LXRX

SEC source: 0001127602-18-009728 · form4.xml · nonDerivative · entry 1

Lapuerta Pablo · CIK 0001516368 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,434

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-18-009725 · form4.xml · derivative · entry 7

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,088

Underlying: Common Stock · 5,362 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F5 · derivative.exercise_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2018 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

F5 · derivative.expiration_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2018 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

SEC source: 0001127602-18-009725 · form4.xml · derivative · entry 6

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,780

Underlying: Common Stock · 8,390 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F4 · derivative.exercise_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2017 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

F4 · derivative.expiration_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2017 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

SEC source: 0001127602-18-009725 · form4.xml · derivative · entry 5

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,835

Underlying: Common Stock · 10,836 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2016 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 25% of the shares subject to the restricted stock units on February 28, 2016 and vest an additional 25% on February 28 of each of the three succeeding years thereafter.

SEC source: 0001127602-18-009725 · form4.xml · nonDerivative · entry 4

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,079

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-18-009725 · form4.xml · nonDerivative · entry 3

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,573

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-18-009725 · form4.xml · nonDerivative · entry 2

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,211

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-18-009725 · form4.xml · nonDerivative · entry 1

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,821

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-18-005209 · form4.xml · derivative · entry 2

WADE JEFFREY L · CIK 0001225767 · EVP, Corp Adm Affairs and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,550

Underlying: Common Stock · 79,550 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005209 · form4.xml · derivative · entry 1

WADE JEFFREY L · CIK 0001225767 · EVP, Corp Adm Affairs and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,665

Underlying: Common Stock · 28,665 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005208 · form4.xml · derivative · entry 2

TYLE PRAVEEN · CIK 0001296936 · EVP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,820

Underlying: Common Stock · 82,820 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005208 · form4.xml · derivative · entry 1

TYLE PRAVEEN · CIK 0001296936 · EVP, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,180

Underlying: Common Stock · 29,180 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005207 · form4.xml · derivative · entry 2

Tessmer James F · CIK 0001434095 · VP, Finance & Accounting

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,970

Underlying: Common Stock · 18,970 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005207 · form4.xml · derivative · entry 1

Tessmer James F · CIK 0001434095 · VP, Finance & Accounting

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,640

Underlying: Common Stock · 12,640 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005204 · form4.xml · derivative · entry 2

Santini Alexander A · CIK 0001690619 · EVP and CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,940

Underlying: Common Stock · 71,940 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005204 · form4.xml · derivative · entry 1

Santini Alexander A · CIK 0001690619 · EVP and CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,390

Underlying: Common Stock · 25,390 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005202 · form4.xml · derivative · entry 2

MAIN ALAN J · CIK 0001227372 · EVP, Commercial Supply Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,940

Underlying: Common Stock · 69,940 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005202 · form4.xml · derivative · entry 1

MAIN ALAN J · CIK 0001227372 · EVP, Commercial Supply Ops

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,890

Underlying: Common Stock · 24,890 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005201 · form4.xml · derivative · entry 2

Lapuerta Pablo · CIK 0001516368 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,330

Underlying: Common Stock · 72,330 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005201 · form4.xml · derivative · entry 1

Lapuerta Pablo · CIK 0001516368 · EVP and CMO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,710

Underlying: Common Stock · 25,710 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005199 · form4.xml · derivative · entry 2

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 211,610

Underlying: Common Stock · 211,610 shares

Expires 2028-02-08

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/8/2019) and vests 1/48th per month for each month of service thereafter.

SEC source: 0001127602-18-005199 · form4.xml · derivative · entry 1

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,540

Underlying: Common Stock · 70,540 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

F2 · derivative.expiration_date: Restricted stock units vest with respect to one third of the shares subject to the restricted stock units on February 28, 2019 and vest an additional one third on February 28 of each of the two succeeding years thereafter.

SEC source: 0001127602-18-005197 · form5.xml · nonDerivative · entry 1

WADE JEFFREY L · CIK 0001225767 · EVP, Corp Adm Affairs and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,597

SEC source: 0000899243-17-026881 · doc4.xml · nonDerivative · entry 2

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Minne Pascal · CIK 0001460839 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,550,000

F1 · kind: The purchases were made in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F3 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F6 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. Artal International S.C.A. is the managing member of each of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). Mr. Pascal Minne is the sole member of the board of the Stichting.

F7 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-17-032220 · form4.xml · nonDerivative · entry 1

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,985

SEC source: 0000899243-17-026881 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Minne Pascal · CIK 0001460839 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,500,000

F1 · kind: The purchases were made in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F2 · price: The shares reported as purchased on November 15, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.75 to $10.49 per share. The price reported reflects the weighted average purchase price for the transactions. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F3 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F6 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. Artal International S.C.A. is the managing member of each of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). Mr. Pascal Minne is the sole member of the board of the Stichting.

F7 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000899243-17-026246 · doc4.xml · nonDerivative · entry 3

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Minne Pascal · CIK 0001460839 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,369,273

F1 · kind: The purchases were made in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F2 · price: The shares reported as purchased on November 10, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.12 to $9.98 per share, the shares reported as purchased on November 13, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.50 to $9.83 per share, and the shares reported as purchased on November 14, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.23 to $9.68 per share, in each case exclusive of any fees, commissions or other expenses. The price reported reflects the weighted average purchase price for the transactions. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F3 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F6 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. Artal International S.C.A. is the managing member of each of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). Mr. Pascal Minne is the sole member of the board of the Stichting.

F7 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-17-032116 · form4.xml · nonDerivative · entry 1

WADE JEFFREY L · CIK 0001225767 · EVP, Corp Adm Affairs and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,597

SEC source: 0000899243-17-026246 · doc4.xml · nonDerivative · entry 2

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Minne Pascal · CIK 0001460839 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,154,140

F1 · kind: The purchases were made in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F2 · price: The shares reported as purchased on November 10, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.12 to $9.98 per share, the shares reported as purchased on November 13, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.50 to $9.83 per share, and the shares reported as purchased on November 14, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.23 to $9.68 per share, in each case exclusive of any fees, commissions or other expenses. The price reported reflects the weighted average purchase price for the transactions. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F3 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F6 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. Artal International S.C.A. is the managing member of each of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). Mr. Pascal Minne is the sole member of the board of the Stichting.

F7 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000899243-17-026246 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Minne Pascal · CIK 0001460839 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 939,007

F1 · kind: The purchases were made in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act").

F2 · price: The shares reported as purchased on November 10, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.12 to $9.98 per share, the shares reported as purchased on November 13, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.50 to $9.83 per share, and the shares reported as purchased on November 14, 2017 were purchased in multiple transactions at actual purchase prices ranging from $9.23 to $9.68 per share, in each case exclusive of any fees, commissions or other expenses. The price reported reflects the weighted average purchase price for the transactions. The Reporting Persons undertake to provide, upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F3 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F6 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. Artal International S.C.A. is the managing member of each of Invus Public Equities Advisors, LLC and Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A., both of which are wholly owned subsidiaries of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). Mr. Pascal Minne is the sole member of the board of the Stichting.

F7 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 25

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,985

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 24

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,585

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 23

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,285

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 22

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,985

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 21

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,385

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 20

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,085

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 19

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,785

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 18

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,479

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 17

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,279

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 16

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,179

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 15

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,779

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 14

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,585

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 13

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,436

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 12

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,236

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 11

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,936

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 10

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,336

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 9

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,336

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 8

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,385

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 7

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,985

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.

SEC source: 0001127602-17-027540 · form4.xml · nonDerivative · entry 6

COATS LONNEL · CIK 0001612528 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,585

F1 · ownership.direct: Since the date of Mr. Coats' last ownership report, he transferred 17,782 shares of common stock to his ex-wife pursuant to a domestic relations order. Mr. Coats no longer reports as beneficially owned any securities owned by his ex-wife.