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BeOne Medicines Ltd.

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2168
SEC CIK
0001651308
Parsed reports
543

Last 12 months

Inside the activity.

0 purchase rows · 204 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 2025017
Dec 2025026
Jan 202601
Feb 202602
Mar 202601
Apr 202601
May 202608
Jun 2026032
Jul 2026064
Aug 2026027
Sep 2026020
Oct 202605

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
December 26, 2017 Filed Dec 28, 2017 22:49 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 1,700 $97.83 $166,316.78
Disclosure

SEC source: 0001179110-17-015909 · edgar.xml · nonDerivative · entry 3

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,200

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.31 to $98.15, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 26, 2017 Filed Dec 28, 2017 22:49 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 8,279 $96.68 $800,397.99
Disclosure

SEC source: 0001179110-17-015909 · edgar.xml · nonDerivative · entry 2

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,900

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.23 to $97.09, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 26, 2017 Filed Dec 28, 2017 22:49 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 8,958 $95.55 $855,910.03
Disclosure

SEC source: 0001179110-17-015909 · edgar.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,179

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.22 to $96.21, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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December 22, 2017 Filed Feb 13, 2018 21:25 UTC GiftOrdinary Shares 36,400 $0.00 $0.00
Disclosure

SEC source: 0001179110-18-002002 · edgar.xml · nonDerivative · entry 1

Wang Xiaodong · CIK 0001662982 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,879,311

F1 · shares: Bona fide gift of shares which is exempt from Section 16(b) of the Securities Exchange Act pursuant to Rule 16b-5.

F2 · balance_after: The total reported in Column 5 has been adjusted to correct an error in the total holding reflected in a Form 4 filed on June 30, 2017 and the subsequent Form 4s.

Read SEC document
December 21, 2017 Filed Dec 22, 2017 21:43 UTC
Huang JaneCMO, Hematology
Exercise / conversionShare Option (Right to Buy) · Derivative 13,000 $0.00 Strike: $2.27 $0.00
Disclosure

SEC source: 0001179110-17-015851 · edgar.xml · derivative · entry 4

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,367,500

Underlying: Ordinary Shares · 1,367,500 shares

Expires 2026-09-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F3 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of September 2, 2016 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. All unvested shares subject to this option are subject to accelerated vesting upon certain termination events.

Read SEC document
December 21, 2017 Filed Dec 22, 2017 21:43 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 1,000 $98.00 $98,000.00
Disclosure

SEC source: 0001179110-17-015851 · edgar.xml · nonDerivative · entry 2

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

Read SEC document
December 21, 2017 Filed Dec 22, 2017 21:43 UTC
Huang JaneCMO, Hematology
Exercise / conversionAmerican Depositary Shares 1,000 $29.51 $29,510.00
Disclosure

SEC source: 0001179110-17-015851 · edgar.xml · nonDerivative · entry 1

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

Read SEC document
December 13, 2017 Filed Dec 15, 2017 21:05 UTC
Huang JaneCMO, Hematology
Exercise / conversionShare Option (Right to Buy) · Derivative 19,500 $0.00 Strike: $2.27 $0.00
Disclosure

SEC source: 0001179110-17-015428 · edgar.xml · derivative · entry 5

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,380,500

Underlying: Ordinary Shares · 1,380,500 shares

Expires 2026-09-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F4 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of September 2, 2016 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. All unvested shares subject to this option are subject to accelerated vesting upon certain termination events.

Read SEC document
December 13, 2017 Filed Dec 15, 2017 21:05 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 200 $94.53 $18,906.00
Disclosure

SEC source: 0001179110-17-015428 · edgar.xml · nonDerivative · entry 3

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

Read SEC document
December 13, 2017 Filed Dec 15, 2017 21:05 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 1,300 $94.21 $122,474.82
Disclosure

SEC source: 0001179110-17-015428 · edgar.xml · nonDerivative · entry 2

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.50 to $94.49, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 13, 2017 Filed Dec 15, 2017 21:05 UTC
Huang JaneCMO, Hematology
Exercise / conversionAmerican Depositary Shares 1,500 $29.51 $44,265.00
Disclosure

SEC source: 0001179110-17-015428 · edgar.xml · nonDerivative · entry 1

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

Read SEC document
December 08, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 4,800 $96.67 $464,022.24
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,137

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.21 to $96.86, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 08, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 37,208 $95.62 $3,557,884.77
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 123,937

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.12 to $96.01, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 08, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 10,809 $94.91 $1,025,850.84
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,145

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.11 to $95.10, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 100 $96.66 $9,666.00
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 171,954

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 5,162 $96.12 $496,174.54
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 172,054

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.64 to $96.60, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 7,743 $94.98 $735,434.01
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 177,216

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.60 to $95.58, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 13,213 $93.94 $1,241,235.83
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 184,959

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.60 to $94.59, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 9,439 $93.23 $880,030.06
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 6

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 198,172

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.60 to $93.59, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 07, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 24,080 $92.06 $2,216,763.86
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 5

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 207,611

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $91.55 to $92.53, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 06, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 1,400 $93.96 $131,537.42
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 4

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 231,691

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $93.80 to $94.25, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 06, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 4,000 $93.02 $372,090.00
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 3

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 233,091

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $92.80 to $93.73, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 06, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 18,046 $92.36 $1,666,793.53
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 2

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 237,091

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $91.80 to $92.7821, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 06, 2017 Filed Dec 8, 2017 22:57 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 8,000 $91.48 $731,803.20
Disclosure

SEC source: 0001179110-17-015165 · edgar.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 255,137

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $90.80 to $91.79, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
December 04, 2017 Filed Dec 5, 2017 14:15 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 1,100 $86.00 $94,600.00
Disclosure

SEC source: 0001179110-17-014878 · edgar.xml · nonDerivative · entry 1

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by The Jane Edna Huang Living Trust.

F3 · ownership.nature: These securities are held by The Jane Edna Huang Living Trust.

Read SEC document
November 29, 2017 Filed Nov 29, 2017 22:33 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 36,340 $82.92 $3,013,458.16
Disclosure

SEC source: 0001179110-17-014699 · edgar.xml · nonDerivative · entry 4

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 263,137

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

Read SEC document
November 28, 2017 Filed Nov 29, 2017 22:33 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 32,985 $85.52 $2,820,864.01
Disclosure

SEC source: 0001179110-17-014699 · edgar.xml · nonDerivative · entry 3

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 299,477

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

Read SEC document
November 27, 2017 Filed Nov 29, 2017 22:33 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 235 $87.49 $20,560.15
Disclosure

SEC source: 0001179110-17-014699 · edgar.xml · nonDerivative · entry 2

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332,462

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

Read SEC document
November 27, 2017 Filed Nov 29, 2017 22:33 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 16,346 $86.75 $1,418,022.04
Disclosure

SEC source: 0001179110-17-014699 · edgar.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332,697

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $86.27 to $87.15, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Read SEC document
November 20, 2017 Filed Nov 20, 2017 22:14 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 1,000 $87.00 $87,000.00
Disclosure

SEC source: 0001179110-17-014377 · edgar.xml · nonDerivative · entry 2

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,100

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by The Jane Edna Huang Living Trust.

F3 · ownership.nature: These securities are held by The Jane Edna Huang Living Trust.

Read SEC document
November 16, 2017 Filed Nov 20, 2017 22:14 UTC
Huang JaneCMO, Hematology
SaleAmerican Depositary Shares 600 $85.00 $51,000.00
Disclosure

SEC source: 0001179110-17-014377 · edgar.xml · nonDerivative · entry 1

Huang Jane · CIK 0001683913 · CMO, Hematology

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,100

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by The Jane Edna Huang Living Trust.

F3 · ownership.nature: These securities are held by The Jane Edna Huang Living Trust.

Read SEC document
November 15, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 100 $80.84 $8,084.00
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 349,043

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

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November 15, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 62,170 $80.29 $4,991,790.94
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 349,143

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.79 to $80.77, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 15, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 3,798 $79.16 $300,632.97
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 411,313

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.69 to $79.64, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 14, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 100 $81.00 $8,100.00
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 6

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 415,111

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

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November 14, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 20,407 $80.10 $1,634,500.71
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 5

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 415,211

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.96 to $80.84, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 14, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 39,328 $79.55 $3,128,349.69
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 4

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 435,618

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.96 to $79.95, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 13, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 100 $84.04 $8,404.00
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 3

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 474,946

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

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November 13, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 16,845 $83.24 $1,402,135.69
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 2

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 475,046

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $83.03 to $84.00, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 13, 2017 Filed Nov 16, 2017 01:12 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
SaleAmerican Depositary Shares 8,109 $82.67 $670,375.90
Disclosure

SEC source: 0001179110-17-014171 · edgar.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 491,891

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.03 to $83.02, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 13, 2017 Filed Nov 16, 2017 01:11 UTC
Peterson Amy C.CMO, Immuno-oncology
SaleAmerican Depositary Shares 1,201 $83.31 $100,054.23
Disclosure

SEC source: 0001179110-17-014170 · edgar.xml · nonDerivative · entry 2

Peterson Amy C. · CIK 0001682735 · CMO, Immuno-oncology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $83.13 to $84.04, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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November 13, 2017 Filed Nov 16, 2017 01:11 UTC
Peterson Amy C.CMO, Immuno-oncology
SaleAmerican Depositary Shares 2,400 $82.79 $198,692.88
Disclosure

SEC source: 0001179110-17-014170 · edgar.xml · nonDerivative · entry 1

Peterson Amy C. · CIK 0001682735 · CMO, Immuno-oncology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,201

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.12 to $83.11, inclusive. The Reporting Person has provided the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

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October 13, 2017 Filed Oct 16, 2017 21:47 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
BAKER JULIANDirector · 10% owner
BAKER FELIXDirector · 10% owner
667, L.P.Director · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
OtherAmerican Depositary Shares 7,102 $0.00 $0.00
Disclosure

SEC source: 0001638599-17-001020 · doc4_4974.xml · nonDerivative · entry 7

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,102

F8 · ownership.direct: Reflects 7,102 ADS of the Issuer held directly by Felix J. Baker received from the in-kind pro rata distribution without consideration reported above.

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October 13, 2017 Filed Oct 16, 2017 21:47 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
BAKER JULIANDirector · 10% owner
BAKER FELIXDirector · 10% owner
667, L.P.Director · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
OtherAmerican Depositary Shares 7,102 $0.00 $0.00
Disclosure

SEC source: 0001638599-17-001020 · doc4_4974.xml · nonDerivative · entry 6

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,102

F7 · ownership.direct: Reflects 7,102 ADS of the Issuer held directly by Julian C. Baker received from the in-kind pro rata distribution without consideration reported above.

Read SEC document
October 13, 2017 Filed Oct 16, 2017 21:47 UTC
BAKER BROS. ADVISORS LPDirector · 10% owner
14159, L.P.Director · 10% owner
Baker Bros. Advisors (GP) LLCDirector · 10% owner
BAKER JULIANDirector · 10% owner
BAKER FELIXDirector · 10% owner
667, L.P.Director · 10% owner
Baker Brothers Life Sciences LPDirector · 10% owner
OtherAmerican Depositary Shares 49,200 $0.00 $0.00
Disclosure

SEC source: 0001638599-17-001020 · doc4_4974.xml · nonDerivative · entry 5

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

14159, L.P. · CIK 0001551138 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

F4 · ownership.nature: Represents 49,200 ADS of the Issuer, each representing 13 Ordinary Shares distributed by 14159, L.P. as part of an in-kind pro rata distribution without consideration in accordance with pecuniary interest to Julian C. Baker, Felix J. Baker and other investors in 14159, L.P. Prior to the pro rata distribution, on September 15, 2017, 639,600 Ordinary Shares directly held by 14159, L.P. were converted to 49,200 ADS.

F5 · ownership.nature: As a result of their ownership interest in 14159 Capital (GP), LLC, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Issuer's Ordinary Shares reported in column 5 of Table I directly held by 14159, L.P. ("14159" and together with Life Sciences and 667, the "Funds"), a limited partnership of which the sole general partner is 14159 Capital, L.P., a limited partnership of which the sole general partner is 14159 Capital (GP), LLC, due to 14159 Capital, L.P.'s right to receive an allocation of a portion of the profits from 14159.

F6 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the Investment Adviser to the Funds. In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held by the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds. Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

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September 27, 2017 Filed Oct 2, 2017 11:10 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
GrantShare Option (Right to Buy) · Derivative 935,000 $0.00 Strike: $7.70 $0.00
Disclosure

SEC source: 0001179110-17-012803 · edgar.xml · derivative · entry 6

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 935,000

Underlying: Ordinary Shares · 935,000 shares

Expires 2027-09-26

F6 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F6 · shares: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F7 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

F6 · derivative.underlying_shares: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F6 · balance_after: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

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September 27, 2017 Filed Oct 2, 2017 11:10 UTC
OYLER JOHNDirector · Chief Executive Officer · 10% owner
GrantOrdinary Shares 515,000 $0.00 $0.00
Disclosure

SEC source: 0001179110-17-012803 · edgar.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,745,525

F1 · security: Represents securities underlying restricted share units ("RSUs"). 1/4th of the securities will vest on each anniversary of June 30, 2017, subject to continued service. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events.

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September 27, 2017 Filed Oct 2, 2017 10:41 UTC GrantShare Option (Right to Buy) · Derivative 750,000 $0.00 Strike: $7.70 $0.00
Disclosure

SEC source: 0001179110-17-012802 · edgar.xml · derivative · entry 3

Wang Xiaodong · CIK 0001662982 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 750,000

Underlying: Ordinary Shares · 750,000 shares

Expires 2027-09-26

F3 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F3 · shares: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F4 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service.

F3 · derivative.underlying_shares: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F3 · balance_after: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

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September 27, 2017 Filed Oct 2, 2017 10:41 UTC GrantOrdinary Shares 410,000 $0.00 $0.00
Disclosure

SEC source: 0001179110-17-012802 · edgar.xml · nonDerivative · entry 1

Wang Xiaodong · CIK 0001662982 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,935,393

F1 · security: Represents securities underlying restricted share units ("RSUs"). 1/4th of the securities will vest on each anniversary of June 30, 2017, subject to continued service.

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August 22, 2017 Filed Aug 24, 2017 20:20 UTC
Peterson Amy C.CMO, Immuno-oncology
Tax withholdingOrdinary Shares 28,185 $5.39 $151,829.78
Disclosure

SEC source: 0001179110-17-011812 · edgar.xml · nonDerivative · entry 1

Peterson Amy C. · CIK 0001682735 · CMO, Immuno-oncology

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 271,815

F1 · shares: Represents shares withheld to settle tax liability in connection with the vesting of a restricted share award that was previously granted on August 22, 2016. The share withholding was approved by a committee of non-employee directors in accordance with requirements of Rule 16b-3.

F2 · price: Calculated based off the closing price of the Company's American Depositary Shares ("ADSs") on the date thereof. Each ADS represents 13 Ordinary Shares.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.