JSPR

SEC source: 0001213900-24-051401 · ownership.xml · derivative · entry 1

Brun Scott C. · CIK 0001863614 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Voting Common Stock · 7,500 shares

Expires 2034-06-06

SEC source: 0001213900-24-051405 · ownership.xml · derivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Voting Common Stock · 7,500 shares

Expires 2034-06-06

SEC source: 0001213900-24-051398 · ownership.xml · derivative · entry 1

EMSTER KURT VON · CIK 0001252524 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Voting Common Stock · 7,500 shares

Expires 2034-06-06

SEC source: 0001213900-24-051414 · ownership.xml · derivative · entry 1

Nolet Chris · CIK 0001782814 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Voting Common Stock · 7,500 shares

Expires 2034-06-06

SEC source: 0001213900-24-051409 · ownership.xml · derivative · entry 1

Kapoor Vishal · CIK 0001798946 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Voting Common Stock · 7,500 shares

Expires 2034-06-06

SEC source: 0001213900-24-021961 · ownership.xml · derivative · entry 3

Mahal Jeetinder Singh · CIK 0001882877 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,472

Underlying: Voting Common Stock · 900 shares

Expires 2030-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The exercise price of the option and number of shares subject to the option were adjusted as a result of the Reverse Split, and numbers reported herein reflect the exercise price and number of shares subject to the option after the Reverse Split.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

F5 · derivative.exercise_date: 25% of the original number of shares subject to the option vested on December 12, 2020, and 1/48th of the original number of shares subject to the option vested monthly thereafter.

F4 · balance_after: The exercise price of the option and number of shares subject to the option were adjusted as a result of the Reverse Split, and numbers reported herein reflect the exercise price and number of shares subject to the option after the Reverse Split.

SEC source: 0001213900-24-021961 · ownership.xml · nonDerivative · entry 2

Mahal Jeetinder Singh · CIK 0001882877 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,009

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.14 to $26.79, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-24-021961 · ownership.xml · nonDerivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,909

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

F2 · balance_after: Effective on January 4, 2024, the Issuer conducted a reverse stock split of its voting common stock at a ratio of 1-for-10 (the "Reverse Split"). The number of shares reported herein reflects the number of shares after the Reverse Split.

SEC source: 0001213900-24-015465 · ownership.xml · derivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO and Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Voting Common Stock · 100,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on February 15, 2025, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-24-015462 · ownership.xml · derivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Voting Common Stock · 40,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on February 15, 2025, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-24-015459 · ownership.xml · derivative · entry 1

CROSS HERB · CIK 0001230721 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Voting Common Stock · 40,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on February 15, 2025, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-24-015457 · ownership.xml · derivative · entry 1

Tucker Edwin Jonathan · CIK 0001792296 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Voting Common Stock · 45,000 shares

Expires 2034-02-15

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on February 15, 2025, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0000921895-24-000337 · form412927020_02092024.xml · nonDerivative · entry 1

Velan Capital Investment Management LP · CIK 0001848809 · 10% owner

Velan Capital Master Fund LP · CIK 0001964356 · See Footnote 1

Avego Healthcare Capital, L.P. · CIK 0001822834 · See Footnote 1

Velan Capital Holdings LLC · CIK 0001964353 · See Footnote 1

Avego Healthcare Capital Holdings, LLC · CIK 0001964446 · See Footnote 1

Avego Management LLC · CIK 0001886177 · See Footnote 1

Velan Capital Management LLC · CIK 0001964355 · 10% owner

VENKATARAMAN BALAJI · CIK 0001114916 · 10% owner

Morgan Adam · CIK 0001964335 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Velan Capital Master Fund LP

Disclosed balance after: 1,188,500

F1 · security: This Form 4 is filed jointly by Velan Capital Master Fund LP ("Velan Master"), Avego Healthcare Capital, L.P. ("Avego Fund"), Velan Capital Holdings LLC ("Velan GP"), Avego Healthcare Capital Holdings, LLC ("Avego GP"), Avego Management, LLC ("Avego Management"), Velan Capital Investment Management LP ("Velan Capital"), Velan Capital Management LLC ("Velan IM GP"), Balaji Venkataraman and Adam Morgan (collectively, the "Reporting Persons"). Each of the Reporting Persons may be deemed to be a member of a Section 13(d) group that no longer collectively beneficially owns more than 10% of the Issuer's outstanding shares. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.

F4 · balance_after: Reflects a 1-for-10 reverse stock split of the Issuer's common stock, effected on January 4, 2024.

F2 · ownership.nature: Securities owned directly by Velan Master. As the general partner of Velan Master, Velan GP may be deemed to beneficially own the securities owned directly by Velan Master. As the investment manager of Velan Master, Velan Capital may be deemed to beneficially own the securities owned directly by Velan Master. As the general partner of Velan Capital, Velan IM GP may be deemed to beneficially own the securities owned directly by Velan Master. As the managing members of Velan GP and Velan IM GP, Messrs. Venkataraman and Morgan may be deemed to beneficially own the securities owned directly by Velan Master.

SEC source: 0000950170-24-014017 · ownership.xml · nonDerivative · entry 1

Carlyle Group Inc. · CIK 0001527166 · Former 10% Owner

Carlyle Holdings I GP Inc. · CIK 0001548626 · 10% owner

Carlyle Holdings I GP Sub L.L.C. · CIK 0001548627 · 10% owner

Carlyle Holdings I L.P. · CIK 0001548628 · 10% owner

CG Subsidiary Holdings L.L.C. · CIK 0001790577 · 10% owner

TC Group, LLC · CIK 0000933790 · 10% owner

Carlyle Investment Management LLC · CIK 0001354120 · 10% owner

Carlyle Genesis UK LLC · CIK 0001941860 · 10% owner

Abingworth LLP · CIK 0001397144 · 10% owner

Abingworth Bioventures VII LP · CIK 0001688313 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 1,066,189

F1 · balance_after: The amount of Voting Common Stock reported herein reflects a 1-for-10 reverse stock split effected by the Issuer on January 4, 2024.

F2 · ownership.nature: Reflects securities held of record by Abingworth Bioventures VII LP ("ABV VII"). ABV VII has delegated to Abingworth LLP all investment and dispositive power over the securities held of record by ABV VII.

F3 · ownership.nature: The Carlyle Group Inc., which is a publicly traded entity listed on Nasdaq, is the sole shareholder of Carlyle Holdings I GP Inc., which is the sole member of Carlyle Holdings I GP Sub L.L.C., which is the general partner of Carlyle Holdings I L.P., which, with respect to the securities reported herein, is the managing member of CG Subsidiary Holdings L.L.C., which is the managing member of TC Group, L.L.C., which is the managing member of Carlyle Investment Management, L.L.C., which is the sole member of Carlyle Genesis UK LLC, which is the principal member of Abingworth LLP. Accordingly, each of the foregoing entities may be deemed to share beneficial ownership of the securities held of record by ABV VII, but each disclaims beneficial ownership of such securities except to the extent of their pecuniary interest therein, if any.

SEC source: 0001213900-23-091458 · ownership.xml · nonDerivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.6311 to $0.669, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-23-089579 · ownership.xml · nonDerivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.63 to $0.65, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-23-088896 · ownership.xml · nonDerivative · entry 3

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

F2 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.616 to $0.64, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-23-088896 · ownership.xml · nonDerivative · entry 2

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.5889 to $0.60, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-23-088896 · ownership.xml · nonDerivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

SEC source: 0001213900-23-082883 · ownership.xml · derivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Voting Common Stock · 110,000 shares

Expires 2033-11-01

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on November 1, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001013762-23-003901 · ownership.xml · nonDerivative · entry 1

Lis William · CIK 0001574558 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,521

F1 · kind: The transaction reported in this Form 4 was effected pursuant to a trading plan intended to comply with Rule 10b5-1(c) and adopted by the Reporting Person on June 15, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.84 to $0.8717, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001013762-23-003902 · ownership.xml · nonDerivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO & Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 331,188

F1 · shares: These shares were withheld by the Issuer in order to satisfy certain tax withholding obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001013762-23-003903 · ownership.xml · nonDerivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,097

F1 · shares: These shares were withheld by the Issuer in order to satisfy certain tax withholding obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-079569 · ownership.xml · derivative · entry 1

CROSS HERB · CIK 0001230721 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 550,000

Underlying: Voting Common Stock · 550,000 shares

Expires 2033-09-22

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on September 22, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-050220 · ownership.xml · derivative · entry 1

Brun Scott C. · CIK 0001863614 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,000

Underlying: Voting Common Stock · 94,000 shares

Expires 2033-06-20

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on June 20, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-048683 · ownership.xml · derivative · entry 3

Mahal Jeetinder Singh · CIK 0001882877 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 173,713

Underlying: Voting Common Stock · 9,000 shares

Expires 2030-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

F3 · derivative.exercise_date: 25% of the original number of shares subject to the option vested on December 12, 2020, and 1/48th of the original number of shares have vested and shall vest monthly thereafter, subject to the Reporting Person's continued service to the Issuer through each such vesting date.

SEC source: 0001213900-23-048683 · ownership.xml · nonDerivative · entry 2

Mahal Jeetinder Singh · CIK 0001882877 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 287,223

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.62 to $1.69, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price.

SEC source: 0001213900-23-048683 · ownership.xml · nonDerivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 296,223

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 15, 2023.

SEC source: 0001213900-23-048681 · ownership.xml · derivative · entry 1

Tucker Edwin Jonathan · CIK 0001792296 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Voting Common Stock · 400,000 shares

Expires 2033-06-12

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on June 12, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-047570 · ownership.xml · derivative · entry 1

Shizuru Judith Anne · CIK 0001883000 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047567 · ownership.xml · derivative · entry 1

French Anna Louise · CIK 0001871871 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047571 · ownership.xml · derivative · entry 1

EMSTER KURT VON · CIK 0001252524 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047568 · ownership.xml · derivative · entry 1

Lis William · CIK 0001574558 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047573 · ownership.xml · derivative · entry 1

Klein Lawrence Otto · CIK 0001762583 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047569 · ownership.xml · derivative · entry 1

Nolet Chris · CIK 0001782814 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-047574 · ownership.xml · derivative · entry 1

Kapoor Vishal · CIK 0001798946 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,000

Underlying: Voting Common Stock · 47,000 shares

Expires 2033-06-07

SEC source: 0001213900-23-029901 · ownership.xml · nonDerivative · entry 1

French Anna Louise · CIK 0001871871 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,750

F1 · shares: These shares were sold by the Reporting Person solely in order to satisfy certain tax obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-029900 · ownership.xml · nonDerivative · entry 1

EMSTER KURT VON · CIK 0001252524 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,175

F1 · shares: These shares were sold by the Reporting Person solely in order to satisfy certain tax obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-029888 · ownership.xml · nonDerivative · entry 1

Lis William · CIK 0001574558 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,486

F1 · shares: These shares were sold by the Reporting Person solely in order to satisfy certain tax obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-029896 · ownership.xml · nonDerivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO and Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 418,719

F1 · shares: These shares were withheld by the Issuer in order to satisfy certain tax withholding obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-029893 · ownership.xml · nonDerivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 287,223

F1 · shares: These shares were withheld by the Issuer in order to satisfy certain tax withholding obligations in connection with the issuance of shares of the Issuer's common stock upon the vesting of restricted stock units.

SEC source: 0001213900-23-021493 · marketforms-60958.xml · derivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO and Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 500,000

Underlying: Voting Common Stock · 500,000 shares

Expires 2033-03-17

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on March 3, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-021494 · marketforms-60959.xml · derivative · entry 1

Mahal Jeetinder Singh · CIK 0001882877 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Voting Common Stock · 350,000 shares

Expires 2033-03-17

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on March 3, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-012598 · ownership.xml · derivative · entry 1

Kapoor Vishal · CIK 0001798946 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,383

Underlying: Voting Common stock · 109,383 shares

Expires 2033-02-16

F1 · derivative.exercise_date: 1/3rd of the shares subject to the option shall vest on February 16, 2024, and 1/3rd of the shares subject to the option shall vest on each anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-23-007992 · ownership.xml · derivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO & Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,093,831

Underlying: Voting Common Stock · 1,093,831 shares

Expires 2033-02-02

F1 · derivative.exercise_date: 1/4th of the shares subject to the option shall vest on February 2, 2024, and 1/48th of the shares subject to the option shall vest following each one-month period thereafter, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0000899243-23-003059 · doc4.xml · nonDerivative · entry 1

Carlyle Group Inc. · CIK 0001527166 · 10% owner

Abingworth LLP · CIK 0001397144 · 10% owner

Carlyle Holdings I GP Inc. · CIK 0001548626 · 10% owner

Carlyle Holdings I GP Sub L.L.C. · CIK 0001548627 · 10% owner

Carlyle Holdings I L.P. · CIK 0001548628 · 10% owner

CG Subsidiary Holdings L.L.C. · CIK 0001790577 · 10% owner

TC Group, LLC · CIK 0000933790 · 10% owner

Carlyle Investment Management LLC · CIK 0001354120 · 10% owner

Carlyle Genesis UK LLC · CIK 0001941860 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 8,761,891

F1 · ownership.nature: Reflects securities held of record by Abingworth Bioventures VII LP ("ABV VII"). ABV VII has delegated to Abingworth LLP all investment and dispositive power over the securities held of record by ABV VII.

F2 · ownership.nature: The Carlyle Group Inc., which is a publicly traded entity listed on Nasdaq, is the sole shareholder of Carlyle Holdings I GP Inc., which is the sole member of Carlyle Holdings I GP Sub L.L.C., which is the general partner of Carlyle Holdings I L.P., which, with respect to the securities reported herein, is the managing member of CG Subsidiary Holdings L.L.C., which is the managing member of TC Group, L.L.C., which is the managing member of Carlyle Investment Management, L.L.C., which is the sole member of Carlyle Genesis UK LLC, which is the principal member of Abingworth LLP. Accordingly, each of the foregoing entities may be deemed to share beneficial ownership of the securities held of record by ABV VII, but each disclaims beneficial ownership of such securities except to the extent of their pecuniary interest therein, if any.

SEC source: 0001209191-23-024058 · doc4.xml · nonDerivative · entry 1

Qiming U.S. Healthcare Fund II, L.P. · CIK 0001765710 · 10% owner

Qiming U.S. Healthcare GP II, LLC · CIK 0001868862 · 10% owner

MCDADE MARK · CIK 0001242126 · 10% owner

RIESCHEL GARY E · CIK 0001248153 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,519,648

F1 · ownership.direct: The securities are directly held by Qiming U.S. Healthcare Fund II, L.P. ("Qiming"). The general partner of Qiming is Qiming U.S. Healthcare GP II, LLC ("Qiming GP"). Gary Rieschel and Mark McDade are the managing partners of Qiming GP and may be deemed to share voting and dispositive power over the shares held by Qiming. Each of Qiming GP and Messrs. Rieschel and McDade disclaims beneficial ownership of such shares except to the extent of its or his pecuniary interest therein.

SEC source: 0001104659-23-007094 · tm234575-1_4seq1.xml · nonDerivative · entry 1

ROCHE HOLDING LTD · CIK 0000889131 · 10% owner

ROCHE FINANCE LTD · CIK 0001053942 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 4,549,606

F1 · ownership.nature: Represents shares held by Roche Finance Ltd ("Roche Finance"). Roche Finance is a wholly owned subsidiary of Roche Holding Ltd ("Roche Holding"), a Swiss corporation whose shares are traded on the SIX Swiss Exchange. Roche Holding is the indirect beneficial owner of these securities of the Issuer. This Form 4 shall not be deemed an admission that any reporting person or other person is a beneficial owner of any securities of the Issuer for any purpose, other than the securities reported in this Form 4.

SEC source: 0001213900-22-063943 · ownership.xml · nonDerivative · entry 1

Shizuru Judith Anne · CIK 0001883000 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,159,012

F1 · shares: The reported securities are represented by restricted stock units, 1/2 of which shall vest on each of April 12, 2023 and October 12, 2023, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.

SEC source: 0001213900-22-063949 · ownership.xml · nonDerivative · entry 1

MARTELL RON · CIK 0001177079 · Director · President, CEO and Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 506,250

F1 · shares: The reported securities are represented by restricted stock units, 1/2 of which shall vest on each of April 12, 2023 and October 12, 2023, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive.