PALI

SEC source: 0001493152-26-046201 · ownership.xml · derivative · entry 5

Finley John David · CIK 0001851034 · Director · CEO CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,508,249

Underlying: Common Stock · 167,584 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following ten quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F6 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following ten quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-046201 · ownership.xml · derivative · entry 4

Finley John David · CIK 0001851034 · Director · CEO CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,119,600

Underlying: Common Stock · 3,059,800 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F5 · derivative.expiration_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-046201 · ownership.xml · nonDerivative · entry 2

Finley John David · CIK 0001851034 · Director · CEO CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,944,690

F2 · kind: Represents the number of shares of common stock the Issuer has withheld to satisfy the Reporting Person's income tax withholding and remittance obligations as part of the settlement of vested RSUs. Accordingly, no shares of common stock will be sold in the public market to satisfy such income tax withholding and remittance obligations associated with the settlement of these vested RSUs.

SEC source: 0001493152-26-046201 · ownership.xml · nonDerivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,356,672

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs").

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs").

SEC source: 0001493152-26-046202 · ownership.xml · derivative · entry 4

Jones Mitchell Lawrence · CIK 0001993292 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 590,249

Underlying: Common Stock · 65,584 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following ten quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F5 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following ten quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-046202 · ownership.xml · derivative · entry 3

Jones Mitchell Lawrence · CIK 0001993292 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,110,534

Underlying: Common Stock · 2,555,266 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F4 · derivative.expiration_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-046202 · ownership.xml · nonDerivative · entry 2

Jones Mitchell Lawrence · CIK 0001993292 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,683,757

F2 · kind: Represents the number of shares of common stock the Issuer has withheld to satisfy the Reporting Person's income tax withholding and remittance obligations as part of the settlement of vested RSUs. Accordingly, no shares of common stock will be sold in the public market to satisfy such income tax withholding and remittance obligations associated with the settlement of these vested RSUs.

SEC source: 0001493152-26-046202 · ownership.xml · nonDerivative · entry 1

Jones Mitchell Lawrence · CIK 0001993292 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,714,859

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs").

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs").

SEC source: 0001493152-26-045772 · ownership.xml · nonDerivative · entry 2

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,590,294

SEC source: 0001493152-26-045772 · ownership.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,580,294

SEC source: 0001493152-26-039746 · ownership.xml · nonDerivative · entry 2

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Indirect · By FCW Investments, LLC

Disclosed balance after: 88,451

F1 · kind: The Reporting Person transferred these shares to FCW Investments, LLC. The Reporting Person is the managing member of FCW Investments, LLC and has the sole investment and voting power over the securities held by this entity.

SEC source: 0001493152-26-039746 · ownership.xml · nonDerivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 129,288

F1 · kind: The Reporting Person transferred these shares to FCW Investments, LLC. The Reporting Person is the managing member of FCW Investments, LLC and has the sole investment and voting power over the securities held by this entity.

SEC source: 0001493152-26-032884 · ownership.xml · nonDerivative · entry 2

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 461,904

F2 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $1.9298 to $1.98. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-032884 · ownership.xml · nonDerivative · entry 1

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 436,904

F1 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $1.98 to $2.00. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-032559 · ownership.xml · derivative · entry 6

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 133 shares

Expires 2027-08-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_price: As adjusted in accordance with the terms of the Series 2 Common Stock Purchase Warrants following the public offering that closed on October 2, 2025.

F9 · shares: Reflects adjustments pursuant to the Issuer's 1-for-50 reverse stock split effective November 15, 2022, and the Issuer's 1-for-15 reverse stock split effective April 5, 2024.

F10 · derivative.exercise_date: Represents Series 2 Common Stock Purchase Warrants received as part of the Units purchased by Reporting Person. The Series 2 Warrants became exercisable upon receipt of stockholder approval per Nasdaq rules, which was obtained on October 6, 2022.

SEC source: 0001493152-26-032559 · ownership.xml · nonDerivative · entry 3

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,688

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001493152-26-032559 · ownership.xml · nonDerivative · entry 2

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 217,555

F3 · kind: The sale reported in this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.045 to $2.09, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001493152-26-032563 · ownership.xml · nonDerivative · entry 2

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 416,904

F2 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $2.00 to $2.07. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-032561 · ownership.xml · nonDerivative · entry 2

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,009

F3 · kind: The sale reported in this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.045 to $2.06, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001493152-26-032559 · ownership.xml · derivative · entry 5

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,675,833

Underlying: Common Stock · 335,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F7 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F7 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-032559 · ownership.xml · nonDerivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 364,353

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 9, 2026.

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 9, 2026.

F2 · balance_after: Includes 1,899 shares acquired under the Issuer's Employee Stock Purchase Plan on May 20, 2026. In addition, the amount of securities beneficially owned was reduced by 66 shares due to an administrative error in the total reported in the Form 4 filed February 13, 2026.

SEC source: 0001493152-26-032563 · ownership.xml · nonDerivative · entry 1

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 386,904

F1 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $2.04 to $2.068. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-032561 · ownership.xml · derivative · entry 3

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 655,833

Underlying: Common Stock · 131,167 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F6 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-032561 · ownership.xml · nonDerivative · entry 1

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,889

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 9, 2026.

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 9, 2026.

F2 · balance_after: Includes 1,459 shares acquired under the Issuer's Employee Stock Purchase Plan on May 20, 2026.

SEC source: 0001493152-26-032229 · ownership.xml · nonDerivative · entry 2

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 366,904

F1 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $1.97 to $1.99. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-032229 · ownership.xml · nonDerivative · entry 1

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 356,904

F1 · price: The price reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $1.97 to $1.99. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001493152-26-028574 · ownership.xml · derivative · entry 3

Wei Binxian · CIK 0001773586 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,400

Underlying: Common Stock · 20,200 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.exercise_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.expiration_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028574 · ownership.xml · nonDerivative · entry 2

Wei Binxian · CIK 0001773586 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 613,355

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

F2 · price: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

SEC source: 0001493152-26-028574 · ownership.xml · nonDerivative · entry 1

Wei Binxian · CIK 0001773586 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 593,155

F1 · kind: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

F1 · price: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028572 · ownership.xml · derivative · entry 4

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,334

Underlying: Common Stock · 60,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.exercise_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.expiration_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028572 · ownership.xml · nonDerivative · entry 2

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,570,294

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

F2 · price: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

SEC source: 0001493152-26-028572 · ownership.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,509,628

F1 · kind: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

F1 · price: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028570 · ownership.xml · derivative · entry 3

Chuang Emil · CIK 0001921045 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,400

Underlying: Common Stock · 20,200 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.exercise_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F3 · derivative.expiration_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2026 annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028570 · ownership.xml · nonDerivative · entry 2

Chuang Emil · CIK 0001921045 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 612,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

F2 · price: The Reporting Person was granted RSUs. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs vested on June 10, 2026.

SEC source: 0001493152-26-028570 · ownership.xml · nonDerivative · entry 1

Chuang Emil · CIK 0001921045 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 592,300

F1 · kind: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

F1 · price: The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the earlier of (i) the date of the 2027 annual meeting of stockholders or (ii) the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-028568 · ownership.xml · nonDerivative · entry 1

Zwick Jordan Michael · CIK 0002138319 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 336,904

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-029329 · ownership.xml · nonDerivative · entry 1

Baltera Robert Jr. · CIK 0001536555 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 336,904

F1 · kind: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

F1 · price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, with the first installment vesting on the anniversary of June 10, 2026, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-26-006831 · ownership.xml · nonDerivative · entry 2

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,353

F3 · kind: The sale reported in this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs.

SEC source: 0001493152-26-006833 · ownership.xml · nonDerivative · entry 2

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,263

F3 · kind: The sale reported in this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs.

SEC source: 0001493152-26-006831 · ownership.xml · derivative · entry 4

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,667

Underlying: Common Stock · 13,333 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F6 · derivative.exercise_date: The RSUs shall vest in three equal annual installments beginning on February 11, 2026, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F6 · derivative.expiration_date: The RSUs shall vest in three equal annual installments beginning on February 11, 2026, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-006831 · ownership.xml · nonDerivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,249

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 11, 2025.

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 11, 2025.

F2 · balance_after: Includes 4,444 shares acquired under the Issuer's Employee Stock Purchase Plan on November 20, 2025.

SEC source: 0001493152-26-006833 · ownership.xml · derivative · entry 3

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 8,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: The RSUs shall vest in three equal annual installments beginning on February 11, 2026, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F5 · derivative.expiration_date: The RSUs shall vest in three equal annual installments beginning on February 11, 2026, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-006833 · ownership.xml · nonDerivative · entry 1

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,252

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 11, 2025.

F1 · price: The shares were issued pursuant to settlement of vested Restricted Stock Units ("RSUs") granted on February 11, 2025.

F2 · balance_after: Includes 3,400 shares acquired under the Issuer's Employee Stock Purchase Plan on November 20, 2025.

SEC source: 0001493152-26-006255 · ownership.xml · derivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,011,000

Underlying: Common Stock · 2,011,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.

F2 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F2 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-006257 · ownership.xml · derivative · entry 1

Jones Mitchell Lawrence · CIK 0001993292 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 787,000

Underlying: Common Stock · 787,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.

F2 · derivative.exercise_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F2 · derivative.expiration_date: The RSUs shall vest with respect to 1/6th of the shares on July 6, 2026 and quarterly thereafter over the following 10 quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-26-003078 · ownership.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,728

SEC source: 0001493152-26-002107 · ownership.xml · nonDerivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,728

SEC source: 0001493152-25-017475 · ownership.xml · derivative · entry 1

Finley John David · CIK 0001851034 · Director · CEO, CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,179,400

Underlying: Common Stock · 9,179,400 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.

F2 · derivative.exercise_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

F2 · derivative.expiration_date: The RSUs shall vest with respect to 1/3rd of the shares on October 6, 2026 and quarterly thereafter over the following eight quarters, subject to the Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001493152-25-017481 · ownership.xml · derivative · entry 1

Williams Donald Allen · CIK 0001620013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,538,700

Underlying: Common Stock · 1,538,700 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.

F2 · derivative.exercise_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, which shall be satisfied on the earlier of (i) the date of the next annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F2 · derivative.expiration_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, which shall be satisfied on the earlier of (i) the date of the next annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

SEC source: 0001493152-25-017479 · ownership.xml · derivative · entry 1

Wei Binxian · CIK 0001773586 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 510,700

Underlying: Common Stock · 510,700 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock, provided that, until such time as the Issuer has sufficient shares of Issuer common stock reserved under its 2021 Equity Incentive Plan to issue upon settlement of all outstanding grants thereunder, the RSUs may be settled upon vesting in cash.

F2 · derivative.exercise_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, which shall be satisfied on the earlier of (i) the date of the next annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.

F2 · derivative.expiration_date: The RSUs are subject to a service-based vesting requirement and shall vest in three equal annual installments, which shall be satisfied on the earlier of (i) the date of the next annual meeting of stockholders or (ii) the anniversary of October 6, 2025, subject to the Reporting Person's continuous service with the Issuer through such date.