MDGL

SEC source: 0000899243-22-039463 · doc4.xml · nonDerivative · entry 1

Sukhija Remy · CIK 0001806949 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: All transactions reported herein were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. After giving effect to these transactions, the reporting person's Rule 10b5-1 trading plan has been concluded and no more trading will be conducted thereunder.

SEC source: 0000899243-22-028491 · doc4.xml · derivative · entry 1

Lynch Brian Joseph · CIK 0001776196 · SVP and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2032-08-10

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (08/10/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-023232 · doc4.xml · derivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-023234 · doc4.xml · derivative · entry 1

BATE KENNETH · CIK 0001210238 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-023233 · doc4.xml · derivative · entry 1

MILLIGAN DAVID V · CIK 0001222252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-023231 · doc4.xml · derivative · entry 1

Levy Richard S · CIK 0001454983 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-023230 · doc4.xml · derivative · entry 1

Daly James M · CIK 0001560782 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-023229 · doc4.xml · derivative · entry 1

Gollust Keith R · CIK 0001325712 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,470

Underlying: Common Stock · 9,470 shares

Expires 2025-06-16

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-22-007774 · doc4.xml · derivative · entry 1

Waltermire Robert E. · CIK 0001876996 · Senior VP, Chief Pharma Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,250

Underlying: Common Stock · 12,250 shares

Expires 2022-02-24

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/24/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-007779 · doc4.xml · derivative · entry 1

Howarth Alex G. · CIK 0001795798 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2032-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-007776 · doc4.xml · derivative · entry 1

Lynch Brian Joseph · CIK 0001776196 · SVP and General Councel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2032-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-007775 · doc4.xml · derivative · entry 1

Sukhija Remy · CIK 0001806949 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2032-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-007769 · doc4.xml · derivative · entry 1

Taub Rebecca · CIK 0001423898 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,500

Underlying: Common Stock · 61,500 shares

Expires 2032-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-007766 · doc4.xml · derivative · entry 1

FRIEDMAN PAUL A · CIK 0001236927 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2032-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2023) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-22-004133 · doc5.xml · nonDerivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 361,358

F1 · kind: Represents a bona fide gift of 3,000 shares of common stock from Dr. Craves to the Fred Craves Family Foundation.

SEC source: 0000899243-21-047115 · doc4.xml · nonDerivative · entry 3

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,261

F7 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F4 · ownership.nature: These securities are held by BCC. Dr. Craves disclaims beneficial ownership of these securities held by BCC, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-21-047115 · doc4.xml · nonDerivative · entry 2

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

F7 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F7 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F3 · ownership.nature: These securities were held by Co-Investment IV. Dr. Craves disclaims beneficial ownership of these securities previously held by Co-Investment IV, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-21-047115 · doc4.xml · nonDerivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,510,521

F7 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: These securities are held by Fund IV. Dr. Craves disclaims beneficial ownership of these securities held by Fund IV, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-21-047117 · doc4.xml · nonDerivative · entry 3

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,261

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.direct: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-21-047117 · doc4.xml · nonDerivative · entry 2

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F3 · ownership.nature: The securities were held by Co-Investment IV.

SEC source: 0000899243-21-047117 · doc4.xml · nonDerivative · entry 1

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,510,521

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: The securities are held by Fund IV.

SEC source: 0000899243-21-042719 · doc4.xml · derivative · entry 1

Howarth Alex G. · CIK 0001795798 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2031-11-01

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (11/1/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date. This option was granted under our 2015 stock plan at a regularly scheduled meeting of the Compensation Committee of our Board of Directors on November 1, 2021.

SEC source: 0000899243-21-031720 · doc4.xml · derivative · entry 1

Waltermire Robert E. · CIK 0001876996 · Senior VP, Chief Pharma Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2031-08-02

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (08/02/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-024668 · doc4.xml · derivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-024669 · doc4.xml · derivative · entry 1

Daly James M · CIK 0001560782 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-024666 · doc4.xml · derivative · entry 1

MILLIGAN DAVID V · CIK 0001222252 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-024665 · doc4.xml · derivative · entry 1

BATE KENNETH · CIK 0001210238 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-024663 · doc4.xml · derivative · entry 1

Gollust Keith R · CIK 0001325712 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-024664 · doc4.xml · derivative · entry 1

Levy Richard S · CIK 0001454983 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,489

Underlying: Common Stock · 12,489 shares

Expires 2024-06-17

F1 · derivative.exercise_date: The option vests as to 100% of underlying shares on the first anniversary of the grant date, provided that the Reporting Person continues to serve as a director of the Issuer until such anniversary date.

SEC source: 0000899243-21-019909 · doc4.xml · derivative · entry 1

Howarth Alex G. · CIK 0001795798 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2031-05-17

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (05/17/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-007765 · doc4.xml · derivative · entry 1

FRIEDMAN PAUL A · CIK 0001236927 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2031-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-007763 · doc4.xml · derivative · entry 1

Schneebaum Marc R · CIK 0001396871 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2031-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-007761 · doc4.xml · derivative · entry 1

Sukhija Remy · CIK 0001806949 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2031-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-007759 · doc4.xml · derivative · entry 1

Lynch Brian Joseph · CIK 0001776196 · SVP and General Councel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2031-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-007758 · doc4.xml · derivative · entry 1

Taub Rebecca · CIK 0001423898 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,000

Underlying: Common Stock · 44,000 shares

Expires 2031-02-22

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (02/22/2022) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.

SEC source: 0000899243-21-005912 · doc5.xml · nonDerivative · entry 2

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 317,579

F3 · kind: Represents a bona fide gift of 15,000 shares of common stock from Dr. Craves to the Fred Craves Family Foundation.

F4 · balance_after: Reflects a transfer of 43,537 shares of common stock from BCC to Dr. Craves and a transfer of 80,974 shares of common stock from Dr. Craves to a former spouse pursuant to a court approved divorce settlement agreement.

F3 · ownership.direct: Represents a bona fide gift of 15,000 shares of common stock from Dr. Craves to the Fred Craves Family Foundation.

F4 · ownership.direct: Reflects a transfer of 43,537 shares of common stock from BCC to Dr. Craves and a transfer of 80,974 shares of common stock from Dr. Craves to a former spouse pursuant to a court approved divorce settlement agreement.

SEC source: 0000899243-20-032411 · doc4.xml · nonDerivative · entry 1

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 2,310,521

F1 · kind: Represents a transfer, without the payment of any consideration, to an affiliate.

F1 · ownership.nature: Represents a transfer, without the payment of any consideration, to an affiliate.

F2 · ownership.nature: Includes 2,260,791 shares of common stock held by Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and 49,730 shares of common stock held by Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV"). Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Fund IV and Co-Investment IV are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-20-024410 · doc4.xml · nonDerivative · entry 3

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 43,537

F6 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F4 · ownership.nature: These securities are held by BCC. Dr. Craves disclaims beneficial ownership of these securities held by BCC, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-024410 · doc4.xml · nonDerivative · entry 2

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 49,730

F6 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F3 · ownership.nature: These securities are held by Co-Investment IV. Dr. Craves disclaims beneficial ownership of these securities held by Co-Investment IV, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-024410 · doc4.xml · nonDerivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 2,260,791

F6 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F6 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: These securities are held by Fund IV. Dr. Craves disclaims beneficial ownership of these securities held by Fund IV, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-024411 · doc4.xml · nonDerivative · entry 3

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,537

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.direct: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-20-024411 · doc4.xml · nonDerivative · entry 2

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 49,730

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F3 · ownership.nature: The securities are held by Co-Investment IV.

SEC source: 0000899243-20-024411 · doc4.xml · nonDerivative · entry 1

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 2,260,791

F4 · kind: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · shares: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · price: Represents transfers, without the payment of any consideration, to their partners and employees.

F4 · acquired: Represents transfers, without the payment of any consideration, to their partners and employees.

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: The securities are held by Fund IV.

SEC source: 0000899243-20-022971 · doc4.xml · nonDerivative · entry 3

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 42,875

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: These securities are held by BCC. Dr. Craves disclaims beneficial ownership of these securities held by BCC, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-022972 · doc4.xml · nonDerivative · entry 3

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,875

F1 · ownership.direct: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-20-022971 · doc4.xml · nonDerivative · entry 2

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 50,178

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: These securities are held by BCC. Dr. Craves disclaims beneficial ownership of these securities held by BCC, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-022972 · doc4.xml · nonDerivative · entry 2

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,178

F1 · ownership.direct: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-20-022971 · doc4.xml · nonDerivative · entry 1

CRAVES FRED B · CIK 0001014095 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 60,375

F1 · ownership.nature: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

F2 · ownership.nature: These securities are held by BCC. Dr. Craves disclaims beneficial ownership of these securities held by BCC, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such shares, except to the extent of his pecuniary interest, if any, in the securities by virtue of the limited liability company interests he owns in BCC.

SEC source: 0000899243-20-022972 · doc4.xml · nonDerivative · entry 1

BAY CITY CAPITAL LLC · CIK 0001288452 · 10% owner

Bay City Capital Management IV LLC · CIK 0001359070 · 10% owner

Bay City Capital Fund IV, L.P. · CIK 0001360243 · 10% owner

BAY CITY CAPITAL FUND IV CO INVESMENT FUND LP · CIK 0001333817 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,375

F1 · ownership.direct: Bay City Capital LLC, a Delaware limited liability company ("BCC"), Bay City Capital Management IV LLC, a Delaware limited liability company ("Management IV"), Bay City Capital Fund IV, L.P., a Delaware limited partnership ("Fund IV"), and Bay City Capital Fund IV Co-Investment Fund, L.P., a Delaware limited partnership ("Co-Investment IV") are deemed to be a "group" for the purposes of Section 13(d) under the Securities Exchange Act of 1934. Management IV is the general partner of Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV. BCC, the manager of Management IV, is also an advisor to Fund IV and Co-Investment IV and has sole voting and dispositive power with respect to the securities held by Fund IV and Co-Investment IV.

SEC source: 0000899243-20-021949 · doc4.xml · derivative · entry 1

Lynch Brian Joseph · CIK 0001776196 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-08-06

F1 · derivative.exercise_date: The option vests as to 25% of the shares on the first anniversary of the date of grant (August 6, 2021) and, thereafter, 6.25% of the shares shall vest on the last day of each successive three month period, provided the Reporting Person continues in service with the Issuer on each such date.