MRNA

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 6

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,315,615

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.08 to $149.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,317,216

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.05 to $148.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,323,613

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $146.04 to $147.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,326,644

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $145.04 to $146.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,327,907

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $144.04 to $145.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-073912 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,328,315

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $142.49 to $143.43, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes shares received in distributions-in-kind from Flagship Ventures Fund IV, L.P. ("Flagship Fund IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx") made prior to the filing of this report in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000950170-24-072122 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Flagship Ventures Fund IV-Rx, L.P.

Disclosed balance after: 1,528,557

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.00 to $149.755, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · ownership.nature: The shares are held directly by Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx"). Flagship Fund IV GP is the general partner of Flagship Fund IV-Rx. The reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-072122 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Flagship Ventures Fund IV, L.P.

Disclosed balance after: 7,930,725

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.00 to $149.755, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F2 · ownership.nature: The shares are held directly by Flagship Ventures Fund IV, L.P. ("Flagship Fund IV"). Flagship Ventures Fund IV General Partner LLC ("Flagship Fund IV GP") is the general partner of Flagship Fund IV. The reporting person is the sole manager of Flagship Fund IV GP and disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-072122 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Flagship Ventures Fund IV-Rx, L.P.

Disclosed balance after: 1,529,789

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.00 to $148.99, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · ownership.nature: The shares are held directly by Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx"). Flagship Fund IV GP is the general partner of Flagship Fund IV-Rx. The reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

SEC source: 0000950170-24-072122 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Flagship Ventures Fund IV, L.P.

Disclosed balance after: 7,937,145

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.00 to $148.99, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F2 · ownership.nature: The shares are held directly by Flagship Ventures Fund IV, L.P. ("Flagship Fund IV"). Flagship Ventures Fund IV General Partner LLC ("Flagship Fund IV GP") is the general partner of Flagship Fund IV. The reporting person is the sole manager of Flagship Fund IV GP and disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.

SEC source: 0001127602-24-018351 · form4.xml · nonDerivative · entry 3

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,947

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-018351 · form4.xml · derivative · entry 5

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,108 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 100% of the shares subject to this restricted stock unit award vested on June 7, 2024.

F4 · derivative.expiration_date: 100% of the shares subject to this restricted stock unit award vested on June 7, 2024.

SEC source: 0001127602-24-018351 · form4.xml · derivative · entry 4

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,555

Underlying: Common Stock · 1,139 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on June 7, 2022 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F3 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on June 7, 2022 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-24-018351 · form4.xml · nonDerivative · entry 2

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,125

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-24-018351 · form4.xml · nonDerivative · entry 1

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,017

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 9

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,946,931

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F10 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $154.47 to $155.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 8

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,948,652

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $153.46 to $154.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 7

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,949,052

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $152.46 to $153.43, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 6

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,951,489

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $151.37 to $152.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,955,391

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $150.37 to $151.36, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,958,231

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $149.32 to $149.37, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,958,531

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $148.17 to $149.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,960,331

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.11 to $148.09, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-070980 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,961,031

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $145.40 to $146.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-24-017742 · form4.xml · nonDerivative · entry 2

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,878

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-017754 · form4.xml · nonDerivative · entry 2

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,472,089

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-017764 · form4.xml · nonDerivative · entry 2

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,506

F2 · kind: Represents the number of shares required to be sold by the reporting person to cover tax withholding obligations in connection with the vesting of Performance Stock Units. This "sell-to-cover" transaction was mandated by the Issuer's equity incentive plan and does not represent a discretionary trade by the reporting person.

SEC source: 0001127602-24-017742 · form4.xml · derivative · entry 3

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,629

Underlying: Common Stock · 232 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F3 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-24-017742 · form4.xml · nonDerivative · entry 1

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-24-017754 · form4.xml · derivative · entry 5

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,562

Underlying: Common Stock · 651 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F4 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-24-017754 · form4.xml · nonDerivative · entry 1

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,472,428

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-24-017764 · form4.xml · derivative · entry 4

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,978

Underlying: Common Stock · 1,326 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Performance stock units convert into common stock on a one-for-one basis.

F1 · kind: Performance stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this performance stock unit award vested on May 31, 2024 upon determination of achievement of the performance criteria, with the remainder vesting in three (3) equal installments on August 27, 2024, November 27, 2024 and February 27, 2025.

F3 · derivative.expiration_date: 25% of the shares subject to this performance stock unit award vested on May 31, 2024 upon determination of achievement of the performance criteria, with the remainder vesting in three (3) equal installments on August 27, 2024, November 27, 2024 and February 27, 2025.

SEC source: 0001127602-24-017764 · form4.xml · derivative · entry 3

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,304

Underlying: Common Stock · 5,304 shares

Expires not disclosed

F1 · derivative.exercise_price: Performance stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this performance stock unit award vested on May 31, 2024 upon determination of achievement of the performance criteria, with the remainder vesting in three (3) equal installments on August 27, 2024, November 27, 2024 and February 27, 2025.

F3 · derivative.expiration_date: 25% of the shares subject to this performance stock unit award vested on May 31, 2024 upon determination of achievement of the performance criteria, with the remainder vesting in three (3) equal installments on August 27, 2024, November 27, 2024 and February 27, 2025.

SEC source: 0001127602-24-017764 · form4.xml · nonDerivative · entry 1

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,197

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Performance stock units convert into common stock on a one-for-one basis.

F1 · price: Performance stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-24-016975 · form4.xml · nonDerivative · entry 2

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,768

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-016963 · form4.xml · nonDerivative · entry 2

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,471,777

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-016987 · form4.xml · nonDerivative · entry 2

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,871

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 8

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,961,931

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F9 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $147.51 to $148.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 7

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,965,108

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $146.51 to $147.49, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 6

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,967,337

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $145.50 to $146.45, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,972,918

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $144.48 to $145.45, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,975,318

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $143.43 to $144.41, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,976,818

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $142.39 to $143.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,977,918

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $141.37 to $142.35, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-24-067560 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,980,931

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023, as amended on November 7, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $140.34 to $141.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-24-016773 · form4.xml · nonDerivative · entry 2

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,623

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-016777 · form4.xml · nonDerivative · entry 2

Mock James M · CIK 0001736359 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,726

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-24-016975 · form4.xml · derivative · entry 3

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,617

Underlying: Common Stock · 328 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on February 28, 2024 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F3 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on February 28, 2024 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-24-016975 · form4.xml · nonDerivative · entry 1

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,951

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-24-016963 · form4.xml · derivative · entry 5

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,716

Underlying: Common Stock · 610 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on February 28, 2024 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F4 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on February 28, 2024 with the remainder vesting in twelve (12) equal quarterly installments thereafter.