices ranging from $67.33 to $68.26, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
SaleOrdinary Shares, par value $0.01 per share | 1,757 | $66.35 | $116,584.33 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · nonDerivative · entry 2 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 6,088 F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. F2 · price: The transaction was executed in multiple trades in prices ranging from $66.14 to $67.04, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Read SEC document |
| October 01, 2021 Filed Oct 2, 2021 01:18 UTC |
Selkoe Dennis J.Director
|
Exercise / conversionOrdinary Shares, par value $0.01 per share | 5,000 | $9.23 | $46,150.00 |
DisclosureSEC source: 0001140361-21-033351 · form4.xml · nonDerivative · entry 1 Selkoe Dennis J. · CIK 0001582306 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 7,845 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| September 29, 2021 Filed Oct 1, 2021 20:31 UTC |
Smith Brandon S.Chief Operating Officer
|
GrantStock Option (Right to Buy) · Derivative | 25,000 | $0.00 Strike: $70.81 | $0.00 |
DisclosureSEC source: 0001567619-21-017749 · doc1.xml · derivative · entry 1 Smith Brandon S. · CIK 0001805226 · Chief Operating Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 25,000 Underlying: Ordinary Shares · 25,000 shares Expires 2031-09-29 F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on September 29, 2022 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
| September 09, 2021 Filed Sep 10, 2021 17:06 UTC |
Karp Carol D.Chief Regulatory Officer
|
Exercise / conversionStock Option (Right to Buy) · Derivative | 10,000 | $0.00 Strike: $15.04 | $0.00 |
DisclosureSEC source: 0001140361-21-030941 · form4.xml · derivative · entry 4 Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 140,000 Underlying: Ordinary Shares · 10,000 shares Expires 2028-06-21 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on June 21, 2019 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.