NKTR

SEC source: 0001209191-21-065592 · doc4.xml · nonDerivative · entry 1

Labrucherie Gil M · CIK 0001394875 · SVP, COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 259,682

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.84 to $13.52. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F3 · balance_after: This number includes 997 shares held by the reporting person in the Issuer's 401(K) plan and 4,218 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-065229 · doc4.xml · nonDerivative · entry 1

Zalevsky Jonathan · CIK 0001789857 · Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 252,953

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSU"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of Common Stock of the Issuer. These RSUs were granted on December 12, 2019 under the Issuer's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements. The time-based vesting is on a quarterly pro-rata basis over a period of three (3) years from the date of grant.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Issuer determined that the performance-based vesting requirement for these RSUs was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these RSUs vested on the next quarterly vesting date (November 15, 2021) following the date that the performance-based vesting requirement was satisfied.

SEC source: 0001209191-21-065225 · doc4.xml · nonDerivative · entry 1

Wilson Mark Andrew · CIK 0001808356 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 93,000

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSU"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of Common Stock of the Issuer. These RSUs were granted on December 12, 2019 under the Issuer's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements. The time-based vesting is on a quarterly pro-rata basis over a period of three (3) years from the date of grant.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Issuer determined that the performance-based vesting requirement for these RSUs was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these RSUs vested on the next quarterly vesting date (November 15, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · balance_after: This number includes 3,107 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under the plan is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-065223 · doc4.xml · nonDerivative · entry 1

Thomsen Jillian B. · CIK 0001433457 · SVP & Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,722

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSU"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of Common Stock of the Issuer. These RSUs were granted on December 12, 2019 under the Issuer's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements. The time-based vesting is on a quarterly pro-rata basis over a period of three (3) years from the date of grant.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Issuer determined that the performance-based vesting requirement for these RSUs was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these RSUs vested on the next quarterly vesting date (November 15, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · balance_after: This number includes 988 shares held by the reporting person in the Issuer's 401(K) plan and 5,690 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-065222 · doc4.xml · nonDerivative · entry 1

ROBIN HOWARD W · CIK 0001206869 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 518,223

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSU"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of Common Stock of the Issuer. These RSUs were granted on December 12, 2019 under the Issuer's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements. The time-based vesting is on a quarterly pro-rata basis over a period of three (3) years from the date of grant.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Issuer determined that the performance-based vesting requirement for these RSUs was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these RSUs vested on the next quarterly vesting date (November 15, 2021) following the date that the performance-based vesting requirement was satisfied.

SEC source: 0001209191-21-065220 · doc4.xml · nonDerivative · entry 1

Labrucherie Gil M · CIK 0001394875 · SVP, COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,831

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSU"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of Common Stock of the Issuer. These RSUs were granted on December 12, 2019 under the Issuer's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements. The time-based vesting is on a quarterly pro-rata basis over a period of three (3) years from the date of grant.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Issuer determined that the performance-based vesting requirement for these RSUs was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these RSUs vested on the next quarterly vesting date (November 15, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · balance_after: This number includes 997 shares held by the reporting person in the Issuer's 401(K) plan and 4,218 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-064508 · doc4.xml · derivative · entry 2

Brainard Diana · CIK 0001818070 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,720

Underlying: Common Stock · 36,720 shares

Expires 2029-11-10

F3 · derivative.exercise_date: This stock option vests in equal monthly installments over the three-year period beginning on November 11, 2021.

SEC source: 0001209191-21-064508 · doc4.xml · nonDerivative · entry 1

Brainard Diana · CIK 0001818070 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,360

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests over three years in equal annual installments beginning on November 11, 2021.

SEC source: 0001209191-21-063656 · doc4.xml · derivative · entry 2

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires 2023-09-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-063656 · doc4.xml · nonDerivative · entry 1

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 293,374

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-060513 · doc4.xml · derivative · entry 1

Zalevsky Jonathan · CIK 0001789857 · Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,550

Underlying: Common Stock · 71,550 shares

Expires 2027-12-11

F1 · security: These stock options were granted on December 12, 2019 under the Company's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Company determined that the performance-based vesting requirement for these stock options was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these stock options vested on the next monthly vesting date (October 12, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · derivative.exercise_date: These stock options vest on a monthly pro-rata basis over a period of four years from the grant date (December 12, 2019).

SEC source: 0001209191-21-060512 · doc4.xml · derivative · entry 1

Wilson Mark Andrew · CIK 0001808356 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,800

Underlying: Common Stock · 35,800 shares

Expires 2027-12-11

F1 · security: These stock options were granted on December 12, 2019 under the Company's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Company determined that the performance-based vesting requirement for these stock options was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these stock options vested on the next monthly vesting date (October 12, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · derivative.exercise_date: These stock options vest on a monthly pro-rata basis over a period of four years from the grant date (December 12, 2019).

SEC source: 0001209191-21-060511 · doc4.xml · derivative · entry 1

Thomsen Jillian B. · CIK 0001433457 · SVP & Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,600

Underlying: Common Stock · 26,600 shares

Expires 2027-12-11

F1 · security: These stock options were granted on December 12, 2019 under the Company's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Company determined that the performance-based vesting requirement for these stock options was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these stock options vested on the next monthly vesting date (October 12, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · derivative.exercise_date: These stock options vest on a monthly pro-rata basis over a period of four years from the grant date (December 12, 2019).

SEC source: 0001209191-21-060510 · doc4.xml · derivative · entry 1

ROBIN HOWARD W · CIK 0001206869 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 167,650

Underlying: Common Stock · 167,650 shares

Expires 2027-12-11

F1 · security: These stock options were granted on December 12, 2019 under the Company's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Company determined that the performance-based vesting requirement for these stock options was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these stock options vested on the next monthly vesting date (October 12, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · derivative.exercise_date: These stock options vest on a monthly pro-rata basis over a period of four years from the grant date (December 12, 2019).

SEC source: 0001209191-21-060509 · doc4.xml · derivative · entry 1

Labrucherie Gil M · CIK 0001394875 · SVP, COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,550

Underlying: Common Stock · 71,550 shares

Expires 2027-12-11

F1 · security: These stock options were granted on December 12, 2019 under the Company's Amended and Restated 2017 Performance Incentive Plan (the "2017 Plan") and at the time of their grant were subject to both performance-based and time-based vesting requirements.

F2 · date: The Organization and Compensation Committee of the Board of Directors of the Company determined that the performance-based vesting requirement for these stock options was satisfied on September 15, 2021. Pursuant to the terms of the 2017 Plan, these stock options vested on the next monthly vesting date (October 12, 2021) following the date that the performance-based vesting requirement was satisfied.

F3 · derivative.exercise_date: These stock options vest on a monthly pro-rata basis over a period of four years from the grant date (December 12, 2019).

SEC source: 0001209191-21-057708 · doc4.xml · derivative · entry 4

WHITFIELD ROY A · CIK 0000936728 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F3 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057708 · doc4.xml · nonDerivative · entry 1

WHITFIELD ROY A · CIK 0000936728 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 236,050

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-057707 · doc4.xml · derivative · entry 2

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F3 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057707 · doc4.xml · nonDerivative · entry 1

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,874

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-057706 · doc4.xml · derivative · entry 2

EASTHAM KARIN · CIK 0001231845 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F3 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057706 · doc4.xml · nonDerivative · entry 1

EASTHAM KARIN · CIK 0001231845 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,300

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-057704 · doc4.xml · derivative · entry 3

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F4 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057704 · doc4.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,775

F3 · shares: Represents the number of shares required to be sold by the reporting person to cover tax obligations in connection with the vesting of certain RSUs held by the reporting person. This sale is mandated by the reporting person's previous election under the Issuer's equity incentive plans to require the satisfaction of tax obligations to be funded by a "sell to cover" transaction.

F3 · balance_after: Represents the number of shares required to be sold by the reporting person to cover tax obligations in connection with the vesting of certain RSUs held by the reporting person. This sale is mandated by the reporting person's previous election under the Issuer's equity incentive plans to require the satisfaction of tax obligations to be funded by a "sell to cover" transaction.

SEC source: 0001209191-21-057704 · doc4.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,440

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-057703 · doc4.xml · derivative · entry 6

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F6 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057703 · doc4.xml · nonDerivative · entry 2

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 279,873

F3 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $17.59 to $18.28. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issues.

SEC source: 0001209191-21-057703 · doc4.xml · nonDerivative · entry 1

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284,473

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-057702 · doc4.xml · derivative · entry 3

Ajer Jeffrey Robert · CIK 0001557533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,400

Underlying: Common Stock · 20,400 shares

Expires 2029-09-21

F4 · derivative.exercise_date: This stock option vests in equal monthly installments over the one-year period beginning on September 22, 2021.

SEC source: 0001209191-21-057702 · doc4.xml · nonDerivative · entry 2

Ajer Jeffrey Robert · CIK 0001557533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,510

F3 · shares: Represents the number of shares required to be sold by the reporting person to cover tax obligations in connection with the vesting of certain RSUs held by the reporting person. This sale is mandated by the reporting person's previous election under the Issuer's equity incentive plans to require the satisfaction of tax obligations to be funded by a "sell to cover" transaction.

SEC source: 0001209191-21-057702 · doc4.xml · nonDerivative · entry 1

Ajer Jeffrey Robert · CIK 0001557533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,175

F1 · security: Common stock was acquired pursuant to a grant of restricted stock units ("RSUs"). Each RSU awarded represents a contingent right to receive, upon vesting of the unit, one share of the Issuer's common stock.

F2 · deemedExecutionDate: This RSU award vests in full, one year following September 22, 2021.

SEC source: 0001209191-21-056728 · doc4.xml · derivative · entry 4

WHITFIELD ROY A · CIK 0000936728 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 40,000 shares

Expires 2021-09-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-056728 · doc4.xml · nonDerivative · entry 1

WHITFIELD ROY A · CIK 0000936728 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,850

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-055543 · doc4.xml · derivative · entry 9

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,279 shares

Expires 2021-09-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

SEC source: 0001209191-21-055543 · doc4.xml · nonDerivative · entry 4

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 274,273

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

F3 · price: This transaction was executed in multiple trades at prices ranging from $15.76 to $16.26. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001209191-21-055543 · doc4.xml · nonDerivative · entry 3

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284,552

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

SEC source: 0001209191-21-055543 · doc4.xml · derivative · entry 8

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,279

Underlying: Common Stock · 8,000 shares

Expires 2021-09-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

SEC source: 0001209191-21-055543 · doc4.xml · nonDerivative · entry 2

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 274,273

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.85 to $16.14. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001209191-21-055543 · doc4.xml · nonDerivative · entry 1

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 282,273

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person for certain options expiring on September 18, 2021.

SEC source: 0001209191-21-054136 · doc4.xml · derivative · entry 2

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 45,000 shares

Expires 2022-09-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-054136 · doc4.xml · nonDerivative · entry 1

GREER R SCOTT · CIK 0001211703 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 270,674

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-21-053541 · doc4.xml · nonDerivative · entry 4

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by son

Disclosed balance after: 2,100

F1 · kind: This transaction involved a gift of shares by the reporting person to his children.

F2 · balance_after: The reporting person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-21-053541 · doc4.xml · nonDerivative · entry 3

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by daughter

Disclosed balance after: 2,100

F1 · kind: This transaction involved a gift of shares by the reporting person to his children.

F2 · balance_after: The reporting person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-21-053541 · doc4.xml · nonDerivative · entry 2

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by daughter

Disclosed balance after: 2,100

F1 · kind: This transaction involved a gift of shares by the reporting person to his children.

F2 · balance_after: The reporting person disclaims beneficial ownership of these shares, and this report shall not be deemed an admission that the reporting person is the beneficial owner of these shares for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-21-053541 · doc4.xml · nonDerivative · entry 1

CHESS ROBERT · CIK 0001227886 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 274,273

F1 · kind: This transaction involved a gift of shares by the reporting person to his children.

SEC source: 0001209191-21-052384 · doc4.xml · nonDerivative · entry 2

Labrucherie Gil M · CIK 0001394875 · SVP, COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 240,231

F4 · security: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · balance_after: This number includes 997 shares held by the reporting person in the Issuer's 401(K) plan and 4,218 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-052395 · doc4.xml · nonDerivative · entry 1

Zalevsky Jonathan · CIK 0001789857 · Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 212,803

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.69 to $14.32. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F3 · balance_after: Since the date of the last ownership report of the reporting person, he transferred 14,600 shares of NKTR common stock to his ex-spouse pursuant to a domestic relations order. The reporting person no longer reports as beneficially owned any securities owned by his ex-spouse.

SEC source: 0001209191-21-052393 · doc4.xml · nonDerivative · entry 1

Wilson Mark Andrew · CIK 0001808356 · SVP & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,900

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.69 to $14.32. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F3 · balance_after: This number includes 3,107 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).

SEC source: 0001209191-21-052391 · doc4.xml · nonDerivative · entry 1

ROBIN HOWARD W · CIK 0001206869 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 424,123

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.69 to $14.32. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001209191-21-052385 · doc4.xml · nonDerivative · entry 1

NORTHCOTT JOHN · CIK 0001615000 · SVP & Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,915

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.69 to $14.32. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001209191-21-052390 · doc4.xml · nonDerivative · entry 1

Thomsen Jillian B. · CIK 0001433457 · SVP & Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,822

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of the RSUs held by the reporting person. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary trade by the reporting person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.69 to $14.32. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide full information regarding the number of shares and the prices at which the transactions were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F3 · balance_after: This number includes 988 shares held by the reporting person in the Issuer's 401(K) plan and 5,690 shares held by the reporting person in the Issuer's ESPP plan. The acquisition of these shares under both plans is exempt under Rule 16b-3(c).