PMVP

SEC source: 0001415889-24-024627 · form4-10032024_081022.xml · derivative · entry 2

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 68,100 shares

Expires 2033-02-10

F4 · price: On August 13, 2024, the issuer cancelled, pursuant to the issuer's option exchange program, an option for 68,100 shares of PMV common stock granted to the reporting person on February 10, 2022. In exchange, the reporting person received a replacement option, for 68,100 shares, having an exercise price of $1.48 per share.

F3 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on March 10, 2022.

SEC source: 0001415889-24-024627 · form4-10032024_081022.xml · derivative · entry 1

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 22,674 shares

Expires 2031-05-11

F2 · price: On August 13, 2024, the issuer cancelled, pursuant to the issuer's option exchange program, an option for 22,674 shares of PMV common stock granted to the reporting person on May 12, 2021. In exchange, the reporting person received a replacement option, for 22,674 shares, having an exercise price of $1.48 per share.

F1 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on June 12, 2021.

SEC source: 0001415889-24-016208 · form4-06102024_080606.xml · derivative · entry 3

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

F2 · ownership.nature: The securities are held of record by The Gallagher Revocable Trust dated May 10, 2011 for which the reporting person serves as a trustee.

SEC source: 0001415889-24-016208 · form4-06102024_080606.xml · derivative · entry 2

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016236 · form4-06102024_080620.xml · derivative · entry 1

LEVINE ARNOLD J · CIK 0001124164 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016202 · form4-06102024_080652.xml · derivative · entry 1

FLOWERS KIRSTEN · CIK 0001797209 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016208 · form4-06102024_080606.xml · derivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016199 · form4-06102024_080633.xml · derivative · entry 1

BAUM CHARLES M · CIK 0001579824 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016214 · form4-06102024_080647.xml · derivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001415889-24-016238 · form4-06102024_080637.xml · derivative · entry 1

Stelzer Laurie · CIK 0001644348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,500

Underlying: Common Stock · 67,500 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The option vests as follows: 22,500 shares vest on the earlier of (i) June 6, 2025 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders and the remaining 45,000 shares vest in 36 equal monthly installments beginning on July 6, 2024.

SEC source: 0001209191-24-001995 · doc4.xml · derivative · entry 2

Carulli Michael · CIK 0002006668 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 204,630

Underlying: Common Stock · 204,630 shares

Expires 2034-01-18

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on February 18, 2024.

SEC source: 0001209191-24-001995 · doc4.xml · nonDerivative · entry 1

Carulli Michael · CIK 0002006668 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,286

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, all of which vest on June 30, 2025.

SEC source: 0001209191-24-001993 · doc4.xml · derivative · entry 5

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 519,915

Underlying: Common Stock · 519,915 shares

Expires 2034-01-18

F4 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on February 18, 2024.

SEC source: 0001209191-24-001993 · doc4.xml · nonDerivative · entry 1

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 442,460

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, all of which vest on June 30, 2025.

SEC source: 0001209191-24-001999 · doc4.xml · derivative · entry 2

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,095

Underlying: Common Stock · 225,095 shares

Expires 2034-01-18

F2 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on February 18, 2024.

SEC source: 0001209191-24-001999 · doc4.xml · nonDerivative · entry 1

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,501

F1 · shares: The reported shares are represented by restricted stock units, or RSUs, all of which vest on June 30, 2025.

SEC source: 0000947871-23-001104 · ownership.xml · nonDerivative · entry 1

ORBIMED ADVISORS LLC · CIK 0001055951 · 10% owner

OrbiMed Capital GP V LLC · CIK 0001615374 · 10% owner

OrbiMed Genesis GP LLC · CIK 0001808744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

F1 · ownership.nature: These securities are held of record by OrbiMed Genesis Master Fund, L.P. ("Genesis Master Fund"). OrbiMed Genesis GP LLC ("Genesis GP") is the general partner of Genesis Master Fund and OrbiMed Advisors LLC ("OrbiMed Advisors"), a registered investment advisor under the Investment Advisors Act of 1940, as amended, is the managing member of Genesis GP. By virtue of such relationships, Genesis GP and OrbiMed Advisors may be deemed to have voting and investment power with respect to the securities held by Genesis Master Fund. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by Genesis Master Fund.

F3 · ownership.nature: This report on Form 4 is jointly filed by OrbiMed Advisors, GP V and Genesis GP. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1943, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity is a beneficial owner of such securities for purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0001209191-23-054997 · doc4.xml · nonDerivative · entry 3

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 165,307

F1 · ownership.nature: The shares are held of record by the Stinson 2021 Irrevocable Trust. The reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest therein.

SEC source: 0001209191-23-054997 · doc4.xml · nonDerivative · entry 2

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 278,570

SEC source: 0001209191-23-054997 · doc4.xml · nonDerivative · entry 1

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,877

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-049759 · doc4.xml · nonDerivative · entry 1

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,946

F1 · kind: The reported shares were sold to cover the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-049751 · doc4.xml · nonDerivative · entry 1

Alland Leila · CIK 0001825216 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,909

F1 · kind: The reported shares were sold to satisfy the reporting person's tax obligations in connection with the vesting of restricted stock units, or RSUs.

SEC source: 0001209191-23-045010 · doc4.xml · derivative · entry 5

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 307,866

Underlying: Common Stock · 85,500 shares

Expires 2025-05-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option are fully vested and immediately exercisable.

SEC source: 0001209191-23-045010 · doc4.xml · nonDerivative · entry 1

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,470

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-054997 · doc4.xml · derivative · entry 6

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,459

Underlying: Common Stock · 198,407 shares

Expires 2025-05-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option are fully vested and immediately exercisable.

SEC source: 0001209191-23-036449 · doc4.xml · derivative · entry 1

LEVINE ARNOLD J · CIK 0001124164 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036373 · doc4.xml · derivative · entry 1

FLOWERS KIRSTEN · CIK 0001797209 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036383 · doc4.xml · derivative · entry 3

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

F2 · ownership.nature: The securities are held of record by The Gallagher Revocable Trust dated May 10, 2011 for which the reporting person serves as a trustee.

SEC source: 0001209191-23-036383 · doc4.xml · derivative · entry 2

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036383 · doc4.xml · derivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036368 · doc4.xml · derivative · entry 1

BAUM CHARLES M · CIK 0001579824 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2023-06-08

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036427 · doc4.xml · derivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-036456 · doc4.xml · derivative · entry 1

Stelzer Laurie · CIK 0001644348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,500

Underlying: Common Stock · 21,500 shares

Expires 2033-06-07

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 8, 2024 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-23-029594 · doc4.xml · derivative · entry 1

Kung Winston · CIK 0001666963 · COO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2033-05-12

F1 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on June 12, 2023.

SEC source: 0001209191-23-029586 · doc4.xml · derivative · entry 1

Mack David Henry · CIK 0001341642 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 330,000

Underlying: Common Stock · 330,000 shares

Expires 2033-05-12

F1 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on June 12, 2023.

SEC source: 0001209191-23-029612 · doc4.xml · derivative · entry 1

Jalota Deepika · CIK 0001825192 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2033-05-12

F1 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on June 12, 2023.

SEC source: 0001209191-23-029609 · doc4.xml · derivative · entry 1

Alland Leila · CIK 0001825216 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-05-12

F1 · derivative.exercise_date: Shares subject to the option vest in 48 equal monthly installments beginning on June 12, 2023.

SEC source: 0001209191-23-005476 · doc4.xml · nonDerivative · entry 1

Kung Winston · CIK 0001666963 · COO, CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,600

F1 · shares: The reported shares were acquired under the Issuer's stock purchase plan on November 20, 2022.

SEC source: 0001209191-22-056102 · doc4.xml · derivative · entry 3

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 39,000

Underlying: Common Stock · 39,000 shares

Expires 2032-11-03

F1 · derivative.exercise_date: Shares subject to the option vest in 36 equal, monthly installments beginning on December 4, 2022.

F2 · ownership.nature: The securities are held of record by The Gallagher Revocable Trust dated May 10, 2011 for which the reporting person serves as a trustee.

SEC source: 0001209191-22-056102 · doc4.xml · derivative · entry 2

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,000

Underlying: Common Stock · 39,000 shares

Expires 2032-11-03

F1 · derivative.exercise_date: Shares subject to the option vest in 36 equal, monthly installments beginning on December 4, 2022.

SEC source: 0001209191-22-056102 · doc4.xml · derivative · entry 1

Gallagher Carol Giltner · CIK 0001329959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,000

Underlying: Common Stock · 39,000 shares

Expires 2032-11-03

F1 · derivative.exercise_date: Shares subject to the option vest in 36 equal, monthly installments beginning on December 4, 2022.

SEC source: 0001209191-22-049694 · doc4.xml · nonDerivative · entry 1

Jalota Deepika · CIK 0001825192 · SVP, Regulatory Affairs and QA

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,050

F1 · shares: The reported shares are represented by restricted stock units, or RSUS. One- third of the RSUs vest on September 9, 2023 and the remaining shares vest on September 9, 2024.

SEC source: 0001209191-22-049692 · doc4.xml · nonDerivative · entry 1

Alland Leila · CIK 0001825216 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,200

F1 · shares: The reported shares are represented by restricted stock units, or RSUS. One- third of the RSUs vest on September 9, 2023 and the remaining shares vest on September 9, 2024.

SEC source: 0001209191-21-039245 · doc4.xml · derivative · entry 1

Thompson Peter A. · CIK 0001357522 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,333

Underlying: Common Stock · 16,333 shares

Expires 2031-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2022 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

F2 · ownership.direct: Pursuant to an agreement with OrbiMed Advisors LLC and OrbiMed Capital GP V LLC, the Reporting Person is obligated to transfer any securities issued under any such stock options or other awards, or the economic benefit thereof, to OrbiMed Advisors LLC and OrbiMed Capital GP V LLC, which will in turn ensure that such securities or economic benefits are provided to OrbiMed Private Investments V, LP.

SEC source: 0001209191-22-034622 · doc4.xml · derivative · entry 1

LEVINE ARNOLD J · CIK 0001124164 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2032-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2023 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-22-034618 · doc4.xml · derivative · entry 1

FLOWERS KIRSTEN · CIK 0001797209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2032-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2023 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-22-034607 · doc4.xml · derivative · entry 1

BAUM CHARLES M · CIK 0001579824 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2032-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2023 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders

SEC source: 0001209191-22-034620 · doc4.xml · derivative · entry 1

Heyman Richard A. · CIK 0001584759 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2032-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2023 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0001209191-22-034634 · doc4.xml · derivative · entry 1

Stelzer Laurie · CIK 0001644348 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Underlying: Common Stock · 19,500 shares

Expires 2032-06-01

F1 · derivative.exercise_date: Shares subject to the option vest on the earlier of (i) June 2, 2023 or (ii) the day prior to the date of the Issuer's next annual meeting of stockholders.

SEC source: 0000947871-22-000675 · ownership.xml · nonDerivative · entry 1

ORBIMED ADVISORS LLC · CIK 0001055951 · 10% owner

OrbiMed Capital GP V LLC · CIK 0001615374 · 10% owner

OrbiMed Genesis GP LLC · CIK 0001808744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 87,786

F1 · kind: Represents the sale of shares of the Issuer's common stock ("Shares"), which was effected after market close on May 26, 2022.

F2 · price: These Shares were sold in multiple transactions at prices ranging from $15.55 to $16.09. The price reported reflects the weighted average sale price. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of Shares purchased at each separate price within the ranges set forth in this footnote.

F3 · ownership.nature: The Shares are held of record by OrbiMed Genesis Master Fund, L.P. ("Genesis Master Fund"). OrbiMed Genesis GP LLC ("Genesis GP") is the general partner of Genesis Master Fund and OrbiMed Advisors LLC ("OrbiMed Advisors"), a registered investment advisor under the Investment Advisors Act of 1940, as amended, is the managing member of Genesis GP. By virtue of such relationships, Genesis GP and OrbiMed Advisors may be deemed to have voting and investment power with respect to the securities held by Genesis Master Fund. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by Genesis Master Fund.

F5 · ownership.nature: This report on Form 4 is jointly filed by OrbiMed Advisors, GP V and Genesis GP. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1943, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity is a beneficial owner of such securities for purpose of Section 16 of the Exchange Act, or for any other purpose.