MCRB

SEC source: 0000899243-21-024993 · doc4.xml · derivative · entry 1

Dere Willard H · CIK 0001311569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option will vest in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-024990 · doc4.xml · derivative · entry 1

Kender Richard N · CIK 0001381205 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-024997 · doc4.xml · derivative · entry 1

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-025000 · doc4.xml · derivative · entry 1

Biondi Paul · CIK 0001744508 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-024994 · doc4.xml · derivative · entry 1

Behar Gregory · CIK 0001643766 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option vests in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-024989 · doc4.xml · derivative · entry 1

Zausner Meryl · CIK 0001742142 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,000

Underlying: Common Stock · 23,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: The option will vest in full on the earlier of June 16, 2022 or the day immediately prior to the company's 2022 annual meeting of shareholders.

SEC source: 0000899243-21-021446 · doc4.xml · derivative · entry 2

Arkowitz David · CIK 0001296999 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: 100% of the restricted stock units will vest and settle on June 15, 2022. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: 100% of the restricted stock units will vest and settle on June 15, 2022. The restricted stock units have no expiration date.

SEC source: 0000899243-21-021446 · doc4.xml · derivative · entry 1

Arkowitz David · CIK 0001296999 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 270,000

Underlying: Common Stock · 270,000 shares

Expires 2031-05-31

F1 · derivative.exercise_date: This option will vest and become exercisable as to 25% of the shares on June 1, 2022. The remainder of the shares will vest and become exercisable in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-020015 · doc4.xml · nonDerivative · entry 1

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,962,963

F1 · kind: On May 17, 2021, Nutritional Health LTP Fund, L.P. ("Nutritional LTP") distributed to its limited partner(s), pro rata and without consideration, 295,171 shares of the Issuer's common stock. The aforementioned distribution was made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F2 · ownership.nature: Shares held by Nutritional LTP. Nutritional Health LTP Fund General Partner LLC ("Nutritional LTP GP") is the general partner of Nutritional LTP. Noubar B. Afeyan Ph.D. is the sole member and manager of Nutritional LTP GP. Each of the reporting persons except for Nutritional LTP disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-21-005250 · doc4.xml · derivative · entry 1

von Moltke Lisa · CIK 0001808592 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2031-02-03

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005255 · doc4.xml · derivative · entry 1

DesRosier Thomas · CIK 0001435744 · Chief Legal Officer and EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2031-02-03

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005254 · doc4.xml · derivative · entry 2

Chapman Marcus · CIK 0001770404 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2031-02-03

F3 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005254 · doc4.xml · derivative · entry 1

Chapman Marcus · CIK 0001770404 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: The restricted stock units will vest and settle as to 25% of the restricted stock units on March 15, 2022. The remainder of the restricted stock units will vest and settle in 12 equal quarterly installments thereafter.

F2 · derivative.expiration_date: The restricted stock units will vest and settle as to 25% of the restricted stock units on March 15, 2022. The remainder of the restricted stock units will vest and settle in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005247 · doc4.xml · derivative · entry 1

Young Teresa L. · CIK 0001814656 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2031-02-03

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005245 · doc4.xml · derivative · entry 1

Shaff Eric D. · CIK 0001643734 · Director · President, CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2031-02-03

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-21-005242 · doc4.xml · derivative · entry 1

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2031-02-03

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on February 4, 2022. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-032667 · doc4.xml · derivative · entry 9

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,938

Underlying: Common Stock · 27,562 shares

Expires 2029-01-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option has vested as to 25% of the shares on January 25, 2020. The remainder of the shares will vest or have vested in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-032667 · doc4.xml · derivative · entry 8

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,750

Underlying: Common Stock · 26,250 shares

Expires 2024-08-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option has vested as to 25% of the shares on January 26, 2018. The remainder of the shares will vest or have vested in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-032667 · doc4.xml · derivative · entry 7

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 26,000 shares

Expires 2024-08-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 6

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 15, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.145 to $28.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 5

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,841

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 15, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.10 to $28.08, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 4

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,106

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 15, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.07 to $27.03, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 3

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,812

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 2

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-032667 · doc4.xml · nonDerivative · entry 1

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 6

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F7 · kind: On November 23, 2020, Flagship Pioneering Fund VI, L.P. ("Flagship Fund VI") distributed to its limited partners and sole general partner, Flagship Pioneering Fund VI General Partner LLC ("Flagship Fund VI GP"), pro rata and without consideration, 1,481,481 shares of the Issuer's common stock. Flagship Fund VI GP, in turn, distributed to its members, pro rata and without consideration, the 43,154 shares it received from Flagship Fund VI. Each of Noubar B. Afeyan, Ph.D. and a trust for the benefit of Dr. Afeyan's children received 12,853 shares through Flagship Fund VI GP's distribution. The aforementioned distributions were made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F9 · ownership.nature: Shares held by Flagship Fund VI GP. Flagship Pioneering is the manager of Flagship Fund VI GP. Noubar B. Afeyan Ph.D. is the CEO, sole shareholder and director of Flagship Pioneering. Each of the reporting persons except Flagship Fund VI GP disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 5

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,962,963

F7 · kind: On November 23, 2020, Flagship Pioneering Fund VI, L.P. ("Flagship Fund VI") distributed to its limited partners and sole general partner, Flagship Pioneering Fund VI General Partner LLC ("Flagship Fund VI GP"), pro rata and without consideration, 1,481,481 shares of the Issuer's common stock. Flagship Fund VI GP, in turn, distributed to its members, pro rata and without consideration, the 43,154 shares it received from Flagship Fund VI. Each of Noubar B. Afeyan, Ph.D. and a trust for the benefit of Dr. Afeyan's children received 12,853 shares through Flagship Fund VI GP's distribution. The aforementioned distributions were made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F8 · ownership.nature: Shares held by Flagship Fund VI. Flagship Fund VI GP is the general partner of Flagship Fund VI. Flagship Pioneering, Inc. ("Flagship Pioneering") is the manager of Flagship Fund VI GP. Noubar B. Afeyan Ph.D. is the CEO, sole shareholder and director of Flagship Pioneering. Each of the reporting persons except Flagship Fund VI disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 4

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 3,258,134

F5 · kind: On November 23, 2020, Nutritional Health LTP Fund, L.P. ("Nutritional LTP") distributed to its limited partners, pro rata and without consideration, 1,186,310 shares of the Issuer's common stock. The aforementioned distribution was made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F6 · ownership.nature: Shares held by Nutritional LTP. Nutritional Health LTP Fund General Partner LLC ("Nutritional LTP GP") is the general partner of Nutritional LTP. Noubar B. Afeyan Ph.D. is the sole member and manager of Nutritional LTP GP. Each of the reporting persons except for Nutritional LTP disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 3

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · kind: On November 23, 2020, Flagship Ventures Fund IV, L.P. ("Flagship Fund IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx") distributed to its limited partners and sole general partner, Flagship Ventures Fund IV General Partner, LLC ("Flagship Fund IV GP"), pro rata and without consideration, 3,587,820 shares and 642,180 shares, respectively, of the Issuer's common stock. Flagship Fund IV GP, in turn, distributed to its members, pro rata and without consideration, the 837,782 shares and 128,452 shares it received from Flagship Fund IV and Flagship Fund IV-Rx, respectively. Noubar B. Afeyan, Ph.D. received 335,171 shares through Flagship Fund IV GP's distribution. The aforementioned distributions were made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F4 · ownership.nature: Shares held by Flagship Fund IV GP. Noubar B. Afeyan, Ph.D. is the sole manager of Flagship Fund IV GP. Each of the reporting persons except for Flagship Fund IV GP disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 2

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,283,282

F1 · kind: On November 23, 2020, Flagship Ventures Fund IV, L.P. ("Flagship Fund IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx") distributed to its limited partners and sole general partner, Flagship Ventures Fund IV General Partner, LLC ("Flagship Fund IV GP"), pro rata and without consideration, 3,587,820 shares and 642,180 shares, respectively, of the Issuer's common stock. Flagship Fund IV GP, in turn, distributed to its members, pro rata and without consideration, the 837,782 shares and 128,452 shares it received from Flagship Fund IV and Flagship Fund IV-Rx, respectively. Noubar B. Afeyan, Ph.D. received 335,171 shares through Flagship Fund IV GP's distribution. The aforementioned distributions were made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F3 · ownership.nature: Shares held by Flagship Fund IV-Rx. Flagship Fund IV GP is the general partner of Flagship Fund IV-Rx. Noubar B. Afeyan, Ph.D. is the sole manager of Flagship Fund IV GP. Each of the reporting persons except for Flagship Fund IV-Rx disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein.

SEC source: 0000899243-20-032200 · doc4.xml · nonDerivative · entry 1

Flagship Ventures Fund IV General Partner LLC · CIK 0001508051 · 10% owner

Flagship Ventures Fund IV, L.P. · CIK 0001503559 · 10% owner

Flagship Ventures Fund IV-Rx, L.P. · CIK 0001590973 · 10% owner

Nutritional Health LTP Fund General Partner LLC · CIK 0001780951 · 10% owner

Nutritional Health LTP Fund, L.P. · CIK 0001780956 · 10% owner

Flagship Pioneering Inc. · CIK 0001400240 · 10% owner

Flagship Pioneering Fund VI General Partner LLC · CIK 0001724957 · 10% owner

Flagship Pioneering Fund VI, L.P. · CIK 0001716926 · 10% owner

AFEYAN NOUBAR · CIK 0001222012 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,434,600

F1 · kind: On November 23, 2020, Flagship Ventures Fund IV, L.P. ("Flagship Fund IV") and Flagship Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx") distributed to its limited partners and sole general partner, Flagship Ventures Fund IV General Partner, LLC ("Flagship Fund IV GP"), pro rata and without consideration, 3,587,820 shares and 642,180 shares, respectively, of the Issuer's common stock. Flagship Fund IV GP, in turn, distributed to its members, pro rata and without consideration, the 837,782 shares and 128,452 shares it received from Flagship Fund IV and Flagship Fund IV-Rx, respectively. Noubar B. Afeyan, Ph.D. received 335,171 shares through Flagship Fund IV GP's distribution. The aforementioned distributions were made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

F2 · ownership.nature: Shares held by Flagship Fund IV. Flagship Fund IV GP is the general partner of Flagship Fund IV. Noubar B. Afeyan, Ph.D. is the sole manager of Flagship Fund IV GP. Each of the reporting persons except for Flagship Fund IV disclaims beneficial ownership of such shares except to the extent of his or its pecuniary interest therein. Edwin M. Kania, Jr. is retired both from Flagship Pioneering and as a manager of Flagship Fund IV GP.

SEC source: 0000899243-20-032202 · doc4.xml · nonDerivative · entry 1

Berenson Stephen · CIK 0001760671 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,589

F1 · kind: Represents the receipt of shares by the reporting person pursuant to a pro rata distribution-in-kind, without consideration, of shares of the Issuer's common stock effected on November 23, 2020 by Flagship Pioneering Fund VI, L.P. ("Flagship Fund VI"). The aforementioned distribution was made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-20-028909 · doc4.xml · derivative · entry 1

Ege David S. · CIK 0001829360 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2030-10-18

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on October 19, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-018111 · doc4.xml · derivative · entry 1

Young Teresa L. · CIK 0001814656 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2030-06-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on June 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-017357 · doc4.xml · derivative · entry 1

Berenson Stephen · CIK 0001760671 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017356 · doc4.xml · derivative · entry 1

Graves Kurt · CIK 0001406337 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017353 · doc4.xml · derivative · entry 1

Dere Willard H · CIK 0001311569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option will vest in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017354 · doc4.xml · derivative · entry 1

Kender Richard N · CIK 0001381205 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017361 · doc4.xml · derivative · entry 1

Ausiello Dennis A · CIK 0001381994 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017363 · doc4.xml · derivative · entry 1

Biondi Paul · CIK 0001744508 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017355 · doc4.xml · derivative · entry 1

Zausner Meryl · CIK 0001742142 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option will vest in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-017347 · doc4.xml · derivative · entry 1

Behar Gregory · CIK 0001643766 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The option vests in full on the earlier of June 18, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0000899243-20-011277 · doc4.xml · derivative · entry 1

Chapman Marcus · CIK 0001770404 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,596

Underlying: Common Stock · 18,596 shares

Expires 2030-04-21

F1 · derivative.exercise_date: The option will vest in full on April 22, 2021.

SEC source: 0000899243-20-010407 · doc4.xml · derivative · entry 1

von Moltke Lisa · CIK 0001808592 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 325,000

Underlying: Common Stock · 325,000 shares

Expires 2030-04-05

F1 · derivative.exercise_date: The option will vest as to 25% of the underlying shares on the first anniversary of April 6, 2020 and as to an additional 6.25% upon the completion of each three-month period of continuous service to the company thereafter.

SEC source: 0000899243-20-009250 · doc4.xml · derivative · entry 1

Biondi Paul · CIK 0001744508 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2030-03-19

F1 · derivative.exercise_date: The option will vest in four equal installments on each anniversary of March 20, 2020 or in full immediately prior to the occurrence of a change in control.

SEC source: 0000899243-20-002420 · doc4.xml · derivative · entry 1

DesRosier Thomas · CIK 0001435744 · Chief Legal Officer and EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2030-01-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on January 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-002423 · doc4.xml · derivative · entry 1

Shaff Eric D. · CIK 0001643734 · President CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000,000

Underlying: Common Stock · 1,000,000 shares

Expires 2030-01-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on January 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-002422 · doc4.xml · derivative · entry 1

Chapman Marcus · CIK 0001770404 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2030-01-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on January 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-002418 · doc4.xml · derivative · entry 1

Aunins John G. · CIK 0001643756 · Chief Technology Officer & EVP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2030-01-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on January 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.

SEC source: 0000899243-20-002419 · doc4.xml · derivative · entry 1

Henn Matthew R. · CIK 0001767321 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2030-01-28

F1 · derivative.exercise_date: The option will vest as to 25% of the shares on January 29, 2021. The remainder of the shares will vest in 12 equal quarterly installments thereafter.