MLYS

SEC source: 0001672659-26-000008 · wk-form4_1768959233.xml · derivative · entry 3

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,834

Underlying: Common Stock · 416 shares

Expires 2033-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F2 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000008 · wk-form4_1768959233.xml · nonDerivative · entry 2

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,437

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000008 · wk-form4_1768959233.xml · nonDerivative · entry 1

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,853

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · nonDerivative · entry 4

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,437

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $31.99 to $32.91. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · derivative · entry 6

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 104,167

Underlying: Common Stock · 4,167 shares

Expires 2034-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F4 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · derivative · entry 5

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 131,042

Underlying: Common Stock · 3,542 shares

Expires 2035-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F3 · derivative.exercise_date: The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following the date of grant.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · nonDerivative · entry 3

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,804

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · nonDerivative · entry 2

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,513

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000006 · wk-form4_1768522053.xml · nonDerivative · entry 1

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 65,346

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001693134-26-000002 · wk-form4_1768355015.xml · nonDerivative · entry 1

Levy Adam Scott · CIK 0001693134 · CFO and Secretary

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,638

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 14, 2023.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $31.90 to $32.37. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · derivative · entry 6

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 38,092

Underlying: Common Stock · 6,348 shares

Expires 2032-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F3 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · nonDerivative · entry 4

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,804

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $32.01 to $32.93. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · nonDerivative · entry 3

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,152

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001644975-26-000002 · wk-form4_1768355020.xml · nonDerivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 639,151

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on January 28, 2025.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $32.8439 to $33.5000. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0001644975-26-000002 · wk-form4_1768355020.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 646,268

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on January 28, 2025.

F2 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $31.8400 to $32.8028. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · derivative · entry 5

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,218

Underlying: Common Stock · 2,170 shares

Expires 2033-02-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F3 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · nonDerivative · entry 2

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,804

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000004 · wk-form4_1768355008.xml · nonDerivative · entry 1

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,974

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 23

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,334

Underlying: Common Stock · 67,473 shares

Expires 2034-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 22

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,388

Underlying: Common Stock · 53,630 shares

Expires 2033-02-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 21

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 134,584

Underlying: Common Stock · 26,069 shares

Expires 2035-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F7 · derivative.exercise_date: The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following the date of grant.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 20

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,250

Underlying: Common Stock · 10,121 shares

Expires 2033-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 19

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,440

Underlying: Common Stock · 28,038 shares

Expires 2032-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 13

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,804

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F5 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $35.2100 to $35.7700. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 12

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,274

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F4 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $34.2100 to $35.2021. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 11

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 254,519

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 10

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 187,046

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 9

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 133,416

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 8

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 107,347

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 7

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,226

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 18

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 175,807

Underlying: Common Stock · 24,193 shares

Expires 2034-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 17

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,018

Underlying: Common Stock · 20,168 shares

Expires 2033-02-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 16

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 160,653

Underlying: Common Stock · 9,347 shares

Expires 2035-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F7 · derivative.exercise_date: The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following the date of grant.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 15

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,371

Underlying: Common Stock · 3,629 shares

Expires 2033-03-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · derivative · entry 14

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,478

Underlying: Common Stock · 10,053 shares

Expires 2032-07-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F6 · derivative.exercise_date: The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 6

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 69,188

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F3 · price: The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $35.6550 to $36.4522. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 5

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 139,225

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 4

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,032

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 3

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 94,864

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 2

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,517

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

SEC source: 0001672659-26-000002 · wk-form4_1767745246.xml · nonDerivative · entry 1

Rodman David Malcom · CIK 0001672659 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 81,888

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025.

F2 · balance_after: This balance includes 680 shares purchased under the Mineralys Therapeutics, Inc. 2023 Employee Stock Purchase Plan that were not previously reported.

SEC source: 0001644975-25-000006 · wk-form4_1764022035.xml · derivative · entry 2

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 24,082 shares

Expires 2031-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Due to a rounding error, the exercise price for this stock option was originally reported as $0.53 per share on the Reporting Person's Form 3 filed on February 9, 2023.

F2 · derivative.exercise_date: The stock option vested with respect to 25% of the underlying shares on March 12, 2022 and the remaining shares in 36 substantially equal monthly installments thereafter.

SEC source: 0001644975-25-000006 · wk-form4_1764022035.xml · nonDerivative · entry 1

Congleton Jon · CIK 0001644975 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 655,387

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001933414-25-000156 · wk-form4_1763766476.xml · nonDerivative · entry 1

Slingsby Brian Taylor · CIK 0001963901 · Director · 10% owner

Catalys Pacific Fund, LP · CIK 0001746274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 7,903,838

F1 · ownership.nature: Represents securities held directly by Catalys Pacific Fund, LP. The general partner of Catalys Pacific Fund, LP is Catalys Pacific Fund GP, LP. Brian Taylor Slingsby is the managing partner of Catalys Pacific, LLC, which is the general partner of Catalys Pacific Fund GP, LP. Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby may be deemed to have voting and investment power over the shares held of record by Catalys Pacific Fund, LP. Each of Catalys Pacific, LLC, Catalys Pacific Fund GP, LP and Brian Taylor Slingsby disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001933414-25-000149 · wk-form4_1763078474.xml · derivative · entry 13

Gold Alexander M · CIK 0002026429 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,000

Underlying: Common Stock · 10,000 shares

Expires 2034-06-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option vests in 36 monthly installments beginning on July 13, 2024.

SEC source: 0001933414-25-000149 · wk-form4_1763078474.xml · derivative · entry 12

Gold Alexander M · CIK 0002026429 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,225

Underlying: Common Stock · 2,742 shares

Expires 2035-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option vests in 12 monthly installments following the date of grant.

SEC source: 0001933414-25-000149 · wk-form4_1763078474.xml · nonDerivative · entry 9

Gold Alexander M · CIK 0002026429 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001933414-25-000149 · wk-form4_1763078474.xml · nonDerivative · entry 8

Gold Alexander M · CIK 0002026429 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,742

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001933414-25-000149 · wk-form4_1763078474.xml · nonDerivative · entry 7

Gold Alexander M · CIK 0002026429 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,742

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001933414-25-000150 · wk-form4_1763078481.xml · derivative · entry 4

Karydas Daphne · CIK 0001816952 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,900

Underlying: Common Stock · 15,000 shares

Expires 2035-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option vests in 12 monthly installments following the date of grant.