Last 12 months
Inside the activity.
0 purchase rows · 9 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 0 |
| Dec 2025 | 0 | 0 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 0 |
| Mar 2026 | 0 | 1 |
| Apr 2026 | 0 | 2 |
| May 2026 | 0 | 1 |
| Jun 2026 | 0 | 0 |
| Jul 2026 | 0 | 3 |
| Aug 2026 | 0 | 1 |
| Sep 2026 | 0 | 0 |
| Oct 2026 | 0 | 1 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| January 17, 2026 Filed Jan 22, 2026 02:25 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Exercise / conversionRestricted Share Units · Derivative | 35,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001745347-26-000004 · form4-01222026_020138.xml · derivative · entry 3 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 35,000 Underlying: Ordinary Shares · 35,000 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. F1 · derivative.expiration_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:25 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Tax withholdingOrdinary Shares | 13,951 | $7.42 | $103,516.42 |
DisclosureSEC source: 0001745347-26-000004 · form4-01222026_020138.xml · nonDerivative · entry 2 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 168,340 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:25 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Exercise / conversionOrdinary Shares | 35,000 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001745347-26-000004 · form4-01222026_020138.xml · nonDerivative · entry 1 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 182,291 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-half of restricted share units granted on January 17, 2024. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:13 UTC |
Giroux RichardCFO & COO
|
Exercise / conversionRestricted Share Units · Derivative | 310,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001742734-26-000004 · form4-01222026_020136.xml · derivative · entry 5 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 310,000 Underlying: Ordinary Shares · 310,000 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. F1 · derivative.expiration_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:13 UTC |
Giroux RichardCFO & COO
|
Tax withholdingOrdinary Shares | 163,916 | $7.42 | $1,216,256.72 |
DisclosureSEC source: 0001742734-26-000004 · form4-01222026_020136.xml · nonDerivative · entry 2 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 999,256 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:13 UTC |
Giroux RichardCFO & COO
|
Exercise / conversionOrdinary Shares | 310,000 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001742734-26-000004 · form4-01222026_020136.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,163,172 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-half of restricted share units granted on January 17, 2024. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:15 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Exercise / conversionRestricted Share Units · Derivative | 75,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001742771-26-000004 · form4-01222026_020126.xml · derivative · entry 3 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 75,000 Underlying: Ordinary Shares · 75,000 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. F1 · derivative.expiration_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:15 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Tax withholdingOrdinary Shares | 35,250 | $7.42 | $261,555.00 |
DisclosureSEC source: 0001742771-26-000004 · form4-01222026_020126.xml · nonDerivative · entry 2 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 682,916 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:15 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Exercise / conversionOrdinary Shares | 75,000 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001742771-26-000004 · form4-01222026_020126.xml · nonDerivative · entry 1 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 718,166 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-half of restricted share units granted on January 17, 2024. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:10 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Exercise / conversionRestricted Share Units · Derivative | 310,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001678604-26-000004 · form4-01222026_020148.xml · derivative · entry 3 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 310,000 Underlying: Ordinary Shares · 310,000 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. F1 · derivative.expiration_date: Represents vesting of one-half of restricted share units granted on January 17, 2024. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:10 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Tax withholdingOrdinary Shares | 163,916 | $7.42 | $1,216,256.72 |
DisclosureSEC source: 0001678604-26-000004 · form4-01222026_020148.xml · nonDerivative · entry 2 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,482,243 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 17, 2026 Filed Jan 22, 2026 02:10 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Exercise / conversionOrdinary Shares | 310,000 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001678604-26-000004 · form4-01222026_020148.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,646,159 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-half of restricted share units granted on January 17, 2024. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:01 UTC |
Wollin Robert JGENERAL COUNSEL AND SECRETARY
|
Exercise / conversionRestricted Share Units · Derivative | 7,500 | $0.00 | $0.00 |
DisclosureSEC source: 0001815161-26-000002 · form4-01092026_020151.xml · derivative · entry 3 Wollin Robert J · CIK 0001815161 · GENERAL COUNSEL AND SECRETARY 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 7,500 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F1 · derivative.expiration_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:01 UTC |
Wollin Robert JGENERAL COUNSEL AND SECRETARY
|
Tax withholdingOrdinary Shares | 4,364 | $7.73 | $33,733.72 |
DisclosureSEC source: 0001815161-26-000002 · form4-01092026_020151.xml · nonDerivative · entry 2 Wollin Robert J · CIK 0001815161 · GENERAL COUNSEL AND SECRETARY 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 29,282 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:01 UTC |
Wollin Robert JGENERAL COUNSEL AND SECRETARY
|
Exercise / conversionOrdinary Shares | 7,500 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001815161-26-000002 · form4-01092026_020151.xml · nonDerivative · entry 1 Wollin Robert J · CIK 0001815161 · GENERAL COUNSEL AND SECRETARY 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 33,646 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:03 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Exercise / conversionRestricted Share Units · Derivative | 17,500 | $0.00 | $0.00 |
DisclosureSEC source: 0001745347-26-000002 · form4-01092026_020105.xml · derivative · entry 3 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 17,500 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F1 · derivative.expiration_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:03 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Tax withholdingOrdinary Shares | 6,729 | $7.73 | $52,015.17 |
DisclosureSEC source: 0001745347-26-000002 · form4-01092026_020105.xml · nonDerivative · entry 2 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 147,291 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:03 UTC |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Exercise / conversionOrdinary Shares | 17,500 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001745347-26-000002 · form4-01092026_020105.xml · nonDerivative · entry 1 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 154,020 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:00 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Exercise / conversionRestricted Share Units · Derivative | 37,500 | $0.00 | $0.00 |
DisclosureSEC source: 0001742771-26-000002 · form4-01092026_020126.xml · derivative · entry 3 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 37,500 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F1 · derivative.expiration_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:00 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Tax withholdingOrdinary Shares | 17,625 | $7.73 | $136,241.25 |
DisclosureSEC source: 0001742771-26-000002 · form4-01092026_020126.xml · nonDerivative · entry 2 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 643,166 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 02:00 UTC |
Naylor StuartCHIEF DEV. OFFICER
|
Exercise / conversionOrdinary Shares | 37,500 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001742771-26-000002 · form4-01092026_020126.xml · nonDerivative · entry 1 Naylor Stuart · CIK 0001742771 · CHIEF DEV. OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 660,791 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:58 UTC |
Giroux RichardCFO & COO
|
Exercise / conversionRestricted Share Units · Derivative | 52,500 | $0.00 | $0.00 |
DisclosureSEC source: 0001742734-26-000002 · form4-01092026_010135.xml · derivative · entry 3 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 52,500 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F1 · derivative.expiration_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:58 UTC |
Giroux RichardCFO & COO
|
Tax withholdingOrdinary Shares | 28,822 | $7.73 | $222,794.06 |
DisclosureSEC source: 0001742734-26-000002 · form4-01092026_010135.xml · nonDerivative · entry 2 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 853,172 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:58 UTC |
Giroux RichardCFO & COO
|
Exercise / conversionOrdinary Shares | 52,500 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001742734-26-000002 · form4-01092026_010135.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 881,994 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:56 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Exercise / conversionRestricted Share Units · Derivative | 62,500 | $0.00 | $0.00 |
DisclosureSEC source: 0001678604-26-000002 · form4-01092026_010134.xml · derivative · entry 3 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 62,500 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F1 · derivative.exercise_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F1 · derivative.expiration_date: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:56 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Tax withholdingOrdinary Shares | 34,074 | $7.73 | $263,392.02 |
DisclosureSEC source: 0001678604-26-000002 · form4-01092026_010134.xml · nonDerivative · entry 2 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,336,159 F3 · shares: Shares withheld for payment of taxes upon vesting of award. Read SEC document |
| January 07, 2026 Filed Jan 9, 2026 01:56 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
Exercise / conversionOrdinary Shares | 62,500 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001678604-26-000002 · form4-01092026_010134.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,370,233 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · shares: Represents vesting of one-quarter of restricted share units granted on January 7, 2022. F2 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| January 07, 2026 Filed Apr 29, 2026 01:04 UTC Amendment |
Zeldin Robert KCHIEF MEDICAL OFFICER
|
Tax withholdingOrdinary Shares | 7,814 | $7.73 | $60,402.22 |
DisclosureSEC source: 0001745347-26-000008 · form4a-04292026_010445.xml · nonDerivative · entry 1 Zeldin Robert K · CIK 0001745347 · CHIEF MEDICAL OFFICER 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 146,204 F1 · shares: Shares withheld for payment of taxes upon vesting of award. F2 · shares: Due to an administrative error, this Form 4 is being amended to reflect the correct number of shares withheld for payment of taxes upon vesting of award as well as the number of securities beneficially owned following the reported transaction. F2 · balance_after: Due to an administrative error, this Form 4 is being amended to reflect the correct number of shares withheld for payment of taxes upon vesting of award as well as the number of securities beneficially owned following the reported transaction. F3 · balance_after: Amount of securities beneficially owned has also been adjusted down by two shares due to rounding errors on two prior reports. Read SEC document |
| December 31, 2025 Filed Jan 2, 2026 21:15 UTC |
PERCEPTIVE ADVISORS LLCDirector · 10% owner
EDELMAN JOSEPHDirector · 10% owner
PERCEPTIVE LIFE SCIENCES MASTER FUND LTDDirector · 10% owner
|
Disposition to issuerOrdinary Shares | 2,300,000 | $7.91 | $18,193,000.00 |
DisclosureSEC source: 0001193125-26-000939 · ownership.xml · nonDerivative · entry 1 PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · See Footnote Disclosed balance after: 10,231,103 F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. Read SEC document |
| December 23, 2025 Filed Dec 24, 2025 01:58 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
GiftOrdinary Shares | 6,250 | $0.00 | $0.00 |
DisclosureSEC source: 0001678604-25-000010 · form4-12242025_011215.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 1,307,733 Read SEC document |
| November 20, 2025 Filed Nov 25, 2025 01:54 UTC |
Wollin Robert JGENERAL COUNSEL AND SECRETARY
|
GiftOrdinary Shares | 5,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001815161-25-000005 · form4-11252025_011112.xml · nonDerivative · entry 1 Wollin Robert J · CIK 0001815161 · GENERAL COUNSEL AND SECRETARY 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 26,146 Read SEC document |
| October 21, 2025 Filed Oct 22, 2025 01:19 UTC |
Giroux RichardCFO & COO
|
SaleOrdinary Shares | 24,000 | $8.87 | $212,880.00 |
DisclosureSEC source: 0001742734-25-000008 · form4-10222025_011032.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 829,494 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 29, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $8.65 to $9.06, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Read SEC document |
| October 07, 2025 Filed Oct 8, 2025 01:49 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
SaleOrdinary Shares | 47,500 | $8.39 | $398,525.00 |
DisclosureSEC source: 0001678604-25-000008 · form4-10082025_011031.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,313,983 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 21, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $8.23 to $8.53, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Read SEC document |
| July 22, 2025 Filed Jul 23, 2025 01:01 UTC |
Giroux RichardCFO & COO
|
SaleOrdinary Shares | 24,000 | $8.52 | $204,480.00 |
DisclosureSEC source: 0001415889-25-020154 · form4-07232025_010731.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 853,494 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 29, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $8.38 to $8.61, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Read SEC document |
| July 08, 2025 Filed Jul 9, 2025 00:57 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
SaleOrdinary Shares | 47,500 | $7.97 | $378,575.00 |
DisclosureSEC source: 0001415889-25-019555 · form4-07092025_120706.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,361,483 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 21, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $7.73 to $8.15, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Read SEC document |
| June 30, 2025 Filed Jul 3, 2025 01:09 UTC |
Giroux RichardCFO & COO
|
GiftOrdinary Shares | 5,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-019186 · form4-07032025_010716.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 877,494 Read SEC document |
| June 12, 2025 Filed Jun 16, 2025 20:31 UTC |
PERCEPTIVE ADVISORS LLCDirector · 10% owner
PERCEPTIVE LIFE SCIENCES MASTER FUND LTDDirector · 10% owner
EDELMAN JOSEPHDirector · 10% owner
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001062993-25-011743 · form4.xml · derivative · entry 1 PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: No plan indicated Ownership: Indirect · See Footnote Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share of the Issuer upon settlement. The restricted share units become settleable when Ellen Hukkelhoven ("Ms. Hukkelhoven") ceases to be a director of the Issuer. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F3 · ownership.nature: Ms. Hukkelhoven is a Managing Director of Perceptive Advisors, LLC (the "Advisor"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman ("Mr. Edelman") is the managing member of the Advisor. Each of Mr. Edelman, the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:15 UTC |
Yu DebraDirector
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017459 · form4-06172025_010602.xml · derivative · entry 1 Yu Debra · CIK 0001869480 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:10 UTC |
Mendoza NeilDirector
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017456 · form4-06172025_010632.xml · derivative · entry 1 Mendoza Neil · CIK 0001742502 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:12 UTC |
Seligman NicoleDirector
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017457 · form4-06172025_010612.xml · derivative · entry 1 Seligman Nicole · CIK 0001683100 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:13 UTC |
SHENK THOMAS EDirector
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017458 · form4-06172025_010651.xml · derivative · entry 1 SHENK THOMAS E · CIK 0001204362 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:09 UTC |
Hukkelhoven EllenDirector
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017455 · form4-06172025_010635.xml · derivative · entry 1 Hukkelhoven Ellen · CIK 0001743337 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. The reporting person elected to have the restricted share units become settleable when the reporting person ceases to be a director. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 01:09 UTC Amendment |
Harris Keith R.Director
|
GrantRestricted Share Units · Derivative | 75,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017454 · form4a-06172025_010605.xml · derivative · entry 1 Harris Keith R. · CIK 0001742703 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 75,000 Underlying: Ordinary Shares · 75,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. F2 · shares: Due to an administrative error, this Form 4 is being amended to reflect the correct number of restricted share units granted. F3 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F3 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.underlying_shares: Due to an administrative error, this Form 4 is being amended to reflect the correct number of restricted share units granted. F2 · balance_after: Due to an administrative error, this Form 4 is being amended to reflect the correct number of restricted share units granted. Read SEC document |
| June 12, 2025 Filed Jun 17, 2025 00:51 UTC |
Harris Keith R.Director
|
GrantRestricted Share Units · Derivative | 45,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-017451 · form4-06172025_120617.xml · derivative · entry 1 Harris Keith R. · CIK 0001742703 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 45,000 Underlying: Ordinary Shares · 45,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon settlement. F2 · derivative.exercise_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. F2 · derivative.expiration_date: The restricted share units shall vest in a single annual installment upon the earlier of (i) June 12, 2026 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2026. Read SEC document |
| June 06, 2025 Filed Jun 10, 2025 00:57 UTC |
Harris Keith R.Director
|
Exercise / conversionRestricted Share Units · Derivative | 75,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-016391 · form4-06102025_120626.xml · derivative · entry 2 Harris Keith R. · CIK 0001742703 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 0 Underlying: Ordinary Shares · 75,000 shares Expires not disclosed Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F2 · derivative.exercise_date: The restricted share units vest in a single annual installment upon the earlier of (i) June 6, 2025 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2025. F2 · derivative.expiration_date: The restricted share units vest in a single annual installment upon the earlier of (i) June 6, 2025 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2025. Read SEC document |
| June 06, 2025 Filed Jun 10, 2025 00:57 UTC |
Harris Keith R.Director
|
Exercise / conversionOrdinary Shares | 75,000 | Not disclosed | Not disclosed |
DisclosureSEC source: 0001415889-25-016391 · form4-06102025_120626.xml · nonDerivative · entry 1 Harris Keith R. · CIK 0001742703 · Director 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 125,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · price: Each restricted share unit converts into one ordinary share upon vesting. Read SEC document |
| April 22, 2025 Filed Apr 23, 2025 00:54 UTC |
Giroux RichardCFO & COO
|
SaleOrdinary Shares | 24,000 | $6.00 | $144,000.00 |
DisclosureSEC source: 0001415889-25-011189 · form4-04232025_120424.xml · nonDerivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 882,494 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 29, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $5.795 to $6.23, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. F4 · balance_after: Amount of securities beneficially owned has been adjusted down by one share due to a rounding error on a prior report. Read SEC document |
| April 08, 2025 Filed Apr 9, 2025 01:05 UTC |
Forbes AlexandriaDirector · PRESIDENT & CEO
|
SaleOrdinary Shares | 47,500 | $5.34 | $253,650.00 |
DisclosureSEC source: 0001415889-25-010444 · form4-04092025_010454.xml · nonDerivative · entry 1 Forbes Alexandria · CIK 0001678604 · Director · PRESIDENT & CEO 10b5-1 filing: Plan reported Ownership: Direct Disclosed balance after: 1,408,983 F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 21, 2024. F2 · price: The price reported reflects the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $5.10 to $5.92, inclusive. F3 · price: The reporting person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price. Read SEC document |
| April 03, 2025 Filed Apr 8, 2025 01:02 UTC |
Wollin Robert JGENERAL COUNSEL AND SECRETARY
|
GrantRestricted Share Units · Derivative | 100,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-010319 · form4-04082025_010453.xml · derivative · entry 1 Wollin Robert J · CIK 0001815161 · GENERAL COUNSEL AND SECRETARY 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 100,000 Underlying: Ordinary Shares · 100,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F2 · derivative.exercise_date: Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date. F2 · derivative.expiration_date: Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date. Read SEC document |
| April 03, 2025 Filed Apr 8, 2025 01:05 UTC |
Giroux RichardCFO & COO
|
GrantRestricted Share Units · Derivative | 950,000 | $0.00 | $0.00 |
DisclosureSEC source: 0001415889-25-010322 · form4-04082025_010428.xml · derivative · entry 1 Giroux Richard · CIK 0001742734 · CFO & COO 10b5-1 filing: No plan indicated Ownership: Direct Disclosed balance after: 950,000 Underlying: Ordinary Shares · 950,000 shares Expires not disclosed F1 · derivative.exercise_price: Each restricted share unit converts into one ordinary share upon vesting. F2 · derivative.exercise_date: Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date. F2 · derivative.expiration_date: Fifty percent of the restricted share unit award will vest on the second anniversary of the grant date and twenty-five percent of the restricted share unit award will vest on each of the third and fourth anniversaries of the grant date. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.