LYEL

SEC source: 0001866154-25-000006 · form4-11132025_011153.xml · nonDerivative · entry 1

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,750

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

SEC source: 0001327111-25-000007 · form4-11132025_011139.xml · nonDerivative · entry 1

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,159

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

SEC source: 0001907345-25-000006 · form4-11132025_011126.xml · nonDerivative · entry 1

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,366

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

SEC source: 0001866154-25-000005 · form4-10292025_091048.xml · derivative · entry 2

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2035-10-26

F1 · derivative.exercise_date: 12.5% of the option shares will vest on April 27, 2026, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001907345-25-000005 · form4-10292025_091031.xml · derivative · entry 2

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,000

Underlying: Common Stock · 68,000 shares

Expires 2035-10-26

F1 · derivative.exercise_date: 12.5% of the option shares will vest on April 27, 2026, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001327111-25-000006 · form4-10292025_091010.xml · derivative · entry 2

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2035-10-26

F1 · derivative.exercise_date: 12.5% of the option shares will vest on April 27, 2026, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-022741 · form4-08222025_080821.xml · nonDerivative · entry 2

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,306

F2 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F3 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.49 to $10.64 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

SEC source: 0001415889-25-022746 · form4-08222025_080857.xml · nonDerivative · entry 2

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,845

F2 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F3 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.49 to $10.64 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

SEC source: 0001415889-25-022740 · form4-08222025_080803.xml · nonDerivative · entry 2

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,504

F2 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F3 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.49 to $10.64 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

SEC source: 0001415889-25-022747 · form4-08222025_080818.xml · nonDerivative · entry 2

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,571

F2 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F3 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.49 to $10.64 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

SEC source: 0001415889-25-022741 · form4-08222025_080821.xml · nonDerivative · entry 1

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,759

F1 · shares: Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 4,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date and 4,000 shares will be issued on August 20, 2026, subject to the reporting person providing service through such date.

SEC source: 0001415889-25-022746 · form4-08222025_080857.xml · nonDerivative · entry 1

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,849

F1 · shares: Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 4,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date and 4,000 shares will be issued on August 20, 2026, subject to the reporting person providing service through such date.

SEC source: 0001415889-25-022740 · form4-08222025_080803.xml · nonDerivative · entry 1

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,957

F1 · shares: Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 4,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date and 4,000 shares will be issued on August 20, 2026, subject to the reporting person providing service through such date.

SEC source: 0001415889-25-022747 · form4-08222025_080818.xml · nonDerivative · entry 1

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,828

F1 · shares: Pursuant to performance-based restricted stock units granted to the reporting person on February 9, 2024, 20,000 shares were issued on the Transaction Date upon the achievement of certain performance criteria certified by the compensation committee of the Issuer's board of directors on the Transaction Date and 20,000 shares will be issued on August 20, 2026, subject to the reporting person providing service through such date.

SEC source: 0001415889-25-021691 · form4-08142025_010858.xml · nonDerivative · entry 2

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,759

F5 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F6 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.120 to $10.415 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F7 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021693 · form4-08142025_010830.xml · nonDerivative · entry 2

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,849

F5 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F6 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.120 to $10.415 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F7 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021692 · form4-08142025_010810.xml · nonDerivative · entry 2

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,957

F5 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F6 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.120 to $10.415 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F7 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021694 · form4-08142025_010843.xml · nonDerivative · entry 2

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,828

F4 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F5 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.120 to $10.415 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F6 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021691 · form4-08142025_010858.xml · nonDerivative · entry 1

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,895

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F2 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.045 to $11.00 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Fonn 4.

F3 · balance_after: Includes 390 shares acquired on May 18, 2025 under the Issuer's 2021 Employee Stock Purchase Plan.

F4 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021693 · form4-08142025_010830.xml · nonDerivative · entry 1

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,943

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F2 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.045 to $11.00 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F3 · balance_after: Includes 390 shares acquired on May 18, 2025 under the Issuer's 2021 Employee Stock Purchase Plan.

F4 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021692 · form4-08142025_010810.xml · nonDerivative · entry 1

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,093

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F2 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.045 to $11.00 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F3 · balance_after: Includes 390 shares acquired on May 18, 2025 under the Issuer's 2021 Employee Stock Purchase Plan.

F4 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-021694 · form4-08142025_010843.xml · nonDerivative · entry 1

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,234

F1 · shares: Shares automatically sold to cover tax withholding obligation from settlement of vested restricted stock units.

F2 · price: The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $10.045 to $11.00 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4.

F3 · balance_after: On May 30, 2025, the Issuer effected a 1-for-20 reverse stock split of its common stock. All share and amounts reported herein reflect the reverse stock split.

SEC source: 0001415889-25-016728 · form4-06112025_090645.xml · derivative · entry 2

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,750

Underlying: Common Stock · 43,750 shares

Expires 2035-06-08

F2 · derivative.exercise_date: 25% of the option shares will vest on June 9, 2026, with the remaining option shares to vest in equal monthly installments over the following thirty-six months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-016728 · form4-06112025_090645.xml · nonDerivative · entry 1

Shook David · CIK 0001959742 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,900

F1 · shares: Represents restricted stock units granted under the Issuer's 2021 Equity Incentive Plan ("RSUs"). 25% of the total shares subject to the RSUs will vest on June 9, 2026, and an additional 1/16th of the total shares subject to the RSUs per quarter thereafter, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-016730 · form4-06112025_090624.xml · derivative · entry 1

Bachleda Mark · CIK 0001887762 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,000

Underlying: Common Stock · 13,000 shares

Expires 2035-06-08

F1 · derivative.exercise_date: 1/36th of the shares of Common Stock subject to the option shall vest on a monthly basis following the grant date on the same day of the month as such grant date (or on the last day of the month, if there is no corresponding day in such month), subject to the Reporting Person remaining in service as a director through the applicable vesting date.

SEC source: 0001415889-25-016729 · form4-06112025_090608.xml · derivative · entry 1

Meltz Mark A · CIK 0001771329 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-06-08

F1 · derivative.exercise_date: 25% of the option shares will vest on June 9, 2026, with the remaining option shares to vest in equal monthly installments over the following thirty-six months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-013723 · form4-05192025_100514.xml · derivative · entry 3

Klausner Richard · CIK 0001591178 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F2 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-013719 · form4-05192025_100545.xml · derivative · entry 1

RIEFLIN WILLIAM JL · CIK 0001182471 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F1 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-013712 · form4-05192025_100556.xml · derivative · entry 3

FRIEDMAN CATHY · CIK 0001411874 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F3 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-013710 · form4-05192025_100517.xml · derivative · entry 2

BRAWLEY OTIS W · CIK 0001213029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F1 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-013707 · form4-05192025_100536.xml · derivative · entry 1

NABEL ELIZABETH G · CIK 0001619929 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F1 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-013705 · form4-05192025_100544.xml · derivative · entry 2

Ramachandra Sumant · CIK 0001439368 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 130,000

Underlying: Common Stock · 130,000 shares

Expires 2035-05-14

F2 · derivative.exercise_date: The option shares shall vest on the earlier of (a) the date of the next annual meeting of the stockholders that occurs following May 15, 2025 (or the date immediately prior to such date if the Reporting Person's service as a director ends at such annual meeting due to the Reporting Person's failure to be reelected or the Reporting Person not standing for re-election); or (b) the first anniversary of May 15, 2025, subject to the Reporting Person providing continuous service through such date.

SEC source: 0001415889-25-009604 · form4-04022025_070458.xml · nonDerivative · entry 1

BRAWLEY OTIS W · CIK 0001213029 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,640

SEC source: 0001415889-25-008942 · form4-03252025_100313.xml · nonDerivative · entry 1

Ramachandra Sumant · CIK 0001439368 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · Grantor and Trustee

Disclosed balance after: 200,000

F1 · price: The price reported above reflects the weighted average price of the shares purchased. These shares were purchased in multiple transactions at prices ranging from $0.5487 to $0.5879, inclusive. Upon request from the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares purchased at each separate price within the range set forth in this range.

F2 · ownership.nature: Shares held by the Sumant Ramachandra Rev Trust DTD 01/24/12. The Reporting Person is grantor and trustee of the Sumant Ramachandra Rev Trust DTD 01/24/12.

SEC source: 0001415889-25-008517 · form4-03182025_110331.xml · nonDerivative · entry 1

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · Co-grantor and Co-trustee

Disclosed balance after: 200,000

F1 · price: The price reported above reflects the weighted average price of the shares purchased. These shares were purchased in multiple transactions at prices ranging from $0.54 to $0.56, inclusive. Upon request from the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares purchased at each separate price within the range set forth in this range

F2 · ownership.nature: Shares held by The Charles & Lisa Newton Living Trust. The Reporting Person is co-trustee and co-grantor of The Charles & Lisa Newton Living Trust.

SEC source: 0001415889-25-008540 · form4-03192025_120347.xml · nonDerivative · entry 1

Klausner Richard · CIK 0001591178 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · Grantor and Trustee

Disclosed balance after: 843,365

F1 · price: The price reported above reflects the weighted average price of the shares purchased. These shares were purchased in multiple transactions at prices ranging from $0.59 to $0.62, inclusive. Upon request from the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares purchased at each separate price within the range set forth in this range.

F2 · ownership.nature: Consists of 158,000 shares held by The Klausner Family Revocable Trust of May 8, 2014, 245,515 shares held by The Ariella Klausner Delaware Trust, 194,335 shares held by The Eli Klausner Delaware Trust and 245,515 shares held by The Olivia Klausner Delaware Trust (collectively, The Ariella Klausner Delaware Trust, The Eli Klausner Delaware Trust and The Olivia Klausner Delaware Trust, the "Delaware Trusts"). The Reporting Person is grantor and trustee of The Klausner Family Revocable Trust of May 8, 2014 and grantor of each of the Delaware Trusts. The JTC Trust Company (Delaware) Limited is the trustee of each of the Delaware Trusts. The Reporting Person disclaims beneficial ownership of all shares held by the Delaware Trusts except to any pecuniary interest therein.

SEC source: 0001415889-25-008509 · form4-03182025_100315.xml · nonDerivative · entry 1

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 712,500

F1 · price: The price reported above reflects the weighted average price of the shares purchased. These shares were purchased in multiple transactions at prices ranging from $0.59980 to $0.62020, inclusive. Upon request from the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares purchased at each separate price within the range set forth in this range.

SEC source: 0001415889-25-005753 · form4-02272025_120230.xml · derivative · entry 3

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,250

Underlying: Common Stock · 56,250 shares

Expires 2035-02-09

F4 · derivative.exercise_date: The reported transaction involved the reporting person's receipt of a grant of performance-based options, subject to vesting upon the achievement of specified performance criteria.

SEC source: 0001415889-25-005753 · form4-02272025_120230.xml · derivative · entry 2

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2035-02-09

F3 · derivative.exercise_date: 12.5% of the option shares will vest on August 9, 2025, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-005753 · form4-02272025_120230.xml · nonDerivative · entry 1

Newton Charles W. · CIK 0001866219 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,725

F1 · kind: 12.5% of the total number of restricted stock units will vest on August 9, 2025, and thereafter an additional 1/16th of the total number of restricted stock units will vest quarterly thereafter, subject to the reporting person providing service through the applicable vesting date

F2 · balance_after: Includes 7,800 shares acquired on May 17, 2024 and 3,696 shares acquired on November 18, 2024 under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001415889-25-005760 · form4-02272025_120219.xml · derivative · entry 3

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,250

Underlying: Common Stock · 56,250 shares

Expires 2035-02-09

F4 · derivative.exercise_date: The reported transaction involved the reporting person's receipt of a grant of performance-based options, subject to vesting upon the achievement of specified performance criteria.

SEC source: 0001415889-25-005760 · form4-02272025_120219.xml · derivative · entry 2

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2035-02-09

F3 · derivative.exercise_date: 12.5% of the option shares will vest on August 9, 2025, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-005760 · form4-02272025_120219.xml · nonDerivative · entry 1

Hill Stephen J. · CIK 0001866154 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,899

F1 · kind: 12.5% of the total number of restricted stock units will vest on August 9, 2025, and thereafter an additional 1/16th of the total number of restricted stock units will vest quarterly thereafter, subject to the reporting person providing service through the applicable vesting date.

F2 · balance_after: Includes 7,707 shares acquired on May 17, 2024 and 3,764 shares acquired on November 18, 2024 under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001415889-25-005775 · form4-02272025_120200.xml · derivative · entry 3

Lang Matthew · CIK 0001712069 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,250

Underlying: Common Stock · 56,250 shares

Expires 2035-02-09

F3 · derivative.exercise_date: The reported transaction involved the reporting person's receipt of a grant of performance-based options, subject to vesting upon the achievement of specified performance criteria.

SEC source: 0001415889-25-005775 · form4-02272025_120200.xml · derivative · entry 2

Lang Matthew · CIK 0001712069 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2035-02-09

F2 · derivative.exercise_date: 12.5% of the option shares will vest on August 9, 2025, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-005775 · form4-02272025_120200.xml · nonDerivative · entry 1

Lang Matthew · CIK 0001712069 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,500

F1 · kind: 12.5% of the total number of restricted stock units will vest on August 9, 2025, and thereafter an additional 1/16th of the total number of restricted stock units will vest quarterly thereafter, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-005747 · form4-02272025_120251.xml · derivative · entry 3

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,250

Underlying: Common Stock · 56,250 shares

Expires 2035-02-09

F4 · derivative.exercise_date: The reported transaction involved the reporting person's receipt of a grant of performance-based options, subject to vesting upon the achievement of specified performance criteria.

SEC source: 0001415889-25-005747 · form4-02272025_120251.xml · derivative · entry 2

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 450,000

Underlying: Common Stock · 450,000 shares

Expires 2035-02-09

F3 · derivative.exercise_date: 12.5% of the option shares will vest on August 9, 2025, with the remaining option shares to vest in equal monthly installments over the following forty-two months, subject to the reporting person providing service through the applicable vesting date.

SEC source: 0001415889-25-005747 · form4-02272025_120251.xml · nonDerivative · entry 1

Lee Gary K. · CIK 0001907345 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 176,696

F1 · kind: 12.5% of the total number of restricted stock units will vest on August 9, 2025, and thereafter an additional 1/16th of the total number of restricted stock units will vest quarterly thereafter, subject to the reporting person providing service through the applicable vesting date.

F2 · balance_after: Includes 7,800 shares acquired on May 17, 2024 and 3,696 shares acquired on November 18, 2024 under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0001415889-25-005768 · form4-02272025_120243.xml · derivative · entry 3

Seely Lynn · CIK 0001327111 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,750

Underlying: Common Stock · 168,750 shares

Expires 2035-02-09

F3 · derivative.exercise_date: The reported transaction involved the reporting person's receipt of a grant of performance-based options, subject to vesting upon the achievement of specified performance criteria.