OMER

SEC source: 0000899243-16-035087 · doc4.xml · derivative · entry 7

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 204,084

Underlying: Common Stock · 102,040 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,884,985

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted earlier this year by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. The 306,124 shares of common stock sold during this reporting period complete the sale of all shares associated with the options expiring on December 11, 2016. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan.

F2 · kind: (Continued from Footnote 1) A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used to fund in part the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016.

F3 · price: This transaction was executed in multiple trades at prices ranging from $10.49 to $11.15; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,987,025

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-035089 · doc4.xml · derivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2026-12-04

F1 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2016. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-034882 · doc4.xml · derivative · entry 12

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 181,163 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

F7 · derivative.exercise_date: On December 2, 2016, the reporting person exercised incentive stock options to purchase 181,163 shares of common stock, which are being retained by the reporting person.

SEC source: 0000899243-16-034882 · doc4.xml · derivative · entry 11

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 306,124

Underlying: Common Stock · 102,040 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 8

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,884,985

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 7

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,703,822

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan. A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used in part to fund the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016. See note (7) below.

F5 · price: This transaction was executed in multiple trades at prices ranging from $10.84 to $11.30; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 6

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,805,862

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-034882 · doc4.xml · derivative · entry 10

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 408,164

Underlying: Common Stock · 106,521 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 5

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,703,822

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan. A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used in part to fund the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016. See note (7) below.

F4 · price: This transaction was executed in multiple trades at prices ranging from $12.27 to $12.37; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 4

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,704,821

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan. A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used in part to fund the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016. See note (7) below.

F3 · price: This transaction was executed in multiple trades at prices ranging from $11.27 to $12.26; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 3

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,810,343

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-034882 · doc4.xml · derivative · entry 9

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 514,685

Underlying: Common Stock · 97,559 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,703,822

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan. A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used in part to fund the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016. See note (7) below.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.06 to $12.59; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-034882 · doc4.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,801,381

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-031631 · doc4.xml · derivative · entry 2

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,040

Underlying: Common Stock · 3,004 shares

Expires 2020-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of April 1, 2010. Installments vested and became exercisable on each monthly anniversary thereafter. On October 12, 2016, the reporting person exercised options to purchase 3,004 of these shares and held such shares for her account.

SEC source: 0000899243-16-031631 · doc4.xml · nonDerivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 166,601

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-029181 · doc4.xml · derivative · entry 3

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 16,000 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on November 1, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-029181 · doc4.xml · nonDerivative · entry 2

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 163,597

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 3, 2014, and amended on May 13, 2016, which provided for the exercise and sale of options to purchase 175,000 shares of common stock that expire on December 11, 2016. The May 13, 2016 amendment to Ms. Kelbon's trading plan provided for the future exercise and sale of certain other series of the issuer's stock options. Under the plan, the options expiring on December 11, 2016 would be exercised and sold at fixed sale periods, price and numbers set at the time the plan was adopted in 2014 over a one-year period beginning in November 2015, with sale periods commencing approximately monthly and with approximately 15,900 such options to be exercised and sold in each sale period. This sale was the last scheduled sale of options expiring in 2016 under the plan. Consistent with applicable trading rules, Ms. Kelbon has had no further control over the terms or timing of sales under the plan.

F2 · kind: (Continued from Footnote 1) A portion of the proceeds from the exercise of the options expiring on December 11, 2016 are being used to fund Ms. Kelbon's exercise of other series of the issuer's stock options and retention of the underlying shares, and may also be used to fund the payment of taxes incurred by the exercise of such options.

F3 · price: This transaction was executed in multiple trades at prices ranging from $10.69 to $11.08; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-029181 · doc4.xml · nonDerivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.