MRKR

SEC source: 0001768011-25-000003 · primary_doc.xml · derivative · entry 2

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,330

Underlying: Common Stock · 137,330 shares

Expires 2035-11-17

F2 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for service as a director for the year 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001768011-25-000003 · primary_doc.xml · derivative · entry 1

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,411

Underlying: Common Stock · 84,411 shares

Expires 2035-11-17

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for the remaining options due as service as a director for the year 2024. 30,000 shares were previously granted on February 12, 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001270905-25-000003 · primary_doc.xml · derivative · entry 2

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,330

Underlying: Common Stock · 137,330 shares

Expires 2035-11-17

F2 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for service as a director for the year 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001270905-25-000003 · primary_doc.xml · derivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,411

Underlying: Common Stock · 84,411 shares

Expires 2035-11-17

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for the remaining options due as service as a director for the year 2024. 30,000 shares were previously granted on February 12, 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001104659-25-114081 · tm2531774-1_4seq1.xml · derivative · entry 2

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,330

Underlying: Common Stock · 137,330 shares

Expires 2035-11-17

F2 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for service as a director for the year 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

F2 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for service as a director for the year 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001104659-25-114081 · tm2531774-1_4seq1.xml · derivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,411

Underlying: Common Stock · 84,411 shares

Expires 2035-11-17

F1 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for the remaining options due as service as a director for the year 2024. 30,000 shares were previously granted on February 12, 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan for the remaining options due as service as a director for the year 2024. 30,000 shares were previously granted on February 12, 2025. The options vest on the anniversary of the grant date. The option exercise price is the closing price on the date of the grant, November 17, 2025.

SEC source: 0001884123-25-000010 · primary_doc.xml · derivative · entry 1

Corzo Kathryn Penkus · CIK 0001884123 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,611

Underlying: Common Stock · 147,611 shares

Expires 2035-10-31

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. The shares vest equally over thirty six (36) monthly installments, subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, October 31, 2025.

SEC source: 0001755495-25-000003 · primary_doc.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2035-10-31

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One fourth of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second, third and fourth anniversary of the grant date upon the continued performance of services by the Reporting Person to the Company through the vesting dates. The option exercise price is the closing price on the date of the grant, October 31, 2025.

SEC source: 0001104659-25-014321 · tm256716-7_4seq1.xml · derivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-02-12

F1 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

SEC source: 0001104659-25-014318 · tm256716-6_4seq1.xml · derivative · entry 1

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-02-12

F1 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

SEC source: 0001104659-25-014317 · tm256716-5_4seq1.xml · derivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-02-12

F1 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date subject to the Reporting Person's continued service as a director. The option exercise price is the closing price on the date of the grant, February 12, 2025.

SEC source: 0001104659-25-014315 · tm256716-4_4seq1.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2035-02-12

F1 · shares: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date upon the continued performance of services by the Reporting Person to the Company through the vesting dates. The option exercise price is the closing price on the date of the grant, February 12, 2025.

F1 · derivative.exercise_date: Represents options granted under the Company's 2020 Omnibus Stock Ownership Plan. One third of the shares vest on the first anniversary of the grant date and the remainder of the shares subsequently vest in equal annual installments over the second and third anniversary of the grant date upon the continued performance of services by the Reporting Person to the Company through the vesting dates. The option exercise price is the closing price on the date of the grant, February 12, 2025.

SEC source: 0000950170-24-139630 · ownership.xml · nonDerivative · entry 1

New Enterprise Associates 16, L.P. · CIK 0001694560 · 10% owner

NEA Partners 16, L.P. · CIK 0001712881 · 10% owner

NEA 16 GP, LLC · CIK 0001712882 · 10% owner

BASKETT FOREST · CIK 0001277631 · 10% owner

Chang Carmen · CIK 0001746342 · 10% owner

Behbahani Ali · CIK 0001613867 · 10% owner

Florence Anthony A. Jr. · CIK 0001559827 · 10% owner

Makhzoumi Mohamad · CIK 0001630226 · 10% owner

SANDELL SCOTT D · CIK 0001237289 · 10% owner

Walker Paul Edward · CIK 0001553150 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,625,678

F1 · kind: Acquired from the Issuer on December 23, 2024 pursuant to a Securities Purchase Agreement dated December 19, 2024.

F2 · balance_after: On January 26, 2023, the Issuer effected a 1-for-10 reverse stock split of its common stock (the "Reverse Stock Split"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split.

F3 · ownership.direct: The securities are directly held by New Enterprise Associates 16, L.P. ("NEA 16"), and indirectly held by NEA Partners 16, L.P. ("NEA Partners 16"), the sole general partner of NEA 16, NEA 16 GP, LLC ("NEA 16 GP"), the sole general partner of NEA Partners 16, and the individual managers of NEA 16 GP (NEA Partners 16, NEA 16 GP and the individual managers of NEA 16 GP, together, the "Indirect Reporting Persons").The individual managers of NEA 16 GP are Forest Baskett, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad Makhzoumi, Scott D. Sandell, and Paul Walker. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares of the Issuer held by NEA 16 in which the Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001104659-24-131704 · tm2432058-1_4seq1.xml · nonDerivative · entry 2

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 325,370

F2 · shares: Acquired from the Issuer on December 23, 2024 pursuant to a Securities Purchase Agreement dated December 19, 2024.

F1 · balance_after: On January 26, 2023, the Issuer effected a 1-for-10 reverse stock split of its common stock (the "Reverse Stock Split"). The amount of securities reported on this Form 4 have been adjusted to reflect the Reverse Stock Split.

F2 · balance_after: Acquired from the Issuer on December 23, 2024 pursuant to a Securities Purchase Agreement dated December 19, 2024.

F3 · balance_after: The reportable securities are directly owned by Aisling Capital IV, LP ("Aisling"), and which may be deemed to be beneficially owned by Aisling Capital Partners IV, LP ("Aisling GP"), as general partner of Aisling, Aisling Capital Partners IV LLC ("Aisling Partners"), as general partner of Aisling GP, and each of the individual managing members and partners (collectively, the "Managers") of Aisling GP and Aisling Partners. The Managers of Aisling Partners are Dr. Andrew Schiff and Steve Elms, who have shared voting and dispositive power over the shares. Mr. Elms, the Reporting Person, disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein, and the inclusion of these securities herein shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.

F3 · ownership.nature: The reportable securities are directly owned by Aisling Capital IV, LP ("Aisling"), and which may be deemed to be beneficially owned by Aisling Capital Partners IV, LP ("Aisling GP"), as general partner of Aisling, Aisling Capital Partners IV LLC ("Aisling Partners"), as general partner of Aisling GP, and each of the individual managing members and partners (collectively, the "Managers") of Aisling GP and Aisling Partners. The Managers of Aisling Partners are Dr. Andrew Schiff and Steve Elms, who have shared voting and dispositive power over the shares. Mr. Elms, the Reporting Person, disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein, and the inclusion of these securities herein shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-23-035617 · doc4.xml · derivative · entry 5

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2033-06-05

F3 · derivative.exercise_date: This option vests on June 6, 2024, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-23-035616 · doc4.xml · derivative · entry 1

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2033-06-05

F1 · derivative.exercise_date: This option vests on June 6, 2024, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-23-035615 · doc4.xml · derivative · entry 1

Wilson John Robert · CIK 0001755569 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2033-06-05

F1 · derivative.exercise_date: This option vests on June 6, 2024, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-23-035614 · doc4.xml · derivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2033-06-05

F1 · derivative.exercise_date: This option vests on June 6, 2024, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-23-028846 · doc4.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-05-10

F1 · derivative.exercise_date: This option vests in equal annual installments on May 10, 2024, May 10, 2025, May 10, 2026 and May 10, 2027 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014157 · doc4.xml · derivative · entry 1

Szymanska Anna · CIK 0001804499 · Vice President, Quality

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,947

Underlying: Common Stock · 29,947 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014168 · doc4.xml · derivative · entry 1

Hoang Tsvetelina P · CIK 0001763023 · VP, Research and Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,159

Underlying: Common Stock · 33,159 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014165 · doc4.xml · derivative · entry 1

Koneru Mythili · CIK 0001776659 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,918

Underlying: Common Stock · 51,918 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014161 · doc4.xml · derivative · entry 1

Loiacono Michael · CIK 0001679119 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,480

Underlying: Common Stock · 38,480 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014158 · doc4.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Director · Chief Scientific Officer & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,487

Underlying: Common Stock · 46,487 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-23-014155 · doc4.xml · derivative · entry 1

Agopyan Nadia · CIK 0001784758 · SVP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,154

Underlying: Common Stock · 34,154 shares

Expires 2033-02-27

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 27, 2023 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-032180 · doc4.xml · derivative · entry 1

Wilson John Robert · CIK 0001755569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2032-05-23

F1 · derivative.exercise_date: This option vests on May 24, 2023, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-22-032175 · doc4.xml · derivative · entry 1

Laskow-Pooley David · CIK 0001638533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2032-05-23

F1 · derivative.exercise_date: This option vests on May 24, 2023, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-22-032172 · doc4.xml · derivative · entry 1

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2032-05-23

F1 · derivative.exercise_date: This option vests on May 24, 2023, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-22-032166 · doc4.xml · derivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2032-05-23

F1 · derivative.exercise_date: This option vests on May 24, 2023, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-22-032169 · doc4.xml · derivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2032-05-23

F1 · derivative.exercise_date: This option vests on May 24, 2023, subject to the Reporting Person's continued service as a director through the vesting date.

SEC source: 0001209191-22-021395 · doc4.xml · nonDerivative · entry 2

Vera Juan · CIK 0001755495 · Director · Chief Scientific Officer & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,671,845

F2 · shares: Represents shares withheld to satisfy tax obligations with respect to the vesting of the RSUs.

SEC source: 0001209191-22-021395 · doc4.xml · nonDerivative · entry 1

Vera Juan · CIK 0001755495 · Director · Chief Scientific Officer & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,705,310

F1 · shares: Represents a restricted stock unit ("RSU") award.

SEC source: 0001209191-22-021396 · doc4.xml · nonDerivative · entry 2

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 483,286

F2 · shares: Represents shares withheld to satisfy tax obligations with respect to the vesting of the RSUs.

SEC source: 0001209191-22-021396 · doc4.xml · nonDerivative · entry 1

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 531,662

F1 · shares: Represents a restricted stock unit ("RSU") award.

SEC source: 0001209191-22-021394 · doc4.xml · nonDerivative · entry 2

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,436

F2 · shares: Represents shares withheld to satisfy tax obligations with respect to the vesting of the RSUs.

SEC source: 0001209191-22-021394 · doc4.xml · nonDerivative · entry 1

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,512

F1 · shares: Represents a restricted stock unit ("RSU") award.

SEC source: 0001209191-22-011761 · doc4.xml · derivative · entry 1

Garrett Gerald · CIK 0001804510 · Vice President, Clinical Ops.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011786 · doc4.xml · derivative · entry 1

Szymanska Anna · CIK 0001804499 · Vice President, Quality

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011791 · doc4.xml · derivative · entry 1

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 430,000

Underlying: Common Stock · 430,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011787 · doc4.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Director · Chief Scientific Officer & COO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Stock · 160,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011782 · doc4.xml · derivative · entry 1

Loiacono Michael · CIK 0001679119 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011779 · doc4.xml · derivative · entry 1

Koneru Mythili · CIK 0001776659 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Stock · 160,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011776 · doc4.xml · derivative · entry 1

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Stock · 160,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011769 · doc4.xml · derivative · entry 1

Hoang Tsvetelina P · CIK 0001763023 · VP, Research and Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-22-011745 · doc4.xml · derivative · entry 1

Agopyan Nadia · CIK 0001784758 · VP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-02-17

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 17, 2022 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-068837 · doc4.xml · derivative · entry 1

Knobil Katharine · CIK 0001768011 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2031-12-07

F1 · derivative.exercise_date: This option vests in equal monthly installments over a three-year period commencing on January 8, 2022, subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-039635 · doc4.xml · nonDerivative · entry 1

Wasserman Frederick Gerald · CIK 0001384383 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,223

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2020 Equity Incentive Plan and based on the closing price of $3.16 per share, on the day immediately preceding the date of the Company's 2021 annual meeting.

SEC source: 0001209191-21-039634 · doc4.xml · nonDerivative · entry 1

Laskow-Pooley David · CIK 0001638533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,223

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2020 Equity Incentive Plan and based on the closing price of $3.16 per share, on the day immediately preceding the date of the Company's 2021 annual meeting.

SEC source: 0001209191-21-039632 · doc4.xml · nonDerivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,680

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2020 Equity Incentive Plan and based on the closing price of $3.16 per share, on the day immediately preceding the date of the Company's 2021 annual meeting.

SEC source: 0001209191-21-039631 · doc4.xml · nonDerivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,940

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2020 Equity Incentive Plan and based on the closing price of $3.16 per share, on the day immediately preceding the date of the Company's 2021 annual meeting.