ONC

SEC source: 0001209191-23-055211 · doc4.xml · nonDerivative · entry 7

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 877,603

F1 · ownership.nature: American Depositary Shares ("ADS") of BeiGene, Ltd. (the "Issuer") each represent 13 Ordinary Shares ("Ordinary Shares") of the Issuer.

F5 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to 667 and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the benefit of the Funds.

F6 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F15 · ownership.nature: After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the ADS reported in column 5 of Table I held directly by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.

SEC source: 0001651308-23-000128 · wf-form4_169101062121566.xml · nonDerivative · entry 2

Lee Chan Henry · CIK 0001980648 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of July 29, 2022, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $216.068 to $216.2962, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-23-000104 · wf-form4_168867731225214.xml · nonDerivative · entry 2

Wang Julia Aijun · CIK 0001860279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 30, 2020, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $179.5185 to $179.665, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-23-000103 · wf-form4_168790103763021.xml · nonDerivative · entry 5

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F5 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 22, 2022, subject to continued service.

SEC source: 0001651308-23-000103 · wf-form4_168790103763021.xml · nonDerivative · entry 4

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5

F5 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 22, 2022, subject to continued service.

SEC source: 0001651308-23-000100 · wf-form4_168790078913526.xml · nonDerivative · entry 5

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F5 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 22, 2022, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000102 · wf-form4_168790094090281.xml · nonDerivative · entry 2

Wang Julia Aijun · CIK 0001860279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 22, 2022, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000101 · wf-form4_168790086732122.xml · nonDerivative · entry 3

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $182.34 to $183.05, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-23-000101 · wf-form4_168790086732122.xml · nonDerivative · entry 2

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 478

F1 · security: Each American Depositary Share represents 13 Ordinary Shares.

F2 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 16, 2023.

SEC source: 0001651308-23-000091 · wf-form4_168730145579147.xml · nonDerivative · entry 2

Wang Julia Aijun · CIK 0001860279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F3 · kind: The sale was effected pursuant to a mandatory tax withholding provision in the Reporting Person's restricted share unit award agreement in connection with the vesting of a restricted share unit award previously granted to the Reporting Person. 1/4th of the securities will vest on each anniversary of June 16, 2021, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $192.50 to $192.58, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-23-000092 · wf-form4_168730157221116.xml · nonDerivative · entry 4

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares.

F7 · kind: The sale was effected pursuant to mandatory tax withholding provisions in the Reporting Person's restricted share unit award agreements in connection with the vesting of two restricted share unit awards previously granted to the Reporting Person. 1/4th of the securities under one award will vest on each anniversary of June 17, 2020 and under the other award on each anniversary June 16, 2021, subject to continued service.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $192.4118 to $192.70, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-23-000090 · wf-form4_168730136898919.xml · nonDerivative · entry 5

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to mandatory tax withholding provisions in the Reporting Person's restricted share unit award agreements in connection with the vesting of two restricted share unit awards previously granted to the Reporting Person. 1/4th of the securities under one award will vest on each anniversary of June 17, 2020 and under the other award on each anniversary June 16, 2021, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $192.41 to $192.61, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001209191-23-038543 · doc4.xml · derivative · entry 10

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 53,950

Underlying: Ordinary Shares · 53,950 shares

Expires 2033-06-14

F16 · derivative.exercise_date: Includes 26,975 Share Options granted by the Issuer to each of Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer pursuant to the 2016 Plan. The Share Options have a strike price of $16.41 and vest on the earlier of June 14, 2024 or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise.

F1 · ownership.nature: American Depositary Shares ("ADS") of BeiGene, Ltd. (the "Issuer") each represent 13 Ordinary Shares ("Ordinary Shares") of the Issuer.

F5 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to 667 and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift ofthe Funds.

F6 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F7 · ownership.nature: After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares or ADS, as applicable, reported in column 5 of Table I and the Share Options (as defined below) reported in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.

F12 · ownership.nature: Pursuant to the policies of the Adviser, Michael Goller and Ranjeev Krishana do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the Ordinary Shares received upon vesting of RSUs and non-qualified share options convertible solely into Ordinary Shares of the Issuer ("Share Options") received as a result of their service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares received upon vesting of RSUs, Share Options, and Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest).

F13 · ownership.nature: The Adviser has voting and dispositive power over the Share Options, RSUs and any Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.

F14 · ownership.nature: The acquisitions of the RSUs and Share Options (as defined below) reported on this form represent grants to each of Michael Goller and Ranjeev Krishana of 12,922 RSUs on Table I and 26,975 Share Options on Table II. These grants, totaling 25,844 RSUs and 53,950 Share Options for Michael Goller and Ranjeev Krishana in the aggregate, are reported for each of the Funds as each has an indirect pecuniary interest in such securities.

F15 · ownership.nature: Pursuant to agreements between Julian C. Baker and the Adviser and the policies of the Adviser, the Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

F16 · ownership.nature: Includes 26,975 Share Options granted by the Issuer to each of Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer pursuant to the 2016 Plan. The Share Options have a strike price of $16.41 and vest on the earlier of June 14, 2024 or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise.

F17 · ownership.nature: The Share Options expire on June 14, 2033. Michael Goller and Ranjeev Krishana serve on the Board of the Issuer as representatives of the Funds. Unvested Share Options are subject to accelerated vesting upon a change in control and certain termination events.

SEC source: 0001209191-23-038543 · doc4.xml · derivative · entry 9

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 53,950

Underlying: Ordinary Shares · 53,950 shares

Expires 2033-06-14

F16 · derivative.exercise_date: Includes 26,975 Share Options granted by the Issuer to each of Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer pursuant to the 2016 Plan. The Share Options have a strike price of $16.41 and vest on the earlier of June 14, 2024 or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise.

F1 · ownership.nature: American Depositary Shares ("ADS") of BeiGene, Ltd. (the "Issuer") each represent 13 Ordinary Shares ("Ordinary Shares") of the Issuer.

F4 · ownership.nature: After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, L.P. ("667"), Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the Ordinary Shares or ADS, as applicable, reported in column 5 of Table I and the Share Options (as defined below) reported in column 9 of Table II held directly by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.

F5 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to 667 and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift ofthe Funds.

F6 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F12 · ownership.nature: Pursuant to the policies of the Adviser, Michael Goller and Ranjeev Krishana do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the Ordinary Shares received upon vesting of RSUs and non-qualified share options convertible solely into Ordinary Shares of the Issuer ("Share Options") received as a result of their service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares received upon vesting of RSUs, Share Options, and Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest).

F13 · ownership.nature: The Adviser has voting and dispositive power over the Share Options, RSUs and any Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.

F14 · ownership.nature: The acquisitions of the RSUs and Share Options (as defined below) reported on this form represent grants to each of Michael Goller and Ranjeev Krishana of 12,922 RSUs on Table I and 26,975 Share Options on Table II. These grants, totaling 25,844 RSUs and 53,950 Share Options for Michael Goller and Ranjeev Krishana in the aggregate, are reported for each of the Funds as each has an indirect pecuniary interest in such securities.

F15 · ownership.nature: Pursuant to agreements between Julian C. Baker and the Adviser and the policies of the Adviser, the Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

F16 · ownership.nature: Includes 26,975 Share Options granted by the Issuer to each of Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer pursuant to the 2016 Plan. The Share Options have a strike price of $16.41 and vest on the earlier of June 14, 2024 or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of Share Options granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise.

F17 · ownership.nature: The Share Options expire on June 14, 2033. Michael Goller and Ranjeev Krishana serve on the Board of the Issuer as representatives of the Funds. Unvested Share Options are subject to accelerated vesting upon a change in control and certain termination events.

SEC source: 0001209191-23-038543 · doc4.xml · nonDerivative · entry 8

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 93,417

F10 · shares: Includes 12,922 restricted stock units (each an "RSU") granted by the Issuer to each of Michael Goller and Ranjeev Krishana on June 15, 2023, pursuant to the Issuer's Second Amended and Restated 2016 Share Option and Incentive Plan (the "2016 Plan"). The RSUs vest on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of RSUs granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. Michael Goller and Ranjeev Krishana serve on the Board as representatives of the Funds and their affiliates.

F1 · ownership.nature: American Depositary Shares ("ADS") of BeiGene, Ltd. (the "Issuer") each represent 13 Ordinary Shares ("Ordinary Shares") of the Issuer.

F5 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to 667 and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift ofthe Funds.

F6 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F7 · ownership.nature: After giving effect to the transaction reported herein and as a result of their ownership interest in (i) Baker Brothers Life Sciences Capital, L.P. and (ii) Life Sciences, Julian C. Baker and Felix J. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares or ADS, as applicable, reported in column 5 of Table I and the Share Options (as defined below) reported in column 9 of Table II directly held by or held for the benefit of Life Sciences, a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital, L.P., a limited partnership of which the sole general partner is Baker Brothers Life Sciences Capital (GP), LLC, due to their interest in Life Sciences and Baker Brothers Life Sciences Capital, L.P.'s right to receive an allocation of a portion of the profits from Life Sciences.

F10 · ownership.nature: Includes 12,922 restricted stock units (each an "RSU") granted by the Issuer to each of Michael Goller and Ranjeev Krishana on June 15, 2023, pursuant to the Issuer's Second Amended and Restated 2016 Share Option and Incentive Plan (the "2016 Plan"). The RSUs vest on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of RSUs granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. Michael Goller and Ranjeev Krishana serve on the Board as representatives of the Funds and their affiliates.

F11 · ownership.nature: Includes beneficial ownership of 33,774 Ordinary Shares received from vested RSUs each previously granted to Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer. Michael Goller and Ranjeev Krishana serve on the board of directors of the Issuer (the "Board") as representatives of the Funds.

F12 · ownership.nature: Pursuant to the policies of the Adviser, Michael Goller and Ranjeev Krishana do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the Ordinary Shares received upon vesting of RSUs and non-qualified share options convertible solely into Ordinary Shares of the Issuer ("Share Options") received as a result of their service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares received upon vesting of RSUs, Share Options, and Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest).

F13 · ownership.nature: The Adviser has voting and dispositive power over the Share Options, RSUs and any Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.

F14 · ownership.nature: The acquisitions of the RSUs and Share Options (as defined below) reported on this form represent grants to each of Michael Goller and Ranjeev Krishana of 12,922 RSUs on Table I and 26,975 Share Options on Table II. These grants, totaling 25,844 RSUs and 53,950 Share Options for Michael Goller and Ranjeev Krishana in the aggregate, are reported for each of the Funds as each has an indirect pecuniary interest in such securities.

F15 · ownership.nature: Pursuant to agreements between Julian C. Baker and the Adviser and the policies of the Adviser, the Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

SEC source: 0001209191-23-038543 · doc4.xml · nonDerivative · entry 7

BAKER BROS. ADVISORS LP · CIK 0001263508 · Director · 10% owner

667, L.P. · CIK 0001551139 · Director · 10% owner

BAKER JULIAN · CIK 0001087939 · Director · 10% owner

BAKER FELIX · CIK 0001087940 · Director · 10% owner

Baker Bros. Advisors (GP) LLC · CIK 0001580575 · Director · 10% owner

Baker Brothers Life Sciences LP · CIK 0001363364 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 93,413

F10 · shares: Includes 12,922 restricted stock units (each an "RSU") granted by the Issuer to each of Michael Goller and Ranjeev Krishana on June 15, 2023, pursuant to the Issuer's Second Amended and Restated 2016 Share Option and Incentive Plan (the "2016 Plan"). The RSUs vest on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of RSUs granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. Michael Goller and Ranjeev Krishana serve on the Board as representatives of the Funds and their affiliates.

F1 · ownership.nature: American Depositary Shares ("ADS") of BeiGene, Ltd. (the "Issuer") each represent 13 Ordinary Shares ("Ordinary Shares") of the Issuer.

F4 · ownership.nature: After giving effect to the transactions reported herein and as a result of their ownership interest in (i) Baker Biotech Capital, L.P. and (ii) 667, L.P. ("667"), Julian C. Baker and Felix J. Baker each may be deemed to have an indirect pecuniary interest in the Ordinary Shares or ADS, as applicable, reported in column 5 of Table I and the Share Options (as defined below) reported in column 9 of Table II held directly by or held for the benefit of 667, a limited partnership of which the sole general partner is Baker Biotech Capital, L.P., a limited partnership of which the sole general partner is Baker Biotech Capital (GP), LLC, due to their interest in 667 and Baker Biotech Capital, L.P.'s right to receive an allocation of a portion of the profits from 667.

F5 · ownership.nature: Baker Bros. Advisors LP (the "Adviser") serves as the investment adviser to 667 and Baker Brothers Life Sciences, L.P. ("Life Sciences", and together with 667, the "Funds"). In connection with the services provided by the Adviser, the Adviser receives an asset-based management fee that does not confer any pecuniary interest in the securities held directly by or held for the benefit of the Funds. Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. Julian C. Baker and Felix J. Baker are managing members of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift of the Funds. The general partners of the Funds relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held directly by or held for the beneift ofthe Funds.

F6 · ownership.nature: Julian C. Baker, Felix J. Baker, the Adviser GP and the Adviser disclaim beneficial ownership of the securities held directly by or held for the benefit of the Funds except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that any of Julian C. Baker, Felix J. Baker, the Adviser GP or the Adviser is a beneficial owner of such securities for purposes of Section 16 or any other purpose.

F10 · ownership.nature: Includes 12,922 restricted stock units (each an "RSU") granted by the Issuer to each of Michael Goller and Ranjeev Krishana on June 15, 2023, pursuant to the Issuer's Second Amended and Restated 2016 Share Option and Incentive Plan (the "2016 Plan"). The RSUs vest on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting of the Issuer, provided, however, that all vesting of RSUs granted to a director shall cease if that director resigns from the Board or otherwise ceases to serve as a director, unless the Board determines otherwise. Michael Goller and Ranjeev Krishana serve on the Board as representatives of the Funds and their affiliates.

F11 · ownership.nature: Includes beneficial ownership of 33,774 Ordinary Shares received from vested RSUs each previously granted to Michael Goller and Ranjeev Krishana, full-time employees of the Adviser, in their capacity as directors of the Issuer. Michael Goller and Ranjeev Krishana serve on the board of directors of the Issuer (the "Board") as representatives of the Funds.

F12 · ownership.nature: Pursuant to the policies of the Adviser, Michael Goller and Ranjeev Krishana do not have any right to any of the Issuer's securities issued as part of their service on the Board and the Funds are entitled to an indirect proportionate pecuniary interest in the securities. The Funds each own an indirect proportionate pecuniary interest in the Ordinary Shares received upon vesting of RSUs and non-qualified share options convertible solely into Ordinary Shares of the Issuer ("Share Options") received as a result of their service on the Board. Solely as a result of their ownership interest in (i) the general partners of the Funds and (ii) the Funds, Felix J. Baker and Julian C. Baker may be deemed to have an indirect pecuniary interest in the Ordinary Shares received upon vesting of RSUs, Share Options, and Ordinary Shares received upon the exercise of Share Options (i.e. no direct pecuniary interest).

F13 · ownership.nature: The Adviser has voting and dispositive power over the Share Options, RSUs and any Ordinary Shares received as a result of the exercise of Share Options or vesting of RSUs.

F14 · ownership.nature: The acquisitions of the RSUs and Share Options (as defined below) reported on this form represent grants to each of Michael Goller and Ranjeev Krishana of 12,922 RSUs on Table I and 26,975 Share Options on Table II. These grants, totaling 25,844 RSUs and 53,950 Share Options for Michael Goller and Ranjeev Krishana in the aggregate, are reported for each of the Funds as each has an indirect pecuniary interest in such securities.

F15 · ownership.nature: Pursuant to agreements between Julian C. Baker and the Adviser and the policies of the Adviser, the Adviser has voting and dispositive power over the Stock Options, RSUs and any Common Stock received as a result of the exercise of Stock Options or vesting of RSUs.

SEC source: 0001651308-23-000088 · wf-form4_168730117072256.xml · derivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,349,907

Underlying: Ordinary Shares · 1,349,907 shares

Expires 2033-06-14

F7 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F7 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F8 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested shares are subject to accelerated vesting upon change of control or certain termination events.

SEC source: 0001651308-23-000088 · wf-form4_168730117072256.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,971,554

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001651308-23-000093 · wf-form4_168730171982754.xml · derivative · entry 2

Lee Chan Henry · CIK 0001980648 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,950

Underlying: Ordinary Shares · 248,950 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F3 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000093 · wf-form4_168730171982754.xml · nonDerivative · entry 1

Lee Chan Henry · CIK 0001980648 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,597

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000091 · wf-form4_168730145579147.xml · derivative · entry 3

Wang Julia Aijun · CIK 0001860279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 409,058

Underlying: Ordinary Shares · 409,058 shares

Expires 2033-06-14

F5 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F5 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F6 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000091 · wf-form4_168730145579147.xml · nonDerivative · entry 1

Wang Julia Aijun · CIK 0001860279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 342,303

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000092 · wf-form4_168730157221116.xml · derivative · entry 5

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 507,234

Underlying: Ordinary Shares · 507,234 shares

Expires 2033-06-14

F9 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F9 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F10 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service.

SEC source: 0001651308-23-000092 · wf-form4_168730157221116.xml · nonDerivative · entry 1

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,614,431

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service.

SEC source: 0001651308-23-000097 · wf-form4_168730201626632.xml · derivative · entry 3

Malley Thomas · CIK 0001403322 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F3 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F3 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F4 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000097 · wf-form4_168730201626632.xml · nonDerivative · entry 1

Malley Thomas · CIK 0001403322 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 46,696

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000096 · wf-form4_168730193754018.xml · derivative · entry 2

HOOPER ANTHONY C · CIK 0001277244 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000096 · wf-form4_168730193754018.xml · nonDerivative · entry 1

HOOPER ANTHONY C · CIK 0001277244 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,414

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000099 · wf-form4_168730246724090.xml · derivative · entry 2

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000099 · wf-form4_168730246724090.xml · nonDerivative · entry 1

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,414

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000098 · wf-form4_168730207645417.xml · derivative · entry 2

Riva Alessandro · CIK 0001867172 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000098 · wf-form4_168730207645417.xml · nonDerivative · entry 1

Riva Alessandro · CIK 0001867172 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,614

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000095 · wf-form4_168730187423688.xml · derivative · entry 2

Glazer Donald W. · CIK 0001660940 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 Ordinary Shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000095 · wf-form4_168730187423688.xml · nonDerivative · entry 1

Glazer Donald W. · CIK 0001660940 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,784,143

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000094 · wf-form4_168730179559441.xml · derivative · entry 2

Dugan Margaret · CIK 0001909734 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The option was granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000094 · wf-form4_168730179559441.xml · nonDerivative · entry 1

Dugan Margaret · CIK 0001909734 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,614

F1 · security: Represents securities underlying restricted share units. The restricted share units shall become fully vested on the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the director resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events. The restricted share units were granted under the Company's Independent Director Compensation Policy, as amended.

SEC source: 0001651308-23-000090 · wf-form4_168730136898919.xml · derivative · entry 6

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 760,851

Underlying: Ordinary Shares · 760,851 shares

Expires 2033-06-14

F8 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F8 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares.

F9 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000090 · wf-form4_168730136898919.xml · nonDerivative · entry 1

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,033,432

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events following a change in control.

SEC source: 0001651308-23-000089 · wf-form4_168730125834444.xml · derivative · entry 6

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 327,249

Underlying: Ordinary Shares · 327,249 shares

Expires 2033-06-14

F6 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F6 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each American Depositary Share represents 13 ordinary shares.

F7 · derivative.exercise_date: These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service.

SEC source: 0001651308-23-000089 · wf-form4_168730125834444.xml · nonDerivative · entry 1

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,531,328

F1 · security: Represents securities underlying restricted share units. 1/4th of the securities will vest on each anniversary of June 15, 2023, subject to continued service.

SEC source: 0000902664-23-003641 · ownership.xml · derivative · entry 2

Yi Qingqing · CIK 0001662556 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,975

Underlying: Ordinary Shares · 26,975 shares

Expires 2033-06-14

F2 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each ADS represents 13 ordinary shares.

F2 · shares: The number of securities underlying each option and the exercise price therefor are represented in ordinary shares. Each ADS represents 13 ordinary shares.

F3 · derivative.exercise_date: The option shall become exercisable in full upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0000902664-23-003641 · ownership.xml · nonDerivative · entry 1

Yi Qingqing · CIK 0001662556 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,614

F1 · security: Represents securities underlying RSUs. All RSUs will vest upon the earlier to occur of the first anniversary of the grant date or the date of the next annual general meeting; provided, however, that all vesting shall cease if the Reporting Person resigns from the board of directors or otherwise ceases to serve as a director, unless the board determines otherwise. Unvested securities are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0000902664-23-003603 · ownership.xml · nonDerivative · entry 3

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 142,888,241

F1 · price: The shares sold were in the form of ADS. The reported price is the price of each ADS sold, the price was paid in USD. Each ADS represents 13 Ordinary Shares.

F4 · balance_after: Consists of (i) 129,439,923 ordinary shares held by funds managed by HHLR (as defined below), of which 53,853,800 ordinary shares are held in the form of 4,142,600 ADSs and (ii) 13,448,318 ordinary shares held by a fund managed by HIM (as defined below), of which 13,445,978 ordinary shares are held in the form of 1,034,306 ADSs.

F5 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F6 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003603 · ownership.xml · nonDerivative · entry 2

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 143,161,969

F2 · price: The ordinary shares were sold through the Stock Exchange of Hong Kong, the price was paid in HKD.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from HKD127.75 to HKD128.5985, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of ordinary shares sold at each separate price.

F5 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F6 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003603 · ownership.xml · nonDerivative · entry 1

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 143,475,369

F1 · price: The shares sold were in the form of ADS. The reported price is the price of each ADS sold, the price was paid in USD. Each ADS represents 13 Ordinary Shares.

F5 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F6 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003537 · ownership.xml · nonDerivative · entry 5

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 144,086,369

F1 · price: The shares sold were in the form of ADS. The reported price is the price of each ADS sold, the price was paid in USD. Each ADS represents 13 Ordinary Shares.

F5 · balance_after: Consists of (i) 130,638,051 ordinary shares held by funds managed by HHLR (as defined below), of which 54,737,800 ordinary shares are held in the form of 4,210,600 ADSs and (ii) 13,448,318 ordinary shares held by a fund managed by HIM (as defined below), of which 13,445,978 ordinary shares are held in the form of 1,034,306 ADSs.

F6 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F7 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003537 · ownership.xml · nonDerivative · entry 4

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 145,055,181

F2 · price: The ordinary shares were sold through the Stock Exchange of Hong Kong, the price was paid in HKD.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from HKD131.7943 to HKD131.0298 inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of ordinary shares sold at each separate price.

F6 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F7 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003537 · ownership.xml · nonDerivative · entry 3

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 145,336,581

F1 · price: The shares sold were in the form of ADS. The reported price is the price of each ADS sold, the price was paid in USD. Each ADS represents 13 Ordinary Shares.

F6 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F7 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003537 · ownership.xml · nonDerivative · entry 2

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 145,665,533

F2 · price: The ordinary shares were sold through the Stock Exchange of Hong Kong, the price was paid in HKD.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from HKD130.2787 to HKD130.550, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of ordinary shares sold at each separate price.

F6 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F7 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0000902664-23-003537 · ownership.xml · nonDerivative · entry 1

HHLR ADVISORS, LTD. · CIK 0001762304 · 10% owner

HILLHOUSE INVESTMENT MANAGEMENT, LTD. · CIK 0001510589 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 145,879,233

F1 · price: The shares sold were in the form of ADS. The reported price is the price of each ADS sold, the price was paid in USD. Each ADS represents 13 Ordinary Shares.

F6 · ownership.nature: This form is filed by (i) HHLR Advisors, Ltd., an exempted Cayman Islands company ("HHLR") and (ii) Hillhouse Investment Management, Ltd., an exempted Cayman Islands company ("HIM"). The foregoing persons are hereinafter sometimes each referred to as a "Reporting Person" and collectively referred to as the "Reporting Persons." HHLR and HIM are under common control and share certain policies, personnel and resources. Accordingly, HHLR and HIM are filing this Form 4 jointly.

F7 · ownership.nature: The securities to which this filing relates are held by HHLR Fund, L.P., an exempted Cayman Islands limited partnership ("HHLR Fund"), YHG Investment, L.P., an exempted Cayman Islands limited partnership ("YHG"), and BGN Holdings Limited, an exempted Cayman Islands company ("BGN"). HHLR acts as the sole management company of HHLR Fund and the sole investment manager of YHG. HIM acts as the sole management company of Hillhouse Fund II, L.P. ("Fund II"). BGN is wholly owned by Fund II. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.