ONC

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,382

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $247.54 to $248.51, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,982

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $246.52 to $247.42, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,900

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $246.52 to $247.24, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,090

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.52 to $246.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,190

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.52 to $246.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 7

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,590

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

SEC source: 0001651308-25-000048 · wk-form4_1741396652.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,600,803

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · derivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,559,391

Underlying: Ordinary Shares · 1,007,578 shares

Expires 2025-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F16 · derivative.exercise_date: These securities vest over a five-year period as follows: 20% on July 19, 2016, and the remaining in 48 successive equal monthly installments, subject to continued service.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $262.81 to $263.37, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,800

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $261.56 to $262.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,200

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $260.50 to $261.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,106

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $259.44 to $260.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,811

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $258.44 to $259.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,011

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $257.41 to $258.39, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,609

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

F8 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $256.28 to $257.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 8

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,109

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · security: Each American Depositary Share represents 13 Ordinary Shares

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 2

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,892,056

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001651308-25-000047 · wk-form4_1741393557.xml · nonDerivative · entry 1

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,405,895

F1 · shares: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested shares are subject to accelerated vesting upon change of control or certain termination events.

SEC source: 0001651308-25-000043 · wk-form4_1741393174.xml · nonDerivative · entry 1

Rosenberg Aaron · CIK 0002031182 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 167,128

F1 · shares: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested securities are subject to accelerated vesting upon certain termination events.

SEC source: 0001651308-25-000044 · wk-form4_1741393244.xml · nonDerivative · entry 1

Lee Chan Henry · CIK 0001980648 · SVP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 246,142

F1 · shares: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested securities are subject to accelerated vesting upon certain termination events.

SEC source: 0001651308-25-000045 · wk-form4_1741393346.xml · nonDerivative · entry 1

Wang Lai · CIK 0001852291 · Global Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 990,171

F1 · shares: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested securities are subject to accelerated vesting upon certain termination events.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · derivative · entry 12

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 214,201

Underlying: Ordinary Shares · 583,349 shares

Expires 2029-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our ADSs on the date of grant, as each ADS represents 13 ordinary shares.

F11 · derivative.exercise_date: These securities vest over a five-year period as follows: 20% on April 30, 2019, and the remaining in 48 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · derivative · entry 11

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2

Underlying: Ordinary Shares · 91,624 shares

Expires 2028-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_price: The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our ADSs on the date of grant, as each ADS represents 13 ordinary shares.

F11 · derivative.exercise_date: These securities vest over a five-year period as follows: 20% on April 30, 2019, and the remaining in 48 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 10

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2024.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 9

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 200

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2024.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $262.00 to $262.98, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 8

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,737

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2024.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $261.00 to $261.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 7

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,097

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

F6 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 13, 2024.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $260.00 to $260.99, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 6

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,921

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 5

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,048

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · security: Each American Depositary Share represents 13 Ordinary Shares.

SEC source: 0001651308-25-000046 · wk-form4_1741393434.xml · nonDerivative · entry 1

Wu Xiaobin · CIK 0001739452 · President, COO & GM China

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,175,210

F1 · shares: Represents the total number of ordinary shares underlying the performance share units earned by Reporting Person. The earned performance share units will vest in 2027, subject to the Reporting Person continuing to provide service to the Company through such vesting date. Unvested securities are subject to accelerated vesting upon certain termination events.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 11

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $257.37 to $257.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 10

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 323

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $256.37 to $257.28, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 9

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 2,132

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $255.36 to $256.34, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 8

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 3,346

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $254.24 to $255.11, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 7

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 4,621

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $253.23 to $254.21, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 6

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 5,446

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $252.18 to $253.16, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000042 · wk-form4_1741297695.xml · nonDerivative · entry 5

Wang Xiaodong · CIK 0001662982 · Director · Chair, Scientific Advisory Brd

10b5-1 filing: Plan reported

Ownership: Indirect · See Footnote

Disclosed balance after: 7,446

F4 · kind: The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on August 12, 2024.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $251.15 to $252.11, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

F2 · ownership.nature: These securities are held by Wang Investment LLC, of which 99% of the limited liability company interest is owned by two grantor retained annuity trusts, of which the Reporting Person's wife is a trustee, for which the Reporting Person disclaims beneficial ownership.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · derivative · entry 20

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,566,969

Underlying: Ordinary Shares · 2,533,531 shares

Expires 2025-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F20 · derivative.exercise_date: These securities vest over a five-year period as follows: 20% on July 19, 2016, and the remaining in 48 successive equal monthly installments, subject to continued service.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 19

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F19 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $249.10 to $249.38, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 18

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F18 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $248.09 to $249.00, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 17

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,500

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F17 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $247.09 to $248.08, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 16

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,980

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F16 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $246.08 to $247.03, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 15

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,223

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F15 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.05 to $246.02, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 14

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,455

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F14 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $245.25 to $245.50, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 13

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,545

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F13 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $244.05 to $245.04, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 12

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,931

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F12 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $244.17 to $245.12, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 11

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,841

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F11 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $243.025 to $244.02, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 10

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,036

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $242.00 to $242.9422, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

SEC source: 0001651308-25-000039 · wk-form4_1741211959.xml · nonDerivative · entry 9

OYLER JOHN · CIK 0001042047 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,228

F6 · security: Each American Depositary Share represents 13 Ordinary Shares

F7 · kind: The sale was effected solely to cover the exercise cost and satisfy tax obligations for the share options that were exercised. The expiration date of the share option is July 19, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $241.00 to $241.95, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.