ONC

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,591

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.61 to $307.59, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,188

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.96 to $305.605, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000015 · wk-form4_1784324169.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,628

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · derivative · entry 33

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,282,034

Underlying: Ordinary Shares · 911,248 shares

Expires 2029-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F24 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F28 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 5, 2020, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · derivative · entry 32

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,254,513 shares

Expires 2028-06-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F24 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F27 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 26, 2019, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 28

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F23 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $323.495 to $323.625, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 27

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 520

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F22 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $322.455 to $323.405, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 26

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,080

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F21 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $321.39 to $322.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 25

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,189

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F20 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $320.38 to $321.35, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 24

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,694

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F19 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $319.36 to $320.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 23

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,791

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F18 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $318.30 to $319.11, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 22

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,193

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F17 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $317.28 to $318.265, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 21

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 99,991

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $316.28 to $317.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 20

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 132,215

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $315.28 to $316.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 19

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 151,967

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $314.27 to $315.24, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 18

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 161,483

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.27 to $314.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 166,364

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 166,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,501

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · derivative · entry 31

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,254,513

Underlying: Ordinary Shares · 55,575 shares

Expires 2028-06-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F24 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F27 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 26, 2019, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · derivative · entry 30

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9

Underlying: Ordinary Shares · 996,801 shares

Expires 2028-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F24 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F26 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on April 30, 2019, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · derivative · entry 29

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1

Underlying: Ordinary Shares · 462,865 shares

Expires 2027-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F24 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F25 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $313.36 to $313.90, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,640

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $312.35 to $313.345, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 56,297

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $311.35 to $312.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,154

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $310.35 to $311.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,490

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $309.31 to $310.30, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,557

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,282

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000014 · wk-form4_1784323860.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,605

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · derivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 462,866

Underlying: Ordinary Shares · 472,134 shares

Expires 2027-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F16 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.

F17 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · derivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,264,666 shares

Expires 2026-11-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F14 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F15 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.46 to $307.87, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,834

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.455 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,615

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.455 to $306.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 94,510

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.45 to $305.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 133,600

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,282

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.54 to $304.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000013 · wk-form4_1784078797.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,122

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.48 to $303.46, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · derivative · entry 25

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,264,666

Underlying: Ordinary Shares · 630,760 shares

Expires 2026-11-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F22 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F23 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 23

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F21 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.35 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 22

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 320

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F20 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.32 to $307.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 21

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,560

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F19 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.30 to $306.23, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 20

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,406

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F18 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.30 to $305.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 19

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,844

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F17 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.30 to $304.29, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 18

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 43,138

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.29 to $303.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,722

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.23 to $302.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,520

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001042047-26-000011 · wk-form4_1784078719.xml · derivative · entry 24

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,895,426

Underlying: Ordinary Shares · 152,074 shares

Expires 2026-11-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F22 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.

F23 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.