PGEN

SEC source: 0001213900-25-113771 · marketforms-71276.xml · nonDerivative · entry 3

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Kapital Joe

Disclosed balance after: 5,554,244

F3 · ownership.nature: Randal J. Kirk controls each of Kapital Joe, LLC ("Kapital Joe"), R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-113771 · marketforms-71276.xml · nonDerivative · entry 2

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Kapital Joe

Disclosed balance after: 6,491,552

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.90 to $4.42, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

F3 · ownership.nature: Randal J. Kirk controls each of Kapital Joe, LLC ("Kapital Joe"), R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-113771 · marketforms-71276.xml · nonDerivative · entry 1

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Kapital Joe

Disclosed balance after: 7,434,384

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.31 to $4.68, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4.

F3 · ownership.nature: Randal J. Kirk controls each of Kapital Joe, LLC ("Kapital Joe"), R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-094114 · marketforms-70882.xml · nonDerivative · entry 1

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Sunset 2020

Disclosed balance after: 14,597,161

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.35 to $3.62, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4.

F2 · ownership.nature: Randal J. Kirk controls each of Sunset 2020 LLC ("Sunset 2020"), R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), Kapital Joe, LLC ("Kapital Joe"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0000950103-25-012666 · dp235320_4-kindler.xml · nonDerivative · entry 2

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 346,070

F2 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $3.3500 to $3.4250, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

SEC source: 0000950103-25-012557 · dp235186_4-tennant.xml · nonDerivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,031

SEC source: 0000950103-25-012666 · dp235320_4-kindler.xml · nonDerivative · entry 1

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 452,907

F1 · price: The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $3.5700 to $3.6350, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission (SEC), upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4.

SEC source: 0000950103-25-012312 · dp235005_4-thomasian.xml · nonDerivative · entry 2

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 468,626

SEC source: 0000950103-25-012560 · dp235185_4-shah.xml · nonDerivative · entry 1

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 405,959

SEC source: 0000950103-25-012312 · dp235005_4-thomasian.xml · nonDerivative · entry 1

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 465,694

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.53 to $3.67, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote (1) to this Form 4.

SEC source: 0001213900-25-089726 · ea0258156.xml · nonDerivative · entry 3

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Kapital Joe

Disclosed balance after: 8,520,537

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.63 to $3.79, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (3) to this Form 4.

F4 · ownership.nature: Randal J. Kirk controls each of R.J. Kirk DOT, Kapital Joe, LLC ("Kapital Joe"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-089726 · ea0258156.xml · nonDerivative · entry 2

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by Kapital Joe

Disclosed balance after: 12,117,429

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.78 to $3.95, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) to this Form 4.

F4 · ownership.nature: Randal J. Kirk controls each of R.J. Kirk DOT, Kapital Joe, LLC ("Kapital Joe"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-089726 · ea0258156.xml · derivative · entry 18

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by R.J. Kirk DOT

Disclosed balance after: 0

Underlying: Common Stock · 17,385,257 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F1 · price: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F1 · derivative.exercise_date: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F1 · derivative.expiration_date: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F1 · derivative.underlying_shares: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F4 · ownership.nature: Randal J. Kirk controls each of R.J. Kirk DOT, Kapital Joe, LLC ("Kapital Joe"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001213900-25-089726 · ea0258156.xml · nonDerivative · entry 1

KIRK RANDAL J · CIK 0001091823 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · by R.J. Kirk DOT

Disclosed balance after: 82,164,767

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F1 · price: On December 27, 2024, the issuer entered into a Securities Purchase Agreement with certain existing and new investors, including R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), pursuant to which the issuer agreed to sell its 8.00% Series A Convertible Perpetual Preferred Stock (the "Preferred Stock") in a private placement transaction. The Preferred Stock was convertible into shares of common stock of the issuer (i) at the option of the holder at anytime on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time.

F4 · ownership.nature: Randal J. Kirk controls each of R.J. Kirk DOT, Kapital Joe, LLC ("Kapital Joe"), Parkview 2020 Limited Partnership ("Parkview 2020"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Lotus Capital (2000) Company, Inc. ("Lotus"), Sunset 2020 LLC ("Sunset 2020") and Third Security, LLC ("Third Security"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0000950103-25-011723 · dp234445_4-tennant.xml · derivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_price: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.exercise_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.expiration_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.expiration_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

SEC source: 0000950103-25-011722 · dp234443_4-shah.xml · derivative · entry 1

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_price: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.exercise_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.expiration_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.expiration_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

SEC source: 0000950103-25-011725 · dp234444_4-thomasian.xml · derivative · entry 1

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_price: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.exercise_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.expiration_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.expiration_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

SEC source: 0000950103-25-011726 · dp234441_4-sabzevari.xml · derivative · entry 1

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 825,000

Underlying: Common Stock · 825,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_price: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.exercise_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.expiration_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.expiration_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

SEC source: 0000950103-25-011724 · dp234442_4-lehr.xml · derivative · entry 1

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,000

Underlying: Common Stock · 54,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_price: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.exercise_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.exercise_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

F1 · derivative.expiration_date: Represents the vesting of the second installment of performance stock units ("PSUs") originally granted on August 28, 2024 based on the achievement of the applicable performance condition for such installment.

F2 · derivative.expiration_date: Each PSU is payable in a share of the Issuer's common stock or in a cash amount having an equivalent value.

SEC source: 0000950103-25-011343 · dp234072_4-agee.xml · nonDerivative · entry 1

AGEE NANCY H · CIK 0001314626 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,841

SEC source: 0000950103-25-010987 · dp233686_4-agee.xml · nonDerivative · entry 2

AGEE NANCY H · CIK 0001314626 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 202,841

SEC source: 0000950103-25-010987 · dp233686_4-agee.xml · nonDerivative · entry 1

AGEE NANCY H · CIK 0001314626 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 192,196

SEC source: 0000950103-25-008513 · dp231316_4-agee.xml · derivative · entry 2

AGEE NANCY H · CIK 0001314626 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 126,760 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vested in full on July 05, 2025.

F2 · derivative.expiration_date: The RSUs vested in full on July 05, 2025.

SEC source: 0000950103-25-008513 · dp231316_4-agee.xml · nonDerivative · entry 1

AGEE NANCY H · CIK 0001314626 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 176,836

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-007995 · dp230755_4-tennant.xml · derivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

F2 · derivative.expiration_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-007992 · dp230576_4-shah.xml · derivative · entry 1

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 180,000

Underlying: Common Stock · 180,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

F2 · derivative.expiration_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-007989 · dp230758_4-thomasian.xml · derivative · entry 1

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

F2 · derivative.expiration_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-007991 · dp230757_4-lehr.xml · derivative · entry 1

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

F2 · derivative.expiration_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-007990 · dp230754_4-sabzevari.xml · derivative · entry 1

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Common Stock · 500,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

F2 · derivative.expiration_date: The RSUs vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006451 · dp229263_4-tennant.xml · derivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2035-05-23

F1 · derivative.exercise_date: The options vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006452 · dp229262_4-shah.xml · derivative · entry 1

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 360,000

Underlying: Common Stock · 360,000 shares

Expires 2035-05-23

F1 · derivative.exercise_date: The options vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006454 · dp229260_4-thomasian.xml · derivative · entry 1

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2035-05-23

F1 · derivative.exercise_date: The options vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006453 · dp229261_4-lehr.xml · derivative · entry 1

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2035-05-23

F1 · derivative.exercise_date: The options vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006450 · dp229264_4-sabzevari.xml · derivative · entry 1

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,000,000

Underlying: Common Stock · 1,000,000 shares

Expires 2035-05-23

F1 · derivative.exercise_date: The options vest 50% on May 23, 2026 and in equal monthly installments for three years thereafter.

SEC source: 0000950103-25-006147 · dp228967_4-tennant.xml · derivative · entry 3

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 66,441 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F3 · derivative.exercise_date: The RSUs vested in full on May 16, 2025.

F3 · derivative.expiration_date: The RSUs vested in full on May 16, 2025.

SEC source: 0000950103-25-006147 · dp228967_4-tennant.xml · nonDerivative · entry 2

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,031

F2 · shares: Represents the number of shares of common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

SEC source: 0000950103-25-006147 · dp228967_4-tennant.xml · nonDerivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 82,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-006148 · dp228968_4-shah.xml · derivative · entry 3

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 174,460 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F3 · derivative.exercise_date: The RSUs vested in full on May 16, 2025.

F3 · derivative.expiration_date: The RSUs vested in full on May 16, 2025.

SEC source: 0000950103-25-006148 · dp228968_4-shah.xml · nonDerivative · entry 2

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 403,959

F2 · shares: Represents the number of shares of common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs

SEC source: 0000950103-25-006148 · dp228968_4-shah.xml · nonDerivative · entry 1

Shah Rutul R · CIK 0001947221 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 462,055

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-006144 · dp228970_4-thomasian.xml · derivative · entry 3

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 154,475 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F3 · derivative.exercise_date: The RSUs vested in full on May 16, 2025.

F3 · derivative.expiration_date: The RSUs vested in full on May 16, 2025.

SEC source: 0000950103-25-006144 · dp228970_4-thomasian.xml · nonDerivative · entry 2

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 457,410

F2 · shares: Represents the number of shares of common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

SEC source: 0000950103-25-006144 · dp228970_4-thomasian.xml · nonDerivative · entry 1

Thomasian Harry Jr. · CIK 0001886301 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 508,851

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-006145 · dp228969_4-lehr.xml · derivative · entry 3

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 165,468 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F3 · derivative.exercise_date: The RSUs vested in full on May 16, 2025.

F3 · derivative.expiration_date: The RSUs vested in full on May 16, 2025.

SEC source: 0000950103-25-006145 · dp228969_4-lehr.xml · nonDerivative · entry 2

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 681,649

F2 · shares: Represents the number of shares of common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

SEC source: 0000950103-25-006145 · dp228969_4-lehr.xml · nonDerivative · entry 1

Lehr Donald P. · CIK 0001583187 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 736,750

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-006143 · dp228971_4-sabzevari.xml · derivative · entry 3

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,079,137 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F3 · derivative.exercise_date: The RSUs vested in full on May 16, 2025.

F3 · derivative.expiration_date: The RSUs vested in full on May 16, 2025.

SEC source: 0000950103-25-006143 · dp228971_4-sabzevari.xml · nonDerivative · entry 2

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,317,022

F2 · shares: Represents the number of shares of common stock withheld by the Issuer to satisfy income tax withholding obligations in connection with the settlement of the RSUs.

SEC source: 0000950103-25-006143 · dp228971_4-sabzevari.xml · nonDerivative · entry 1

Sabzevari Helen · CIK 0001724195 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,838,246

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

SEC source: 0000950103-25-005067 · dp227912_4-tennant.xml · derivative · entry 1

Tennant Phil · CIK 0002030874 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,441

Underlying: Common Stock · 66,441 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of Precigen common stock.

F2 · derivative.exercise_date: The RSUs will vest in full on May 16, 2025.

F2 · derivative.expiration_date: The RSUs will vest in full on May 16, 2025.