NKTX

SEC source: 0000950170-24-088659 · ownership.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 139,945

F1 · date: This transaction is inadvertently filed late due to an administrative error.

F2 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on August 20, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0000950170-24-075730 · ownership.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,524

F1 · shares: Represents shares sold as required by the applicable award terms to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.59 to $5.60. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-075723 · ownership.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,743

F1 · shares: Represents shares sold as required by the applicable award terms to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.58 to $5.60. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-075733 · ownership.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,959

F1 · shares: Represents shares sold as required by the applicable award terms to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.56 to $5.60. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-075732 · ownership.xml · nonDerivative · entry 1

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240,737

F1 · shares: Represents shares sold as required by the applicable award terms to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.58 to $5.60. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-075728 · ownership.xml · nonDerivative · entry 1

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 107,215

F1 · shares: Represents shares sold as required by the applicable award terms to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $5.58 to $5.60. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-073639 · ownership.xml · derivative · entry 1

Vratsanos George · CIK 0002025731 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: This option is scheduled to vest and become exercisable in three substantially equal installments on each of the first, second and third anniversaries of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000950170-24-073652 · ownership.xml · derivative · entry 1

Scheiner Zachary · CIK 0001816523 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund") and the RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund and the Nexus Fund to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying common stock.

SEC source: 0000950170-24-073641 · ownership.xml · derivative · entry 1

Thedinga Angela · CIK 0001804588 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0000950170-24-073643 · ownership.xml · derivative · entry 1

PATTERSON LEONE D · CIK 0001233539 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001415889-24-016893 · form4-06142024_080600.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award, subject to Dr. Scheiner's continued service through the applicable vesting date. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Dr. Scheiner's separation from service with the Issuer due to the his death or "disability" (as described in the applicable award agreement).

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. Each of the Adviser, the Adviser GP, the Fund, the Nexus Fund, Dr. Kolchinsky and Mr. Shah disclaims beneficial ownership of any of the reported securities, except to the extent of its or his respective pecuniary interest therein.

F3 · ownership.nature: Zachary Scheiner is a Principal of the Adviser who serves on the Issuer's board of directors. Under Dr. Scheiner's arrangement with the Adviser, Dr. Scheiner holds the option for the benefit of the Fund and the Nexus Fund. Dr. Scheiner is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

SEC source: 0000950170-24-073730 · ownership.xml · derivative · entry 1

George Simeon · CIK 0001595117 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0000950170-24-073642 · ownership.xml · derivative · entry 1

Dybbs Michael · CIK 0001601264 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0000950170-24-073729 · ownership.xml · derivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2034-06-12

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 13, 2025 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0000950170-24-038089 · ownership.xml · nonDerivative · entry 2

George Simeon · CIK 0001595117 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 3

Disclosed balance after: 451,659

F1 · kind: Reports the purchase of shares in the underwritten public offering of common stock of the Issuer.

F3 · ownership.nature: The Reporting Person is the sole managing member of SR One Capital Management, which is the sole general partner of SR One Capital Partners II, LP ("SR One Partners II"). SR One Partners II is the sole general partner of SR One Capital Fund II Aggregator, LP ("SR One Fund II Aggregator"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended ("Section 16"), or otherwise of such portion of the securities held by SR One Fund II Aggregator in which the Reporting Person has no pecuniary interest.

SEC source: 0000950170-24-038089 · ownership.xml · nonDerivative · entry 1

George Simeon · CIK 0001595117 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 1,548,341

F1 · kind: Reports the purchase of shares in the underwritten public offering of common stock of the Issuer.

F2 · ownership.nature: The Reporting Person is the sole managing member of SR One Capital Management, LLC ("SR One Capital Management"), which is the sole general partner of SR One Capital Opportunities Partners I, LP ("SR One Opportunities Partners I"). SR One Opportunities Partners I is the sole general partner of SR One Capital Opportunities Fund I, LP ("SR One Opportunities Fund I"), which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 or otherwise of such portion of the securities held by SR One Opportunities Fund I in which the Reporting Person has no pecuniary interest.

SEC source: 0001415889-24-009447 · form4-03292024_090355.xml · derivative · entry 3

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 3,000,031

Underlying: Common Stock · 3,000,031 shares

Expires not disclosed

F4 · derivative.exercise_date: The Pre-Funded Warrants have no expiration date and are exercisable at any time after the date of issuance. A holder of Pre-Funded Warrants may not exercise the Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 19.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise.

F4 · derivative.expiration_date: The Pre-Funded Warrants have no expiration date and are exercisable at any time after the date of issuance. A holder of Pre-Funded Warrants may not exercise the Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 19.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise.

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: Held directly by the Fund.

SEC source: 0001415889-24-009447 · form4-03292024_090355.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 10,050,818

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: Held directly by the Fund.

SEC source: 0000950170-24-026055 · ownership.xml · nonDerivative · entry 2

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240,507

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on June 27, 2022.

F3 · price: This transaction was executed in multiple trades at prices ranging from $13.00 to $13.85. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-026001 · ownership.xml · derivative · entry 5

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,629

Underlying: Common Stock · 2,955 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on September 2, 2022.

F4 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on July 1, 2024.

SEC source: 0000950170-24-026001 · ownership.xml · derivative · entry 4

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,445

Underlying: Common Stock · 3,808 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on September 2, 2022.

F3 · derivative.exercise_date: The options exercised were fully vested.

SEC source: 0000950170-24-026001 · ownership.xml · nonDerivative · entry 3

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,972

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on September 2, 2022.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.50 to $12.58. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-026001 · ownership.xml · nonDerivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,339

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on September 2, 2022.

SEC source: 0000950170-24-026001 · ownership.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,384

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on September 2, 2022.

SEC source: 0000950170-24-026055 · ownership.xml · nonDerivative · entry 1

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 378,149

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on June 27, 2022.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.00 to $13.01. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-015564 · ownership.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 149,415

F1 · kind: The transaction reported in this Form 4 was effected automatically pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person and most recently amended on June 22, 2022.

SEC source: 0000950170-24-005431 · ownership.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,980

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.74 to $8.96. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-005427 · ownership.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,576

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.74 to $8.96. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-005429 · ownership.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 153,558

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.74 to $8.96. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-005426 · ownership.xml · nonDerivative · entry 1

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 390,507

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.74 to $8.96. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000950170-24-005425 · ownership.xml · nonDerivative · entry 1

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 107,942

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $8.74 to $8.96. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001209191-24-001159 · doc4.xml · derivative · entry 2

Levin Alyssa · CIK 0001981854 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 112,500 shares

Expires 2034-01-03

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001159 · doc4.xml · nonDerivative · entry 1

Levin Alyssa · CIK 0001981854 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,000

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-24-001165 · doc4.xml · derivative · entry 2

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 112,500 shares

Expires 2034-01-03

F3 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001165 · doc4.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,532

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

F2 · balance_after: Includes 2,000 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on November 30, 2023.

SEC source: 0001209191-24-001163 · doc4.xml · derivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 112,500 shares

Expires 2034-01-03

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001163 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,088

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-24-001161 · doc4.xml · derivative · entry 2

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 112,500 shares

Expires 2034-01-03

F3 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001161 · doc4.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,118

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

F2 · balance_after: Includes 2,000 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on November 30, 2023.

SEC source: 0001209191-24-001160 · doc4.xml · derivative · entry 2

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 509,500

Underlying: Common Stock · 509,500 shares

Expires 2034-01-03

F3 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001160 · doc4.xml · nonDerivative · entry 1

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,204

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

F2 · balance_after: Includes 1,802 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on November 30, 2023.

SEC source: 0001209191-24-001158 · doc4.xml · derivative · entry 2

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,500

Underlying: Common Stock · 112,500 shares

Expires 2034-01-03

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2024.

SEC source: 0001209191-24-001158 · doc4.xml · nonDerivative · entry 1

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,496

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on January 14, 2025. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-23-047037 · doc4.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,532

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0001209191-23-041004 · doc4.xml · derivative · entry 1

Levin Alyssa · CIK 0001981854 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 442,400

Underlying: Common Stock · 442,400 shares

Expires 2033-06-30

F1 · derivative.exercise_date: The option is scheduled to vest and become exercisable as to 25% of the shares subject to the grant on July 1, 2024. The remaining portion of the option is scheduled to vest and become exercisable in 36 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following July 1, 2024.

SEC source: 0001209191-23-040969 · doc4.xml · derivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,000

Underlying: Common Stock · 208,000 shares

Expires 2033-06-30

F1 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following July 1, 2023.

SEC source: 0001209191-23-039056 · doc4.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,863

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · balance_after: Includes 2,000 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on May 31, 2023.

SEC source: 0001209191-23-039059 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,088

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0001209191-23-039054 · doc4.xml · nonDerivative · entry 1

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,776

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · balance_after: Includes 2,000 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on May 31, 2023.

SEC source: 0001209191-23-039061 · doc4.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,118

F1 · shares: Represents shares sold to satisfy tax withholding obligations in connection with the vesting and settlement of Restricted Stock Units and does not represent a discretionary transaction by the Reporting Person.

F2 · balance_after: Includes 2,000 shares acquired under the Issuer's 2020 Employee Stock Purchase Plan on May 31, 2023.