MIRM

SEC source: 0001415889-24-013354 · form4-05162024_040526.xml · nonDerivative · entry 1

Vig Pamela · CIK 0001780069 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,406

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 94 shares by the Reporting Person on May 10, 2024 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001415889-24-013355 · form4-05162024_040530.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,770

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 817 shares by the Reporting Person on May 10, 2024 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001415889-24-013356 · form4-05162024_040533.xml · nonDerivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,470

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 470 shares by the Reporting Person on May 10, 2024 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001415889-24-009280 · form4-03282024_120312.xml · nonDerivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,000

SEC source: 0001415889-24-009046 · form4-03252024_090335.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,013

F1 · price: The weighted average sale price for the transaction reported was $25.80, and the range of prices were between $25.80 and $25.825. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001415889-24-008311 · form4-03182024_090313.xml · nonDerivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,000

SEC source: 0001415889-24-002412 · form4-02032024_020214.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,759

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-002757 · form4-02062024_020209.xml · nonDerivative · entry 1

Vig Pamela · CIK 0001780069 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,691

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-002756 · form4-02062024_020236.xml · nonDerivative · entry 1

Longpre Lara · CIK 0001780347 · CHIEF DEVELOPMENT OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,407

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-002755 · form4-02062024_020222.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,695

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-002754 · form4-02062024_020203.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,112

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-002412 · form4-02032024_020214.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,543

Underlying: Common Stock · 1,772 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F3 · derivative.exercise_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 31, 2024. 1,772 shares vested on January 31, 2024 ; 1,772 shares will vest January 31, 2025 and the remaining 1,771 shares will vest on January 31, 2026.

F3 · derivative.expiration_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 31, 2024. 1,772 shares vested on January 31, 2024 ; 1,772 shares will vest January 31, 2025 and the remaining 1,771 shares will vest on January 31, 2026.

SEC source: 0001415889-24-002412 · form4-02032024_020214.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,494

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001415889-24-001827 · form4-01252024_070108.xml · derivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,500

Underlying: Common Stock · 4,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001827 · form4-01252024_070108.xml · derivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 18,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001826 · form4-01252024_070108.xml · derivative · entry 2

Vig Pamela · CIK 0001780069 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001826 · form4-01252024_070108.xml · derivative · entry 1

Vig Pamela · CIK 0001780069 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001825 · form4-01252024_070106.xml · derivative · entry 2

Longpre Lara · CIK 0001780347 · CHIEF DEVELOPMENT OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001825 · form4-01252024_070106.xml · derivative · entry 1

Longpre Lara · CIK 0001780347 · CHIEF DEVELOPMENT OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001824 · form4-01252024_070104.xml · derivative · entry 2

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001824 · form4-01252024_070104.xml · derivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001823 · form4-01252024_070101.xml · derivative · entry 2

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,250

Underlying: Common Stock · 17,250 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001823 · form4-01252024_070101.xml · derivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001822 · form4-01252024_070102.xml · derivative · entry 2

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001822 · form4-01252024_070102.xml · derivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2034-01-22

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 23, 2024 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001561 · form4-01192024_120106.xml · derivative · entry 2

Quan Joanne · CIK 0001670138 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 16, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 16, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-001561 · form4-01192024_120106.xml · derivative · entry 1

Quan Joanne · CIK 0001670138 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2034-01-15

F1 · derivative.exercise_date: 1/4th of the shares subject to the option will vest one year after January 16, 2024 (the "Vesting Commencement Date") and the balance of the shares will vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-24-000880 · form4-01102024_010137.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 722

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-000882 · form4-01102024_010110.xml · nonDerivative · entry 1

Vig Pamela · CIK 0001780069 · HEAD OF RESEARCH & DEVELOPMENT

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,905

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-000884 · form4-01102024_010106.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · CHIEF OPERATING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,485

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-000883 · form4-01102024_010122.xml · nonDerivative · entry 1

Longpre Lara · CIK 0001780347 · CHIEF DEVELOPMENT OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,254

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-000881 · form4-01102024_010133.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · PRESIDENT AND CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,125

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-24-000880 · form4-01102024_010137.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,250

Underlying: Common Stock · 1,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F3 · derivative.exercise_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 6, 2023. 1,250 shares vested on each of January 6, 2023 and January 6, 2024 and the remaining 1,250 shares will vest on January 6, 2025.

F3 · derivative.expiration_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 6, 2023. 1,250 shares vested on each of January 6, 2023 and January 6, 2024 and the remaining 1,250 shares will vest on January 6, 2025.

SEC source: 0001415889-24-000880 · form4-01102024_010137.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001209191-23-057650 · doc4.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, Global Controller

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,400

Underlying: Common Stock · 2,500 shares

Expires 2029-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/4th of the 62,500 shares originally subject to the option vested one year after February 28, 2019, and the balance of the shares vest in a series of 36 successive equal monthly installments at the end of each month thereafter.

SEC source: 0001209191-23-057650 · doc4.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, Global Controller

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001209191-23-057650 · doc4.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, Global Controller

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-055436 · doc4.xml · nonDerivative · entry 1

Vig Pamela · CIK 0001780069 · Head of Research & Development

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,313

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 527 shares by the Reporting Person on November 10, 2023 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-23-055434 · doc4.xml · nonDerivative · entry 1

Longpre Lara · CIK 0001780347 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,273

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 434 shares by the Reporting Person on November 10, 2023 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-23-055433 · doc4.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,893

F1 · kind: This Form 4 is being filed voluntarily to report the acquisition of 218 shares by the Reporting Person on November 10, 2023 pursuant to the Issuer's Employee Stock Purchase Plan.

SEC source: 0001209191-23-055180 · doc4.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 161,963

F1 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person and James N. Topper are the managing members of FHMLS X, L.L.C. and share voting and dispositive power over the shares held by Frazier Life Sciences X, L.P. The Reporting Person disclaims beneficial ownership of the shares, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-049511 · doc4.xml · derivative · entry 8

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 331,176

Underlying: Common Stock · 14,216 shares

Expires 2029-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/4th of the shares vest one year after November 5, 2018, and the balance of the shares vest in a series of 36 successive equal monthly installments at the end of each month thereafter. The shares subject to this option are early exercisable, subject to the Issuer's right of repurchase.

SEC source: 0001209191-23-049511 · doc4.xml · nonDerivative · entry 4

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Reported transaction occurred pursuant to a Rule 10b5-1 Plan adopted August 30, 2022.

SEC source: 0001209191-23-049511 · doc4.xml · nonDerivative · entry 3

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,216

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-049511 · doc4.xml · derivative · entry 7

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 345,392

Underlying: Common Stock · 392 shares

Expires 2029-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 1/4th of the shares vest one year after November 5, 2018, and the balance of the shares vest in a series of 36 successive equal monthly installments at the end of each month thereafter. The shares subject to this option are early exercisable, subject to the Issuer's right of repurchase.

SEC source: 0001209191-23-049511 · doc4.xml · nonDerivative · entry 2

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Reported transaction occurred pursuant to a Rule 10b5-1 Plan adopted August 30, 2022.

SEC source: 0001209191-23-049511 · doc4.xml · nonDerivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 392

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-049614 · doc4.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 159,053

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $30.9633 to $31.0499, inclusive. The Reporting Person undertakes to provide to Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in footnote (1) to this Form 4.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person and James N. Topper are the managing members of FHMLS X, L.L.C. and share voting and dispositive power over the shares held by Frazier Life Sciences X, L.P. The Reporting Person disclaims beneficial ownership of the shares, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-049292 · doc4.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 156,428

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $30.2781 to $30.7970, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person and James N. Topper are the managing members of FHMLS X, L.L.C. and share voting and dispositive power over the shares held by Frazier Life Sciences X, L.P. The Reporting Person disclaims beneficial ownership of the shares, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-049133 · doc4.xml · derivative · entry 3

BJERKHOLT ERIC · CIK 0001197350 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires not disclosed

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: The restricted stock units vest in a series of three successive equal annual installments beginning on the one year anniversary of September 11, 2023.

F4 · derivative.expiration_date: The restricted stock units vest in a series of three successive equal annual installments beginning on the one year anniversary of September 11, 2023.